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This framework positions altered microbial composition as one among many environmental factors that modulate brain resilience across aging and disease contexts. Chronic low-grade inflammation driven by compositional and functional changes in the gut microbiota, intestinal barrier dysfunction, and alterations in bacterial metabolites contributes to systemic immune activation, affecting blood-brain barrier integrity, microglial function, and neuronal stress responses. These mechanisms operate across neurodegeneration, viral-associated cognitive decline, and brain tumor progression without constituting primary disease triggers. Aging amplifies microbiota-mediated inflammatory effects through progressive loss of microbial diversity and increased intestinal permeability. Evidence demonstrates associations between altered microbial composition and brain pathology, though these relationships reflect shared inflammatory pathways rather than direct microbial causation and are substantially confounded by diet, medication use, geographic variation, and disease-related behavioral changes. The vulnerability threshold framework proposed here is distinct from multi-hit models: rather than constituting an independent pathogenic insult, microbiota-derived signals modulate the quantitative threshold at which a given level of neurological stress produces clinical disease expression. This vulnerability-threshold model generates testable predictions: microbiota normalization should delay but not prevent neurodegeneration in high-genetic-risk individuals, and the severity of microbiota-associated inflammatory burden should predict the rate of progression rather than disease identity, predictions that longitudinal intervention trials can now begin to test.<\/jats:p>","DOI":"10.1186\/s12974-026-03824-0","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T03:46:33Z","timestamp":1776829593000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Microbiota as a regulator of brain vulnerability across lifespan and disease contexts"],"prefix":"10.1186","volume":"23","author":[{"given":"Maryline","family":"Santerre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Shcherbik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassel E","family":"Sawaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"issue":"5","key":"3824_CR1","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S1474-4422(18)30499-X","volume":"18","author":"GBD 2016 Neurology Collaborators","year":"2019","unstructured":"GBD 2016 Neurology Collaborators. 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