{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:23:42Z","timestamp":1788189822739,"version":"build-2803163510"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Health"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Polycystic ovary syndrome (PCOS) is marked in 30 to 40% by insulin resistance and hyperandrogenism. Myo-inositol (MI) increases insulin sensitivity, decreases hyperandrogenism and improves the menstrual cycle. Its effect during assisted reproductive technologies (ART) has been studied by many authors. We conducted a review of the literature on the impact of MI administration in PCOS women in assisted reproductive technologies. Myo-inositol is effective in normalizing ovarian function, improving oocyte and embryo quality in PCOS, however further evaluations by large multicentre randomized controlled trials are needed to assess the clinical pregnancy and live birth rates in ART.<\/jats:p>","DOI":"10.1186\/s12978-021-01073-3","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T14:03:01Z","timestamp":1611064981000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Impact of myo-inositol treatment in women with polycystic ovary syndrome in assisted reproductive technologies"],"prefix":"10.1186","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0184-0880","authenticated-orcid":false,"given":"Philippe","family":"Merviel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pandora","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Bou\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Le Guillou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Rince","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Nachtergaele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Kerlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"key":"1073_CR1","first-page":"623","volume":"45","author":"P Merviel","year":"2017","unstructured":"Merviel P, Bou\u00e9e S, M\u00e9nard M, Le Martelot MT, Roche S, Leli\u00e8vre C, et al. Which ovarian stimulation to which women: the polycystic ovary syndrome (PCOS). Gynecol Obstet Fertil Senol. 2017;45:623\u201331.","journal-title":"Gynecol Obstet Fertil Senol"},{"key":"1073_CR2","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1093\/humrep\/17.6.1591","volume":"17","author":"TTY Chiu","year":"2002","unstructured":"Chiu TTY, Rogers MS, Law ELK, Britton-Jones CM, Cheung LP, Haines CJ. Follicular fluid and serum concentrations of myo-inositol in patients undergoing IVF\u202f: relationship with oocyte quality. Hum Reprod. 2002;17:1591\u20136.","journal-title":"Hum Reprod"},{"key":"1073_CR3","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.tem.2018.09.001","volume":"29","author":"AS Lagana","year":"2018","unstructured":"Lagana AS, Garzon S, Casarin J, Franchi M, Ghazzi F. Inositol in polycystic ovary syndrome: restoring fertility through a pathophysiology-based approach. Trends Endocrinol Metab. 2018;29:768\u201380.","journal-title":"Trends Endocrinol Metab"},{"key":"1073_CR4","first-page":"347","volume":"11","author":"S Gerli","year":"2007","unstructured":"Gerli S, Papaleo E, Ferrari A, Di Renzo GC. Randomized, double-blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS. Eur Rev Med Pharmacol Sci. 2007;11:347\u201354.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"1073_CR5","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1080\/15604280212528","volume":"3","author":"J Larner","year":"2002","unstructured":"Larner J. D-chiro-inositol \u2013 its functional role in insulin action and its deficit in insulin resistance. Int J Exp Diabetes Res. 2002;3:47\u201360.","journal-title":"Int J Exp Diabetes Res"},{"key":"1073_CR6","first-page":"452","volume":"15","author":"V Unfer","year":"2011","unstructured":"Unfer V, Carlomagno G, Rizzo P, Raffone E, Roseff S. Myo-inositol rather than D-chiro-inositol is able to improve oocyte quality in intracytoplasmic sperm injection cycles: a prospective, controlled, randomized trial. Eur Rev Med Pharm Sci. 2011;15:452\u20137.","journal-title":"Eur Rev Med Pharm Sci"},{"key":"1073_CR7","first-page":"5512","volume":"23","author":"M Nordio","year":"2019","unstructured":"Nordio M, Basciani S, Camajani E. The 40:1 myo-inositol\/D-chiro-inositol plasma ratio is able to restore ovulation in PCOS patients: comparison with other ratios. Eur Rev Med Pharmacol Sci. 2019;23:5512\u201321.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"1073_CR8","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1080\/09513590903015544","volume":"25","author":"MM Zacche","year":"2009","unstructured":"Zacche MM, Caputo L, Filippis S, Zacche G, Dindelli M, Ferrari A. Efficacy of myo-inositol in the treatment of cutaneous disorders on young women with polycystic ovary syndrome. 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