{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:13:02Z","timestamp":1788873182632,"version":"build-2803163510"},"reference-count":114,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":77,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"National Health and Medical Research Council of Australia Ideas Grant"},{"name":"National Health and Medical Research Council of Australia Investigator Leadership Grant"},{"name":"National Health and Medical Research Council of Australia Development Grant"},{"name":"Rebecca Cooper Medical Research Foundation Fellowship"},{"name":"Priority-driven Collaborative Cancer Research Scheme and co-funded by Cancer Australia, Cure Cancer, and Leukaemia Foundation of Australia","award":["1163245"],"award-info":[{"award-number":["1163245"]}]},{"name":"The Hospital Research Foundation Research Fellowship"},{"name":"The Hospital Research Foundation Innovations in Pain Management grant"},{"name":"Cancer Council SA\u2019s Beat Cancer Project on behalf of its donors and the State Government of South Australia through the Department of Health and Wellbeing"},{"name":"The Hospital Research Foundation Myeloma Fellowship"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"DOI":"10.1186\/s12974-026-03909-w","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:04:56Z","timestamp":1782212696000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bortezomib-induced gastrointestinal dysfunction, peripheral neuropathy and neuroimmune signalling are influenced by the gut microbiota in mice"],"prefix":"10.1186","volume":"23","author":[{"given":"Jacqui S.","family":"Scott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadia","family":"Munir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam A.","family":"Lynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jvaughn A.","family":"Duggan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M.","family":"Harrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart M.","family":"Brierley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Schober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Cash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernice","family":"Gutschmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Hutchinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina","family":"Yong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel P.","family":"Costello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suranjana","family":"Sikdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawanrat","family":"Tangseefa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan R.","family":"Hewett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney B.","family":"Cross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna B.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feargal J.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C. W.","family":"Zannettino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Lynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Vandyke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah R.","family":"Wardill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof M.","family":"Mrozik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"3909_CR1","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1002\/ajh.27422","volume":"99","author":"SV Rajkumar","year":"2024","unstructured":"Rajkumar SV. Multiple myeloma: 2024 update on diagnosis, risk-stratification, and management. Am J Hematol. 2024;99:1802\u201324.","journal-title":"Am J Hematol"},{"key":"3909_CR2","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s40265-022-01830-z","volume":"83","author":"G Palladini","year":"2023","unstructured":"Palladini G, Milani P. Diagnosis and Treatment of AL Amyloidosis. Drugs. 2023;83:203\u201316.","journal-title":"Drugs"},{"key":"3909_CR3","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s10555-017-9707-8","volume":"36","author":"S Gandolfi","year":"2017","unstructured":"Gandolfi S, Laubach JP, Hideshima T, Chauhan D, Anderson KC, Richardson PG. The proteasome and proteasome inhibitors in multiple myeloma. Cancer Metastasis Rev. 2017;36:561\u201384.","journal-title":"Cancer Metastasis Rev"},{"key":"3909_CR4","doi-asserted-by":"publisher","first-page":"104353","DOI":"10.1016\/j.critrevonc.2024.104353","volume":"197","author":"Y Yang","year":"2024","unstructured":"Yang Y, Zhao B, Lan H, Sun J, Wei G. Bortezomib-induced peripheral neuropathy: Clinical features, molecular basis, and therapeutic approach. Crit Rev Oncol Hematol. 2024;197:104353.","journal-title":"Crit Rev Oncol Hematol"},{"key":"3909_CR5","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1080\/14740338.2018.1513487","volume":"17","author":"G Cengiz Seval","year":"2018","unstructured":"Cengiz Seval G, Beksac M. The safety of bortezomib for the treatment of multiple myeloma. Expert Opin Drug Saf. 2018;17:953\u201362.","journal-title":"Expert Opin Drug Saf"},{"key":"3909_CR6","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1111\/j.1365-2141.2008.07359.x","volume":"143","author":"S Jagannath","year":"2008","unstructured":"Jagannath S, Barlogie B, Berenson JR, et al. Updated survival analyses after prolonged follow-up of the phase 2, multicenter CREST study of bortezomib in relapsed or refractory multiple myeloma. Br J Haematol. 2008;143:537\u201340.","journal-title":"Br J Haematol"},{"key":"3909_CR7","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1002\/ajh.23933","volume":"90","author":"MV Mateos","year":"2015","unstructured":"Mateos MV, Richardson PG, Dimopoulos MA, et al. Effect of cumulative bortezomib dose on survival in multiple myeloma patients receiving bortezomib-melphalan-prednisone in the phase III VISTA study. Am J Hematol. 