{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:44:32Z","timestamp":1792788272178,"version":"4.5.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Zhejiang Province New Talent Program","award":["2024R413C091"],"award-info":[{"award-number":["2024R413C091"]}]},{"name":"Zhejiang Province Medical and Health Science and Technology Program","award":["2024KY1288"],"award-info":[{"award-number":["2024KY1288"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"DOI":"10.1186\/s12974-025-03606-0","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T12:51:51Z","timestamp":1764766311000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["SIK2 mediated mitochondrial homeostasis in spinal cord injury: modulating oxidative stress and the AIM2 inflammasome via CRTC1\/CREB signaling"],"prefix":"10.1186","volume":"22","author":[{"given":"Nongtao","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yige","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yikang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangji","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaosen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"3606_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.18","volume":"3","author":"CS Ahuja","year":"2017","unstructured":"Ahuja CS, Wilson JR, Nori S, Kotter MRN, Druschel C, Curt A, et al. Traumatic spinal cord injury. Nat Rev Dis Primers. 2017;3:17018.","journal-title":"Nat Rev Dis Primers"},{"key":"3606_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00282","volume":"10","author":"A Alizadeh","year":"2019","unstructured":"Alizadeh A, Dyck SM, Karimi-Abdolrezaee S. Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms. Front Neurol. 2019;10:282.","journal-title":"Front Neurol"},{"key":"3606_CR3","doi-asserted-by":"publisher","first-page":"S9","DOI":"10.1093\/neuros\/nyw080","volume":"80","author":"CS Ahuja","year":"2017","unstructured":"Ahuja CS, Nori S, Tetreault L, Wilson J, Kwon B, Harrop J, Choi D, Fehlings MG. Traumatic spinal cord Injury-Repair and regeneration. Neurosurgery. 2017;80:S9\u201322.","journal-title":"Neurosurgery"},{"key":"3606_CR4","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01477-6","volume":"8","author":"X Hu","year":"2023","unstructured":"Hu X, Xu W, Ren Y, Wang Z, He X, Huang R, et al. Spinal cord injury: molecular mechanisms and therapeutic interventions. Signal Transduct Target Ther. 2023;8:245.","journal-title":"Signal Transduct Target Ther"},{"key":"3606_CR5","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.269","volume":"11","author":"S Xu","year":"2021","unstructured":"Xu S, Wang J, Zhong J, Shao M, Jiang J, Song J, et al. CD73 alleviates GSDMD-mediated microglia pyroptosis in spinal cord injury through PI3K\/AKT\/Foxo1 signaling. Clin Transl Med. 2021;11:e269.","journal-title":"Clin Transl Med"},{"key":"3606_CR6","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1038\/nm.4354","volume":"23","author":"M Hara","year":"2017","unstructured":"Hara M, Kobayakawa K, Ohkawa Y, Kumamaru H, Yokota K, Saito T, et al. Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin-N-cadherin pathway after spinal cord injury. Nat Med. 2017;23:818\u201328.","journal-title":"Nat Med"},{"key":"3606_CR7","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/s41422-025-01107-6","volume":"35","author":"P Broz","year":"2025","unstructured":"Broz P. Pyroptosis: molecular mechanisms and roles in disease. Cell Res. 2025;35:334\u201344.","journal-title":"Cell Res"},{"key":"3606_CR8","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.7150\/ijbs.45467","volume":"16","author":"X Hu","year":"2020","unstructured":"Hu X, Chen H, Xu H, Wu Y, Wu C, Jia C, et al. Role of pyroptosis in traumatic brain and spinal cord injuries. Int J Biol Sci. 2020;16:2042\u201350.","journal-title":"Int J Biol Sci"},{"key":"3606_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1649790","volume":"16","author":"L Shi","year":"2025","unstructured":"Shi L, Qian Q, Xie J, Yang T, Zhao X, Meng X, et al. Microglial pyroptosis as a therapeutic target after traumatic spinal cord injury: current progress and future directions. Front Immunol. 