{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:01:48Z","timestamp":1790294508078,"version":"4.1.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":83,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K16905"],"award-info":[{"award-number":["22K16905"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K09749"],"award-info":[{"award-number":["20K09749"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"DOI":"10.1186\/s12974-026-03939-4","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T07:18:29Z","timestamp":1783149509000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dysregulated glia and periglomerular cells in the olfactory bulb and altered lipocalins in the olfactory epithelium underlie olfactory dysfunction in a murine model of eosinophilic chronic rhinosinusitis"],"prefix":"10.1186","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4094-1609","authenticated-orcid":false,"given":"Ryoji","family":"Kagoya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Nishijima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyohei","family":"Horikiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Kishimoto-Urata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Urata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,4]]},"reference":[{"issue":"4","key":"3939_CR1","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.bj.2018.08.004","volume":"41","author":"L Denney","year":"2018","unstructured":"Denney L, Ho LP. The role of respiratory epithelium in host defence against influenza virus infection. Biomed J. 2018;41(4):218\u201333. https:\/\/doi.org\/10.1016\/j.bj.2018.08.004.","journal-title":"Biomed J"},{"issue":"1","key":"3939_CR2","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s11882-024-01187-1","volume":"25","author":"JJ Otten","year":"2024","unstructured":"Otten JJ, Fokkens WJ, Reitsma S. Olfactory dysfunction in chronic rhinosinusitis with nasal polyps: effect of treatment with emphasis on biological therapy. Curr Allergy Asthma Rep. 2024;25(1):6. https:\/\/doi.org\/10.1007\/s11882-024-01187-1.","journal-title":"Curr Allergy Asthma Rep"},{"issue":"1","key":"3939_CR3","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1002\/ca.22338","volume":"27","author":"RM Patel","year":"2014","unstructured":"Patel RM, Pinto JM. Olfaction: anatomy, physiology, and disease. Clin Anat. 2014;27(1):54\u201360. https:\/\/doi.org\/10.1002\/ca.22338.","journal-title":"Clin Anat"},{"issue":"5","key":"3939_CR4","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s11882-016-0617-6","volume":"16","author":"P Rombaux","year":"2016","unstructured":"Rombaux P, Huart C, Levie P, Cingi C, Hummel T. Olfaction in chronic rhinosinusitis. Curr Allergy Asthma Rep. 2016;16(5):41. https:\/\/doi.org\/10.1007\/s11882-016-0617-6.","journal-title":"Curr Allergy Asthma Rep"},{"issue":"6","key":"3939_CR5","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1111\/coa.13202","volume":"43","author":"EM Shehata","year":"2018","unstructured":"Shehata EM, Tomoum MO, Amer MA, Alarabawy RA, Eltomey MA. Olfactory bulb neuroplasticity: a prospective cohort study in patients with chronic rhinosinusitis with nasal polyps. Clin Otolaryngol. 2018;43(6):1528\u201334. https:\/\/doi.org\/10.1111\/coa.13202.","journal-title":"Clin Otolaryngol"},{"key":"3939_CR6","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/1742-2094-9-109","volume":"9","author":"RP Herbert","year":"2012","unstructured":"Herbert RP, Harris J, Chong KP, Chapman J, West AK, Chuah MI. Cytokines and olfactory bulb microglia in response to bacterial challenge in the compromised primary olfactory pathway. J Neuroinflammation. 2012;9:109. https:\/\/doi.org\/10.1186\/1742-2094-9-109.","journal-title":"J Neuroinflammation"},{"issue":"1","key":"3939_CR7","doi-asserted-by":"publisher","first-page":"11605","DOI":"10.1038\/s41598-017-10229-w","volume":"7","author":"S Hasegawa-Ishii","year":"2017","unstructured":"Hasegawa-Ishii S, Shimada A, Imamura F. Lipopolysaccharide-initiated persistent rhinitis causes gliosis and synaptic loss in the olfactory bulb. Sci Rep. 2017;7(1):11605. https:\/\/doi.org\/10.1038\/s41598-017-10229-w.","journal-title":"Sci Rep"},{"issue":"3","key":"3939_CR8","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/j.jaci.2018.09.028","volume":"143","author":"S Hasegawa-Ishii","year":"2019","unstructured":"Hasegawa-Ishii S, Shimada A, Imamura F. Neuroplastic changes in the olfactory bulb associated with nasal infammation in mice. J Allergy Clin Immunol. 