{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:10:32Z","timestamp":1793293832893,"version":"4.5.0"},"reference-count":201,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":49,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100032551","name":"Haleon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100032551","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Immun Ageing"],"DOI":"10.1186\/s12979-026-00569-5","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:07:17Z","timestamp":1777442837000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inflammaging and the role of micronutrients as immunomodulators: a pathway to healthy aging"],"prefix":"10.1186","volume":"23","author":[{"given":"Sheryl S.L.","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandana","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijeet","family":"Dhiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitu","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Conway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"569_CR1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s40520-025-03021-8","volume":"37","author":"V Gianfredi","year":"2025","unstructured":"Gianfredi V, Nucci D, Pennisi F, Maggi S, Veronese N, Soysal P. Aging, longevity, and healthy aging: the public health approach. Aging Clin Exp Res. 2025;37:125. https:\/\/doi.org\/10.1007\/s40520-025-03021-8.","journal-title":"Aging Clin Exp Res"},{"key":"569_CR2","unstructured":"World Health Organisation. Ageing and health. 2025 [cited 2025 Oct 14]. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/ageing-and-health. Accessed 14 Oct 2025."},{"key":"569_CR3","unstructured":"Nations U. Oct. Ageing. U. N. United Nations; [cited 2025 Oct 10]. https:\/\/www.un.org\/en\/global-issues\/ageing. Accessed 10 2025."},{"key":"569_CR4","doi-asserted-by":"publisher","first-page":"afac328","DOI":"10.1093\/ageing\/afac328","volume":"52","author":"B Dugan","year":"2023","unstructured":"Dugan B, Conway J, Duggal NA. Inflammaging as a target for healthy ageing. Age Ageing. 2023;52:afac328. https:\/\/doi.org\/10.1093\/ageing\/afac328.","journal-title":"Age Ageing"},{"key":"569_CR5","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3389\/fcvm.2018.00012","volume":"5","author":"F Sanada","year":"2018","unstructured":"Sanada F, Taniyama Y, Muratsu J, Otsu R, Shimizu H, Rakugi H, et al. Source of Chronic Inflammation in Aging. Front Cardiovasc Med. 2018;5:12. https:\/\/doi.org\/10.3389\/fcvm.2018.00012.","journal-title":"Front Cardiovasc Med"},{"key":"569_CR6","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","volume":"15","author":"L Ferrucci","year":"2018","unstructured":"Ferrucci L, Fabbri E. Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Nat Rev Cardiol. 2018;15:505\u201322. https:\/\/doi.org\/10.1038\/s41569-018-0064-2.","journal-title":"Nat Rev Cardiol"},{"key":"569_CR7","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","volume":"908","author":"C Franceschi","year":"2000","unstructured":"Franceschi C, Bonaf\u00e8 M, Valensin S, Olivieri F, De Luca M, Ottaviani E, et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci. 2000;908:244\u201354. https:\/\/doi.org\/10.1111\/j.1749-6632.2000.tb06651.x.","journal-title":"Ann N Y Acad Sci"},{"key":"569_CR8","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.3389\/fimmu.2017.01960","volume":"8","author":"T Fulop","year":"2018","unstructured":"Fulop T, Larbi A, Dupuis G, Le Page A, Frost EH, Cohen AA, et al. Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes? Front Immunol. 2018;8:1960. https:\/\/doi.org\/10.3389\/fimmu.2017.01960.","journal-title":"Front Immunol"},{"key":"569_CR9","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s13670-020-00338-2","volume":"9","author":"SML Ribeiro","year":"2020","unstructured":"Ribeiro SML, Fernandez SSM, Rogero MM. Nutrition and Diabetes in the Context of Inflammaging. Curr Geriatr Rep. 2020;9:251\u201360. https:\/\/doi.org\/10.1007\/s13670-020-00338-2.","journal-title":"Curr Geriatr Rep"},{"key":"569_CR10","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3390\/cells11030359","volume":"11","author":"T Teissier","year":"2022","unstructured":"Teissier T, Boulanger E, Cox LS. Interconnections between Inflammageing and Immunosenescence during Ageing. Cells. 2022;11:359. https:\/\/doi.org\/10.3390\/cells11030359.","journal-title":"Cells"},{"key":"569_CR11","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41392-023-01451-2","volume":"8","author":"Z Liu","year":"2023","unstructured":"Liu Z, Liang Q, Ren Y, Guo C, Ge X, Wang L, et al. Immunosenescence: molecular mechanisms and diseases. Signal Transduct Target Ther. 2023;8:200. https:\/\/doi.org\/10.1038\/s41392-023-01451-2.","journal-title":"Signal Transduct Target Ther"},{"key":"569_CR12","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/s41392-023-01502-8","volume":"8","author":"X Li","year":"2023","unstructured":"Li X, Li C, Zhang W, Wang Y, Qian P, Huang H. Inflammation and aging: signaling pathways and intervention therapies. Signal Transduct Target Ther Nat Publishing Group. 2023;8:239. https:\/\/doi.org\/10.1038\/s41392-023-01502-8.","journal-title":"Signal Transduct Target Ther Nat Publishing Group"},{"key":"569_CR13","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3389\/fimmu.2019.00483","volume":"10","author":"N Rodriguez-Zhurbenko","year":"2019","unstructured":"Rodriguez-Zhurbenko N, Quach TD, Hopkins TJ, Rothstein TL, Hernandez AM. Human B-1 Cells and B-1 Cell Antibodies Change With Advancing Age. Front Immunol. 2019;10:483. https:\/\/doi.org\/10.3389\/fimmu.2019.00483.","journal-title":"Front Immunol"},{"key":"569_CR14","doi-asserted-by":"publisher","unstructured":"Dou L, Peng Y, Zhang B, Yang H, Zheng K. Immune Remodeling during Aging and the Clinical Significance of Immunonutrition in Healthy Aging. Aging Dis. 2023;0. https:\/\/doi.org\/10.14336\/AD.2023.0923.","DOI":"10.14336\/AD.2023.0923"},{"key":"569_CR15","doi-asserted-by":"publisher","first-page":"3759","DOI":"10.3390\/nu12123759","volume":"12","author":"VD Badal","year":"2020","unstructured":"Badal VD, Vaccariello ED, Murray ER, Yu KE, Knight R, Jeste DV, et al. The Gut Microbiome, Aging, and Longevity: A Systematic Review. Nutrients. 2020;12:3759. https:\/\/doi.org\/10.3390\/nu12123759.","journal-title":"Nutrients"},{"key":"569_CR16","doi-asserted-by":"publisher","first-page":"2817","DOI":"10.3390\/ijms22062817","volume":"22","author":"V Mariaule","year":"2021","unstructured":"Mariaule V, Kriaa A, Soussou S, Rhimi S, Boudaya H, Hernandez J, et al. Digestive Inflammation: Role of Proteolytic Dysregulation. Int J Mol Sci. 2021;22:2817. https:\/\/doi.org\/10.3390\/ijms22062817.","journal-title":"Int J Mol Sci"},{"key":"569_CR17","doi-asserted-by":"publisher","first-page":"942796","DOI":"10.3389\/fimmu.2022.942796","volume":"13","author":"Y Wang","year":"2022","unstructured":"Wang Y, Dong C, Han Y, Gu Z, Sun C. Immunosenescence, aging and successful aging. Front Immunol. 2022;13:942796. https:\/\/doi.org\/10.3389\/fimmu.2022.942796.","journal-title":"Front Immunol"},{"key":"569_CR18","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00011-021-01510-w","volume":"71","author":"S Shenoy","year":"2022","unstructured":"Shenoy S, Gut microbiome, Vitamin D. ACE2 interactions are critical factors in immune-senescence and inflammaging: key for vaccine response and severity of COVID-19 infection. Inflamm Res. 2022;71:13\u201326. https:\/\/doi.org\/10.1007\/s00011-021-01510-w.","journal-title":"Inflamm Res"},{"key":"569_CR19","doi-asserted-by":"publisher","first-page":"236","DOI":"10.3390\/nu12010236","volume":"12","author":"AF Gombart","year":"2020","unstructured":"Gombart AF, Pierre A, Maggini S. A Review of Micronutrients and the Immune System\u2013Working in Harmony to Reduce the Risk of Infection. Nutrients. 2020;12:236. https:\/\/doi.org\/10.3390\/nu12010236.","journal-title":"Nutrients"},{"key":"569_CR20","doi-asserted-by":"publisher","first-page":"e18390","DOI":"10.1111\/jcmm.18390","volume":"28","author":"L Lan","year":"2024","unstructured":"Lan L, Feng Z, Liu X, Zhang B. The roles of essential trace elements in T cell biology. J Cell Mol Med. 2024;28:e18390. https:\/\/doi.org\/10.1111\/jcmm.18390.","journal-title":"J Cell Mol Med"},{"key":"569_CR21","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1146\/annurev.nutr.24.012003.132306","volume":"24","author":"MJ Koury","year":"2004","unstructured":"Koury MJ, Ponka P, NEW INSIGHTS INTO, ERYTHROPOIESIS. The Roles of Folate, Vitamin B12, and Iron. Annu Rev Nutr. 2004;24:105\u201331. https:\/\/doi.org\/10.1146\/annurev.nutr.24.012003.132306.","journal-title":"Annu Rev Nutr"},{"key":"569_CR22","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.3390\/nu9111211","volume":"9","author":"A Carr","year":"2017","unstructured":"Carr A, Maggini S, Vitamin C, Function I. Nutrients. 2017;9:1211. https:\/\/doi.org\/10.3390\/nu9111211.","journal-title":"Nutrients"},{"key":"569_CR23","doi-asserted-by":"publisher","first-page":"2764","DOI":"10.3390\/nu13082764","volume":"13","author":"K Norman","year":"2021","unstructured":"Norman K, Ha\u00df U, Pirlich M. Malnutrition in Older Adults\u2014Recent Advances and Remaining Challenges. Nutrients. 2021;13:2764. https:\/\/doi.org\/10.3390\/nu13082764.","journal-title":"Nutrients"},{"key":"569_CR24","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1002\/biof.1835","volume":"48","author":"M Barone","year":"2022","unstructured":"Barone M, D\u2019Amico F, Brigidi P, Turroni S. Gut microbiome-micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins? BioFactors. 2022;48:307\u201314. https:\/\/doi.org\/10.1002\/biof.1835.","journal-title":"BioFactors"},{"key":"569_CR25","doi-asserted-by":"publisher","first-page":"1082500","DOI":"10.3389\/fnut.2022.1082500","volume":"9","author":"C Munteanu","year":"2022","unstructured":"Munteanu C, Schwartz B. The relationship between nutrition and the immune system. Front Nutr. 2022;9:1082500. https:\/\/doi.org\/10.3389\/fnut.2022.1082500.","journal-title":"Front Nutr"},{"key":"569_CR26","doi-asserted-by":"publisher","first-page":"101596","DOI":"10.1016\/j.arr.2022.101596","volume":"77","author":"P Di Giosia","year":"2022","unstructured":"Di Giosia P, Stamerra CA, Giorgini P, Jamialahamdi T, Butler AE, Sahebkar A. The role of nutrition in inflammaging. Ageing Res Rev. 2022;77:101596. https:\/\/doi.org\/10.1016\/j.arr.2022.101596.","journal-title":"Ageing Res Rev"},{"key":"569_CR27","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s12979-024-00492-7","volume":"21","author":"BS Balamurugan","year":"2024","unstructured":"Balamurugan BS, Marimuthu MMC, Sundaram VA, Saravanan B, Chandrababu P, Chopra H, et al. Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity. Immun Ageing. 2024;21:88. https:\/\/doi.org\/10.1186\/s12979-024-00492-7.","journal-title":"Immun Ageing"},{"key":"569_CR28","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s41073-019-0064-8","volume":"4","author":"C Baethge","year":"2019","unstructured":"Baethge C, Goldbeck-Wood S, Mertens S. SANRA\u2014a scale for the quality assessment of narrative review articles. Res Integr Peer Rev. 2019;4:5. https:\/\/doi.org\/10.1186\/s41073-019-0064-8.","journal-title":"Res Integr Peer Rev"},{"key":"569_CR29","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/s41392-021-00646-9","volume":"6","author":"X Zhu","year":"2021","unstructured":"Zhu X, Chen Z, Shen W, Huang G, Sedivy JM, Wang H, et al. Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention. Signal Transduct Target Ther. 2021;6:245. https:\/\/doi.org\/10.1038\/s41392-021-00646-9.","journal-title":"Signal Transduct Target Ther"},{"key":"569_CR30","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.cell.2019.10.005","volume":"179","author":"V Gorgoulis","year":"2019","unstructured":"Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, et al. Cellular Senescence: Defining a Path Forward. Cell. 2019;179:813\u201327. https:\/\/doi.org\/10.1016\/j.cell.2019.10.005.","journal-title":"Cell"},{"key":"569_CR31","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s12979-023-00352-w","volume":"20","author":"D Saavedra","year":"2023","unstructured":"Saavedra D, A\u00f1\u00e9-Kour\u00ed AL, Barzilai N, Caruso C, Cho K-H, Fontana L, et al. Aging and chronic inflammation: highlights from a multidisciplinary workshop. Immun Ageing A. 2023;20:25. https:\/\/doi.org\/10.1186\/s12979-023-00352-w.","journal-title":"Immun Ageing A"},{"key":"569_CR32","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","volume":"186","author":"C L\u00f3pez-Ot\u00edn","year":"2023","unstructured":"L\u00f3pez-Ot\u00edn C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: An expanding universe. Cell. 2023;186:243\u201378. https:\/\/doi.org\/10.1016\/j.cell.2022.11.001.","journal-title":"Cell"},{"key":"569_CR33","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.mam.2005.07.007","volume":"26","author":"BN Ames","year":"2005","unstructured":"Ames BN, Atamna H, Killilea DW. Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging. Mol Aspects Med. 2005;26:363\u201378. https:\/\/doi.org\/10.1016\/j.mam.2005.07.007.","journal-title":"Mol Aspects Med"},{"key":"569_CR34","doi-asserted-by":"publisher","first-page":"6338","DOI":"10.4049\/jimmunol.1101765","volume":"188","author":"J Sugimoto","year":"2012","unstructured":"Sugimoto J, Romani AM, Valentin-Torres AM, Luciano AA, Ramirez Kitchen CM, Funderburg N, et al. Magnesium Decreases Inflammatory Cytokine Production: A Novel Innate Immunomodulatory Mechanism. J Immunol. 2012;188:6338\u201346. https:\/\/doi.org\/10.4049\/jimmunol.1101765.","journal-title":"J Immunol"},{"key":"569_CR35","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1080\/10409238.2019.1611734","volume":"54","author":"MT Cantorna","year":"2019","unstructured":"Cantorna MT, Snyder L, Arora J. Vitamin A and vitamin D regulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis. Crit Rev Biochem Mol Biol. 2019;54:184\u201392. https:\/\/doi.org\/10.1080\/10409238.2019.1611734.","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"569_CR36","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.1084\/jem.20111490","volume":"208","author":"B Dykstra","year":"2011","unstructured":"Dykstra B, Olthof S, Schreuder J, Ritsema M, De Haan G. Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells. J Exp Med. 2011;208:2691\u2013703. https:\/\/doi.org\/10.1084\/jem.20111490.","journal-title":"J Exp Med"},{"key":"569_CR37","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/s41586-024-07238-x","volume":"628","author":"JB Ross","year":"2024","unstructured":"Ross JB, Myers LM, Noh JJ, Collins MM, Carmody AB, Messer RJ, et al. Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity. Nat Nat Publishing Group. 2024;628:162\u201370. https:\/\/doi.org\/10.1038\/s41586-024-07238-x.","journal-title":"Nat Nat Publishing Group"},{"key":"569_CR38","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.3390\/cells10061386","volume":"10","author":"P Bousounis","year":"2021","unstructured":"Bousounis P, Bergo V, Trompouki E, Inflammation. Aging and Hematopoiesis: A Complex Relationship. Cells. 2021;10:1386. https:\/\/doi.org\/10.3390\/cells10061386.","journal-title":"Cells"},{"key":"569_CR39","doi-asserted-by":"publisher","first-page":"7130","DOI":"10.1038\/s41467-021-27460-9","volume":"12","author":"JJ Mistry","year":"2021","unstructured":"Mistry JJ, Hellmich C, Moore JA, Jibril A, Macaulay I, Moreno-Gonzalez M, et al. Free fatty-acid transport via CD36 drives \u03b2-oxidation-mediated hematopoietic stem cell response to infection. Nat Commun. 2021;12:7130. https:\/\/doi.org\/10.1038\/s41467-021-27460-9.","journal-title":"Nat Commun"},{"key":"569_CR40","doi-asserted-by":"publisher","first-page":"100923","DOI":"10.1016\/j.mam.2020.100923","volume":"77","author":"G Hajishengallis","year":"2021","unstructured":"Hajishengallis G, Li X, Chavakis T. Immunometabolic control of hematopoiesis. Mol Aspects Med. 2021;77:100923. https:\/\/doi.org\/10.1016\/j.mam.2020.100923.","journal-title":"Mol Aspects Med"},{"key":"569_CR41","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1017\/S0007114507832880","volume":"98","author":"W Savino","year":"2007","unstructured":"Savino W, Dardenne M, Velloso LA, Dayse Silva-Barbosa S. The thymus is a common target in malnutrition and infection. Br J Nutr. 2007;98:S11\u20136. https:\/\/doi.org\/10.1017\/S0007114507832880.","journal-title":"Br J Nutr"},{"key":"569_CR42","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.3390\/nu12072097","volume":"12","author":"N Charoenngam","year":"2020","unstructured":"Charoenngam N, Holick MF. Immunologic Effects of Vitamin D on Human Health and Disease. Nutrients. 2020;12:2097. https:\/\/doi.org\/10.3390\/nu12072097.","journal-title":"Nutrients"},{"key":"569_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s43152-020-00001-0","volume":"1","author":"G Brown","year":"2020","unstructured":"Brown G, Kutner A, Marcinkowska E. Vitamin D and Haematopoiesis. Curr Tissue Microenviron Rep. 2020;1:1\u201311. https:\/\/doi.org\/10.1007\/s43152-020-00001-0.","journal-title":"Curr Tissue Microenviron Rep"},{"key":"569_CR44","doi-asserted-by":"publisher","first-page":"131","DOI":"10.18632\/aging.100642","volume":"6","author":"F Qian","year":"2014","unstructured":"Qian F, Guo X, Wang X, Yuan X, Chen S, Malawista SE, et al. Reduced bioenergetics and toll-like receptor 1 function in human polymorphonuclear leukocytes in aging. Aging. 2014;6:131\u20139. https:\/\/doi.org\/10.18632\/aging.100642.","journal-title":"Aging"},{"key":"569_CR45","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/s41368-024-00332-w","volume":"17","author":"Z Wang","year":"2025","unstructured":"Wang Z, Saxena A, Yan W, Uriarte SM, Siqueira R, Li X. The impact of aging on neutrophil functions and the contribution to periodontitis. Int J Oral Sci. 2025;17:10. https:\/\/doi.org\/10.1038\/s41368-024-00332-w.","journal-title":"Int J Oral Sci"},{"key":"569_CR46","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1016\/0024-3205(89)90482-7","volume":"44","author":"Y Niwa","year":"1989","unstructured":"Niwa Y, Kasama T, Miyachi Y, Kanoh T. Neutrophil chemotaxis, phagocytosis and parameters of reactive oxygen species in human aging: Cross-sectional and longitudinal studies. Life Sci. 1989;44:1655\u201364. https:\/\/doi.org\/10.1016\/0024-3205(89)90482-7.","journal-title":"Life Sci"},{"key":"569_CR47","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1159\/000519183","volume":"14","author":"X Liao","year":"2022","unstructured":"Liao X, Lan Y, Shao R, Liu J, Liang S, Yin Z, et al. Vitamin D Enhances Neutrophil Generation and Function in Zebrafish (Danio rerio). J Innate Immun. 2022;14:229\u201342. https:\/\/doi.org\/10.1159\/000519183.","journal-title":"J Innate Immun"},{"key":"569_CR48","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.3390\/nu9121286","volume":"9","author":"I Wessels","year":"2017","unstructured":"Wessels I, Maywald M, Rink L. Zinc as a Gatekeeper of Immune Function. Nutrients. 2017;9:1286. https:\/\/doi.org\/10.3390\/nu9121286.","journal-title":"Nutrients"},{"key":"569_CR49","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.3390\/nu10101531","volume":"10","author":"S Maggini","year":"2018","unstructured":"Maggini S, Pierre A, Calder PC. Immune Function and Micronutrient Requirements Change over the Life Course. Nutrients. 2018;10:1531. https:\/\/doi.org\/10.3390\/nu10101531.","journal-title":"Nutrients"},{"key":"569_CR50","doi-asserted-by":"publisher","first-page":"eaaw8330","DOI":"10.1126\/sciadv.aaw8330","volume":"5","author":"Y Elyahu","year":"2019","unstructured":"Elyahu Y, Hekselman I, Eizenberg-Magar I, Berner O, Strominger I, Schiller M, et al. Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes. Sci Adv. 2019;5:eaaw8330. https:\/\/doi.org\/10.1126\/sciadv.aaw8330.","journal-title":"Sci Adv"},{"key":"569_CR51","doi-asserted-by":"publisher","first-page":"733566","DOI":"10.3389\/fimmu.2021.733566","volume":"12","author":"J De Mol","year":"2021","unstructured":"De Mol J, Kuiper J, Tsiantoulas D, Foks AC. The Dynamics of B Cell Aging in Health and Disease. Front Immunol. 2021;12:733566. https:\/\/doi.org\/10.3389\/fimmu.2021.733566.","journal-title":"Front Immunol"},{"key":"569_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/7871814","volume":"2018","author":"SS Gounder","year":"2018","unstructured":"Gounder SS, Abdullah BJJ, Radzuanb NEIBM, Zain FDBM, Sait NBM, Chua C, et al. Effect of Aging on NK Cell Population and Their Proliferation at Ex Vivo Culture Condition. Anal Cell Pathol. 2018;2018:1\u20136. https:\/\/doi.org\/10.1155\/2018\/7871814.","journal-title":"Anal Cell Pathol"},{"key":"569_CR53","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.4049\/jimmunol.1500250","volume":"195","author":"RL Indrev\u00e6r","year":"2015","unstructured":"Indrev\u00e6r RL, Moskaug J\u00d8, Paur I, B\u00f8hn SK, J\u00f8rgensen SF, Blomhoff R, et al. IRF4 Is a Critical Gene in Retinoic Acid\u2013Mediated Plasma Cell Formation and Is Deregulated in Common Variable Immunodeficiency\u2013Derived B Cells. J Immunol. 