2015;90:314\u20139.","journal-title":"Am J Hematol"},{"key":"3909_CR8","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1182\/blood-2008-04-149385","volume":"112","author":"AA Argyriou","year":"2008","unstructured":"Argyriou AA, Iconomou G, Kalofonos HP. Bortezomib-induced peripheral neuropathy in multiple myeloma: a comprehensive review of the literature. Blood. 2008;112:1593\u20139.","journal-title":"Blood"},{"key":"3909_CR9","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.jpain.2006.09.014","volume":"8","author":"JP Cata","year":"2007","unstructured":"Cata JP, Weng HR, Burton AW, Villareal H, Giralt S, Dougherty PM. Quantitative sensory findings in patients with bortezomib-induced pain. J Pain. 2007;8:296\u2013306.","journal-title":"J Pain"},{"key":"3909_CR10","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1002\/hon.2706","volume":"38","author":"T Li","year":"2020","unstructured":"Li T, Timmins HC, King T, Kiernan MC, Goldstein D, Park SB. Characteristics and risk factors of bortezomib induced peripheral neuropathy: A systematic review of phase III trials. Hematol Oncol. 2020;38:229\u201343.","journal-title":"Hematol Oncol"},{"key":"3909_CR11","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.1056\/NEJMoa030288","volume":"348","author":"PG Richardson","year":"2003","unstructured":"Richardson PG, Barlogie B, Berenson J, et al. A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med. 2003;348:2609\u201317.","journal-title":"N Engl J Med"},{"key":"3909_CR12","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/j.1365-2141.2004.05188.x","volume":"127","author":"S Jagannath","year":"2004","unstructured":"Jagannath S, Barlogie B, Berenson J, et al. A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma. Br J Haematol. 2004;127:165\u201372.","journal-title":"Br J Haematol"},{"key":"3909_CR13","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s12974-019-1461-0","volume":"16","author":"G Moschetti","year":"2019","unstructured":"Moschetti G, Amodeo G, Maftei D, et al. Targeting prokineticin system counteracts hypersensitivity, neuroinflammation, and tissue damage in a mouse model of bortezomib-induced peripheral neuropathy. J Neuroinflammation. 2019;16:89.","journal-title":"J Neuroinflammation"},{"key":"3909_CR14","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/s12974-018-1270-x","volume":"15","author":"C Meregalli","year":"2018","unstructured":"Meregalli C, Marjanovic I, Scali C, et al. High-dose intravenous immunoglobulins reduce nerve macrophage infiltration and the severity of bortezomib-induced peripheral neurotoxicity in rats. J Neuroinflammation. 2018;15:232.","journal-title":"J Neuroinflammation"},{"key":"3909_CR15","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1186\/s12974-018-1327-x","volume":"15","author":"K Chen","year":"2018","unstructured":"Chen K, Fan J, Luo ZF, Yang Y, Xin WJ, Liu CC. Reduction of SIRT1 epigenetically upregulates NALP1 expression and contributes to neuropathic pain induced by chemotherapeutic drug bortezomib. J Neuroinflammation. 2018;15:292.","journal-title":"J Neuroinflammation"},{"key":"3909_CR16","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.1056\/NEJMoa043445","volume":"352","author":"PG Richardson","year":"2005","unstructured":"Richardson PG, Sonneveld P, Schuster MW, et al. Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. N Engl J Med. 2005;352:2487\u201398.","journal-title":"N Engl J Med"},{"key":"3909_CR17","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/S0140-6736(16)31594-X","volume":"389","author":"BGM Durie","year":"2017","unstructured":"Durie BGM, Hoering A, Abidi MH, et al. Bortezomib with lenalidomide and dexamethasone versus lenalidomide and dexamethasone alone in patients with newly diagnosed myeloma without intent for immediate autologous stem-cell transplant (SWOG S0777): a randomised, open-label, phase 3 trial. Lancet. 2017;389:519\u201327.","journal-title":"Lancet"},{"key":"3909_CR18","doi-asserted-by":"publisher","first-page":"2210907","DOI":"10.1080\/16078454.2023.2210907","volume":"28","author":"W Zhao","year":"2023","unstructured":"Zhao W, Liu J, Wang L, Wang W. Study on autonomic neuropathy of the digestive system caused by bortezomib in the treatment of multiple myeloma. Hematology. 2023;28:2210907.","journal-title":"Hematology"},{"key":"3909_CR19","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1097\/SPC.0000000000000266","volume":"11","author":"RL Stansborough","year":"2017","unstructured":"Stansborough RL, Gibson RJ. Proteasome inhibitor-induced gastrointestinal toxicity. Curr Opin Support Palliat Care. 2017;11:133\u20137.","journal-title":"Curr Opin Support Palliat Care"},{"key":"3909_CR20","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1200\/JCO.2004.02.106","volume":"22","author":"CN Papandreou","year":"2004","unstructured":"Papandreou CN, Daliani DD, Nix D, et al. Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancer. J Clin Oncol. 2004;22:2108\u201321.","journal-title":"J Clin Oncol"},{"key":"3909_CR21","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s10238-015-0337-6","volume":"16","author":"G Mele","year":"2016","unstructured":"Mele G, Coppi MR, Melpignano A, Quarta G. Paralytic ileus following subcutaneous bortezomib therapy: focus on the clinical emergency-report of two cases. Clin Exp Med. 2016;16:99\u2013101.","journal-title":"Clin Exp Med"},{"key":"3909_CR22","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1097\/MEG.0b013e32811ebffe","volume":"19","author":"V Perfetti","year":"2007","unstructured":"Perfetti V, Palladini G, Brunetti L, et al. Bortezomib-induced paralytic ileus is a potential gastrointestinal side effect of this first-in-class anticancer proteasome inhibitor. Eur J Gastroenterol Hepatol. 2007;19:599\u2013601.