2025;16:1649790.","journal-title":"Front Immunol"},{"key":"3606_CR10","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/imr.12618","volume":"281","author":"J Lugrin","year":"2018","unstructured":"Lugrin J, Martinon F. The AIM2 inflammasome: sensor of pathogens and cellular perturbations. Immunol Rev. 2018;281:99\u2013114.","journal-title":"Immunol Rev"},{"key":"3606_CR11","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/s41586-020-2174-3","volume":"580","author":"CR Lammert","year":"2020","unstructured":"Lammert CR, Frost EL, Bellinger CE, Bolte AC, McKee CA, Hurt ME, et al. AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment. Nature. 2020;580:647\u201352.","journal-title":"Nature"},{"key":"3606_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.05.038","volume":"160","author":"XQ Li","year":"2019","unstructured":"Li XQ, Yu Q, Fang B, Zhang ZL, Ma H. Knockdown of the AIM2 molecule attenuates ischemia-reperfusion-induced spinal neuronal pyroptosis by inhibiting AIM2 inflammasome activation and subsequent release of cleaved caspase-1 and IL-1\u03b2. Neuropharmacology. 2019;160:107661.","journal-title":"Neuropharmacology"},{"key":"3606_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2023.109881","volume":"259","author":"R Fu","year":"2024","unstructured":"Fu R, Zhao L, Guo Y, Qin X, Xu W, Cheng X, et al. AIM2 inflammasome: a potential therapeutic target in ischemic stroke. Clin Immunol. 2024;259:109881.","journal-title":"Clin Immunol"},{"key":"3606_CR14","doi-asserted-by":"publisher","first-page":"4544","DOI":"10.1038\/s41380-020-00971-5","volume":"26","author":"L Poh","year":"2021","unstructured":"Poh L, Fann DY, Wong P, Lim HM, Foo SL, Kang SW, et al. AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia. Mol Psychiatry. 2021;26:4544\u201360.","journal-title":"Mol Psychiatry"},{"key":"3606_CR15","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201796","author":"C Ma","year":"2021","unstructured":"Ma C, Li S, Hu Y, Ma Y, Wu Y, Wu C, et al. AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis. J Exp Med. 2021. https:\/\/doi.org\/10.1084\/jem.20201796.","journal-title":"J Exp Med"},{"key":"3606_CR16","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1002\/glia.24260","volume":"70","author":"WJ Rui","year":"2022","unstructured":"Rui WJ, Li S, Yang L, Liu Y, Fan Y, Hu YC, et al. Microglial AIM2 alleviates antiviral-related neuro-inflammation in mouse models of parkinson\u2019s disease. Glia. 2022;70:2409\u201325.","journal-title":"Glia"},{"key":"3606_CR17","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/s41590-021-01017-w","volume":"22","author":"NJ Bernard","year":"2021","unstructured":"Bernard NJ. Mitochondria control pyroptosis. Nat Immunol. 2021;22:1071.","journal-title":"Nat Immunol"},{"key":"3606_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102322","volume":"52","author":"Y Wang","year":"2022","unstructured":"Wang Y, Chen C, Chen J, Sang T, Peng H, Lin X, et al. Overexpression of NAG-1\/GDF15 prevents hepatic steatosis through inhibiting oxidative stress-mediated DsDNA release and AIM2 inflammasome activation. Redox Biol. 2022;52:102322.","journal-title":"Redox Biol"},{"key":"3606_CR19","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.freeradbiomed.2024.05.032","volume":"222","author":"Y Li","year":"2024","unstructured":"Li Y, Tian L, Li S, Chen X, Lei F, Bao J, et al. Disrupted mitochondrial transcription factor A expression promotes mitochondrial dysfunction and enhances ocular surface inflammation by activating the absent in melanoma 2 inflammasome. Free Radic Biol Med. 2024;222:106\u201321.","journal-title":"Free Radic Biol Med"},{"issue":"8","key":"3606_CR20","doi-asserted-by":"publisher","first-page":"6101","DOI":"10.1007\/s12035-024-03936-9","volume":"61","author":"Y Wang","year":"2024","unstructured":"Wang Y, Fang N, Wang Y, Geng Y, Li Y. Activating MC4R promotes functional recovery by repressing oxidative stress-mediated AIM2 activation post-spinal cord injury. Mol Neurobiol. 