2015;195:2601\u201311. https:\/\/doi.org\/10.4049\/jimmunol.1500250.","journal-title":"J Immunol"},{"key":"569_CR54","doi-asserted-by":"publisher","first-page":"487","DOI":"10.3390\/nu16040487","volume":"16","author":"Y Yu","year":"2024","unstructured":"Yu Y, Lu C, Yu W, Lei Y, Sun S, Liu P, et al. B Cells Dynamic in Aging and the Implications of Nutritional Regulation. Nutrients. 2024;16:487. https:\/\/doi.org\/10.3390\/nu16040487.","journal-title":"Nutrients"},{"key":"569_CR55","doi-asserted-by":"publisher","first-page":"4129","DOI":"10.3390\/nu15194129","volume":"15","author":"H Lahoda Brodska","year":"2023","unstructured":"Lahoda Brodska H, Klempir J, Zavora J, Kohout P. The Role of Micronutrients in Neurological Disorders. Nutrients. 2023;15:4129. https:\/\/doi.org\/10.3390\/nu15194129.","journal-title":"Nutrients"},{"issue":"1","key":"569_CR56","doi-asserted-by":"publisher","first-page":"39","DOI":"10.5411\/wji.v6.i1.39","volume":"6","author":"R Goswami","year":"2016","unstructured":"Goswami R, Kaplan MH. Essential vitamins for an effective T cell response. World J Immunol. 2016;6(1):39\u201359.","journal-title":"World J Immunol"},{"key":"569_CR57","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1093\/advances\/nmac052","volume":"13","author":"PC Calder","year":"2022","unstructured":"Calder PC, Ortega EF, Meydani SN, Adkins Y, Stephensen CB, Thompson B, et al. Nutrition, Immunosenescence, and Infectious Disease: An Overview of the Scientific Evidence on Micronutrients and on Modulation of the Gut Microbiota. Adv Nutr Bethesda Md. 2022;13:S1\u201326. https:\/\/doi.org\/10.1093\/advances\/nmac052.","journal-title":"Adv Nutr Bethesda Md"},{"key":"569_CR58","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.nutres.2024.06.004","volume":"127","author":"M Oh","year":"2024","unstructured":"Oh M, Jung S, Kim Y, Lee GY, Han SN. Dietary vitamin D3 supplementation enhances splenic NK cell activity in healthy and diabetic male mice. Nutr Res. 2024;127:144\u201355. https:\/\/doi.org\/10.1016\/j.nutres.2024.06.004.","journal-title":"Nutr Res"},{"key":"569_CR59","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.jcyt.2015.01.004","volume":"17","author":"MJAJ Huijskens","year":"2015","unstructured":"Huijskens MJAJ, Walczak M, Sarkar S, Atrafi F, Senden-Gijsbers BLMG, Tilanus MGJ, et al. Ascorbic acid promotes proliferation of natural killer cell populations in culture systems applicable for natural killer cell therapy. Cytotherapy. 2015;17:613\u201320. https:\/\/doi.org\/10.1016\/j.jcyt.2015.01.004.","journal-title":"Cytotherapy"},{"key":"569_CR60","doi-asserted-by":"publisher","first-page":"e73754","DOI":"10.7554\/eLife.73754","volume":"11","author":"H-Y Chen","year":"2022","unstructured":"Chen H-Y, Almonte-Loya A, Lay F-Y, Hsu M, Johnson E, Gonz\u00e1lez-Avalos E, et al. Epigenetic remodeling by vitamin C potentiates plasma cell differentiation. eLife. 2022;11:e73754. https:\/\/doi.org\/10.7554\/eLife.73754.","journal-title":"eLife"},{"key":"569_CR61","doi-asserted-by":"publisher","first-page":"108452","DOI":"10.1016\/j.celrep.2020.108452","volume":"33","author":"T Qi","year":"2020","unstructured":"Qi T, Sun M, Zhang C, Chen P, Xiao C, Chang X. Ascorbic Acid Promotes Plasma Cell Differentiation through Enhancing TET2\/3-Mediated DNA Demethylation. Cell Rep. 2020;33:108452. https:\/\/doi.org\/10.1016\/j.celrep.2020.108452.","journal-title":"Cell Rep"},{"key":"569_CR62","doi-asserted-by":"publisher","first-page":"9207279","DOI":"10.1155\/2020\/9207279","volume":"2020","author":"AS Prasad","year":"2020","unstructured":"Prasad AS. Lessons Learned from Experimental Human Model of Zinc Deficiency. J Immunol Res. 2020;2020:9207279. https:\/\/doi.org\/10.1155\/2020\/9207279.","journal-title":"J Immunol Res"},{"key":"569_CR63","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1189\/jlb.0108023","volume":"84","author":"D Wu","year":"2008","unstructured":"Wu D, Meydani SN. Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention. J Leukoc Biol. 2008;84:900\u201314. https:\/\/doi.org\/10.1189\/jlb.0108023.","journal-title":"J Leukoc Biol"},{"key":"569_CR64","doi-asserted-by":"publisher","first-page":"13694","DOI":"10.1073\/pnas.1107594108","volume":"108","author":"BD Rudd","year":"2011","unstructured":"Rudd BD, Venturi V, Li G, Samadder P, Ertelt JM, Way SS, et al. Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions. Proc Natl Acad Sci. 2011;108:13694\u20139. https:\/\/doi.org\/10.1073\/pnas.1107594108.","journal-title":"Proc Natl Acad Sci"},{"key":"569_CR65","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.4049\/jimmunol.1301721","volume":"192","author":"AM Wertheimer","year":"2014","unstructured":"Wertheimer AM, Bennett MS, Park B, Uhrlaub JL, Martinez C, Pulko V, et al. Aging and Cytomegalovirus Infection Differentially and Jointly Affect Distinct Circulating T Cell Subsets in Humans. J Immunol. 2014;192:2143\u201355. https:\/\/doi.org\/10.4049\/jimmunol.1301721.","journal-title":"J Immunol"},{"key":"569_CR66","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12979-020-0173-8","volume":"17","author":"R Thomas","year":"2020","unstructured":"Thomas R, Wang W, Su D-M. Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging. Immun Ageing. 2020;17:2. https:\/\/doi.org\/10.1186\/s12979-020-0173-8.","journal-title":"Immun Ageing"},{"key":"569_CR67","doi-asserted-by":"publisher","unstructured":"Ross AC. Vitamin A and retinoic acid in T cell\u2013related immunity. Am J Clin Nutr. 2012;96. https:\/\/doi.org\/10.3945\/ajcn.112.034637. :1166S-1172S.","DOI":"10.3945\/ajcn.112.034637"},{"key":"569_CR68","doi-asserted-by":"publisher","first-page":"e27","DOI":"10.4110\/in.2018.18.e27","volume":"18","author":"JS Roh","year":"2018","unstructured":"Roh JS, Sohn DH. Damage-Associated Molecular Patterns in Inflammatory Diseases. Immune Netw. 2018;18:e27. https:\/\/doi.org\/10.4110\/in.2018.18.e27.","journal-title":"Immune Netw"},{"key":"569_CR69","doi-asserted-by":"publisher","first-page":"101755","DOI":"10.1016\/j.molmet.2023.101755","volume":"74","author":"JJ Baechle","year":"2023","unstructured":"Baechle JJ, Chen N, Makhijani P, Winer S, Furman D, Winer DA. Chronic inflammation and the hallmarks of aging. Mol Metab. 2023;74:101755. https:\/\/doi.org\/10.1016\/j.molmet.2023.101755.","journal-title":"Mol Metab"},{"key":"569_CR70","doi-asserted-by":"publisher","first-page":"35509","DOI":"10.18632\/oncotarget.5899","volume":"6","author":"F Olivieri","year":"2015","unstructured":"Olivieri F, Albertini MC, Orciani M, Ceka A, Cricca M, Procopio AD, et al. DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging. Oncotarget. 2015;6:35509\u201321. https:\/\/doi.org\/10.18632\/oncotarget.5899.","journal-title":"Oncotarget"},{"key":"569_CR71","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1042\/BJ20111451","volume":"441","author":"J Lee","year":"2012","unstructured":"Lee J, Giordano S, Zhang J. Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J. 2012;441:523\u201340. https:\/\/doi.org\/10.1042\/BJ20111451.","journal-title":"Biochem J"},{"key":"569_CR72","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.mito.2013.01.003","volume":"13","author":"MJ L\u00f3pez-Armada","year":"2013","unstructured":"L\u00f3pez-Armada MJ, Riveiro-Naveira RR, Vaamonde-Garc\u00eda C, Valc\u00e1rcel-Ares MN. Mitochondrial dysfunction and the inflammatory response. Mitochondrion. 2013;13:106\u201318. https:\/\/doi.org\/10.1016\/j.mito.2013.01.003.","journal-title":"Mitochondrion"},{"key":"569_CR73","doi-asserted-by":"publisher","unstructured":"N V K, M S. Aging through the lens of the gut microbiome: Challenges and therapeutic opportunities. Arch Gerontol Geriatr Plus. 2025;2:100142. https:\/\/doi.org\/10.1016\/j.aggp.2025.100142.","DOI":"10.1016\/j.aggp.2025.100142"},{"key":"569_CR74","doi-asserted-by":"publisher","first-page":"8785","DOI":"10.3390\/ijms26188785","volume":"26","author":"C Ramasinghe","year":"2025","unstructured":"Ramasinghe C, Bordiga M, Xu B. A Comprehensive Review of the Triangular Relationship Among Diet, Gut Microbiota, and Aging. Int J Mol Sci. 2025;26:8785. https:\/\/doi.org\/10.3390\/ijms26188785.","journal-title":"Int J Mol Sci"},{"key":"569_CR75","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/all.15972","volume":"79","author":"F Roth-Walter","year":"2024","unstructured":"Roth-Walter F, Berni Canani R, O\u2019Mahony L, Peroni D, Sokolowska M, Vassilopoulou E, et al. Nutrition in chronic inflammatory conditions: Bypassing the mucosal block for micronutrients. Allergy. 2024;79:353\u201383. https:\/\/doi.org\/10.1111\/all.15972.","journal-title":"Allergy"},{"key":"569_CR76","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1007\/s12011-022-03148-z","volume":"201","author":"H Wang","year":"2023","unstructured":"Wang H, Zhang R, Shen J, Jin Y, Chang C, Hong M, et al. Circulating Level of Blood Iron and Copper Associated with Inflammation and Disease Activity of Rheumatoid Arthritis. Biol Trace Elem Res. 2023;201:90\u20137. https:\/\/doi.org\/10.1007\/s12011-022-03148-z.","journal-title":"Biol Trace Elem Res"},{"key":"569_CR77","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1136\/gut.19.10.886","volume":"19","author":"CH Halsted","year":"1978","unstructured":"Halsted CH, Reisenauer AM, Shane B, Tamura T. Availability of monoglutamyl and polyglutamyl folates in normal subjects and in patients with coeliac sprue. Gut. 1978;19:886\u201391. https:\/\/doi.org\/10.1136\/gut.19.10.886.","journal-title":"Gut"},{"key":"569_CR78","doi-asserted-by":"publisher","unstructured":"Meng C, Feng S, Hao Z, Dong C, Liu H. Changes in gut microbiota composition with age and correlations with gut inflammation in rats. Aich P, editor. PLOS ONE. 2022;17:e0265430. https:\/\/doi.org\/10.1371\/journal.pone.0265430","DOI":"10.1371\/journal.pone.0265430"},{"key":"569_CR79","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1159\/000520054","volume":"68","author":"J Wu","year":"2022","unstructured":"Wu J, Ren W, Chen L, Lou Y, Liu C, Huang Y, et al. Age-Related Changes in the Composition of Intestinal Microbiota in Elderly Chinese Individuals. Gerontology. 2022;68:976\u201388. https:\/\/doi.org\/10.1159\/000520054.","journal-title":"Gerontology"},{"key":"569_CR80","doi-asserted-by":"publisher","first-page":"8427","DOI":"10.1007\/s00253-021-11625-z","volume":"105","author":"T Ma","year":"2021","unstructured":"Ma T, Yao C, Shen X, Jin H, Guo Z, Zhai Q, et al. The diversity and composition of the human gut lactic acid bacteria and bifidobacterial microbiota vary depending on age. Appl Microbiol Biotechnol. 