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"3909_CR23","first-page":"2297","volume":"31","author":"T Fukushima","year":"2011","unstructured":"Fukushima T, Nakamura T, Iwao H, et al. Efficacy and safety of bortezomib plus dexamethasone therapy for refractory or relapsed multiple myeloma: once-weekly administration of bortezomib may reduce the incidence of gastrointestinal adverse events. Anticancer Res. 2011;31:2297\u2013302.","journal-title":"Anticancer Res"},{"key":"3909_CR24","doi-asserted-by":"publisher","first-page":"3325","DOI":"10.1200\/JCO.20.01399","volume":"38","author":"CL Loprinzi","year":"2020","unstructured":"Loprinzi CL, Lacchetti C, Bleeker J, et al. Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update. J Clin Oncol. 2020;38:3325\u201348.","journal-title":"J Clin Oncol"},{"key":"3909_CR25","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s00520-025-09190-6","volume":"33","author":"DL Hertz","year":"2025","unstructured":"Hertz DL, Tanay M, Tofthagen C, et al. Patient-reported strategies for prevention and treatment of chemotherapy-induced peripheral neuropathy. Support Care Cancer. 2025;33:142.","journal-title":"Support Care Cancer"},{"key":"3909_CR26","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1136\/gutjnl-2019-320204","volume":"69","author":"RK Weersma","year":"2020","unstructured":"Weersma RK, Zhernakova A, Fu J. Interaction between drugs and the gut microbiome. Gut. 2020;69:1510\u20139.","journal-title":"Gut"},{"key":"3909_CR27","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.jare.2023.11.027","volume":"64","author":"S Li","year":"2024","unstructured":"Li S, Zhu S, Yu J. The role of gut microbiota and metabolites in cancer chemotherapy. J Adv Res. 2024;64:223\u201335.","journal-title":"J Adv Res"},{"key":"3909_CR28","doi-asserted-by":"publisher","first-page":"100464","DOI":"10.1016\/j.xcrm.2021.100464","volume":"2","author":"SJ Blake","year":"2021","unstructured":"Blake SJ, James J, Ryan FJ, et al. The immunotoxicity, but not anti-tumor efficacy, of anti-CD40 and anti-CD137 immunotherapies is dependent on the gut microbiota. Cell Rep Med. 2021;2:100464.","journal-title":"Cell Rep Med"},{"key":"3909_CR29","doi-asserted-by":"publisher","first-page":"7374","DOI":"10.1073\/pnas.1918095117","volume":"117","author":"AP Bhatt","year":"2020","unstructured":"Bhatt AP, Pellock SJ, Biernat KA, et al. Targeted inhibition of gut bacterial beta-glucuronidase activity enhances anticancer drug efficacy. Proc Natl Acad Sci U S A. 2020;117:7374\u201381.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3909_CR30","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/s41577-023-00951-0","volume":"24","author":"SJ Blake","year":"2024","unstructured":"Blake SJ, Wolf Y, Boursi B, Lynn DJ. Role of the microbiota in response to and recovery from cancer therapy. Nat Rev Immunol. 2024;24:308\u201325.","journal-title":"Nat Rev Immunol"},{"key":"3909_CR31","doi-asserted-by":"crossref","unstructured":"Calabro S, Kankowski S, Cescon M, et al. Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions. Int J Mol Sci. 2023;24:8061.","DOI":"10.3390\/ijms24098061"},{"key":"3909_CR32","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1213\/ANE.0000000000005155","volume":"132","author":"W Ding","year":"2021","unstructured":"Ding W, You Z, Chen Q, et al. Gut Microbiota Influences Neuropathic Pain Through Modulating Proinflammatory and Anti-inflammatory T Cells. Anesth Analg. 2021;132:1146\u201355.","journal-title":"Anesth Analg"},{"key":"3909_CR33","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s10194-020-01170-x","volume":"21","author":"B Lin","year":"2020","unstructured":"Lin B, Wang Y, Zhang P, Yuan Y, Zhang Y, Chen G. Gut microbiota regulates neuropathic pain: potential mechanisms and therapeutic strategy. J Headache Pain. 2020;21:103.","journal-title":"J Headache Pain"},{"key":"3909_CR34","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s12929-018-0476-7","volume":"25","author":"MM Pusceddu","year":"2018","unstructured":"Pusceddu MM, Gareau MG. Visceral pain: gut microbiota, a new hope? J Biomed Sci. 2018;25:73.","journal-title":"J Biomed Sci"},{"key":"3909_CR35","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1097\/j.pain.0000000000002438","volume":"163","author":"E Lucarini","year":"2022","unstructured":"Lucarini E, Di Pilato V, Parisio C, et al. Visceral sensitivity modulation by faecal microbiota transplantation: the active role of gut bacteria in pain persistence. Pain. 2022;163:861\u201377.","journal-title":"Pain"},{"key":"3909_CR36","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1038\/nn.4606","volume":"20","author":"S Shen","year":"2017","unstructured":"Shen S, Lim G, You Z, et al. Gut microbiota is critical for the induction of chemotherapy-induced pain. Nat Neurosci. 2017;20:1213\u20136.","journal-title":"Nat Neurosci"},{"key":"3909_CR37","doi-asserted-by":"publisher","first-page":"20324","DOI":"10.1038\/s41598-019-56832-x","volume":"9","author":"C Ramakrishna","year":"2019","unstructured":"Ramakrishna C, Corleto J, Ruegger PM, et al. Dominant Role of the Gut Microbiota in Chemotherapy Induced Neuropathic Pain. Sci Rep. 2019;9:20324.","journal-title":"Sci Rep"},{"key":"3909_CR38","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1099\/mic.0.000149","volume":"161","author":"S Pedroso","year":"2015","unstructured":"Pedroso S, Vieira AT, Bastos RW, et al. Evaluation of mucositis induced by irinotecan after microbial colonization in germ-free mice. Microbiol (Reading). 