{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T18:30:54Z","timestamp":1775500254659,"version":"3.50.1"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T00:00:00Z","timestamp":1496361600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T00:00:00Z","timestamp":1496361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R37 AI50529"],"award-info":[{"award-number":["R37 AI50529"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI120810"],"award-info":[{"award-number":["R01 AI120810"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["F30 AI 112426"],"award-info":[{"award-number":["F30 AI 112426"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["P30 AI 045008"],"award-info":[{"award-number":["P30 AI 045008"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32 AI 055400"],"award-info":[{"award-number":["T32 AI 055400"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["HHSN261200800001E"],"award-info":[{"award-number":["HHSN261200800001E"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Retrovirology"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12977-017-0359-0","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T12:12:44Z","timestamp":1496405564000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effective treatment of SIVcpz-induced immunodeficiency in a captive western chimpanzee"],"prefix":"10.1186","volume":"14","author":[{"given":"Hannah J.","family":"Barbian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raven","family":"Jackson-Jewett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrine S.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Bibollet-Ruche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald H.","family":"Learn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Decker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward F.","family":"Kreider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas N.","family":"Denny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul M.","family":"Sharp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George M.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Lifson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward P.","family":"Acosta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Saag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharine J.","family":"Bar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9400-9887","authenticated-orcid":false,"given":"Beatrice H.","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,6,2]]},"reference":[{"issue":"5786","key":"359_CR1","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1126\/science.1126531","volume":"313","author":"BF Keele","year":"2006","unstructured":"Keele BF, Van Heuverswyn F, Li Y, Bailes E, Takehisa J, Santiago ML, et al. Chimpanzee reservoirs of pandemic and nonpandemic HIV-1. Science. 2006;313(5786):523\u20136.","journal-title":"Science"},{"issue":"13","key":"359_CR2","doi-asserted-by":"publisher","first-page":"7545","DOI":"10.1128\/JVI.77.13.7545-7562.2003","volume":"77","author":"ML Santiago","year":"2003","unstructured":"Santiago ML, Lukasik M, Kamenya S, Li Y, Bibollet-Ruche F, Bailes E, et al. Foci of endemic simian immunodeficiency virus infection in wild-living eastern chimpanzees (Pan troglodytes schweinfurthii). J Virol. 2003;77(13):7545\u201362.","journal-title":"J Virol"},{"issue":"5554","key":"359_CR3","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1126\/science.295.5554.465","volume":"295","author":"ML Santiago","year":"2002","unstructured":"Santiago ML, Rodenburg CM, Kamenya S, Bibollet-Ruche F, Gao F, Bailes E, et al. SIVcpz in wild chimpanzees. Science. 2002;295(5554):465.","journal-title":"Science"},{"issue":"1","key":"359_CR4","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.virol.2007.06.018","volume":"368","author":"F Van Heuverswyn","year":"2007","unstructured":"Van Heuverswyn F, Li Y, Bailes E, Neel C, Lafay B, Keele BF, et al. Genetic diversity and phylogeographic clustering of SIVcpzPtt in wild chimpanzees in Cameroon. Virology. 2007;368(1):155\u201371.","journal-title":"Virology"},{"issue":"19","key":"359_CR5","doi-asserted-by":"publisher","first-page":"10776","DOI":"10.1128\/JVI.01498-12","volume":"86","author":"Y Li","year":"2012","unstructured":"Li Y, Ndjango JB, Learn GH, Ramirez MA, Keele BF, Bibollet-Ruche F, et al. Eastern chimpanzees, but not bonobos, represent a simian immunodeficiency virus reservoir. J Virol. 