2024;61(8):6101\u201318.","journal-title":"Mol Neurobiol"},{"key":"3606_CR21","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.neuron.2010.12.004","volume":"69","author":"T Sasaki","year":"2011","unstructured":"Sasaki T, Takemori H, Yagita Y, Terasaki Y, Uebi T, Horike N, et al. SIK2 is a key regulator for neuronal survival after ischemia via TORC1-CREB. Neuron. 2011;69:106\u201319.","journal-title":"Neuron"},{"key":"3606_CR22","doi-asserted-by":"publisher","first-page":"3108","DOI":"10.1161\/STROKEAHA.117.017681","volume":"48","author":"L Ma","year":"2017","unstructured":"Ma L, Manaenko A, Ou YB, Shao AW, Yang SX, Zhang JH. Bosutinib attenuates inflammation via inhibiting Salt-inducible kinases in experimental model of intracerebral hemorrhage on mice. Stroke. 2017;48:3108\u201316.","journal-title":"Stroke"},{"key":"3606_CR23","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1042\/BCJ20160646","volume":"474","author":"NJ Darling","year":"2017","unstructured":"Darling NJ, Toth R, Arthur JS, Clark K. Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages. Biochem J. 2017;474:521\u201337.","journal-title":"Biochem J"},{"key":"3606_CR24","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.canlet.2019.10.029","volume":"469","author":"T Gao","year":"2020","unstructured":"Gao T, Zhang X, Zhao J, Zhou F, Wang Y, Zhao Z, et al. SIK2 promotes reprogramming of glucose metabolism through PI3K\/AKT\/HIF-1\u03b1 pathway and Drp1-mediated mitochondrial fission in ovarian cancer. Cancer Lett. 2020;469:89\u2013101.","journal-title":"Cancer Lett"},{"key":"3606_CR25","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.biopsych.2018.10.004","volume":"85","author":"B Jiang","year":"2019","unstructured":"Jiang B, Wang H, Wang JL, Wang YJ, Zhu Q, Wang CN, et al. Hippocampal Salt-Inducible Kinase 2 Plays a Role\u00a0in Depression via the CREB-Regulated Transcription Coactivator 1\u2013cAMP Response Element Binding\u2013Brain-Derived Neurotrophic Factor Pathway. Biol Psychiatry. 2019;85:650\u201366.","journal-title":"Biol Psychiatry"},{"key":"3606_CR26","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-025-04001-5","volume":"23","author":"R Zhao","year":"2025","unstructured":"Zhao R, Su Z, Gu J, Zhao H, Bian L, Jiang Y, et al. Enhancing anti-CD3 mAb-mediated diabetes remission in autoimmune diabetes through regulation of dynamin-related protein 1(Drp1)-mediated mitochondrial dynamics in exhausted CD8(+)T-cell subpopulations. BMC Med. 2025;23:189.","journal-title":"BMC Med"},{"key":"3606_CR27","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.jot.2025.01.013","volume":"51","author":"S Su","year":"2025","unstructured":"Su S, Wu X, Li B, Zhang F, Zhang K, Wang H, et al. Inhibition of ERK1\/2 mediated activation of Drp1 alleviates intervertebral disc degeneration via suppressing pyroptosis and apoptosis in nucleus pulposus cells. J Orthop Translat. 2025;51:163\u201375.","journal-title":"J Orthop Translat"},{"key":"3606_CR28","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02337-2","volume":"18","author":"DJ Hellenbrand","year":"2021","unstructured":"Hellenbrand DJ, Quinn CM, Piper ZJ, Morehouse CN, Fixel JA, Hanna AS. Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration. J Neuroinflammation. 2021;18:284.","journal-title":"J Neuroinflammation"},{"key":"3606_CR29","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-024-01539-4","volume":"22","author":"J Guo","year":"2024","unstructured":"Guo J, Tang X, Deng P, Hui H, Chen B, An J, et al. Interleukin-4 from curcumin-activated OECs emerges as a central modulator for increasing M2 polarization of microglia\/macrophage in OEC anti-inflammatory activity for functional repair of spinal cord injury. Cell Commun Signal. 2024;22:162.","journal-title":"Cell Commun Signal"},{"key":"3606_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113310","volume":"329","author":"NA Devanney","year":"2020","unstructured":"Devanney NA, Stewart AN, Gensel JC. Microglia and macrophage metabolism in CNS injury and disease: the role of immunometabolism in neurodegeneration and neurotrauma. Exp Neurol. 