2015;161:1950\u201360.","journal-title":"Microbiol (Reading)"},{"key":"3909_CR39","doi-asserted-by":"publisher","first-page":"e21430","DOI":"10.1096\/fj.202002441R","volume":"35","author":"J Castro","year":"2021","unstructured":"Castro J, Maddern J, Grundy L, et al. A mouse model of endometriosis that displays vaginal, colon, cutaneous, and bladder sensory comorbidities. FASEB J. 2021;35:e21430.","journal-title":"FASEB J"},{"key":"3909_CR40","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3389\/fnmol.2017.00284","volume":"10","author":"JR Deuis","year":"2017","unstructured":"Deuis JR, Dvorakova LS, Vetter I. Methods Used to Evaluate Pain Behaviors in Rodents. Front Mol Neurosci. 2017;10:284.","journal-title":"Front Mol Neurosci"},{"key":"3909_CR41","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.jneumeth.2013.12.010","volume":"224","author":"J Brodkin","year":"2014","unstructured":"Brodkin J, Frank D, Grippo R, et al. Validation and implementation of a novel high-throughput behavioral phenotyping instrument for mice. J Neurosci Methods. 2014;224:48\u201357.","journal-title":"J Neurosci Methods"},{"key":"3909_CR42","doi-asserted-by":"crossref","unstructured":"Castro J, Harrington AM, Lieu T, et al. Activation of pruritogenic TGR5, MrgprA3, and MrgprC11 on colon-innervating afferents induces visceral hypersensitivity. JCI Insight. 2019;4(20):e131712.","DOI":"10.1172\/jci.insight.131712"},{"key":"3909_CR43","doi-asserted-by":"publisher","first-page":"e76772","DOI":"10.1371\/journal.pone.0076772","volume":"8","author":"P Huehnchen","year":"2013","unstructured":"Huehnchen P, Boehmerle W, Endres M. Assessment of paclitaxel induced sensory polyneuropathy with Catwalk automated gait analysis in mice. PLoS ONE. 2013;8:e76772.","journal-title":"PLoS ONE"},{"key":"3909_CR44","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/s41582-024-00955-x","volume":"20","author":"M Khalil","year":"2024","unstructured":"Khalil M, Teunissen CE, Lehmann S, et al. Neurofilaments as biomarkers in neurological disorders - towards clinical application. Nat Rev Neurol. 2024;20:269\u201387.","journal-title":"Nat Rev Neurol"},{"key":"3909_CR45","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1016\/j.tips.2024.08.001","volume":"45","author":"NE Andersen","year":"2024","unstructured":"Andersen NE, Boehmerle W, Huehnchen P, Stage TB. Neurofilament light chain as a biomarker of chemotherapy-induced peripheral neuropathy. Trends Pharmacol Sci. 2024;45:872\u20139.","journal-title":"Trends Pharmacol Sci"},{"key":"3909_CR46","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.pain.2008.01.016","volume":"136","author":"M Rigaud","year":"2008","unstructured":"Rigaud M, Gemes G, Barabas ME, et al. Species and strain differences in rodent sciatic nerve anatomy: implications for studies of neuropathic pain. Pain. 2008;136:188\u2013201.","journal-title":"Pain"},{"key":"3909_CR47","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.coph.2003.06.011","volume":"3","author":"KN Browning","year":"2003","unstructured":"Browning KN. Excitability of nodose ganglion cells and their role in vago-vagal reflex control of gastrointestinal function. Curr Opin Pharmacol. 2003;3:613\u20137.","journal-title":"Curr Opin Pharmacol"},{"key":"3909_CR48","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25:402\u20138.","journal-title":"Methods"},{"key":"3909_CR49","doi-asserted-by":"publisher","first-page":"109564","DOI":"10.1016\/j.celrep.2021.109564","volume":"36","author":"MA Lynn","year":"2021","unstructured":"Lynn MA, Eden G, Ryan FJ, et al. The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life. Cell Rep. 2021;36:109564.","journal-title":"Cell Rep"},{"key":"3909_CR50","doi-asserted-by":"publisher","first-page":"101914","DOI":"10.1016\/j.xpro.2022.101914","volume":"3","author":"MA Lynn","year":"2022","unstructured":"Lynn MA, Ryan FJ, Tee YC, Lynn DJ. Protocol to colonize gnotobiotic mice in early life and assess the impact on early life immune programming. STAR Protoc. 2022;3:101914.","journal-title":"STAR Protoc"},{"key":"3909_CR51","doi-asserted-by":"publisher","first-page":"1979878","DOI":"10.1080\/19490976.2021.1979878","volume":"13","author":"KR Secombe","year":"2021","unstructured":"Secombe KR, Al-Qadami GH, Subramaniam CB, et al. Guidelines for reporting on animal fecal transplantation (GRAFT) studies: recommendations from a systematic review of murine transplantation protocols. Gut Microbes. 2021;13:1979878.","journal-title":"Gut Microbes"},{"key":"3909_CR52","doi-asserted-by":"publisher","first-page":"101220","DOI":"10.1016\/j.xpro.2022.101220","volume":"3","author":"MA Lynn","year":"2022","unstructured":"Lynn MA, Ryan FJ, Tee YC, Benson SC, Lynn DJ. Protocol to assess the impact of early-life antibiotic exposure on murine longevity. STAR Protoc. 2022;3:101220.","journal-title":"STAR Protoc"},{"key":"3909_CR53","doi-asserted-by":"publisher","first-page":"637593","DOI":"10.3389\/fphar.2021.637593","volume":"12","author":"M Selvy","year":"2021","unstructured":"Selvy M, Kerckhove N, Pereira B, et al. Prevalence of Chemotherapy-Induced Peripheral Neuropathy in Multiple Myeloma Patients and its Impact on Quality of Life: A Single Center Cross-Sectional Study. Front Pharmacol. 2021;12:637593.","journal-title":"Front Pharmacol"},{"key":"3909_CR54","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1007\/s00520-015-3032-y","volume":"24","author":"AJ Beijers","year":"2016","unstructured":"Beijers AJ, Vreugdenhil G, Oerlemans S, et al. Chemotherapy-induced neuropathy in multiple myeloma: influence on quality of life and development of a questionnaire to compose common toxicity criteria grading for use in daily clinical practice. Support Care Cancer. 2016;24:2411\u201320.","journal-title":"Support Care Cancer"},{"key":"3909_CR55","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1096\/fba.2019-00073","volume":"2","author":"KM Mrozik","year":"2020","unstructured":"Mrozik KM, Cheong CM, Hewett DR, et al. LCRF-0006, a small molecule mimetic of the N-cadherin antagonist peptide ADH-1, synergistically increases multiple myeloma response to bortezomib. FASEB Bioadv. 