2021;105:8427\u201340. https:\/\/doi.org\/10.1007\/s00253-021-11625-z.","journal-title":"Appl Microbiol Biotechnol"},{"key":"569_CR81","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1007\/s00284-017-1272-4","volume":"74","author":"K Kato","year":"2017","unstructured":"Kato K, Odamaki T, Mitsuyama E, Sugahara H, Xiao J, Osawa R. Age-Related Changes in the Composition of Gut Bifidobacterium Species. Curr Microbiol. 2017;74:987\u201395. https:\/\/doi.org\/10.1007\/s00284-017-1272-4.","journal-title":"Curr Microbiol"},{"key":"569_CR82","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1161\/CIRCRESAHA.119.316448","volume":"127","author":"J Lee","year":"2020","unstructured":"Lee J, d\u2019Aigle J, Atadja L, Quaicoe V, Honarpisheh P, Ganesh BP, et al. Gut Microbiota\u2013Derived Short-Chain Fatty Acids Promote Poststroke Recovery in Aged Mice. Circ Res. 2020;127:453\u201365. https:\/\/doi.org\/10.1161\/CIRCRESAHA.119.316448.","journal-title":"Circ Res"},{"key":"569_CR83","doi-asserted-by":"publisher","first-page":"696186","DOI":"10.3389\/fcimb.2021.696186","volume":"11","author":"Y Xu","year":"2021","unstructured":"Xu Y, Wang Y, Li H, Dai Y, Chen D, Wang M, et al. Altered Fecal Microbiota Composition in Older Adults With Frailty. Front Cell Infect Microbiol. 2021;11:696186. https:\/\/doi.org\/10.3389\/fcimb.2021.696186.","journal-title":"Front Cell Infect Microbiol"},{"key":"569_CR84","doi-asserted-by":"publisher","first-page":"2278225","DOI":"10.1080\/19490976.2023.2278225","volume":"15","author":"MY Lim","year":"2023","unstructured":"Lim MY, Nam Y-D. Gut microbiome in healthy aging versus those associated with frailty. Gut Microbes. 2023;15:2278225. https:\/\/doi.org\/10.1080\/19490976.2023.2278225.","journal-title":"Gut Microbes"},{"key":"569_CR85","doi-asserted-by":"publisher","first-page":"2756","DOI":"10.3390\/ijms20112756","volume":"20","author":"AC Daulagala","year":"2019","unstructured":"Daulagala AC, Bridges MC, Kourtidis A, E-cadherin Beyond, Structure. A Signaling Hub in Colon Homeostasis and Disease. Int J Mol Sci. 2019;20:2756. https:\/\/doi.org\/10.3390\/ijms20112756.","journal-title":"Int J Mol Sci"},{"key":"569_CR86","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1007\/s12602-021-09903-3","volume":"14","author":"R Sharma","year":"2022","unstructured":"Sharma R. Emerging Interrelationship Between the Gut Microbiome and Cellular Senescence in the Context of Aging and Disease: Perspectives and Therapeutic Opportunities. Probiotics Antimicrob Proteins. 2022;14:648\u201363. https:\/\/doi.org\/10.1007\/s12602-021-09903-3.","journal-title":"Probiotics Antimicrob Proteins"},{"key":"569_CR87","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1146\/annurev-immunol-020711-075001","volume":"30","author":"JM Brenchley","year":"2012","unstructured":"Brenchley JM, Douek DC. Microbial Translocation Across the GI Tract. Annu Rev Immunol. 2012;30:149\u201373. https:\/\/doi.org\/10.1146\/annurev-immunol-020711-075001.","journal-title":"Annu Rev Immunol"},{"key":"569_CR88","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11357-024-01451-2","volume":"47","author":"J Escalante","year":"2024","unstructured":"Escalante J, Artaiz O, Diwakarla S, McQuade RM. Leaky gut in systemic inflammation: exploring the link between gastrointestinal disorders and age-related diseases. GeroScience. 2024;47:1\u201322. https:\/\/doi.org\/10.1007\/s11357-024-01451-2.","journal-title":"GeroScience"},{"key":"569_CR89","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s12979-023-00383-3","volume":"20","author":"H-J Kim","year":"2023","unstructured":"Kim H-J, Kim H, Lee J-H, Hwangbo C. Toll-like receptor 4 (TLR4): new insight immune and aging. Immun Ageing. 2023;20:67. https:\/\/doi.org\/10.1186\/s12979-023-00383-3.","journal-title":"Immun Ageing"},{"key":"569_CR90","doi-asserted-by":"publisher","first-page":"7618","DOI":"10.3390\/ijerph17207618","volume":"17","author":"Z Al Bander","year":"2020","unstructured":"Al Bander Z, Nitert MD, Mousa A, Naderpoor N. The Gut Microbiota and Inflammation: An Overview. Int J Environ Res Public Health. 2020;17:7618. https:\/\/doi.org\/10.3390\/ijerph17207618.","journal-title":"Int J Environ Res Public Health"},{"key":"569_CR91","doi-asserted-by":"publisher","first-page":"632","DOI":"10.3390\/antiox12030632","volume":"12","author":"AJ Didier","year":"2023","unstructured":"Didier AJ, Stiene J, Fang L, Watkins D, Dworkin LD, Creeden JF. Antioxidant and Anti-Tumor Effects of Dietary Vitamins A, C, and E. Antioxidants. 2023;12:632. https:\/\/doi.org\/10.3390\/antiox12030632.","journal-title":"Antioxidants"},{"key":"569_CR92","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1080\/10409238.2019.1611734","volume":"54","author":"MT Cantorna","year":"2019","unstructured":"Cantorna MT, Snyder L, Arora J. Vitamin A and vitamin D regulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis. Crit Rev Biochem Mol Biol. 2019;54:184\u201392. https:\/\/doi.org\/10.1080\/10409238.2019.1611734.","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"569_CR93","doi-asserted-by":"publisher","unstructured":"Stefanache A, Lungu I-I, Butnariu I-A, Calin G, Gutu C, Marcu C et al. Understanding How Minerals Contribute to Optimal Immune Function. Roato I, editor. J Immunol Res. 2023;2023:1\u201326. https:\/\/doi.org\/10.1155\/2023\/3355733","DOI":"10.1155\/2023\/3355733"},{"key":"569_CR94","doi-asserted-by":"publisher","first-page":"146","DOI":"10.15430\/JCP.2019.24.3.146","volume":"24","author":"A Yildiz","year":"2019","unstructured":"Yildiz A, Kaya Y, Tanriverdi O. Effect of the Interaction Between Selenium and Zinc on DNA Repair in Association With Cancer Prevention. J Cancer Prev. 2019;24:146\u201354. https:\/\/doi.org\/10.15430\/JCP.2019.24.3.146.","journal-title":"J Cancer Prev"},{"key":"569_CR95","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.3390\/ijms25021228","volume":"25","author":"K Ferenc","year":"2024","unstructured":"Ferenc K, Sokal-Dembowska A, Helma K, Motyka E, Jarmakiewicz-Czaja S, Filip R. Modulation of the Gut Microbiota by Nutrition and Its Relationship to Epigenetics. Int J Mol Sci. 2024;25:1228. https:\/\/doi.org\/10.3390\/ijms25021228.","journal-title":"Int J Mol Sci"},{"key":"569_CR96","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.3389\/fnins.2019.01295","volume":"13","author":"AK Sauer","year":"2019","unstructured":"Sauer AK, Grabrucker AM. Zinc Deficiency During Pregnancy Leads to Altered Microbiome and Elevated Inflammatory Markers in Mice. Front Neurosci. 2019;13:1295. https:\/\/doi.org\/10.3389\/fnins.2019.01295.","journal-title":"Front Neurosci"},{"key":"569_CR97","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.3389\/fnins.2019.01295","volume":"13","author":"AK Sauer","year":"2019","unstructured":"Sauer AK, Grabrucker AM. Zinc Deficiency During Pregnancy Leads to Altered Microbiome and Elevated Inflammatory Markers in Mice. Front Neurosci. 2019;13:1295. https:\/\/doi.org\/10.3389\/fnins.2019.01295.","journal-title":"Front Neurosci"},{"key":"569_CR98","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1079\/BJN2002696","volume":"88","author":"W Zimowska","year":"2002","unstructured":"Zimowska W, Girardeau JP, Kuryszko J, Bayle D, Rayssiguier Y, Mazur A. Morphological and immune response alterations in the intestinal mucosa of the mouse after short periods on a low-magnesium diet. Br J Nutr. 2002;88:515\u201322. https:\/\/doi.org\/10.1079\/BJN2002696.","journal-title":"Br J Nutr"},{"key":"569_CR99","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.bbamem.2017.10.010","volume":"1860","author":"VS Subramanian","year":"2018","unstructured":"Subramanian VS, Sabui S, Moradi H, Marchant JS, Said HM. Inhibition of intestinal ascorbic acid uptake by lipopolysaccharide is mediated via transcriptional mechanisms. Biochim Biophys Acta BBA - Biomembr. 2018;1860:556\u201365. https:\/\/doi.org\/10.1016\/j.bbamem.2017.10.010.","journal-title":"Biochim Biophys Acta BBA - Biomembr"},{"key":"569_CR100","doi-asserted-by":"publisher","first-page":"5997","DOI":"10.1038\/s41467-020-19793-8","volume":"11","author":"RL Thomas","year":"2020","unstructured":"Thomas RL, Jiang L, Adams JS, Xu ZZ, Shen J, Janssen S, et al. Vitamin D metabolites and the gut microbiome in older men. Nat Commun. 2020;11:5997. https:\/\/doi.org\/10.1038\/s41467-020-19793-8.","journal-title":"Nat Commun"},{"key":"569_CR101","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1080\/09637486.2019.1639637","volume":"71","author":"Y Choi","year":"2020","unstructured":"Choi Y, Lee S, Kim S, Lee J, Ha J, Oh H, et al. Vitamin E (\u03b1-tocopherol) consumption influences gut microbiota composition. Int J Food Sci Nutr. 2020;71:221\u20135. https:\/\/doi.org\/10.1080\/09637486.2019.1639637.","journal-title":"Int J Food Sci Nutr"},{"key":"569_CR102","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1002\/biof.1492","volume":"45","author":"L Ran","year":"2019","unstructured":"Ran L, Liu AB, Lee M, Xie P, Lin Y, Yang CS. Effects of antibiotics on degradation and bioavailability of different vitamin E forms in mice. BioFactors. 