{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:35:51Z","timestamp":1774690551464,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","award":["3402284"],"award-info":[{"award-number":["3402284"]}],"id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Health"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Endometriosis is a chronic disease affecting 6\u201310% of women worldwide. Sexual dysfunction has been reported in a significant percentage of these patients. Thus, the present study will be conducted to design, implement, and determine the effectiveness of an interventional program to improve the sexual function of women with endometriosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This mixed-methods study will be carried out in three phases with a sequential exploratory approach. In the first phase (qualitative study) participants will be selected by purposive sampling in Isfahan, Iran. The data will be collected through in-depth interviews and field notes and analyzed using conventional content analysis. The interventional program will be designed in the second phase based on the results of the qualitative study and literature review and using the Delphi method and panel of experts. The interventional program will be implemented at the individual level in the third phase to investigate its effect on improving women\u2019s sexual function. This phase includes quasi-experimental research, in which the pre- and post-intervention data will be collected from the intervention and control groups using the FSFI questionnaire and analyzed by descriptive and inferential statistical methods. Ultimately, a suitable interventional program will be presented by combining the data obtained in the qualitative and quantitative phases of the research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Conducting the present study, along with the design and implementation of an appropriate, native, and culturally sensitive interventional program, can contribute to improving the sexual function of women with endometriosis and enhancing the quality of sexual relations between couples.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12978-024-01759-4","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T16:02:36Z","timestamp":1709049756000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A comprehensive interventional program to improve the sexual function of women with endometriosis: a mixed-methods protocol study"],"prefix":"10.1186","volume":"21","author":[{"given":"Maryam Heidari","family":"Sarvestani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahnaz","family":"Noroozi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Hashemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firoozeh","family":"Mostafavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"1759_CR1","volume-title":"Berek & Novak\u2019s gynecology essentials","author":"JS Berek","year":"2020","unstructured":"Berek JS. Berek & Novak\u2019s gynecology essentials. Lippincott Williams & Wilkins; 2020."},{"issue":"9","key":"1759_CR2","first-page":"761","volume":"20","author":"Z Daneshfar","year":"2022","unstructured":"Daneshfar Z, Jahanian Sadatmahalleh S, Jahangiri N. Comparison of sexual function in infertile women with polycystic ovary syndrome and endometriosis: a cross-sectional study. IJRM. 2022;20(9):761\u20138.","journal-title":"IJRM"},{"issue":"13","key":"1759_CR3","doi-asserted-by":"publisher","first-page":"4683","DOI":"10.3390\/ijerph17134683","volume":"17","author":"L Della Corte","year":"2020","unstructured":"Della Corte L, Di Filippo C, Gabrielli O, Reppuccia S, La Rosa VL, Ragusa R, et al. The burden of endometriosis on women\u2019s lifespan: a narrative overview on quality of life and psychosocial wellbeing. Int J Environ Res Public Health. 2020;17(13):4683.","journal-title":"Int J Environ Res Public Health"},{"issue":"3","key":"1759_CR4","doi-asserted-by":"crossref","first-page":"446","DOI":"10.4103\/ijmr.IJMR_817_18","volume":"154","author":"Y Moradi","year":"2021","unstructured":"Moradi Y, Shams-Beyranvand M, Khateri S, Gharahjeh S, Tehrani S, Varse F, et al. A systematic review on the prevalence of endometriosis in women. IJMR. 2021;154(3):446\u201354.","journal-title":"IJMR"},{"issue":"11","key":"1759_CR5","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1080\/09513590.2020.1812570","volume":"36","author":"FR P\u00e9rez-L\u00f3pez","year":"2020","unstructured":"P\u00e9rez-L\u00f3pez FR, Ornat L, P\u00e9rez-Roncero GR, L\u00f3pez-Baena MT, S\u00e1nchez-Prieto M, Chedraui P. The effect of endometriosis on sexual function as assessed with the Female Sexual Function Index: systematic review and meta-analysis. Gynecol Endocrinol. 