2012;86(19):10776\u201391.","journal-title":"J Virol"},{"issue":"5","key":"359_CR6","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1089\/aid.2005.21.335","volume":"21","author":"WM Switzer","year":"2005","unstructured":"Switzer WM, Parekh B, Shanmugam V, Bhullar V, Phillips S, Ely JJ, et al. The epidemiology of simian immunodeficiency virus infection in a large number of wild- and captive-born chimpanzees: evidence for a recent introduction following chimpanzee divergence. AIDS Res Hum Retroviruses. 2005;21(5):335\u201342.","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"9","key":"359_CR7","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1089\/088922202760019356","volume":"18","author":"AM Prince","year":"2002","unstructured":"Prince AM, Brotman B, Lee D-H, Andrus L, Valinsky J, Marx P. Lack of evidence for HIV type 1-related SIVcpz infection in captive and wild chimpanzees (Pan troglodytes verus) in West Africa. AIDS Res Hum Retroviruses. 2002;18(9):657\u201360.","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"5626","key":"359_CR8","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1126\/science.1080657","volume":"300","author":"E Bailes","year":"2003","unstructured":"Bailes E, Gao F, Bibollet-Ruche F, Courgnaud V, Peeters M, Marx PA, et al. Hybrid origin of SIV in chimpanzees. Science. 2003;300(5626):1713.","journal-title":"Science"},{"issue":"7254","key":"359_CR9","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/nature08200","volume":"460","author":"BF Keele","year":"2009","unstructured":"Keele BF, Jones JH, Terio KA, Estes JD, Rudicell RS, Wilson ML, et al. Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz. Nature. 2009;460(7254):515\u20139.","journal-title":"Nature"},{"issue":"4","key":"359_CR10","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1638\/2010-0237.1","volume":"42","author":"KA Terio","year":"2011","unstructured":"Terio KA, Kinsel MJ, Raphael J, Mlengeya T, Lipende I, Kirchhoff CA, et al. Pathologic lesions in chimpanzees (Pan trogylodytes schweinfurthii) from Gombe National Park, Tanzania, 2004\u20132010. J Zoo Wildl Med. 2011;42(4):597\u2013607.","journal-title":"J Zoo Wildl Med"},{"issue":"9","key":"359_CR11","doi-asserted-by":"publisher","first-page":"e1001116","DOI":"10.1371\/journal.ppat.1001116","volume":"6","author":"RS Rudicell","year":"2010","unstructured":"Rudicell RS, Holland Jones J, Wroblewski EE, Learn GH, Li Y, Robertson JD, et al. Impact of simian immunodeficiency virus infection on chimpanzee population dynamics. PLoS Pathog. 2010;6(9):e1001116.","journal-title":"PLoS Pathog"},{"issue":"2","key":"359_CR12","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/ajp.20179","volume":"67","author":"JJ Ely","year":"2005","unstructured":"Ely JJ, Dye B, Frels WI, Fritz J, Gagneux P, Khun HH, et al. Subspecies composition and founder contribution of the captive U.S. chimpanzee (Pan troglodytes) population. Am J Primatol. 2005;67(2):223\u201341.","journal-title":"Am J Primatol"},{"issue":"1","key":"359_CR13","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1742-4690-8-4","volume":"8","author":"L Etienne","year":"2011","unstructured":"Etienne L, Nerrienet E, LeBreton M, Bibila GT, Foupouapouognigni Y, Rousset D, et al. Characterization of a new simian immunodeficiency virus strain in a naturally infected Pan troglodytes troglodytes chimpanzee with AIDS related symptoms. Retrovirology. 2011;8(1):4.","journal-title":"Retrovirology"},{"issue":"8482","key":"359_CR14","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/S0140-6736(86)91749-6","volume":"327","author":"R Gilden","year":"1986","unstructured":"Gilden R, Arthur L, Robey W, Kelliher J, Graham C, Fischinger P. HTLV-III antibody in a breeding chimpanzee not experimentally exposed to the virus. Lancet. 