2019;45:450\u201362. https:\/\/doi.org\/10.1002\/biof.1492.","journal-title":"BioFactors"},{"key":"569_CR103","doi-asserted-by":"publisher","unstructured":"Liu A, Lv H, Wang H, Yang H, Li Y, Qian J. Aging Increases the Severity of Colitis and the Related Changes to the Gut Barrier and Gut Microbiota in Humans and Mice. Anderson R, editor. J Gerontol Ser A. 2020;75:1284\u201392. https:\/\/doi.org\/10.1093\/gerona\/glz263","DOI":"10.1093\/gerona\/glz263"},{"key":"569_CR104","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1093\/cvr\/cvae240","volume":"121","author":"JF Aranda","year":"2025","unstructured":"Aranda JF, Ram\u00edrez CM, Mittelbrunn M. Inflammageing, a targetable pathway for preventing cardiovascular diseases. Cardiovasc Res. 2025;121:1537\u201350. https:\/\/doi.org\/10.1093\/cvr\/cvae240.","journal-title":"Cardiovasc Res"},{"key":"569_CR105","doi-asserted-by":"publisher","first-page":"101422","DOI":"10.1016\/j.arr.2021.101422","volume":"71","author":"A Santoro","year":"2021","unstructured":"Santoro A, Bientinesi E, Monti D. Immunosenescence and inflammaging in the aging process: age-related diseases or longevity? Ageing Res Rev. 2021;71:101422. https:\/\/doi.org\/10.1016\/j.arr.2021.101422.","journal-title":"Ageing Res Rev"},{"key":"569_CR106","doi-asserted-by":"publisher","first-page":"15722","DOI":"10.3390\/ijms232415722","volume":"23","author":"G Pacinella","year":"2022","unstructured":"Pacinella G, Ciaccio AM, Tuttolomondo A. Endothelial Dysfunction and Chronic Inflammation: The Cornerstones of Vascular Alterations in Age-Related Diseases. Int J Mol Sci. 2022;23:15722. https:\/\/doi.org\/10.3390\/ijms232415722.","journal-title":"Int J Mol Sci"},{"key":"569_CR107","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1093\/cvr\/cvab114","volume":"118","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Zhang S, Li B, Luo Y, Gong Y, Jin X, et al. Gut microbiota dysbiosis promotes age-related atrial fibrillation by lipopolysaccharide and glucose-induced activation of NLRP3-inflammasome. Cardiovasc Res. 2022;118:785\u201397. https:\/\/doi.org\/10.1093\/cvr\/cvab114.","journal-title":"Cardiovasc Res"},{"key":"569_CR108","doi-asserted-by":"publisher","first-page":"882211","DOI":"10.3389\/fcell.2022.882211","volume":"10","author":"YM Puspitasari","year":"2022","unstructured":"Puspitasari YM, Ministrini S, Schwarz L, Karch C, Liberale L, Camici GG. Modern Concepts in Cardiovascular Disease: Inflamm-Aging. Front Cell Dev Biol. 2022;10:882211. https:\/\/doi.org\/10.3389\/fcell.2022.882211.","journal-title":"Front Cell Dev Biol"},{"key":"569_CR109","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1001\/jama.2015.2274","volume":"313","author":"Y Huo","year":"2015","unstructured":"Huo Y, Li J, Qin X, Huang Y, Wang X, Gottesman RF, et al. Efficacy of Folic Acid Therapy in Primary Prevention of Stroke Among Adults With Hypertension in China: The CSPPT Randomized Clinical Trial. JAMA. 2015;313:1325. https:\/\/doi.org\/10.1001\/jama.2015.2274.","journal-title":"JAMA"},{"key":"569_CR110","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1016\/j.jacc.2022.09.048","volume":"80","author":"P An","year":"2022","unstructured":"An P, Wan S, Luo Y, Luo J, Zhang X, Zhou S, et al. Micronutrient Supplementation to Reduce Cardiovascular Risk. J Am Coll Cardiol. 2022;80:2269\u201385. https:\/\/doi.org\/10.1016\/j.jacc.2022.09.048.","journal-title":"J Am Coll Cardiol"},{"key":"569_CR111","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1007\/s12272-001-1291-5","volume":"31","author":"AHG Rasool","year":"2008","unstructured":"Rasool AHG, Rahman AbdRAbd, Yuen KH, Wong AR. Arterial compliance and vitamin E blood levels with a self emulsifying preparation of tocotrienol rich vitamin E. Arch Pharm Res. 2008;31:1212\u20137. https:\/\/doi.org\/10.1007\/s12272-001-1291-5.","journal-title":"Arch Pharm Res"},{"key":"569_CR112","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12959-025-00693-0","volume":"23","author":"X Lyu","year":"2025","unstructured":"Lyu X, Chen L, Wang W. Dietary zinc intake and 10-year atherosclerotic cardiovascular disease risk in diabetes mellitus patients: evidence from NHANES database. Thromb J. 2025;23:18. https:\/\/doi.org\/10.1186\/s12959-025-00693-0.","journal-title":"Thromb J"},{"key":"569_CR113","doi-asserted-by":"publisher","first-page":"1029948","DOI":"10.3389\/fimmu.2022.1029948","volume":"13","author":"H Zheng","year":"2022","unstructured":"Zheng H, Zhang C, Wang Q, Feng S, Fang Y, Zhang S. The impact of aging on intestinal mucosal immune function and clinical applications. Front Immunol. 2022;13:1029948. https:\/\/doi.org\/10.3389\/fimmu.2022.1029948.","journal-title":"Front Immunol"},{"key":"569_CR114","doi-asserted-by":"publisher","first-page":"34","DOI":"10.37290\/ijpp2641-7197.15","volume":"15","author":"M Sajid","year":"2020","unstructured":"Sajid M, Negi S. Gut Microbes: A Plausible Association Between Inflammaging and Metabolic Disorders. Int J Probiotics Prebiotics. 2020;15:34\u201344. https:\/\/doi.org\/10.37290\/ijpp2641-7197.15.","journal-title":"Int J Probiotics Prebiotics"},{"key":"569_CR115","doi-asserted-by":"publisher","first-page":"50","DOI":"10.15420\/ecr.2018.33.1","volume":"14","author":"S Tsalamandris","year":"2019","unstructured":"Tsalamandris S, Antonopoulos AS, Oikonomou E, Papamikroulis G-A, Vogiatzi G, Papaioannou S, et al. The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives. Eur Cardiol Rev. 2019;14:50\u20139. https:\/\/doi.org\/10.15420\/ecr.2018.33.1.","journal-title":"Eur Cardiol Rev"},{"key":"569_CR116","doi-asserted-by":"publisher","first-page":"200238","DOI":"10.1016\/j.hnm.2023.200238","volume":"35","author":"S Younes","year":"2024","unstructured":"Younes S. The role of micronutrients on the treatment of diabetes. Hum Nutr Metab. 2024;35:200238. https:\/\/doi.org\/10.1016\/j.hnm.2023.200238.","journal-title":"Hum Nutr Metab"},{"key":"569_CR117","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s11892-008-0068-0","volume":"8","author":"MF Holick","year":"2008","unstructured":"Holick MF. Diabetes and the vitamin D connection. Curr Diab Rep. 2008;8:393\u20138. https:\/\/doi.org\/10.1007\/s11892-008-0068-0.","journal-title":"Curr Diab Rep"},{"key":"569_CR118","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.jnutbio.2017.09.022","volume":"52","author":"A Dihingia","year":"2018","unstructured":"Dihingia A, Ozah D, Ghosh S, Sarkar A, Baruah PK, Kalita J, et al. Vitamin K1 inversely correlates with glycemia and insulin resistance in patients with type 2 diabetes (T2D) and positively regulates SIRT1\/AMPK pathway of glucose metabolism in liver of T2D mice and hepatocytes cultured in high glucose. J Nutr Biochem. 2018;52:103\u201314. https:\/\/doi.org\/10.1016\/j.jnutbio.2017.09.022.","journal-title":"J Nutr Biochem"},{"key":"569_CR119","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1758-5996-4-13","volume":"4","author":"R Jayawardena","year":"2012","unstructured":"Jayawardena R, Ranasinghe P, Galappatthy P, Malkanthi R, Constantine G, Katulanda P. Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analysis. Diabetol Metab Syndr. 2012;4:13. https:\/\/doi.org\/10.1186\/1758-5996-4-13.","journal-title":"Diabetol Metab Syndr"},{"key":"569_CR120","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.4103\/1673-5374.335837","volume":"17","author":"A Alsegiani","year":"2022","unstructured":"Alsegiani A, Shah Z. The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline. Neural Regen Res. 2022;17:2407. https:\/\/doi.org\/10.4103\/1673-5374.335837.","journal-title":"Neural Regen Res"},{"key":"569_CR121","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1002\/hipo.10114","volume":"13","author":"CL Grady","year":"2003","unstructured":"Grady CL, McIntosh AR, Craik FIM. Age-related differences in the functional connectivity of the hippocampus during memory encoding. Hippocampus. 2003;13:572\u201386. https:\/\/doi.org\/10.1002\/hipo.10114.","journal-title":"Hippocampus"},{"key":"569_CR122","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1177\/2040622311399145","volume":"2","author":"AA Simen","year":"2011","unstructured":"Simen AA, Bordner KA, Martin MP, Moy LA, Barry LC. Cognitive dysfunction with aging and the role of inflammation. Ther Adv Chronic Dis. 2011;2:175\u201395. https:\/\/doi.org\/10.1177\/2040622311399145.","journal-title":"Ther Adv Chronic Dis"},{"key":"569_CR123","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1002\/iub.2507","volume":"74","author":"G Olaso-Gonzalez","year":"2022","unstructured":"Olaso-Gonzalez G, Inzitari M, Bellelli G, Morandi A, Barcons N, Vi\u00f1a J. Impact of supplementation with vitamins B6, B12, and\/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A systematic review. IUBMB Life. 2022;74:74\u201384. https:\/\/doi.org\/10.1002\/iub.2507.","journal-title":"IUBMB Life"},{"key":"569_CR124","doi-asserted-by":"publisher","first-page":"215","DOI":"10.3945\/ajcn.114.103283","volume":"102","author":"F Jerner\u00e9n","year":"2015","unstructured":"Jerner\u00e9n F, Elshorbagy AK, Oulhaj A, Smith SM, Refsum H, Smith AD. Brain atrophy in cognitively impaired elderly: the importance of long-chain \u03c9-3 fatty acids and B vitamin status in a randomized controlled trial. Am J Clin Nutr. 2015;102:215\u201321. https:\/\/doi.org\/10.3945\/ajcn.114.103283.","journal-title":"Am J Clin Nutr"},{"key":"569_CR125","doi-asserted-by":"publisher","first-page":"622","DOI":"10.2174\/1567205016666190725144629","volume":"16","author":"F Ma","year":"2019","unstructured":"Ma F, Zhou X, Li Q, Zhao J, Song A, An P, et al. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design. Curr Alzheimer Res. 2019;16:622\u201332. https:\/\/doi.org\/10.2174\/1567205016666190725144629.","journal-title":"Curr Alzheimer Res"},{"key":"569_CR126","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s00394-021-02656-3","volume":"61","author":"M Sim","year":"2022","unstructured":"Sim M, Hong S, Jung S, Kim J-S, Goo Y-T, Chun WY, et al. Vitamin C supplementation promotes mental vitality in healthy young adults: results from a cross-sectional analysis and a randomized, double-blind, placebo-controlled trial. Eur J Nutr. 2022;61:447\u201359. https:\/\/doi.org\/10.1007\/s00394-021-02656-3.","journal-title":"Eur J Nutr"},{"key":"569_CR127","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1186\/s12883-019-1500-6","volume":"19","author":"B Chai","year":"2019","unstructured":"Chai B, Gao F, Wu R, Dong T, Gu C, Lin Q, et al. Vitamin D deficiency as a risk factor for dementia and Alzheimer\u2019s disease: an updated meta-analysis. BMC Neurol. 2019;19:284. https:\/\/doi.org\/10.1186\/s12883-019-1500-6.","journal-title":"BMC Neurol"},{"key":"569_CR128","doi-asserted-by":"publisher","first-page":"14","DOI":"10.14283\/jpad.2019.44","volume":"7","author":"A Kalra","year":"2020","unstructured":"Kalra A, Teixeira AL, Diniz BS. Association of Vitamin D Levels with Incident All-Cause Dementia in Longitudinal Observational Studies: A Systematic Review and Meta-analysis. J Prev Alzheimers Dis. 2020;7:14\u201320. https:\/\/doi.org\/10.14283\/jpad.2019.44.","journal-title":"J Prev Alzheimers Dis"},{"key":"569_CR129","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1080\/1028415X.2018.1436639","volume":"22","author":"A Jayedi","year":"2019","unstructured":"Jayedi A, Rashidy-Pour A, Shab-Bidar S. Vitamin D status and risk of dementia and Alzheimer\u2019s disease: A meta-analysis of dose-response. Nutr Neurosci. 