2020;329:113310.","journal-title":"Exp Neurol"},{"key":"3606_CR31","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1007\/s10787-022-01090-z","volume":"31","author":"Y Liu","year":"2023","unstructured":"Liu Y, Zhang F, Sun Q, Liang L. Adalimumab combined with erythropoietin improves recovery from spinal cord injury by suppressing microglial M1 polarization-mediated neural inflammation and apoptosis. Inflammopharmacology. 2023;31:887\u201397.","journal-title":"Inflammopharmacology"},{"key":"3606_CR32","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.13070","volume":"32","author":"HJ Zhou","year":"2022","unstructured":"Zhou HJ, Wang LQ, Zhan RY, Zheng XJ, Zheng JS. Lncrna MEG3 restrained the M1 polarization of microglia in acute spinal cord injury through the HuR\/A20\/NF-\u03baB axis. Brain Pathol. 2022;32:e13070.","journal-title":"Brain Pathol"},{"key":"3606_CR33","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1111\/cns.13839","volume":"28","author":"MT Xue","year":"2022","unstructured":"Xue MT, Sheng WJ, Song X, Shi YJ, Geng ZJ, Shen L, et al. Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial\/macrophage polarization. CNS Neurosci Ther. 2022;28:1059\u201371.","journal-title":"CNS Neurosci Ther"},{"key":"3606_CR34","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0014-5793(99)00708-5","volume":"453","author":"Z Wang","year":"1999","unstructured":"Wang Z, Takemori H, Halder SK, Nonaka Y, Okamoto M. Cloning of a novel kinase (SIK) of the SNF1\/AMPK family from high salt diet-treated rat adrenal. FEBS Lett. 1999;453:135\u20139.","journal-title":"FEBS Lett"},{"key":"3606_CR35","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/ejhg.2016.145","volume":"25","author":"C Pr\u00f6schel","year":"2017","unstructured":"Pr\u00f6schel C, Hansen JN, Ali A, Tuttle E, Lacagnina M, Buscaglia G, et al. Epilepsy-causing sequence variations in SIK1 disrupt synaptic activity response gene expression and affect neuronal morphology. Eur J Hum Genet. 2017;25:216\u201321.","journal-title":"Eur J Hum Genet"},{"key":"3606_CR36","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2021.706494","volume":"14","author":"M Badawi","year":"2021","unstructured":"Badawi M, Mori T, Kurihara T, Yoshizawa T, Nohara K, Kouyama-Suzuki E, et al. Risperidone mitigates enhanced excitatory neuronal function and repetitive behavior caused by an ASD-associated mutation of SIK1. Front Mol Neurosci. 2021;14:706494.","journal-title":"Front Mol Neurosci"},{"key":"3606_CR37","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04465-1","volume":"79","author":"K Wang","year":"2022","unstructured":"Wang K, Wang C, Chen D, Huang Y, Li J, Wei P, et al. The role of microglial\/macrophagic salt-inducible kinase 3 on normal and excessive phagocytosis after transient focal cerebral ischemia. Cell Mol Life Sci. 2022;79:439.","journal-title":"Cell Mol Life Sci"},{"key":"3606_CR38","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70341","volume":"31","author":"W Liang","year":"2025","unstructured":"Liang W, Zhang C, Wang D, Su X, Tan X, Yang Y, et al. Inhibition of salt-inducible kinase 2 protects motor neurons from degeneration in ALS by activating autophagic flux and enhancing mTORC1 activity. CNS Neurosci Ther. 2025;31:e70341.","journal-title":"CNS Neurosci Ther"},{"key":"3606_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100428","volume":"296","author":"NJ Darling","year":"2021","unstructured":"Darling NJ, Arthur JSC, Cohen P. Salt-inducible kinases are required for the IL-33-dependent secretion of cytokines and chemokines in mast cells. J Biol Chem. 2021;296:100428.","journal-title":"J Biol Chem"},{"key":"3606_CR40","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02307-8","volume":"18","author":"R Shao","year":"2021","unstructured":"Shao R, Wang X, Xu T, Xia Y, Cui D. The balance between AIM2-associated inflammation and autophagy: the role of CHMP2A in brain injury after cardiac arrest. J Neuroinflammation. 