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TFV could be administered either as tenofovir disoproxil fumarate or tenofovir alafenamide. We evaluated virological response, defined as viral load (VL)\u2009&lt;\u200950\u00a0copies\/ml and\u2009&lt;\u2009200\u00a0copies\/ml at 24 and 48\u00a0weeks after starting this regimen, stratified by baseline VL (&lt;\u200950 or\u2009\u2265\u200950\u00a0copies\/ml at the start of the regimen).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>We included 39 patients (12.8% women). At baseline, 10 (25.6%) patients had VL\u2009&lt;\u200950\u00a0copies\/ml and 29 (74.4%) had\u2009\u2265\u200950\u00a0copies\/ml. Among patients with baseline VL\u2009&lt;\u200950\u00a0copies\/ml, 85.7% and 80.0% had VL\u2009&lt;\u200950\u00a0copies\/ml at 24 and 48\u00a0weeks, respectively, and 100% had VL\u2009&lt;\u2009200\u00a0copies\/ml at 24 and 48\u00a0weeks. Among patients with baseline VL\u2009\u2265\u200950\u00a0copies\/ml, 42.3% and 40.9% had VL\u2009&lt;\u200950\u00a0copies\/ml and 69.2% and 68.2% had VL\u2009&lt;\u2009200\u00a0copies\/ml at 24 and 48\u00a0weeks. During the first 48\u00a0weeks, no patients changed their treatment due to toxicity, and 4 patients (all with baseline VL\u2009\u2265\u200950\u00a0copies\/ml) changed due to virological failure.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>EVG\/COB\/TFV\/FTC\u2009+\u2009DRV was well tolerated and effective in treatment-experienced patients with undetectable viral load as a simplification strategy, allowing once-daily, two-pill regimen with three antiretroviral drug classes. Effectiveness was low in patients with detectable viral loads.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12981-020-00302-2","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T12:04:22Z","timestamp":1595246662000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness of the combination elvitegravir\/cobicistat\/tenofovir\/emtricitabine (EVG\/COB\/TFV\/FTC) plus darunavir among treatment-experienced patients in clinical practice: a multicentre cohort 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