2019;22:750\u20139. https:\/\/doi.org\/10.1080\/1028415X.2018.1436639.","journal-title":"Nutr Neurosci"},{"key":"569_CR130","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.ajcnut.2023.05.011","volume":"118","author":"L-K Yeung","year":"2023","unstructured":"Yeung L-K, Alschuler DM, Wall M, Luttmann-Gibson H, Copeland T, Hale C, et al. Multivitamin Supplementation Improves Memory in Older Adults: A Randomized Clinical Trial. Am J Clin Nutr. 2023;118:273\u201382. https:\/\/doi.org\/10.1016\/j.ajcnut.2023.05.011.","journal-title":"Am J Clin Nutr"},{"key":"569_CR131","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.ajcnut.2023.12.011","volume":"119","author":"CM Vyas","year":"2024","unstructured":"Vyas CM, Manson JE, Sesso HD, Cook NR, Rist PM, Weinberg A, et al. Effect of multivitamin-mineral supplementation versus placebo on cognitive function: results from the clinic subcohort of the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial and meta-analysis of 3 cognitive studies within COSMOS. Am J Clin Nutr. 2024;119:692\u2013701. https:\/\/doi.org\/10.1016\/j.ajcnut.2023.12.011.","journal-title":"Am J Clin Nutr"},{"key":"569_CR132","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1002\/alz.12767","volume":"19","author":"LD Baker","year":"2023","unstructured":"Baker LD, Manson JE, Rapp SR, Sesso HD, Gaussoin SA, Shumaker SA, et al. Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial. Alzheimers Dement. 2023;19:1308\u201319. https:\/\/doi.org\/10.1002\/alz.12767.","journal-title":"Alzheimers Dement"},{"key":"569_CR133","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/s41430-024-01517-6","volume":"79","author":"S Docherty","year":"2025","unstructured":"Docherty S, Wetherell MA, McInnes L, Haskell-Ramsay CF. Improvements to mood, stress and loneliness following 12-week multivitamin supplementation in older adults: a randomised, placebo-controlled, trial. Eur J Clin Nutr. 2025;79:126\u201335. https:\/\/doi.org\/10.1038\/s41430-024-01517-6.","journal-title":"Eur J Clin Nutr"},{"key":"569_CR134","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1002\/hup.1245","volume":"26","author":"E Harris","year":"2011","unstructured":"Harris E, Kirk J, Rowsell R, Vitetta L, Sali A, Scholey AB, et al. The effect of multivitamin supplementation on mood and stress in healthy older men. Hum Psychopharmacol Clin Exp. 2011;26:560\u20137. https:\/\/doi.org\/10.1002\/hup.1245.","journal-title":"Hum Psychopharmacol Clin Exp"},{"key":"569_CR135","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1097\/PSY.0b013e31827d5fbd","volume":"75","author":"S-J Long","year":"2013","unstructured":"Long S-J, Benton D. Effects of Vitamin and Mineral Supplementation on Stress, Mild Psychiatric Symptoms, and Mood in Nonclinical Samples: A Meta-Analysis. Psychosom Med. 2013;75:144\u201353. https:\/\/doi.org\/10.1097\/PSY.0b013e31827d5fbd.","journal-title":"Psychosom Med"},{"key":"569_CR136","doi-asserted-by":"publisher","first-page":"1733798","DOI":"10.3389\/fphar.2026.1733798","volume":"17","author":"Z Liang","year":"2026","unstructured":"Liang Z, Zhang L. Chronic inflammation as a driving factor for sarcopenia: an update on pathophysiology and future therapeutic targets. Front Pharmacol. 2026;17:1733798. https:\/\/doi.org\/10.3389\/fphar.2026.1733798.","journal-title":"Front Pharmacol"},{"key":"569_CR137","doi-asserted-by":"publisher","first-page":"2408","DOI":"10.3390\/nu17152408","volume":"17","author":"D Azzolino","year":"2025","unstructured":"Azzolino D, Carnevale-Schianca M, Bottalico L, Colella M, Felicetti A, Perna S, et al. The Oral\u2013Gut Microbiota Axis as a Mediator of Frailty and Sarcopenia. Nutrients. 2025;17:2408. https:\/\/doi.org\/10.3390\/nu17152408.","journal-title":"Nutrients"},{"key":"569_CR138","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12979-023-00410-3","volume":"21","author":"Y Pan","year":"2024","unstructured":"Pan Y, Ma L. Inflammatory markers and physical frailty: towards clinical application. Immun Ageing A. 2024;21:4. https:\/\/doi.org\/10.1186\/s12979-023-00410-3.","journal-title":"Immun Ageing A"},{"key":"569_CR139","doi-asserted-by":"publisher","first-page":"415","DOI":"10.3390\/biom14040415","volume":"14","author":"E Marzetti","year":"2024","unstructured":"Marzetti E, Lozanoska-Ochser B, Calvani R, Landi F, Coelho-J\u00fanior HJ, Picca A. Restoring Mitochondrial Function and Muscle Satellite Cell Signaling: Remedies against Age-Related Sarcopenia. Biomolecules. 2024;14:415. https:\/\/doi.org\/10.3390\/biom14040415.","journal-title":"Biomolecules"},{"key":"569_CR140","doi-asserted-by":"publisher","first-page":"2861","DOI":"10.3390\/nu11122861","volume":"11","author":"F Remelli","year":"2019","unstructured":"Remelli F, Vitali A, Zurlo A, Volpato S. Vitamin D Deficiency and Sarcopenia in Older Persons. Nutrients. 2019;11:2861. https:\/\/doi.org\/10.3390\/nu11122861.","journal-title":"Nutrients"},{"key":"569_CR141","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1093\/gerona\/glq235","volume":"66A","author":"DK Houston","year":"2011","unstructured":"Houston DK, Tooze JA, Hausman DB, Johnson MA, Nicklas BJ, Miller ME, et al. Change in 25-Hydroxyvitamin D and Physical Performance in Older Adults. J Gerontol Biol Sci Med Sci. 2011;66A:430\u20136. https:\/\/doi.org\/10.1093\/gerona\/glq235.","journal-title":"J Gerontol Biol Sci Med Sci"},{"key":"569_CR142","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/s11657-018-0553-2","volume":"14","author":"C El Hajj","year":"2019","unstructured":"El Hajj C, Fares S, Chardigny JM, Boirie Y, Walrand S. Vitamin D supplementation and muscle strength in pre-sarcopenic elderly Lebanese people: a randomized controlled trial. Arch Osteoporos. 2019;14:4. https:\/\/doi.org\/10.1007\/s11657-018-0553-2.","journal-title":"Arch Osteoporos"},{"key":"569_CR143","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1080\/13697137.2018.1480600","volume":"21","author":"C Suebthawinkul","year":"2018","unstructured":"Suebthawinkul C, Panyakhamlerd K, Yotnuengnit P, Suwan A, Chaiyasit N, Taechakraichana N. The effect of vitamin D2 supplementation on muscle strength in early postmenopausal women: a randomized, double-blind, placebo-controlled trial. Climacteric. 2018;21:491\u20137. https:\/\/doi.org\/10.1080\/13697137.2018.1480600.","journal-title":"Climacteric"},{"key":"569_CR144","doi-asserted-by":"publisher","first-page":"1301831","DOI":"10.3389\/fnut.2024.1301831","volume":"11","author":"Y Liu","year":"2024","unstructured":"Liu Y, Liu X, Duan L, Zhao Y, He Y, Li W, et al. Associations of micronutrient dietary patterns with sarcopenia among US adults: a population-based study. Front Nutr. 2024;11:1301831. https:\/\/doi.org\/10.3389\/fnut.2024.1301831.","journal-title":"Front Nutr"},{"key":"569_CR145","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1475-2891-3-2","volume":"3","author":"AE Fisher","year":"2004","unstructured":"Fisher AE, Naughton DP. Iron supplements: the quick fix with long-term consequences. Nutr J. 2004;3:2. https:\/\/doi.org\/10.1186\/1475-2891-3-2.","journal-title":"Nutr J"},{"key":"569_CR146","doi-asserted-by":"publisher","first-page":"118535","DOI":"10.1016\/j.bbamcr.2019.118535","volume":"1866","author":"D Galaris","year":"2019","unstructured":"Galaris D, Barbouti A, Pantopoulos K. Iron homeostasis and oxidative stress: An intimate relationship. Biochim Biophys Acta BBA - Mol Cell Res. 2019;1866:118535. https:\/\/doi.org\/10.1016\/j.bbamcr.2019.118535.","journal-title":"Biochim Biophys Acta BBA - Mol Cell Res"},{"key":"569_CR147","doi-asserted-by":"publisher","first-page":"207","DOI":"10.4062\/biomolther.2015.003","volume":"23","author":"K Park","year":"2015","unstructured":"Park K. Role of micronutrients in skin health and function. Biomol Ther. 2015;23:207\u201317. https:\/\/doi.org\/10.4062\/biomolther.2015.003.","journal-title":"Biomol Ther"},{"key":"569_CR148","doi-asserted-by":"publisher","first-page":"3849","DOI":"10.3390\/ijms22083849","volume":"22","author":"YI Lee","year":"2021","unstructured":"Lee YI, Choi S, Roh WS, Lee JH, Kim T-G. Cellular Senescence and Inflammaging in the Skin Microenvironment. Int J Mol Sci. 2021;22:3849. https:\/\/doi.org\/10.3390\/ijms22083849.","journal-title":"Int J Mol Sci"},{"key":"569_CR149","doi-asserted-by":"publisher","first-page":"936","DOI":"10.3390\/life12070936","volume":"12","author":"Y Ratanapokasatit","year":"2022","unstructured":"Ratanapokasatit Y, Laisuan W, Rattananukrom T, Petchlorlian A, Thaipisuttikul I, Sompornrattanaphan M. How Microbiomes Affect Skin Aging: The Updated Evidence and Current Perspectives. Life. 2022;12:936. https:\/\/doi.org\/10.3390\/life12070936.","journal-title":"Life"},{"key":"569_CR150","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/s0190-9622(98)70537-7","volume":"38","author":"B Eberlein-K\u00f6nig","year":"1998","unstructured":"Eberlein-K\u00f6nig B, Placzek M, Przybilla B. Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and d-alpha-tocopherol (vitamin E). J Am Acad Dermatol. 1998;38:45\u20138. https:\/\/doi.org\/10.1016\/s0190-9622(98)70537-7.","journal-title":"J Am Acad Dermatol"},{"key":"569_CR151","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1016\/j.jid.2017.04.040","volume":"137","author":"JF Scott","year":"2017","unstructured":"Scott JF, Das LM, Ahsanuddin S, Qiu Y, Binko AM, Traylor ZP, et al. Oral Vitamin D Rapidly Attenuates Inflammation from Sunburn: An Interventional Study. J Invest Dermatol. 2017;137:2078\u201386. https:\/\/doi.org\/10.1016\/j.jid.2017.04.040.","journal-title":"J Invest Dermatol"},{"key":"569_CR152","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s13555-018-0278-6","volume":"9","author":"HM Almohanna","year":"2019","unstructured":"Almohanna HM, Ahmed AA, Tsatalis JP, Tosti A. The Role of Vitamins and Minerals in Hair Loss: A Review. Dermatol Ther. 2019;9:51\u201370. https:\/\/doi.org\/10.1007\/s13555-018-0278-6.","journal-title":"Dermatol Ther"},{"key":"569_CR153","doi-asserted-by":"publisher","first-page":"17","DOI":"10.4103\/0974-7753.114706","volume":"5","author":"RM Bhat","year":"2013","unstructured":"Bhat RM, Sharma R, Pinto AC, Dandekeri S, Martis J. Epidemiological and investigative study of premature graying of hair in higher secondary and pre-university school children. Int J Trichology. 