2021;18:257.","journal-title":"J Neuroinflammation"},{"key":"3606_CR41","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1089\/neu.2021.0464","volume":"39","author":"Z Zhou","year":"2022","unstructured":"Zhou Z, Li C, Bao T, Zhao X, Xiong W, Luo C, et al. Exosome-shuttled miR-672-5p from anti-inflammatory microglia repair traumatic spinal cord injury by inhibiting AIM2\/ASC\/caspase-1 signaling pathway mediated neuronal pyroptosis. J Neurotrauma. 2022;39:1057\u201374.","journal-title":"J Neurotrauma"},{"key":"3606_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110394","volume":"121","author":"X Xiao","year":"2023","unstructured":"Xiao X, Chen XY, Dong YH, Dong HR, Zhou LN, Ding YQ, et al. Pre-treatment of rapamycin transformed M2 microglia alleviates traumatic cervical spinal cord injury via AIM2 signaling pathway in vitro and in vivo. Int Immunopharmacol. 2023;121:110394.","journal-title":"Int Immunopharmacol"},{"key":"3606_CR43","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13860","volume":"22","author":"L Ye","year":"2023","unstructured":"Ye L, Shu S, Jia J, Sun M, Xu S, Bao X, et al. Absent in melanoma 2 mediates aging-related cognitive dysfunction by acting on complement-dependent microglial phagocytosis. Aging Cell. 2023;22:e13860.","journal-title":"Aging Cell"},{"key":"3606_CR44","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-025-03363-0","volume":"22","author":"G Zhang","year":"2025","unstructured":"Zhang G, Wei H, Zhao A, Yan X, Zhang X, Gan J, et al. Mitochondrial DNA leakage: underlying mechanisms and therapeutic implications in neurological disorders. J Neuroinflammation. 2025;22:34.","journal-title":"J Neuroinflammation"},{"key":"3606_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2024.114950","volume":"382","author":"F Gu","year":"2024","unstructured":"Gu F, Wang Z, Ding H, Tao X, Zhang J, Dai K, et al. Microglial mitochondrial DNA release contributes to neuroinflammation after intracerebral hemorrhage through activating AIM2 inflammasome. Exp Neurol. 2024;382:114950.","journal-title":"Exp Neurol"},{"key":"3606_CR46","doi-asserted-by":"publisher","first-page":"2808","DOI":"10.1016\/j.celrep.2018.08.029","volume":"24","author":"KI Kuwako","year":"2018","unstructured":"Kuwako KI, Okano H. The LKB1-SIK pathway controls dendrite Self-Avoidance in purkinje cells. Cell Rep. 2018;24:2808\u2013e28182804.","journal-title":"Cell Rep"},{"key":"3606_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2023.10.045","volume":"684","author":"Y Xu","year":"2023","unstructured":"Xu Y, Xu L, Kong Y, Li K, Li J, Xu F, et al. IGF2BP1 enhances the stability of SIK2 mRNA through m(6)A modification to promote non-small cell lung cancer progression. Biochem Biophys Res Commun. 2023;684:149113.","journal-title":"Biochem Biophys Res Commun"},{"key":"3606_CR48","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.gendis.2022.02.004","volume":"10","author":"J Zhu","year":"2023","unstructured":"Zhu J, Zhang Y, Yan Z, Wang J, Wang P, Liang X, et al. Ubiquitination and degradation of SIK2 by DNA-PKcs deficiency promote radiation-induced mitotic catastrophe. Genes Dis. 2023;10:313\u20136.","journal-title":"Genes Dis"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-025-03606-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12974-025-03606-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-025-03606-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T14:01:51Z","timestamp":1764770511000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-025-03606-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,3]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3606"],"URL":"https:\/\/doi.org\/10.1186\/s12974-025-03606-0","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,3]]},"assertion":[{"value":"17 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experimental procedures were conducted according to the guidelines described in the revised 2011 Chinese Regulations for the Administration of Affairs Concerning Experimental Animals and approved by the Institutional Animal Care and Use Committee of Wenzhou Medical University (Approval No. XMSQ-2024-062).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"283"}}