2019;143(3):978-89.e3. https:\/\/doi.org\/10.1016\/j.jaci.2018.09.028.","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"3939_CR9","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12974-022-02378-1","volume":"19","author":"R Kagoya","year":"2022","unstructured":"Kagoya R, Toma-Hirano M, Yamagishi J, Matsumoto N, Kondo K, Ito K. Immunological status of the olfactory bulb in a murine model of Toll-like receptor 3-mediated upper respiratory tract inflammation. J Neuroinflammation. 2022;19(1):13. https:\/\/doi.org\/10.1186\/s12974-022-02378-1.","journal-title":"J Neuroinflammation"},{"key":"3939_CR10","doi-asserted-by":"publisher","first-page":"5728","DOI":"10.1038\/s41598-022-09731-7","volume":"12","author":"M Kishimoto-Urata","year":"2022","unstructured":"Kishimoto-Urata M, Urata S, Kagoya R, Imamura F, Nagayama S, Reyna RA, et al. Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit. Sci Rep. 2022;12:5728. https:\/\/doi.org\/10.1038\/s41598-022-09731-7.","journal-title":"Sci Rep"},{"key":"3939_CR11","doi-asserted-by":"crossref","unstructured":"Cho JY, Min N, Franzen L, Baker H. Rapid down-regulation of tyrosine hydroxylase expression in the olfactory bulb of naris-occluded adult rats. J Comp Neurol. 1996;369(2):264\u201376. https:\/\/doi.org\/10.1002\/(SICI)1096-9861(19960527)369:2<264::AID-CNE7>3.0.CO;2-1.","DOI":"10.1002\/(SICI)1096-9861(19960527)369:2<264::AID-CNE7>3.3.CO;2-L"},{"issue":"5","key":"3939_CR12","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1111\/all.14627","volume":"76","author":"R Kagoya","year":"2021","unstructured":"Kagoya R, Kondo K, Kishimoto-Urata M, Shimizu Y, Kikuta S, Yamasoba T. A murine model of eosinophilic chronic rhinosinusitis using the topical application of a vitamin D3 analog. Allergy. 2021;76(5):1432\u201342. https:\/\/doi.org\/10.1111\/all.14627.","journal-title":"Allergy"},{"issue":"2","key":"3939_CR13","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.jaci.2024.02.021","volume":"154","author":"WH Huang","year":"2024","unstructured":"Huang WH, Hung YW, Hung W, Lan MY, Yeh CF. Murine model of eosinophilic chronic rhinosinusitis with nasal polyposis inducing neuroinflammation and olfactory dysfunction. J Allergy Clin Immunol. 2024;154(2):325-39.e3. https:\/\/doi.org\/10.1016\/j.jaci.2024.02.021.","journal-title":"J Allergy Clin Immunol"},{"key":"3939_CR14","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.bbi.2025.05.001","volume":"128","author":"X Zhang","year":"2025","unstructured":"Zhang X, Wu W, Zhao H, Li C, Qi L, Wu C, et al. A long-term mixed eosinophilic and neutrophilic chronic rhinosinusitis C57BL\/6 mouse model with neuroinflammation, olfactory dysfunction and anxiety-like behaviors. Brain Behav Immun. 2025;128:654\u201372. https:\/\/doi.org\/10.1016\/j.bbi.2025.05.001.","journal-title":"Brain Behav Immun"},{"issue":"1","key":"3939_CR15","doi-asserted-by":"publisher","first-page":"101","DOI":"10.4193\/Rhin25.164","volume":"64","author":"Z Zhang","year":"2026","unstructured":"Zhang Z, Du Y, Xiong S, Cao W, Jiang H, Wang J, et al. Neuroinflammation and neural activity in the olfactory bulb drives olfactory dysfunction in a rat model of eosinophilic chronic rhinosinusitis. Rhinology. 2026;64(1):101\u201312. https:\/\/doi.org\/10.4193\/Rhin25.164.","journal-title":"Rhinology"},{"issue":"2","key":"3939_CR16","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1177\/0192623308329342","volume":"37","author":"DK Meyerholz","year":"2009","unstructured":"Meyerholz DK, Griffin MA, Castilow EM, Varga SM. Comparison of Histochemical Methods for Murine Eosinophil Detection in an RSV Vaccine-enhanced Inflammation Model. Toxicol Pathol. 