2013;5:17\u201321. https:\/\/doi.org\/10.4103\/0974-7753.114706.","journal-title":"Int J Trichology"},{"key":"569_CR154","doi-asserted-by":"publisher","first-page":"111939","DOI":"10.1016\/j.mad.2024.111939","volume":"219","author":"H Xie","year":"2024","unstructured":"Xie H, Wei L, Ruan G, Zhang H, Shi H. Inflammaging score as a potential prognostic tool for cancer: A population-based cohort study. Mech Ageing Dev. 2024;219:111939. https:\/\/doi.org\/10.1016\/j.mad.2024.111939.","journal-title":"Mech Ageing Dev"},{"key":"569_CR155","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.cpt.2023.08.001","volume":"2","author":"C Hou","year":"2024","unstructured":"Hou C, Wang Z, Lu X. Impact of immunosenescence and inflammaging on the effects of immune checkpoint inhibitors. Cancer Pathog Ther. 2024;2:24\u201330. https:\/\/doi.org\/10.1016\/j.cpt.2023.08.001.","journal-title":"Cancer Pathog Ther"},{"key":"569_CR156","doi-asserted-by":"publisher","first-page":"e295","DOI":"10.1016\/S1470-2045(18)30095-0","volume":"19","author":"A Biragyn","year":"2018","unstructured":"Biragyn A, Ferrucci L. Gut dysbiosis: a potential link between increased cancer risk in ageing and inflammaging. Lancet Oncol. 2018;19:e295\u2013304. https:\/\/doi.org\/10.1016\/S1470-2045(18)30095-0.","journal-title":"Lancet Oncol"},{"key":"569_CR157","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1001\/jama.2008.555","volume":"300","author":"SM Zhang","year":"2008","unstructured":"Zhang SM, Cook NR, Albert CM, Gaziano JM, Buring JE, Manson JE. Effect of Combined Folic Acid, Vitamin B6, and Vitamin B12 on Cancer Risk in Women: A Randomized Trial. JAMA. 2008;300:2012. https:\/\/doi.org\/10.1001\/jama.2008.555.","journal-title":"JAMA"},{"key":"569_CR158","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.1002\/ijc.29277","volume":"136","author":"RC Heine-Br\u00f6ring","year":"2015","unstructured":"Heine-Br\u00f6ring RC, Winkels RM, Renkema JMS, Kragt L, Van Orten\u2010Luiten AB, Tigchelaar EF, et al. Dietary supplement use and colorectal cancer risk: A systematic review and meta\u2010analyses of prospective cohort studies. Int J Cancer. 2015;136:2388\u2013401. https:\/\/doi.org\/10.1002\/ijc.29277.","journal-title":"Int J Cancer"},{"key":"569_CR159","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/sj.bjc.6604540","volume":"99","author":"GC Kabat","year":"2008","unstructured":"Kabat GC, Miller AB, Jain M, Rohan TE. Dietary intake of selected B vitamins in relation to risk of major cancers in women. Br J Cancer. 2008;99:816\u201321. https:\/\/doi.org\/10.1038\/sj.bjc.6604540.","journal-title":"Br J Cancer"},{"key":"569_CR160","doi-asserted-by":"publisher","first-page":"711","DOI":"10.3390\/ph15060711","volume":"15","author":"A Mussa","year":"2022","unstructured":"Mussa A, Mohd Idris RA, Ahmed N, Ahmad S, Murtadha AH, Tengku Din TADAA, et al. High-Dose Vitamin C for Cancer Therapy. Pharm Basel Switz. 2022;15:711. https:\/\/doi.org\/10.3390\/ph15060711.","journal-title":"Pharm Basel Switz"},{"key":"569_CR161","doi-asserted-by":"publisher","first-page":"6092","DOI":"10.3390\/ijms24076092","volume":"24","author":"OF Fagbohun","year":"2023","unstructured":"Fagbohun OF, Gillies CR, Murphy KPJ, Rupasinghe HPV. Role of Antioxidant Vitamins and Other Micronutrients on Regulations of Specific Genes and Signaling Pathways in the Prevention and Treatment of Cancer. Int J Mol Sci. 2023;24:6092. https:\/\/doi.org\/10.3390\/ijms24076092.","journal-title":"Int J Mol Sci"},{"key":"569_CR162","doi-asserted-by":"publisher","first-page":"189057","DOI":"10.1016\/j.bbcan.2023.189057","volume":"1879","author":"A Chen","year":"2024","unstructured":"Chen A, Li J, Shen N, Huang H, Hang Q, Vitamin K. New insights related to senescence and cancer metastasis. Biochim Biophys Acta Rev Cancer. 2024;1879:189057. https:\/\/doi.org\/10.1016\/j.bbcan.2023.189057.","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"569_CR163","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.3945\/ajcn.2009.28691","volume":"91","author":"K Nimptsch","year":"2010","unstructured":"Nimptsch K, Rohrmann S, Kaaks R, Linseisen J. Dietary vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). Am J Clin Nutr. 2010;91:1348\u201358. https:\/\/doi.org\/10.3945\/ajcn.2009.28691.","journal-title":"Am J Clin Nutr"},{"key":"569_CR164","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1093\/annonc\/mdn550","volume":"20","author":"M Rossi","year":"2009","unstructured":"Rossi M, McLaughlin JK, Lagiou P, Bosetti C, Talamini R, Lipworth L, et al. Vitamin D intake and breast cancer risk: a case\u2013control study in Italy. Ann Oncol. 2009;20:374\u20138. https:\/\/doi.org\/10.1093\/annonc\/mdn550.","journal-title":"Ann Oncol"},{"key":"569_CR165","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1002\/ijc.20648","volume":"113","author":"MA Sanjoaquin","year":"2005","unstructured":"Sanjoaquin MA, Allen N, Couto E, Roddam AW, Key TJ. Folate intake and colorectal cancer risk: A meta-analytical approach. Int J Cancer. 2005;113:825\u20138. https:\/\/doi.org\/10.1002\/ijc.20648.","journal-title":"Int J Cancer"},{"key":"569_CR166","doi-asserted-by":"publisher","first-page":"e0138318","DOI":"10.1371\/journal.pone.0138318","volume":"10","author":"I Cancarini","year":"2015","unstructured":"Cancarini I, Krogh V, Agnoli C, Grioni S, Matullo G, Pala V et al. C-J <>Chiu editor 2015 Micronutrients Involved in One-Carbon Metabolism and Risk of Breast Cancer Subtypes. PLoS ONE 10 e0138318 https:\/\/doi.org\/10.1371\/journal.pone.0138318.","journal-title":"PLoS ONE"},{"key":"569_CR167","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1001\/jama.2011.1437","volume":"306","author":"EA Klein","year":"2011","unstructured":"Klein EA, Thompson IM, Tangen CM, Crowley JJ, Lucia MS, Goodman PJ, et al. Vitamin E and the Risk of Prostate Cancer: The Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2011;306:1549. https:\/\/doi.org\/10.1001\/jama.2011.1437.","journal-title":"JAMA"},{"key":"569_CR168","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1001\/jama.290.4.476","volume":"290","author":"Incidence of Cancer and Mortality Following \u03b1-Tocopherol and \u03b2-Carotene Supplementation","year":"2003","unstructured":"Incidence of Cancer and Mortality Following \u03b1-Tocopherol and \u03b2-Carotene Supplementation. A Postintervention Follow-up. JAMA. 2003;290:476. https:\/\/doi.org\/10.1001\/jama.290.4.476.","journal-title":"JAMA"},{"key":"569_CR169","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1056\/NEJM199605023341802","volume":"334","author":"GS Omenn","year":"1996","unstructured":"Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, et al. Effects of a Combination of Beta Carotene and Vitamin A on Lung Cancer and Cardiovascular Disease. N Engl J Med. 1996;334:1150\u20135. https:\/\/doi.org\/10.1056\/NEJM199605023341802.","journal-title":"N Engl J Med"},{"key":"569_CR170","doi-asserted-by":"publisher","unstructured":"Moroni B, \u00d3v\u00e1ri V, Nicastro C, de Salvo R, Ehret A. A real-world evidence study evaluating consumer experience of Supradyn Recharge or Supradyn Magnesium and Potassium during demanding periods. Drugs Context. 2023;12. https:\/\/doi.org\/10.7573\/dic.2023-1-6. :2023-1-6.","DOI":"10.7573\/dic.2023-1-6"},{"key":"569_CR171","doi-asserted-by":"publisher","first-page":"100142","DOI":"10.1016\/j.aggp.2025.100142","volume":"2","author":"MS N v K","year":"2025","unstructured":"N v K MS. Aging through the lens of the gut microbiome: Challenges and therapeutic opportunities. Arch Gerontol Geriatr Plus. 2025;2:100142. https:\/\/doi.org\/10.1016\/j.aggp.2025.100142.","journal-title":"Arch Gerontol Geriatr Plus"},{"key":"569_CR172","doi-asserted-by":"publisher","first-page":"2352","DOI":"10.3390\/nu16142352","volume":"16","author":"J Wang","year":"2024","unstructured":"Wang J, Mei L, Hao Y, Xu Y, Yang Q, Dai Z, et al. Contemporary Perspectives on the Role of Vitamin D in Enhancing Gut Health and Its Implications for Preventing and Managing Intestinal Diseases. Nutrients. 2024;16:2352. https:\/\/doi.org\/10.3390\/nu16142352.","journal-title":"Nutrients"},{"key":"569_CR173","doi-asserted-by":"publisher","first-page":"13074","DOI":"10.3390\/ijms222313074","volume":"22","author":"AV Skalny","year":"2021","unstructured":"Skalny AV, Aschner M, Lei XG, Gritsenko VA, Santamaria A, Alekseenko SI, et al. Gut Microbiota as a Mediator of Essential and Toxic Effects of Zinc in the Intestines and Other Tissues. Int J Mol Sci. 2021;22:13074. https:\/\/doi.org\/10.3390\/ijms222313074.","journal-title":"Int J Mol Sci"},{"key":"569_CR174","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.3390\/ijms25021228","volume":"25","author":"K Ferenc","year":"2024","unstructured":"Ferenc K, Sokal-Dembowska A, Helma K, Motyka E, Jarmakiewicz-Czaja S, Filip R. Modulation of the Gut Microbiota by Nutrition and Its Relationship to Epigenetics. Int J Mol Sci. 2024;25:1228. https:\/\/doi.org\/10.3390\/ijms25021228.","journal-title":"Int J Mol Sci"},{"key":"569_CR175","doi-asserted-by":"publisher","first-page":"100070","DOI":"10.1016\/j.medmic.2022.100070","volume":"14","author":"F Zhang","year":"2022","unstructured":"Zhang F, Fan D, Huang J, Zuo T. The gut microbiome: linking dietary fiber to inflammatory diseases. Med Microecol. 2022;14:100070. https:\/\/doi.org\/10.1016\/j.medmic.2022.100070.","journal-title":"Med Microecol"},{"key":"569_CR176","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/s41574-022-00721-3","volume":"18","author":"J Mayneris-Perxachs","year":"2022","unstructured":"Mayneris-Perxachs J, Moreno-Navarrete JM, Fern\u00e1ndez-Real JM. The role of iron in host\u2013microbiota crosstalk and its effects on systemic glucose metabolism. Nat Rev Endocrinol. 2022;18:683\u201398. https:\/\/doi.org\/10.1038\/s41574-022-00721-3.","journal-title":"Nat Rev Endocrinol"},{"key":"569_CR177","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1093\/infdis\/jiu235","volume":"210","author":"A Assa","year":"2014","unstructured":"Assa A, Vong L, Pinnell LJ, Avitzur N, Johnson-Henry KC, Sherman PM. Vitamin D Deficiency Promotes Epithelial Barrier Dysfunction and Intestinal Inflammation. J Infect Dis. 2014;210:1296\u2013305. https:\/\/doi.org\/10.1093\/infdis\/jiu235.","journal-title":"J Infect Dis"},{"key":"569_CR178","doi-asserted-by":"publisher","first-page":"21641","DOI":"10.1038\/s41598-020-77806-4","volume":"10","author":"P Singh","year":"2020","unstructured":"Singh P, Rawat A, Alwakeel M, Sharif E, Al Khodor S. The potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals. Sci Rep. 2020;10:21641. https:\/\/doi.org\/10.1038\/s41598-020-77806-4.","journal-title":"Sci Rep"},{"key":"569_CR179","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12979-025-00514-y","volume":"22","author":"H Ullah","year":"2025","unstructured":"Ullah H. Gut-vitamin D interplay: key to mitigating immunosenescence and promoting healthy ageing. Immun Ageing. 