1986;327(8482):678\u20139.","journal-title":"Lancet"},{"issue":"10","key":"359_CR15","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1097\/00002030-198910000-00001","volume":"3","author":"M Peeters","year":"1989","unstructured":"Peeters M, Honare C, Huet T, Bedjabaga L, Ossari S, Bussi P, et al. Isolation and partial characterization of an HIV-related virus occurring naturally in chimpanzees in Gabon. AIDS. 1989;3(10):625\u201330.","journal-title":"AIDS"},{"issue":"2","key":"359_CR16","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1128\/JVI.79.2.1312-1319.2005","volume":"79","author":"E Nerrienet","year":"2005","unstructured":"Nerrienet E, Santiago ML, Foupouapouognigni Y, Bailes E, Mundy NI, Njinku B, et al. Simian immunodeficiency virus infection in wild-caught chimpanzees from Cameroon. J Virol. 2005;79(2):1312\u20139.","journal-title":"J Virol"},{"issue":"9","key":"359_CR17","doi-asserted-by":"publisher","first-page":"e1005146","DOI":"10.1371\/journal.ppat.1005146","volume":"11","author":"EJD Greenwood","year":"2015","unstructured":"Greenwood EJD, Schmidt F, Kondova I, Niphuis H, Hodara VL, Clissold L, et al. Simian immunodeficiency virus infection of chimpanzees (Pan troglodytes) shares features of both pathogenic and non-pathogenic lentiviral infections. PLoS Pathog. 2015;11(9):e1005146.","journal-title":"PLoS Pathog"},{"issue":"14","key":"359_CR18","doi-asserted-by":"publisher","first-page":"7208","DOI":"10.1128\/JVI.00382-06","volume":"80","author":"JL Heeney","year":"2006","unstructured":"Heeney JL, Rutjens E, Verschoor EJ, Niphuis H, ten Haaft P, Rouse S, et al. Transmission of simian immunodeficiency virus SIVcpz and the evolution of infection in the presence and absence of concurrent human immunodeficiency virus type 1 infection in chimpanzees. J Virol. 2006;80(14):7208\u201318.","journal-title":"J Virol"},{"issue":"5","key":"359_CR19","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1097\/00002030-199205000-00002","volume":"6","author":"M Peeters","year":"1992","unstructured":"Peeters M, Fransen K, Delaporte E, Van den Haesevelde M, Gershy-Damet GM, Kestens L, et al. Isolation and characterization of a new chimpanzee lentivirus (simian immunodeficiency virus isolate cpz-ant) from a wild-captured chimpanzee. AIDS. 1992;6(5):447\u201351.","journal-title":"AIDS."},{"issue":"1","key":"359_CR20","first-page":"30","volume":"51","author":"M Ihrig","year":"2001","unstructured":"Ihrig M, Tassinary LG, Bernacky B, Keeling ME. Hematologic and serum biochemical reference intervals for the chimpanzee (Pan troglodytes) categorized by age and sex. Comp Med. 2001;51(1):30\u20137.","journal-title":"Comp Med"},{"issue":"3","key":"359_CR21","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1128\/JCM.02792-12","volume":"51","author":"L Etienne","year":"2013","unstructured":"Etienne L, Eymard-Duvernay S, Aghokeng A, Butel C, Monleau M, Peeters M. Single real-time reverse transcription-PCR assay for detection and quantification of genetically diverse HIV-1, SIVcpz, and SIVgor strains. J Clin Microbiol. 2013;51(3):787\u201398.","journal-title":"J Clin Microbiol"},{"issue":"2","key":"359_CR22","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1006\/viro.1996.0384","volume":"221","author":"MM Vanden Haesevelde","year":"1996","unstructured":"Vanden Haesevelde MM, Peeters M, Jannes G, Janssens W, van der Groen G, Sharp P, et al. Sequence analysis of a highly divergent HIV-1-related lentivirus isolated from a wild captured chimpanzee. Virology. 1996;221(2):346\u201350.","journal-title":"Virology"},{"key":"359_CR23","unstructured":"Panel on antiretroviral guidelines for adults and adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. \n                    http:\/\/www.aidsinfo.nih.gov\/ContentFiles\/AdultandAdolescentGL.pdf\n                    \n                  . Accessed Jan 2017 (page F-3)."},{"key":"359_CR24","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jcv.2015.01.001","volume":"64","author":"A Trevi\u00f1o","year":"2015","unstructured":"Trevi\u00f1o A, Cabezas T, Lozano AB, Garc\u00eda-Delgado R, Force L, Fern\u00e1ndez-Montero JM, et al. Dolutegravir for the treatment of HIV-2 infection. J Clin Virol. 2015;64:12\u20135.","journal-title":"J Clin Virol"},{"issue":"1","key":"359_CR25","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1086\/498348","volume":"42","author":"LD Saravolatz","year":"2006","unstructured":"Saravolatz LD, Saag MS. Emtricitabine, a new antiretroviral agent with activity against HIV and hepatitis B virus. Clin Infect Dis. 2006;42(1):126\u201331.","journal-title":"Clin Infect Dis"},{"issue":"9868","key":"359_CR26","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/S0140-6736(12)61853-4","volume":"381","author":"F Raffi","year":"2013","unstructured":"Raffi F, Rachlis A, Stellbrink H-J, Hardy WD, Torti C, Orkin C, et al. Once-daily dolutegravir versus raltegravir in antiretroviral-naive adults with HIV-1 infection: 48 week results from the randomised, double-blind, non-inferiority SPRING-2 study. Lancet. 