2009;37(2):249\u201355. https:\/\/doi.org\/10.1177\/0192623308329342.","journal-title":"Toxicol Pathol"},{"key":"3939_CR17","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/0471142301.ns0824s48","volume":"8","author":"M Yang","year":"2009","unstructured":"Yang M, Crawley JN. Simple behavioral assessment of mouse olfaction. Curr Protoc Neurosci. 2009;8:8\u201324. https:\/\/doi.org\/10.1002\/0471142301.ns0824s48.","journal-title":"Curr Protoc Neurosci"},{"key":"3939_CR18","doi-asserted-by":"publisher","first-page":"22538","DOI":"10.18632\/aging.103663","volume":"12","author":"L Xie","year":"2020","unstructured":"Xie L, Zhang N, Zhang Q, Li C, Sandhu AF, Iii GW, et al. Inflammatory factors and amyloid beta-induced microglial polarization promote inflammatory crosstalk with astrocytes. Aging (Albany NY). 2020;12:22538\u201349. https:\/\/doi.org\/10.18632\/aging.103663.","journal-title":"Aging (Albany NY)"},{"issue":"12","key":"3939_CR19","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1038\/nn2014","volume":"10","author":"B Ajami","year":"2007","unstructured":"Ajami B, Bennett JL, Krieger C, Tetzlaff W, Rossi FM. Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci. 2007;10(12):1538\u201343. https:\/\/doi.org\/10.1038\/nn2014.","journal-title":"Nat Neurosci"},{"key":"3939_CR20","doi-asserted-by":"publisher","first-page":"429815","DOI":"10.1155\/2013\/429815","volume":"2013","author":"F Ferrini","year":"2013","unstructured":"Ferrini F, De Koninck Y. Microglia control neuronal network excitability via BDNF signaling. Neural Plast. 2013;2013:429815. https:\/\/doi.org\/10.1155\/2013\/429815.","journal-title":"Neural Plast"},{"key":"3939_CR21","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/glia.20928","volume":"58","author":"S Lehnardt","year":"2010","unstructured":"Lehnardt S. Innate immunity and neuroinflammation in the CNS: the role of microglia in Toll-like receptor-mediated neuronal injury. Glia. 2010;58:253\u201363. https:\/\/doi.org\/10.1002\/glia.20928.","journal-title":"Glia"},{"issue":"2","key":"3939_CR22","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.bbrc.2018.02.118","volume":"497","author":"J Wang","year":"2018","unstructured":"Wang J, Liu J, Zhou R, Ding X, Zhang Q, Zhang C, et al. Zika virus infected primary microglia impairs NPCs proliferation and differentiation. Biochem Biophys Res Commun. 2018;497(2):619\u201325. https:\/\/doi.org\/10.1016\/j.bbrc.2018.02.118.","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"3939_CR23","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3390\/brainsci6020018","volume":"6","author":"S Mori","year":"2016","unstructured":"Mori S, Maher P, Conti B. Neuroimmunology of the Interleukins 13 and 4. Brain Sci. 2016;6(2):18. https:\/\/doi.org\/10.3390\/brainsci6020018.","journal-title":"Brain Sci"},{"issue":"11","key":"3939_CR24","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1038\/s41423-023-01043-8","volume":"20","author":"T Mamuladze","year":"2023","unstructured":"Mamuladze T, Kipnis J. Type 2 immunity in the brain and brain borders. Cell Mol Immunol. 2023;20(11):1290\u20139. https:\/\/doi.org\/10.1038\/s41423-023-01043-8.","journal-title":"Cell Mol Immunol"},{"issue":"2","key":"3939_CR25","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1084\/jem.20161982","volume":"214","author":"SP Gadani","year":"2016","unstructured":"Gadani SP, Smirnov I, Wiltbank AT, Overall CC, Kipnis J. Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury. J Exp Med. 2016;214(2):285\u201396. https:\/\/doi.org\/10.1084\/jem.20161982.","journal-title":"J Exp Med"},{"key":"3939_CR26","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3389\/fnins.2016.00149","volume":"10","author":"A Gengatharan","year":"2016","unstructured":"Gengatharan A, Bammann RR, Saghatelyan A. The Role of Astrocytes in the Generation, Migration, and Integration of New Neurons in the Adult Olfactory Bulb. Front Neurosci. 2016;10:149. https:\/\/doi.org\/10.3389\/fnins.2016.00149.","journal-title":"Front Neurosci"},{"issue":"6","key":"3939_CR27","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1016\/j.neuron.2013.07.011","volume":"79","author":"K Khodosevich","year":"2013","unstructured":"Khodosevich K, Lazarini F, von Engelhardt J, Kaneko H, Lledo PM, Monyer H. Connective tissue growth factor regulates interneuron survival and information processing in the olfactory bulb. Neuron. 