2025;22:20. https:\/\/doi.org\/10.1186\/s12979-025-00514-y.","journal-title":"Immun Ageing"},{"key":"569_CR180","doi-asserted-by":"publisher","first-page":"1367086","DOI":"10.3389\/fnut.2024.1367086","volume":"11","author":"Z-L Wang","year":"2024","unstructured":"Wang Z-L, Pang S-J, Zhang K-W, Li P-Y, Li P-G, Yang C. Dietary vitamin A modifies the gut microbiota and intestinal tissue transcriptome, impacting intestinal permeability and the release of inflammatory factors, thereby influencing A\u03b2 pathology. Front Nutr. 2024;11:1367086. https:\/\/doi.org\/10.3389\/fnut.2024.1367086.","journal-title":"Front Nutr"},{"key":"569_CR181","doi-asserted-by":"publisher","first-page":"398","DOI":"10.2337\/dc17-1967","volume":"41","author":"D Fangmann","year":"2018","unstructured":"Fangmann D, Theismann E-M, T\u00fcrk K, Schulte DM, Relling I, Hartmann K, et al. Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans. Diabetes Care. 2018;41:398\u2013405. https:\/\/doi.org\/10.2337\/dc17-1967.","journal-title":"Diabetes Care"},{"key":"569_CR182","doi-asserted-by":"publisher","first-page":"1875774","DOI":"10.1080\/19490976.2021.1875774","volume":"13","author":"VT Pham","year":"2021","unstructured":"Pham VT, Fehlbaum S, Seifert N, Richard N, Bruins MJ, Sybesma W, et al. Effects of colon-targeted vitamins on the composition and metabolic activity of the human gut microbiome\u2013 a pilot study. Gut Microbes. 2021;13:1875774. https:\/\/doi.org\/10.1080\/19490976.2021.1875774.","journal-title":"Gut Microbes"},{"key":"569_CR183","doi-asserted-by":"publisher","first-page":"11377","DOI":"10.1038\/s41598-018-29063-9","volume":"8","author":"C-L Shen","year":"2018","unstructured":"Shen C-L, Kaur G, Wanders D, Sharma S, Tomison MD, Ramalingam L, et al. Annatto-extracted tocotrienols improve glucose homeostasis and bone properties in high-fat diet-induced type 2 diabetic mice by decreasing the inflammatory response. Sci Rep. 2018;8:11377. https:\/\/doi.org\/10.1038\/s41598-018-29063-9.","journal-title":"Sci Rep"},{"key":"569_CR184","doi-asserted-by":"publisher","first-page":"14667","DOI":"10.3390\/ijms241914667","volume":"24","author":"D Gothandapani","year":"2023","unstructured":"Gothandapani D, Makpol S. Effects of Vitamin E on the Gut Microbiome in Ageing and Its Relationship with Age-Related Diseases: A Review of the Current Literature. Int J Mol Sci. 2023;24:14667. https:\/\/doi.org\/10.3390\/ijms241914667.","journal-title":"Int J Mol Sci"},{"key":"569_CR185","doi-asserted-by":"publisher","first-page":"832","DOI":"10.2174\/138161210790883679","volume":"16","author":"M Barbagallo","year":"2010","unstructured":"Barbagallo M, Dominguez L, Magnesium. Aging Curr Pharm Des. 2010;16:832\u20139. https:\/\/doi.org\/10.2174\/138161210790883679.","journal-title":"Aging Curr Pharm Des"},{"key":"569_CR186","doi-asserted-by":"publisher","first-page":"961989","DOI":"10.3389\/fmicb.2022.961989","volume":"13","author":"S Cao","year":"2022","unstructured":"Cao S, Huang K, Wen X, Gao J, Cui B, Yao K, et al. Dietary supplementation with potassium-magnesium sulfate modulates the antioxidant capacity, immunity, and gut microbiota in weaned piglets. Front Microbiol. 2022;13:961989. https:\/\/doi.org\/10.3389\/fmicb.2022.961989.","journal-title":"Front Microbiol"},{"key":"569_CR187","doi-asserted-by":"publisher","first-page":"4188","DOI":"10.3390\/nu13124188","volume":"13","author":"F Del Chierico","year":"2021","unstructured":"Del Chierico F, Trapani V, Petito V, Reddel S, Pietropaolo G, Graziani C, et al. Dietary Magnesium Alleviates Experimental Murine Colitis through Modulation of Gut Microbiota. Nutrients. 2021;13:4188. https:\/\/doi.org\/10.3390\/nu13124188.","journal-title":"Nutrients"},{"key":"569_CR188","doi-asserted-by":"publisher","first-page":"496","DOI":"10.3390\/nu16040496","volume":"16","author":"L Dominguez","year":"2024","unstructured":"Dominguez L, Veronese N, Barbagallo M. Magnesium and the Hallmarks of Aging. Nutrients. 2024;16:496. https:\/\/doi.org\/10.3390\/nu16040496.","journal-title":"Nutrients"},{"key":"569_CR189","doi-asserted-by":"publisher","unstructured":"Davis EW, Wong CP, Arnold HK, Kasschau K, Gaulke CA, Sharpton TJ et al. Age and micronutrient effects on the microbiome in a mouse model of zinc depletion and supplementation. Wilson BA, editor. PLOS ONE. 2022;17:e0275352. https:\/\/doi.org\/10.1371\/journal.pone.0275352","DOI":"10.1371\/journal.pone.0275352"},{"key":"569_CR190","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1017\/S0007114515003608","volume":"114","author":"JMG Gomes","year":"2015","unstructured":"Gomes JMG, Costa JA, Alfenas RC. Could the beneficial effects of dietary calcium on obesity and diabetes control be mediated by changes in intestinal microbiota and integrity? Br J Nutr. 2015;114:1756\u201365. https:\/\/doi.org\/10.1017\/S0007114515003608.","journal-title":"Br J Nutr"},{"key":"569_CR191","doi-asserted-by":"publisher","first-page":"100281","DOI":"10.1016\/j.endmts.2025.100281","volume":"19","author":"S Younes","year":"2025","unstructured":"Younes S. The role of micronutrients in gut microbiota and metabolic health. Endocr Metab Sci. 2025;19:100281. https:\/\/doi.org\/10.1016\/j.endmts.2025.100281.","journal-title":"Endocr Metab Sci"},{"key":"569_CR192","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.nut.2019.02.005","volume":"63\u201364","author":"A Finamore","year":"2019","unstructured":"Finamore A, Roselli M, Donini L, Brasili DE, Rami R, Carnevali P, et al. Supplementation with Bifidobacterium longum Bar33 and Lactobacillus helveticus Bar13 mixture improves immunity in elderly humans (over 75 years) and aged mice. Nutrition. 2019;63\u201364:184\u201392. https:\/\/doi.org\/10.1016\/j.nut.2019.02.005.","journal-title":"Nutrition"},{"key":"569_CR193","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1080\/00016357.2019.1609697","volume":"77","author":"Y Yamamoto","year":"2019","unstructured":"Yamamoto Y, Saruta J, Takahashi T, To M, Shimizu T, Hayashi T, et al. Effect of ingesting yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 on influenza virus-bound salivary IgA in elderly residents of nursing homes: a randomized controlled trial. Acta Odontol Scand. 2019;77:517\u201324. https:\/\/doi.org\/10.1080\/00016357.2019.1609697.","journal-title":"Acta Odontol Scand"},{"key":"569_CR194","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/978-981-16-2450-6_13","volume-title":"Anal Infect Dis Probl Covid-19 Their Glob Impact [Internet]","author":"A Trajkovska Petkoska","year":"2021","unstructured":"Trajkovska Petkoska A, Trajkovska-Broach A. Mediterranean Diet\u2014A Healthy Dietary Pattern and Lifestyle for Strong Immunity. In: Agarwal P, Nieto JJ, Ruzhansky M, Torres DFM, editors. Anal Infect Dis Probl Covid-19 Their Glob Impact [Internet]. Singapore: Springer Singapore; 2021. pp. 279\u2013305. [cited 2026 Jan 8]. https:\/\/doi.org\/10.1007\/978-981-16-2450-6_13."},{"key":"569_CR195","doi-asserted-by":"publisher","first-page":"1646750","DOI":"10.3389\/fnut.2025.1646750","volume":"12","author":"JD Richards","year":"2025","unstructured":"Richards JD, Cori H, Rahn M, Finn K, B\u00e1rcena J, Kanellopoulos AK, et al. Micronutrient bioavailability: concepts, influencing factors, and strategies for improvement. Front Nutr. 2025;12:1646750. https:\/\/doi.org\/10.3389\/fnut.2025.1646750.","journal-title":"Front Nutr"},{"key":"569_CR196","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1017\/S0029665118002744","volume":"78","author":"L Kehoe","year":"2019","unstructured":"Kehoe L, Walton J, Flynn A. Nutritional challenges for older adults in Europe: current status and future directions. Proc Nutr Soc. 2019;78:221\u201333. https:\/\/doi.org\/10.1017\/S0029665118002744.","journal-title":"Proc Nutr Soc"},{"key":"569_CR197","doi-asserted-by":"publisher","unstructured":"Allen LH. Micronutrients \u2014 Assessment, Requirements, Deficiencies, and Interventions. Hardin CC, editor. N Engl J Med. 2025;392:1006\u201316. https:\/\/doi.org\/10.1056\/NEJMra2314150","DOI":"10.1056\/NEJMra2314150"},{"key":"569_CR198","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1177\/8755122518780742","volume":"34","author":"JD Prescott","year":"2018","unstructured":"Prescott JD, Drake VJ, Stevens JF. Medications and Micronutrients: Identifying Clinically Relevant Interactions and Addressing Nutritional Needs. J Pharm Technol. 2018;34:216\u201330. https:\/\/doi.org\/10.1177\/8755122518780742.","journal-title":"J Pharm Technol"},{"key":"569_CR199","doi-asserted-by":"publisher","first-page":"798078","DOI":"10.3389\/fnut.2022.798078","volume":"9","author":"J Li","year":"2022","unstructured":"Li J, Cao D, Huang Y, Chen B, Chen Z, Wang R, et al. Zinc Intakes and Health Outcomes: An Umbrella Review. Front Nutr. 2022;9:798078. https:\/\/doi.org\/10.3389\/fnut.2022.798078.","journal-title":"Front Nutr"},{"key":"569_CR200","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s42000-019-00125-5","volume":"19","author":"MP Rayman","year":"2020","unstructured":"Rayman MP. Selenium intake, status, and health: a complex relationship. Hormones. 2020;19:9\u201314. https:\/\/doi.org\/10.1007\/s42000-019-00125-5.","journal-title":"Hormones"},{"key":"569_CR201","doi-asserted-by":"publisher","DOI":"10.18502\/jmehm.v16i5.13313","author":"HS Ejtahed","year":"2023","unstructured":"Ejtahed HS, Parsa M, Larijani B. Ethical challenges in conducting and the clinical application of human microbiome research. J Med Ethics Hist Med [Internet]. 2023. https:\/\/doi.org\/10.18502\/jmehm.v16i5.13313. [cited 2025 Dec 24].","journal-title":"J Med Ethics Hist Med [Internet]"}],"container-title":["Immunity &amp; Ageing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12979-026-00569-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12979-026-00569-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12979-026-00569-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:39:03Z","timestamp":1781656743000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12979-026-00569-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,29]]},"references-count":201,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["569"],"URL":"https:\/\/doi.org\/10.1186\/s12979-026-00569-5","relation":{},"ISSN":["1742-4933"],"issn-type":[{"value":"1742-4933","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,29]]},"assertion":[{"value":"9 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not Applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors give consent for the publication of the manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"19"}}