2013;381(9868):735\u201343.","journal-title":"Lancet"},{"issue":"9","key":"359_CR27","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1097\/00002030-200206140-00008","volume":"16","author":"RT Schooley","year":"2002","unstructured":"Schooley RT, Ruane P, Myers RA, Beall G, Lampiris H, Berger D, et al. Tenofovir DF in antiretroviral-experienced patients: results from a 48-week, randomized, double-blind study. AIDS. 2002;16(9):1257\u201363.","journal-title":"AIDS"},{"issue":"2","key":"359_CR28","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1089\/aid.2015.0130","volume":"32","author":"GQ Del Prete","year":"2015","unstructured":"Del Prete GQ, Smedley J, Macallister R, Jones GS, Li B, Hattersley J, et al. Short Communication: comparative evaluation of coformulated injectable combination antiretroviral therapy regimens in simian immunodeficiency virus-infected rhesus macaques. AIDS Res Hum Retroviruses. 2015;32(2):163\u20138.","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"7","key":"359_CR29","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1093\/jac\/dks097","volume":"67","author":"PMM Mesquita","year":"2012","unstructured":"Mesquita PMM, Rastogi R, Segarra TJ, Teller RS, Torres NM, Huber AM, et al. Intravaginal ring delivery of tenofovir disoproxil fumarate for prevention of HIV and herpes simplex virus infection. J Antimicrob Chemother. 2012;67(7):1730\u20138.","journal-title":"J Antimicrob Chemother"},{"issue":"11","key":"359_CR30","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1007\/s40262-013-0093-2","volume":"52","author":"ML Cottrell","year":"2013","unstructured":"Cottrell ML, Hadzic T, Kashuba ADM. Clinical pharmacokinetic, pharmacodynamic and drug-interaction profile of the integrase inhibitor dolutegravir. Clin Pharmacokinet. 2013;52(11):981\u201394.","journal-title":"Clin Pharmacokinet"},{"issue":"12","key":"359_CR31","doi-asserted-by":"publisher","first-page":"5914","DOI":"10.1128\/AAC.00544-11","volume":"55","author":"PM Flynn","year":"2011","unstructured":"Flynn PM, Mirochnick M, Shapiro DE, Bardeguez A, Rodman J, Robbins B, et al. Pharmacokinetics and safety of single-dose tenofovir disoproxil fumarate and emtricitabine in HIV-1-infected pregnant women and their infants. Antimicrob Agents Chemother. 2011;55(12):5914\u201322.","journal-title":"Antimicrob Agents Chemother"},{"issue":"14","key":"359_CR32","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1097\/QAD.0b013e32834a1dd9","volume":"25","author":"S Min","year":"2011","unstructured":"Min S, Sloan L, DeJesus E, Hawkins T, McCurdy L, Song I, et al. Antiviral activity, safety, and pharmacokinetics\/pharmacodynamics of dolutegravir as 10-day monotherapy in HIV-1-infected adults. AIDS. 2011;25(14):1737\u201345.","journal-title":"AIDS"},{"issue":"6","key":"359_CR33","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1177\/0091270007300951","volume":"47","author":"MR Blum","year":"2007","unstructured":"Blum MR, Chittick GE, Begley JA, Zong J. Steady-state pharmacokinetics of emtricitabine and tenofovir disoproxil fumarate administered alone and in combination in healthy volunteers. J Clin Pharmacol. 2007;47(6):751\u20139.","journal-title":"J Clin Pharmacol"},{"issue":"18","key":"359_CR34","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.2165\/00003495-200464180-00005","volume":"64","author":"TM Dando","year":"2004","unstructured":"Dando TM, Wagstaff AJ. Emtricitabine\/tenofovir disoproxil fumarate. Drugs. 2004;64(18):2075\u201382.","journal-title":"Drugs"},{"issue":"1","key":"359_CR35","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1128\/AAC.00842-09","volume":"54","author":"S Min","year":"2010","unstructured":"Min S, Song I, Borland J, Chen S, Lou Y, Fujiwara T, et al. Pharmacokinetics and safety of S\/GSK1349572, a next-generation HIV integrase inhibitor, in healthy volunteers. Antimicrob Agents Chemother. 