2020;36(11):1015\u201323.","journal-title":"Gynecol Endocrinol"},{"issue":"4","key":"1759_CR6","first-page":"91","volume":"1","author":"D Cristian","year":"2022","unstructured":"Cristian D. The effects of endometriosis on women\u2019s sexual function. IJASS. 2022;1(4):91\u20136.","journal-title":"IJASS"},{"issue":"6","key":"1759_CR7","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1111\/aogs.13031","volume":"96","author":"G Barbara","year":"2017","unstructured":"Barbara G, Facchin F, Meschia M, Berlanda N, Frattaruolo MP, Vercellin IP. When love hurts. A systematic review on the effects of surgical and pharmacological treatments for endometriosis on female sexual functioning. Acta Obst Gyn Scand. 2017;96(6):668\u201387.","journal-title":"Acta Obst Gyn Scand."},{"issue":"2","key":"1759_CR8","doi-asserted-by":"publisher","first-page":"73","DOI":"10.11648\/j.ajns.20180702.15","volume":"7","author":"AMM Emam","year":"2018","unstructured":"Emam AMM, Elmenim S, Sabry SS. Effectiveness of application of PLISSIT counseling modelo on sexuality among women with dyspaurenia. AJNS. 2018;7(2):73\u201383.","journal-title":"AJNS"},{"issue":"1","key":"1759_CR9","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s12905-020-00941-7","volume":"20","author":"S Youseflu","year":"2020","unstructured":"Youseflu S, Jahanian Sadatmahalleh S, Bahri Khomami M, Nasiri M. Influential factors on sexual function in infertile women with endometriosis: a path analysis. BMC Womens Health. 2020;20(1):92.","journal-title":"BMC Womens Health"},{"issue":"6","key":"1759_CR10","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/j.jsxm.2018.03.087","volume":"15","author":"S H\u00e4mmerli","year":"2018","unstructured":"H\u00e4mmerli S, Kohl Schwartz AS, Geraedts K, Imesch P, Rauchfuss M, W\u00f6lfler MM, et al. Does endometriosis affect sexual activity and satisfaction of the man Partner? A comparison of partners from women diagnosed with endometriosis and controls. J Sex Med. 2018;15(6):853\u201365.","journal-title":"J Sex Med"},{"issue":"4","key":"1759_CR11","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1111\/scs.12810","volume":"34","author":"SM Simonsen","year":"2020","unstructured":"Simonsen SM, Str\u00f8mberg C, Zoffmann V, Hartwell D, Olesen ML. About me as a person not only the disease\u2014piloting Guided Self-Determination in an outpatient endometriosis setting. Scand J Caring Sci. 2020;34(4):1017\u201327.","journal-title":"Scand J Caring Sci"},{"issue":"3","key":"1759_CR12","first-page":"197","volume":"12","author":"P Norinho","year":"2020","unstructured":"Norinho P, Martins M, Ferreira H. A systematic review on the effects of endometriosis on sexuality and couple\u2019s relationship. Facts Views Vis Ob Gyn. 2020;12(3):197.","journal-title":"Facts Views Vis Ob Gyn"},{"issue":"4","key":"1759_CR13","first-page":"300060521100438","volume":"49","author":"X Yang","year":"2021","unstructured":"Yang X, Xu X, Lin L, Xu K, Xu M, Ye J, et al. Sexual function in patients with endometriosis: a prospective case-control study in China. JIMR. 2021;49(4):3000605211004388.","journal-title":"JIMR"},{"key":"1759_CR14","volume-title":"Kaplan & Sadock\u2019s synopsis of psychiatry: behavioral sciences\/clinical psychiatry","author":"BJ Sadock","year":"2015","unstructured":"Sadock BJ. Kaplan & Sadock\u2019s synopsis of psychiatry: behavioral sciences\/clinical psychiatry. Philadelphia: Wolters Kluwer; 2015."},{"key":"1759_CR15","volume-title":"Human sexuality and its problems","author":"J Bancroft","year":"2008","unstructured":"Bancroft J. Human sexuality and its problems. 3rd ed. London: Churchill Livingstone; 2008.","edition":"3"},{"issue":"2","key":"1759_CR16","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.nedt.2003.10.001","volume":"24","author":"UH Graneheim","year":"2004","unstructured":"Graneheim UH, Lundman B. Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. Nurse Educ Today. 2004;24(2):105\u201312.","journal-title":"Nurse Educ Today"},{"issue":"5","key":"1759_CR17","doi-asserted-by":"publisher","first-page":"e001431","DOI":"10.1136\/bmjopen-2012-001431","volume":"2","author":"BJ Basger","year":"2012","unstructured":"Basger BJ, Chen TF, Moles RJ. Validation of prescribing appropriateness criteria for older Australians using the RAND\/UCLA appropriateness method. BMJ Open. 2012;2(5):e001431.","journal-title":"BMJ Open"},{"issue":"2","key":"1759_CR18","first-page":"269","volume":"7","author":"M Heydari","year":"2008","unstructured":"Heydari M, Faghihzadeh S. The female sexual function index (FSFI): validation of the Iranian version. Payesh. 2008;7(2):269\u201378.","journal-title":"Payesh"},{"issue":"2","key":"1759_CR19","first-page":"296","volume":"40","author":"V Bernays","year":"2020","unstructured":"Bernays V, Schwartz AK, Geraedts K, Rauchfuss M, W\u00f6lfler MM, Haeberlin F, et al. Qualitative and quantitative aspects of sex life in the context of endometriosis: a multicentre case control study. RBM Online. 2020;40(2):296\u2013304.","journal-title":"RBM Online"},{"issue":"12","key":"1759_CR20","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1177\/1933719117707054","volume":"24","author":"G Barbara","year":"2017","unstructured":"Barbara G, Facchin F, Buggio L, Somigliana E, Berlanda N, Kustermann A, et al. What is known and unknown about the association between endometriosis and sexual functioning: a systematic review of the literature. Reprod Sci. 2017;24(12):1566\u201376.","journal-title":"Reprod Sci"},{"issue":"6","key":"1759_CR21","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1093\/humupd\/dmw031","volume":"22","author":"N Pluchino","year":"2016","unstructured":"Pluchino N, Wenger JM, Petignat P, Tal R, Bolmont M, Taylor HS, et al. Sexual function in endometriosis patients and their partners: effect of the disease and consequences of treatment. Hum Reprod Update. 2016;22(6):762\u201374.","journal-title":"Hum Reprod Update"},{"key":"1759_CR22","volume-title":"Essentials of nursing research: appraising evidence for nursing practice","author":"D Polit","year":"2020","unstructured":"Polit D, Beck C. Essentials of nursing research: appraising evidence for nursing practice. Philadelphia: Lippincott Williams & Wilkins; 2020."},{"key":"1759_CR23","volume-title":"Mixed methods research: merging theory with practice","author":"SN Hesse-Biber","year":"2010","unstructured":"Hesse-Biber SN. Mixed methods research: merging theory with practice. New York: Guilford Press; 2010."},{"key":"1759_CR24","volume-title":"Introduction to nursing research: Incorporating evidence-based practice","author":"C Boswell","year":"2022","unstructured":"Boswell C, Cannon S. Introduction to nursing research: Incorporating evidence-based practice. Jones & Bartlett Learning; 2022."},{"key":"1759_CR25","volume-title":"Designing and conducting mixed methods research","author":"JW Creswell","year":"2011","unstructured":"Creswell JW, Clark VL. Designing and conducting mixed methods research. London: Sage Co; 2011."}],"container-title":["Reproductive Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12978-024-01759-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12978-024-01759-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12978-024-01759-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:48:04Z","timestamp":1731458884000},"score":1,"resource":{"primary":{"URL":"https:\/\/reproductive-health-journal.biomedcentral.com\/articles\/10.1186\/s12978-024-01759-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,27]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1759"],"URL":"https:\/\/doi.org\/10.1186\/s12978-024-01759-4","relation":{},"ISSN":["1742-4755"],"issn-type":[{"value":"1742-4755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,27]]},"assertion":[{"value":"9 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Ethics Committee of the Isfahan University of Medical Sciences in Isfahan, Iran approved the protocol of this study (code number: IR.MUI.NUREMA.REC.1402.095). Written informed consent will take from each participant. In this study, all methods will be carried out in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"29"}}