2020;2:339\u201353.","journal-title":"FASEB Bioadv"},{"key":"3909_CR56","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1111\/bjh.19102","volume":"203","author":"CMD Williams","year":"2023","unstructured":"Williams CMD, Noll JE, Bradey AL, et al. Myeloperoxidase creates a permissive microenvironmental niche for the progression of multiple myeloma. Br J Haematol. 2023;203:614\u201324.","journal-title":"Br J Haematol"},{"key":"3909_CR57","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.expneurol.2010.02.006","volume":"223","author":"J Bruna","year":"2010","unstructured":"Bruna J, Udina E, Ale A, et al. Neurophysiological, histological and immunohistochemical characterization of bortezomib-induced neuropathy in mice. Exp Neurol. 2010;223:599\u2013608.","journal-title":"Exp Neurol"},{"key":"3909_CR58","doi-asserted-by":"publisher","first-page":"6370","DOI":"10.1038\/srep06370","volume":"4","author":"W Boehmerle","year":"2014","unstructured":"Boehmerle W, Huehnchen P, Peruzzaro S, Balkaya M, Endres M. Electrophysiological, behavioral and histological characterization of paclitaxel, cisplatin, vincristine and bortezomib-induced neuropathy in C57Bl\/6 mice. Sci Rep. 2014;4:6370.","journal-title":"Sci Rep"},{"key":"3909_CR59","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.expneurol.2013.12.020","volume":"253","author":"A Ale","year":"2014","unstructured":"Ale A, Bruna J, Morell M, et al. Treatment with anti-TNF alpha protects against the neuropathy induced by the proteasome inhibitor bortezomib in a mouse model. Exp Neurol. 2014;253:165\u201373.","journal-title":"Exp Neurol"},{"key":"3909_CR60","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1146\/annurev-physiol-020518-114525","volume":"81","author":"L Grundy","year":"2019","unstructured":"Grundy L, Erickson A, Brierley SM. Visceral Pain. Annu Rev Physiol. 2019;81:261\u201384.","journal-title":"Annu Rev Physiol"},{"key":"3909_CR61","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1080\/14728222.2023.2247563","volume":"27","author":"T Berta","year":"2023","unstructured":"Berta T, Strong JA, Zhang JM, Ji RR. Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update. Expert Opin Ther Targets. 2023;27:665\u201378.","journal-title":"Expert Opin Ther Targets"},{"key":"3909_CR62","doi-asserted-by":"publisher","first-page":"2997","DOI":"10.1007\/s00415-023-11624-2","volume":"270","author":"N Cebulla","year":"2023","unstructured":"Cebulla N, Schirmer D, Runau E, et al. Neurofilament light chain levels indicate acute axonal damage under bortezomib treatment. J Neurol. 2023;270:2997\u20133007.","journal-title":"J Neurol"},{"key":"3909_CR63","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1158\/1535-7163.MCT-15-0990","volume":"15","author":"HR Wardill","year":"2016","unstructured":"Wardill HR, Gibson RJ, Van Sebille YZ, et al. Irinotecan-Induced Gastrointestinal Dysfunction and Pain Are Mediated by Common TLR4-Dependent Mechanisms. Mol Cancer Ther. 2016;15:1376\u201386.","journal-title":"Mol Cancer Ther"},{"key":"3909_CR64","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.semcdb.2023.07.009","volume":"156","author":"Y Cao","year":"2024","unstructured":"Cao Y, Li R, Bai L. Vagal sensory pathway for the gut-brain communication. Semin Cell Dev Biol. 2024;156:228\u201343.","journal-title":"Semin Cell Dev Biol"},{"key":"3909_CR65","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13099-019-0299-4","volume":"11","author":"Z Fei","year":"2019","unstructured":"Fei Z, Lijuan Y, Xi Y, et al. Gut microbiome associated with chemotherapy-induced diarrhea from the CapeOX regimen as adjuvant chemotherapy in resected stage III colorectal cancer. Gut Pathog. 2019;11:18.","journal-title":"Gut Pathog"},{"key":"3909_CR66","doi-asserted-by":"crossref","unstructured":"Mafe AN, Busselberg D. Microbiome Integrity Enhances the Efficacy and Safety of Anticancer Drug. Biomedicines. 2025;13:422.","DOI":"10.3390\/biomedicines13020422"},{"key":"3909_CR67","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00280-010-1310-4","volume":"67","author":"A Kurita","year":"2011","unstructured":"Kurita A, Kado S, Matsumoto T, et al. Streptomycin alleviates irinotecan-induced delayed-onset diarrhea in rats by a mechanism other than inhibition of beta-glucuronidase activity in intestinal lumen. Cancer Chemother Pharmacol. 2011;67:201\u201313.","journal-title":"Cancer Chemother Pharmacol"},{"key":"3909_CR68","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1038\/s41385-022-00562-3","volume":"15","author":"CA Thomson","year":"2022","unstructured":"Thomson CA, Morgan SC, Ohland C, McCoy KD. From germ-free to wild: modulating microbiome complexity to understand mucosal immunology. Mucosal Immunol. 2022;15:1085\u201394.","journal-title":"Mucosal Immunol"},{"key":"3909_CR69","doi-asserted-by":"publisher","first-page":"1941711","DOI":"10.1080\/19490976.2021.1941711","volume":"13","author":"CE Gheorghe","year":"2021","unstructured":"Gheorghe CE, Ritz NL, Martin JA, Wardill HR, Cryan JF, Clarke G. Investigating causality with fecal microbiota transplantation in rodents: applications, recommendations and pitfalls. Gut Microbes. 2021;13:1941711.","journal-title":"Gut Microbes"},{"key":"3909_CR70","doi-asserted-by":"publisher","first-page":"1149618","DOI":"10.3389\/fneur.2023.1149618","volume":"14","author":"R Solanki","year":"2023","unstructured":"Solanki R, Karande A, Ranganathan P. Emerging role of gut microbiota dysbiosis in neuroinflammation and neurodegeneration. Front Neurol. 2023;14:1149618.","journal-title":"Front Neurol"},{"key":"3909_CR71","doi-asserted-by":"publisher","first-page":"176818","DOI":"10.1016\/j.ejphar.2024.176818","volume":"979","author":"S Shatunova","year":"2024","unstructured":"Shatunova S, Aktar R, Peiris M, Lee JYP, Vetter I, Starobova H. The role of the gut microbiome in neuroinflammation and chemotherapy-induced peripheral neuropathy. Eur J Pharmacol. 