2013;79(6):1136\u201351. https:\/\/doi.org\/10.1016\/j.neuron.2013.07.011.","journal-title":"Neuron"},{"issue":"3","key":"3939_CR28","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1177\/1073858418783959","volume":"25","author":"MK Jha","year":"2019","unstructured":"Jha MK, Jo M, Kim JH, Suk K. Microglia-astrocyte crosstalk: an intimate molecular conversation. Neuroscientist. 2019;25(3):227\u201340. https:\/\/doi.org\/10.1177\/1073858418783959.","journal-title":"Neuroscientist"},{"issue":"2","key":"3939_CR29","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1267\/ahc.17001","volume":"50","author":"A Kubo","year":"2017","unstructured":"Kubo A, Sujino M, Masumoto KH, Fujioka A, Terashima T, Shigeyoshi Y, et al. Profiles of periglomerular cells in the olfactory bulb of prokineticin type 2 receptor-deficient mice. Acta Histochem Cytochem. 2017;50(2):95\u2013104. https:\/\/doi.org\/10.1267\/ahc.17001.","journal-title":"Acta Histochem Cytochem"},{"key":"3939_CR30","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.neures.2019.10.004","volume":"157","author":"T Kosaka","year":"2020","unstructured":"Kosaka T, Pignatelli A, Kosaka K. Heterogeneity of tyrosine hydroxylase expressing neurons in the main olfactory bulb of the mouse. Neurosci Res. 2020;157:15\u201333. https:\/\/doi.org\/10.1016\/j.neures.2019.10.004.","journal-title":"Neurosci Res"},{"key":"3939_CR31","doi-asserted-by":"publisher","first-page":"718221","DOI":"10.3389\/fncir.2021.718221","volume":"15","author":"S Capsoni","year":"2021","unstructured":"Capsoni S, FogliIseppe A, Casciano F, Pignatelli A. Unraveling the Role of Dopaminergic and Calretinin Interneurons in the Olfactory Bulb. Front Neural Circuits. 2021;15:718221. https:\/\/doi.org\/10.3389\/fncir.2021.718221.","journal-title":"Front Neural Circuits"},{"key":"3939_CR32","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3389\/fncel.2016.00231","volume":"10","author":"A FogliIseppe","year":"2016","unstructured":"FogliIseppe A, Pignatelli A, Belluzzi O. Calretinin-Periglomerular Interneurons in mice olfactory bulb: cells of few words. Front Cell Neurosci. 2016;10:231. https:\/\/doi.org\/10.3389\/fncel.2016.00231.","journal-title":"Front Cell Neurosci"},{"key":"3939_CR33","doi-asserted-by":"publisher","first-page":"740006","DOI":"10.3389\/fphys.2021.740006","volume":"12","author":"R Stopkov\u00e1","year":"2021","unstructured":"Stopkov\u00e1 R, Ot\u010den\u00e1\u0161kov\u00e1 T, Mat\u011bjkov\u00e1 T, Kuntov\u00e1 B, Stopka P. Biological roles of lipocalins in chemical communication, reproduction, and regulation of microbiota. Front Physiol. 2021;12:740006. https:\/\/doi.org\/10.3389\/fphys.2021.740006.","journal-title":"Front Physiol"},{"issue":"7","key":"3939_CR34","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1093\/chemse\/bjz048","volume":"44","author":"T Nakamura","year":"2019","unstructured":"Nakamura T, Noumi Y, Yamakawa H, Nakamura A, Wen D, Li X, et al. Enhancement of the olfactory response by lipocalin Cp-Lip1 in newt olfactory receptor cells: an electrophysiological study. Chem Senses. 2019;44(7):523\u201333. https:\/\/doi.org\/10.1093\/chemse\/bjz048.","journal-title":"Chem Senses"},{"issue":"1","key":"3939_CR35","doi-asserted-by":"publisher","first-page":"9984","DOI":"10.1038\/s41598-022-13464-y","volume":"12","author":"C Ijichi","year":"2022","unstructured":"Ijichi C, Kondo K, Kobayashi M, Shirasawa A, Shimbo K, Nakata K, et al. Lipocalin 15 in the olfactory mucus is a biomarker for Bowman\u2019s gland activity. Sci Rep. 2022;12(1):9984. https:\/\/doi.org\/10.1038\/s41598-022-13464-y.","journal-title":"Sci Rep"},{"issue":"20","key":"3939_CR36","doi-asserted-by":"publisher","first-page":"eadu7271","DOI":"10.1126\/sciadv.adu7271","volume":"11","author":"S Chapman","year":"2025","unstructured":"Chapman S, Kondo K, Ihara S, Ijichi C, Sato K, Touhara K. Fibronectin in the olfactory mucus increases sensitivity of olfactory receptor response to odorants. Sci Adv. 