2010;54(1):254\u20138.","journal-title":"Antimicrob Agents Chemother"},{"issue":"10","key":"359_CR36","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1056\/NEJMra025195","volume":"350","author":"F Clavel","year":"2004","unstructured":"Clavel F, Hance AJ. HIV drug resistance. New Engl J Med. 2004;350(10):1023\u201335.","journal-title":"New Engl J Med"},{"issue":"8","key":"359_CR37","doi-asserted-by":"publisher","first-page":"3952","DOI":"10.1128\/JVI.02660-07","volume":"82","author":"JF Salazar-Gonzalez","year":"2008","unstructured":"Salazar-Gonzalez JF, Bailes E, Pham KT, Salazar MG, Guffey MB, Keele BF, et al. Deciphering human immunodeficiency virus type 1 transmission and early envelope diversification by single-genome amplification and sequencing. J Virol. 2008;82(8):3952\u201370.","journal-title":"J Virol"},{"issue":"5","key":"359_CR38","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1111\/j.1368-5031.2004.00100.x","volume":"58","author":"M Nelson","year":"2004","unstructured":"Nelson M, Schiavone M. Emtricitabine (FTC) for the treatment of HIV infection. Int J Clin Pract. 2004;58(5):504\u201310.","journal-title":"Int J Clin Pract"},{"issue":"6","key":"359_CR39","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1093\/infdis\/171.6.1411","volume":"171","author":"R Schuurman","year":"1995","unstructured":"Schuurman R, Nijhuis M, Rv Leeuwen, Schipper P, Jong Dd, Collis P, et al. Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant virus populations in persons treated with lamivudine (3TC). J Infect Dis. 1995;171(6):1411\u20139.","journal-title":"J Infect Dis"},{"issue":"15","key":"359_CR40","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1002\/j.1460-2075.1996.tb00777.x","volume":"15","author":"NK Back","year":"1996","unstructured":"Back NK, Nijhuis M, Keulen W, Boucher CA, Oude Essink BO, van Kuilenburg AB, et al. Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme. EMBO J. 1996;15(15):4040\u20139.","journal-title":"EMBO J"},{"issue":"10","key":"359_CR41","doi-asserted-by":"publisher","first-page":"E1126","DOI":"10.1073\/pnas.1414926112","volume":"112","author":"MK Rothenberger","year":"2015","unstructured":"Rothenberger MK, Keele BF, Wietgrefe SW, Fletcher CV, Beilman GJ, Chipman JG, et al. Large number of rebounding\/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption. Proc Natl Acad Sci USA. 2015;112(10):E1126\u201334.","journal-title":"Proc Natl Acad Sci USA."},{"issue":"3","key":"359_CR42","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1128\/JVI.02139-15","volume":"90","author":"MF Kearney","year":"2016","unstructured":"Kearney MF, Wiegand A, Shao W, Coffin JM, Mellors JW, Lederman M, et al. Origin of rebound plasma HIV includes cells with identical proviruses that are transcriptionally active before stopping of antiretroviral therapy. J Virol. 2016;90(3):1369\u201376.","journal-title":"J Virol"},{"issue":"3","key":"359_CR43","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1093\/infdis\/jiw172","volume":"214","author":"MM Bednar","year":"2016","unstructured":"Bednar MM, Hauser BM, Zhou S, Jacobson JM, Eron JJ Jr, Frank I, et al. Diversity and tropism of HIV-1 rebound virus populations in plasma level after treatment discontinuation. J Infect Dis. 2016;214(3):403\u20137.","journal-title":"J Infect Dis"},{"issue":"21","key":"359_CR44","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1056\/NEJMoa1608243","volume":"375","author":"KJ Bar","year":"2016","unstructured":"Bar KJ, Sneller MC, Harrison LJ, Justement JS, Overton ET, Petrone ME, et al. Effect of HIV antibody VRC01 on viral rebound after treatment interruption. New Engl J Med. 2016;375(21):2037\u201350.","journal-title":"New Engl J Med"},{"issue":"43","key":"359_CR45","doi-asserted-by":"publisher","first-page":"16725","DOI":"10.1073\/pnas.0804192105","volume":"105","author":"B Joos","year":"2008","unstructured":"Joos B, Fischer M, Kuster H, Pillai SK, Wong JK, B\u00f6ni J, et al. HIV rebounds from latently infected cells, rather than from continuing low-level replication. Proc Natl Acad Sci USA. 2008;105(43):16725\u201330.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"359_CR46","doi-asserted-by":"publisher","first-page":"e1000890","DOI":"10.1371\/journal.ppat.1000890","volume":"6","author":"H Li","year":"2010","unstructured":"Li H, Bar KJ, Wang S, Decker JM, Chen Y, Sun C, et al. High multiplicity infection by HIV-1 in men who have sex with men. PLoS Pathog. 