2024;979:176818.","journal-title":"Eur J Pharmacol"},{"key":"3909_CR72","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s10286-012-0164-8","volume":"22","author":"A Stratogianni","year":"2012","unstructured":"Stratogianni A, Tosch M, Schlemmer H, et al. Bortezomib-induced severe autonomic neuropathy. Clin Auton Res. 2012;22:199\u2013202.","journal-title":"Clin Auton Res"},{"key":"3909_CR73","doi-asserted-by":"crossref","unstructured":"Rahman AA, Masango P, Stavely R, Bertrand P, Page A, Nurgali K. Oxaliplatin-Induced Damage to the Gastric Innervation: Role in Nausea and Vomiting. Biomolecules. 2023;13:276.","DOI":"10.3390\/biom13020276"},{"key":"3909_CR74","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.autneu.2008.05.004","volume":"141","author":"PA Cabezos","year":"2008","unstructured":"Cabezos PA, Vera G, Castillo M, Fernandez-Pujol R, Martin MI, Abalo R. Radiological study of gastrointestinal motor activity after acute cisplatin in the rat. Temporal relationship with pica. Auton Neurosci. 2008;141:54\u201365.","journal-title":"Auton Neurosci"},{"key":"3909_CR75","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1097\/MEG.0b013e3282f5f75e","volume":"20","author":"CA Koch","year":"2008","unstructured":"Koch CA, Uwaifo GI. Are gastrointestinal symptoms related to diabetes mellitus and glycemic control? Eur J Gastroenterol Hepatol. 2008;20:822\u20135.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"3909_CR76","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1007\/s11894-007-0031-2","volume":"9","author":"MA Shafi","year":"2007","unstructured":"Shafi MA, Pasricha PJ. Post-surgical and obstructive gastroparesis. Curr Gastroenterol Rep. 2007;9:280\u20135.","journal-title":"Curr Gastroenterol Rep"},{"key":"3909_CR77","doi-asserted-by":"publisher","first-page":"e13380","DOI":"10.1111\/nmo.13380","volume":"30","author":"KH Lu","year":"2018","unstructured":"Lu KH, Cao J, Oleson S, et al. Vagus nerve stimulation promotes gastric emptying by increasing pyloric opening measured with magnetic resonance imaging. Neurogastroenterol Motil. 2018;30:e13380.","journal-title":"Neurogastroenterol Motil"},{"key":"3909_CR78","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s00277-008-0614-5","volume":"88","author":"K Shimura","year":"2009","unstructured":"Shimura K, Shimazaki C, Taniguchi K, Inaba T, Horiike S, Taniwaki M. Bortezomib-induced neurogenic bladder in patients with multiple myeloma. Ann Hematol. 2009;88:383\u20134.","journal-title":"Ann Hematol"},{"key":"3909_CR79","doi-asserted-by":"publisher","first-page":"11671","DOI":"10.1039\/D1FO01848E","volume":"12","author":"R Wei","year":"2021","unstructured":"Wei R, Liu X, Wang Y, et al. (-)-Epigallocatechin-3-gallate mitigates cyclophosphamide-induced intestinal injury by modulating the tight junctions, inflammation and dysbiosis in mice. Food Funct. 2021;12:11671\u201385.","journal-title":"Food Funct"},{"key":"3909_CR80","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s00280-021-04273-7","volume":"88","author":"HR Wardill","year":"2021","unstructured":"Wardill HR, de Mooij CEM, da Silva Ferreira AR, et al. Translational model of melphalan-induced gut toxicity reveals drug-host-microbe interactions that drive tissue injury and fever. Cancer Chemother Pharmacol. 2021;88:173\u201388.","journal-title":"Cancer Chemother Pharmacol"},{"key":"3909_CR81","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1056\/NEJM200009213431204","volume":"343","author":"S Vernino","year":"2000","unstructured":"Vernino S, Low PA, Fealey RD, Stewart JD, Farrugia G, Lennon VA. Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies. N Engl J Med. 2000;343:847\u201355.","journal-title":"N Engl J Med"},{"key":"3909_CR82","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1053\/j.gastro.2004.02.024","volume":"126","author":"R De Giorgio","year":"2004","unstructured":"De Giorgio R, Guerrini S, Barbara G, et al. Inflammatory neuropathies of the enteric nervous system. Gastroenterology. 2004;126:1872\u201383.","journal-title":"Gastroenterology"},{"key":"3909_CR83","doi-asserted-by":"publisher","first-page":"2517","DOI":"10.1007\/s00204-020-02755-w","volume":"94","author":"C Meregalli","year":"2020","unstructured":"Meregalli C, Fumagalli G, Alberti P, et al. Neurofilament light chain: a specific serum biomarker of axonal damage severity in rat models of Chemotherapy-Induced Peripheral Neurotoxicity. Arch Toxicol. 2020;94:2517\u201322.","journal-title":"Arch Toxicol"},{"key":"3909_CR84","doi-asserted-by":"crossref","unstructured":"Balayssac D, Durif J, Lambert C, et al. Exploring Serum Biomarkers for Neuropathic Pain in Rat Models of Chemotherapy-Induced Peripheral Neuropathy: A Comparative Pilot Study with Oxaliplatin, Paclitaxel, Bortezomib, and Vincristine. Toxics. 2023;11:1004.","DOI":"10.3390\/toxics11121004"},{"key":"3909_CR85","doi-asserted-by":"publisher","first-page":"fcaa021","DOI":"10.1093\/braincomms\/fcaa021","volume":"2","author":"P Huehnchen","year":"2020","unstructured":"Huehnchen P, Springer A, Kern J, et al. Bortezomib at therapeutic doses poorly passes the blood-brain barrier and does not impair cognition. Brain Commun. 2020;2:fcaa021.","journal-title":"Brain Commun"},{"key":"3909_CR86","doi-asserted-by":"publisher","first-page":"903455","DOI":"10.3389\/fnagi.2022.903455","volume":"14","author":"Y Sun","year":"2022","unstructured":"Sun Y, Koyama Y, Shimada S. Inflammation From Peripheral Organs to the Brain: How Does Systemic Inflammation Cause Neuroinflammation? Front Aging Neurosci. 