2025;11(20):eadu7271. https:\/\/doi.org\/10.1126\/sciadv.adu7271.","journal-title":"Sci Adv"},{"issue":"1","key":"3939_CR37","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12915-018-0512-9","volume":"16","author":"SA Roberts","year":"2018","unstructured":"Roberts SA, Prescott MC, Davidson AJ, McLean L, Beynon RJ, Hurst JL. Individual odour signatures that mice learn are shaped by involatile major urinary proteins (MUPs). BMC Biol. 2018;16(1):48. https:\/\/doi.org\/10.1186\/s12915-018-0512-9.","journal-title":"BMC Biol"},{"issue":"3","key":"3939_CR38","doi-asserted-by":"publisher","first-page":"245","DOI":"10.2174\/0115672026420545250911091301","volume":"22","author":"C Miao","year":"2025","unstructured":"Miao C, Yu L, Guo L, Liang C, Jiang H. The role of interleukin-4 in olfactory epithelial cells: a preliminary in vitro study. Curr Neurovasc Res. 2025;22(3):245\u201354. https:\/\/doi.org\/10.2174\/0115672026420545250911091301.","journal-title":"Curr Neurovasc Res"},{"issue":"3","key":"3939_CR39","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1002\/alr.23073","volume":"13","author":"A Saraswathula","year":"2023","unstructured":"Saraswathula A, Liu MM, Kulaga H, Lane AP. Chronic interleukin-13 expression in mouse olfactory mucosa results in regional aneuronal epithelium. Int Forum Allergy Rhinol. 2023;13(3):230\u201341. https:\/\/doi.org\/10.1002\/alr.23073.","journal-title":"Int Forum Allergy Rhinol"},{"issue":"10","key":"3939_CR40","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/s41576-020-0258-4","volume":"21","author":"C Buccitelli","year":"2020","unstructured":"Buccitelli C, Selbach M. mRNAs, proteins and the emerging principles of gene expression control. Nat Rev Genet. 2020;21(10):630\u201344. https:\/\/doi.org\/10.1038\/s41576-020-0258-4.","journal-title":"Nat Rev Genet"},{"key":"3939_CR41","doi-asserted-by":"publisher","first-page":"4434","DOI":"10.1046\/j.0953-816x.2000.01319.x","volume":"12","author":"JP Konsman","year":"2000","unstructured":"Konsman JP, Luheshi GN, Bluthe RM, Dantzer R. The vagus nerve mediates behavioural depression, but not fever, in response to peripheral immune signals; a functional anatomical analysis. Eur J Neurosci. 2000;12:4434\u201346. https:\/\/doi.org\/10.1046\/j.0953-816x.2000.01319.x.","journal-title":"Eur J Neurosci"},{"key":"3939_CR42","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/s0165-5728(01)00270-3","volume":"115","author":"HE Romeo","year":"2001","unstructured":"Romeo HE, Tio DL, Rahman SU, Chiappelli F, Taylor AN. The glossopharyngeal nerve as a novel pathway in immuneto-brain communication: relevance to neuroimmune surveillance of the oral cavity. J Neuroimmunol. 2001;115:91\u2013100. https:\/\/doi.org\/10.1016\/s0165-5728(01)00270-3.","journal-title":"J Neuroimmunol"},{"issue":"6","key":"3939_CR43","doi-asserted-by":"publisher","first-page":"689","DOI":"10.4193\/Rhin23.475","volume":"62","author":"JY Chen","year":"2024","unstructured":"Chen JY, Wang X, Luo X, Jian F, Zhou W, Xiao Z, et al. Predictive model for postoperative unrecovered olfactory function in CRSwNP patients with olfactory disorder. Rhinology. 2024;62(6):689\u201399. https:\/\/doi.org\/10.4193\/Rhin23.475.","journal-title":"Rhinology"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12974-026-03939-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-026-03939-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12974-026-03939-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:40:55Z","timestamp":1790293255000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12974-026-03939-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,4]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3939"],"URL":"https:\/\/doi.org\/10.1186\/s12974-026-03939-4","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,4]]},"assertion":[{"value":"11 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All procedures were approved by the University of Tokyo Animal Care Committee and conducted in accordance with the University's guidelines for the handling and care of laboratory animals.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"322"}}