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We aimed to describe birthweight trends of term deliveries in Hungary between 1999 and 2018 and to investigate potential maternal and foetal variables that could drive these changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analysed data from the Hungarian Tauffer registry, a compulsory anonymized data collection of each delivery. We included all singleton term deliveries in 1999\u20132018 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091,591,932). We modelled birthweight trends separately in 1999\u20132008 and 2008\u20132018 in hierarchical multiple linear regression models adjusted for calendar year, newborn sex, maternal age, gestational age at delivery, and other important determinants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median birthweights increased from 3250\/3400\u00a0g (girl\/boy) to 3300\/3440\u00a0g from 1999 to 2008 and decreased to 3260\/3400\u00a0g in 2018. When we adjusted for gestational age at delivery the increase in the first period became more pronounced (5.4\u00a0g\/year). During the second period, similar adjustment substantially decreased the rate of decline from 2.5 to 1.4\u00a0g\/year. Further adjustment for maternal age halved the rate of increase to 2.4\u00a0g\/year in the first period. During the second period, adjustment for maternal age had little effect on the estimate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings of an increasing birthweight trend (mostly related to the aging of the mothers) in 1999\u20132008 may forecast an increased risk of cardiometabolic diseases in offsprings born in this period. In contrast, the decreasing birthweight trends after 2008 may reflect some beneficial effects on perinatal morbidity. However, the long-term effect cannot be predicted, as the trend is mostly explained by the shorter pregnancies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12978-024-01787-0","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T09:01:53Z","timestamp":1712912513000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Birthweight trends and their explanatory factors in Hungary between 1999 and 2018: an analysis of the Hungarian Tauffer registry"],"prefix":"10.1186","volume":"21","author":[{"given":"L\u00e1szl\u00f3","family":"Zsirai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Kun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gergely \u00c1.","family":"Visolyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rk M.","family":"Sv\u00e9bis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrix A.","family":"Domj\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1d\u00e1m","family":"Tab\u00e1k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"1787_CR1","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1097\/AOG.0000000000000388","volume":"124","author":"AA Moraitis","year":"2014","unstructured":"Moraitis AA, Wood AM, Fleming M, Smith GCS. 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After each parturition (24\u201343 weeks of gestation), an anonymized standardized report form is filled in and then collected by the National Healthcare Service Centre. The current analysis uses only unidentifiable information collected according to Hungarian law in agreement with European ethical directives. Thus, no ethical approval or individual consent was required for this analysis.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and\u00a0consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"52"}}