2022;14:903455.","journal-title":"Front Aging Neurosci"},{"key":"3909_CR87","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1126\/science.1188454","volume":"328","author":"S Hapfelmeier","year":"2010","unstructured":"Hapfelmeier S, Lawson MA, Slack E, et al. Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses. Science. 2010;328:1705\u20139.","journal-title":"Science"},{"key":"3909_CR88","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nri2515","volume":"9","author":"JL Round","year":"2009","unstructured":"Round JL, Mazmanian SK. The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol. 2009;9:313\u201323.","journal-title":"Nat Rev Immunol"},{"key":"3909_CR89","doi-asserted-by":"publisher","first-page":"2068365","DOI":"10.1080\/19490976.2022.2068365","volume":"14","author":"TM Cook","year":"2022","unstructured":"Cook TM, Mansuy-Aubert V. Communication between the gut microbiota and peripheral nervous system in health and chronic disease. Gut Microbes. 2022;14:2068365.","journal-title":"Gut Microbes"},{"key":"3909_CR90","doi-asserted-by":"publisher","first-page":"117207","DOI":"10.1016\/j.biopha.2024.117207","volume":"178","author":"S Lu","year":"2024","unstructured":"Lu S, Zhao Q, Guan Y, et al. The communication mechanism of the gut-brain axis and its effect on central nervous system diseases: A systematic review. Biomed Pharmacother. 2024;178:117207.","journal-title":"Biomed Pharmacother"},{"key":"3909_CR91","doi-asserted-by":"publisher","first-page":"110895","DOI":"10.1016\/j.isci.2024.110895","volume":"27","author":"ME Frith","year":"2024","unstructured":"Frith ME, Kashyap PC, Linden DR, Theriault B, Chang EB. Microbiota-dependent early-life programming of gastrointestinal motility. iScience. 2024;27:110895.","journal-title":"iScience"},{"key":"3909_CR92","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.immuni.2009.08.020","volume":"31","author":"V Gaboriau-Routhiau","year":"2009","unstructured":"Gaboriau-Routhiau V, Rakotobe S, Lecuyer E, et al. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity. 2009;31:677\u201389.","journal-title":"Immunity"},{"key":"3909_CR93","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/mi.2012.32","volume":"5","author":"S El Aidy","year":"2012","unstructured":"El Aidy S, van Baarlen P, Derrien M, et al. Temporal and spatial interplay of microbiota and intestinal mucosa drive establishment of immune homeostasis in conventionalized mice. Mucosal Immunol. 2012;5:567\u201379.","journal-title":"Mucosal Immunol"},{"key":"3909_CR94","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.2147\/JPR.S415642","volume":"16","author":"H Shi","year":"2023","unstructured":"Shi H, Chen M, Zheng C, Yinglin B, Zhu B. Fecal Microbiota Transplantation Alleviated Paclitaxel-Induced Peripheral Neuropathy by Interfering with Astrocytes and TLR4\/p38MAPK Pathway in Rats. J Pain Res. 2023;16:2419\u201332.","journal-title":"J Pain Res"},{"key":"3909_CR95","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.neuro.2022.01.011","volume":"89","author":"A Yardim","year":"2022","unstructured":"Yardim A, Gur C, Comakli S, et al. Investigation of the effects of berberine on bortezomib-induced sciatic nerve and spinal cord damage in rats through pathways involved in oxidative stress and neuro-inflammation. Neurotoxicology. 2022;89:127\u201339.","journal-title":"Neurotoxicology"},{"key":"3909_CR96","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3389\/fendo.2020.00025","volume":"11","author":"YP Silva","year":"2020","unstructured":"Silva YP, Bernardi A, Frozza RL. The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication. Front Endocrinol (Lausanne). 2020;11:25.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"3909_CR97","doi-asserted-by":"publisher","first-page":"102537","DOI":"10.1016\/j.arr.2024.102537","volume":"101","author":"J Tahiri","year":"2024","unstructured":"Tahiri J, Mian M, Aftan F, et al. Serotonin in depression and Alzheimer\u2019s disease: Focus on SSRI\u2019s beneficial effects. Ageing Res Rev. 2024;101:102537.","journal-title":"Ageing Res Rev"},{"key":"3909_CR98","doi-asserted-by":"publisher","first-page":"104949","DOI":"10.1016\/j.phrs.2020.104949","volume":"159","author":"QQ Liu","year":"2020","unstructured":"Liu QQ, Yao XX, Gao SH, et al. Role of 5-HT receptors in neuropathic pain: potential therapeutic implications. Pharmacol Res. 2020;159:104949.","journal-title":"Pharmacol Res"},{"key":"3909_CR99","doi-asserted-by":"publisher","first-page":"6458","DOI":"10.1073\/pnas.1720017115","volume":"115","author":"F De Vadder","year":"2018","unstructured":"De Vadder F, Grasset E, Manneras Holm L, et al. Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks. Proc Natl Acad Sci U S A. 2018;115:6458\u201363.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3909_CR100","doi-asserted-by":"publisher","first-page":"16490","DOI":"10.1038\/s41598-019-52893-0","volume":"9","author":"BR Loman","year":"2019","unstructured":"Loman BR, Jordan KR, Haynes B, Bailey MT, Pyter LM. Chemotherapy-induced neuroinflammation is associated with disrupted colonic and bacterial homeostasis in female mice. Sci Rep. 2019;9:16490.","journal-title":"Sci Rep"},{"key":"3909_CR101","doi-asserted-by":"publisher","first-page":"1380713","DOI":"10.3389\/fphys.2024.1380713","volume":"15","author":"TR Dmytriv","year":"2024","unstructured":"Dmytriv TR, Storey KB, Lushchak VI. Intestinal barrier permeability: the influence of gut microbiota, nutrition, and exercise. Front Physiol. 