2010;6(5):e1000890.","journal-title":"PLoS Pathog"},{"issue":"3","key":"359_CR47","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1093\/sysbio\/syq010","volume":"59","author":"S Guindon","year":"2010","unstructured":"Guindon S, Dufayard J-F, Lefort V, Anisimova M, Hordijk W, Gascuel O. New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Syst Biol. 2010;59(3):307\u201321.","journal-title":"Syst Biol"},{"key":"359_CR48","doi-asserted-by":"publisher","first-page":"e11282","DOI":"10.7554\/eLife.11282","volume":"4","author":"F Zanini","year":"2015","unstructured":"Zanini F, Brodin J, Thebo L, Lanz C, Bratt G, Albert J, et al. Population genomics of intrapatient HIV-1 evolution. eLife. 2015;4:e11282.","journal-title":"eLife"},{"issue":"12","key":"359_CR49","doi-asserted-by":"crossref","first-page":"10489","DOI":"10.1128\/JVI.73.12.10489-10502.1999","volume":"73","author":"R Shankarappa","year":"1999","unstructured":"Shankarappa R, Margolick JB, Gange SJ, Rodrigo AG, Upchurch D, Farzadegan H, et al. Consistent viral evolutionary changes associated with the progression of human immunodeficiency virus type 1 infection. J Virol. 1999;73(12):10489\u2013502.","journal-title":"J Virol"},{"issue":"1","key":"359_CR50","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/1471-2148-7-214","volume":"7","author":"AJ Drummond","year":"2007","unstructured":"Drummond AJ, Rambaut A. BEAST: Bayesian evolutionary analysis by sampling trees. BMC Evol Biol. 2007;7(1):214.","journal-title":"BMC Evol Biol"},{"issue":"3","key":"359_CR51","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1128\/JVI.75.3.1533-1539.2001","volume":"75","author":"FJ Novembre","year":"2001","unstructured":"Novembre FJ, de Rosayro J, Nidtha S, O\u2019Neil SP, Gibson TR, Evans-Strickfaden T, et al. Rapid CD4+ T-cell loss induced by human immunodeficiency virus type 1NC in uninfected and previously infected chimpanzees. J Virol. 2001;75(3):1533\u20139.","journal-title":"J Virol"},{"issue":"5","key":"359_CR52","doi-asserted-by":"crossref","first-page":"4086","DOI":"10.1128\/JVI.71.5.4086-4091.1997","volume":"71","author":"FJ Novembre","year":"1997","unstructured":"Novembre FJ, Saucier M, Anderson DC, Klumpp SA, O\u2019Neil SP, Brown CR, et al. Development of AIDS in a chimpanzee infected with human immunodeficiency virus type 1. J Virol. 1997;71(5):4086\u201391.","journal-title":"J Virol"},{"issue":"4","key":"359_CR53","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1086\/315823","volume":"182","author":"SP O\u2019Neil","year":"2000","unstructured":"O\u2019Neil SP, Novembre FJ, Hill AB, Suwyn C, Hart CE, Evans-Strickfaden T, et al. Progressive infection in a subset of HIV-1-positive chimpanzees. J Infect Dis. 2000;182(4):1051\u201362.","journal-title":"J Infect Dis"},{"issue":"4","key":"359_CR54","first-page":"132","volume":"24","author":"AM Wensing","year":"2017","unstructured":"Wensing AM, Calvez V, Gunthard HF, Johnson VA, Paredes R, Pillay D, et al. 2017 update of the drug resistance mutations in HIV-1. Top Antivir Med. 2017;24(4):132\u201341.","journal-title":"Top Antivir Med"},{"issue":"8","key":"359_CR55","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1038\/nmeth.2109","volume":"9","author":"D Darriba","year":"2012","unstructured":"Darriba D, Taboada GL, Doallo R, Posada D. jModelTest 2: more models, new heuristics and high-performance computing. Nat Methods. 2012;9(8):772.","journal-title":"Nat Methods"}],"container-title":["Retrovirology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12977-017-0359-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12977-017-0359-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12977-017-0359-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T09:43:22Z","timestamp":1589535802000},"score":1,"resource":{"primary":{"URL":"https:\/\/retrovirology.biomedcentral.com\/articles\/10.1186\/s12977-017-0359-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,2]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["359"],"URL":"https:\/\/doi.org\/10.1186\/s12977-017-0359-0","relation":{},"ISSN":["1742-4690"],"issn-type":[{"value":"1742-4690","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,2]]},"assertion":[{"value":"27 April 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"35"}}