2024;15:1380713.","journal-title":"Front Physiol"},{"key":"3909_CR102","doi-asserted-by":"publisher","first-page":"1514636","DOI":"10.3389\/fcell.2025.1514636","volume":"13","author":"H Ullah","year":"2025","unstructured":"Ullah H, Arbab S, Chang C, et al. Gut microbiota therapy in gastrointestinal diseases. Front Cell Dev Biol. 2025;13:1514636.","journal-title":"Front Cell Dev Biol"},{"key":"3909_CR103","doi-asserted-by":"publisher","first-page":"796288","DOI":"10.3389\/fimmu.2022.796288","volume":"13","author":"Y Mou","year":"2022","unstructured":"Mou Y, Du Y, Zhou L, et al. Gut Microbiota Interact With the Brain Through Systemic Chronic Inflammation: Implications on Neuroinflammation, Neurodegeneration, and Aging. Front Immunol. 2022;13:796288.","journal-title":"Front Immunol"},{"key":"3909_CR104","doi-asserted-by":"publisher","first-page":"106489","DOI":"10.1016\/j.bbi.2026.106489","volume":"135","author":"JT Beales","year":"2026","unstructured":"Beales JT, Mohanty V, Seng MM, et al. Gut microbiota and metabolite disruption during breast cancer chemotherapy is associated with peripheral neuropathy sensory symptoms and pain. Brain Behav Immun. 2026;135:106489.","journal-title":"Brain Behav Immun"},{"key":"3909_CR105","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1159\/000479000","volume":"96","author":"T Ohtsu","year":"2017","unstructured":"Ohtsu T, Takagi A, Uemura N, et al. The Ameliorating Effect of Lactobacillus gasseri OLL2716 on Functional Dyspepsia in Helicobacter pylori-Uninfected Individuals: A Randomized Controlled Study. Digestion. 2017;96:92\u2013102.","journal-title":"Digestion"},{"key":"3909_CR106","doi-asserted-by":"publisher","first-page":"7490452","DOI":"10.1155\/2016\/7490452","volume":"2016","author":"A Takagi","year":"2016","unstructured":"Takagi A, Yanagi H, Ozawa H, et al. Effects of Lactobacillus gasseri OLL2716 on Helicobacter pylori-Associated Dyspepsia: A Multicenter Randomized Double-Blind Controlled Trial. Gastroenterol Res Pract. 2016;2016:7490452.","journal-title":"Gastroenterol Res Pract"},{"key":"3909_CR107","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/jam.13329","volume":"122","author":"K Nobutani","year":"2017","unstructured":"Nobutani K, Sawada D, Fujiwara S, et al. The effects of administration of the Lactobacillus gasseri strain CP2305 on quality of life, clinical symptoms and changes in gene expression in patients with irritable bowel syndrome. J Appl Microbiol. 2017;122:212\u201324.","journal-title":"J Appl Microbiol"},{"key":"3909_CR108","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s40168-025-02273-w","volume":"14","author":"Y Jiang","year":"2025","unstructured":"Jiang Y, Che L, Li SC. Deciphering the personalized functional redundancy hierarchy in the gut microbiome. Microbiome. 2025;14:17.","journal-title":"Microbiome"},{"key":"3909_CR109","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.pain.2013.10.027","volume":"155","author":"V Vacca","year":"2014","unstructured":"Vacca V, Marinelli S, Pieroni L, Urbani A, Luvisetto S, Pavone F. Higher pain perception and lack of recovery from neuropathic pain in females: a behavioural, immunohistochemical, and proteomic investigation on sex-related differences in mice. Pain. 2014;155:388\u2013402.","journal-title":"Pain"},{"key":"3909_CR110","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.bbi.2025.05.004","volume":"128","author":"MFS Ho","year":"2025","unstructured":"Ho MFS, Farkas O, Faria AV, Plemel JR, Kerr BJ. A recent history of immune cell sex differences in the peripheral nervous system in persistent pain states. Brain Behav Immun. 2025;128:766\u201375.","journal-title":"Brain Behav Immun"},{"key":"3909_CR111","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1080\/19490976.2016.1203502","volume":"7","author":"E Org","year":"2016","unstructured":"Org E, Mehrabian M, Parks BW, et al. Sex differences and hormonal effects on gut microbiota composition in mice. Gut Microbes. 2016;7:313\u201322.","journal-title":"Gut Microbes"},{"key":"3909_CR112","unstructured":"Australian code for the. care and use of animals for scientific purposes. 8th edition 2013 (updated 2021). 2021."},{"key":"3909_CR113","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3324\/haematol.2013.090977","volume":"99","author":"JE Noll","year":"2014","unstructured":"Noll JE, Williams SA, Tong CM, et al. Myeloma plasma cells alter the bone marrow microenvironment by stimulating the proliferation of mesenchymal stromal cells. Haematologica. 2014;99:163\u201371.","journal-title":"Haematologica"},{"key":"3909_CR114","doi-asserted-by":"publisher","first-page":"3176","DOI":"10.3324\/haematol.2020.253526","volume":"106","author":"MN Zeissig","year":"2021","unstructured":"Zeissig MN, Hewett DR, Panagopoulos V, et al. Expression of the chemokine receptor CCR1 promotes the dissemination of multiple myeloma plasma cells in vivo. Haematologica. 2021;106:3176\u201387.","journal-title":"Haematologica"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12974-026-03909-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-026-03909-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-026-03909-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:02:37Z","timestamp":1788872557000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12974-026-03909-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,23]]},"references-count":114,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3909"],"URL":"https:\/\/doi.org\/10.1186\/s12974-026-03909-w","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,23]]},"assertion":[{"value":"12 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal experiments were performed in accordance with protocols approved by the SAHMRI Animal Ethics Committee (SAM-21-012 and SAM-22-056) and complied with the Australian code for the care and use of animals for scientific purposes [\n                      \n                      ].","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"S. P. Costello is a shareholder in BiomeBank and Microbiotica.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"301"}}