{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:21:54Z","timestamp":1722903714807},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["AIDS Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to assess the prevalence and reasons for nonadherence to cotrimoxazole prophylaxis therapy. A cross-sectional study was conducted among people living with HIV attending Ayder Comprehensive Specialized Hospital. Data were collected through interviews and reviews of medical records. Binary logistic regression was employed to analyze factors associated with CPT nonadherence. Approximately two-thirds (65.5%) of the participants were non-adherent to co-trimoxazole prophylaxis therapy. The main reasons for non-adherence were side effects, pill fatigue and forgetfulness. Strategies to improve adherence to co-trimoxazole prophylaxis therapy should focus on the combined patient, clinical and medication related issues of people living with HIV.<\/jats:p>","DOI":"10.1186\/s12981-024-00635-2","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T15:03:59Z","timestamp":1722870239000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brief communication: reasons for non-adherence of co-trimoxazole prophylaxis therapy among people living with HIV in a resource-limited setting, Northern Ethiopia"],"prefix":"10.1186","volume":"21","author":[{"given":"Gebrehiwot","family":"Teklay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meryem","family":"Mohammedbrhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desilu Mahari","family":"Desta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,5]]},"reference":[{"key":"635_CR1","unstructured":"World Health Organization. Guidelines on cotrimoxazole prophylaxis for HIV-related infections among children, adolescents and adults: recommendations for a public health approach. 2006 Geneva,Switzerland. http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/43557\/9789241594707_eng.pdf;jsessionid=B0B8C8A79E7FEDC435CB4F530B53CA90?sequence=1. Accessed 3 Jun 2023."},{"issue":"3","key":"635_CR2","doi-asserted-by":"publisher","first-page":"CD003108","DOI":"10.1002\/14651858.CD003108","volume":"2003","author":"K Grimwade","year":"2003","unstructured":"Grimwade K, Swingler G. Cotrimoxazole prophylaxis for opportunistic infections in adults with HIV. Cochrane Database Syst Rev. 2003;2003(3):CD003108. https:\/\/doi.org\/10.1002\/14651858.CD003108.","journal-title":"Cochrane Database Syst Rev"},{"key":"635_CR3","unstructured":"Mekelle, University. College of Health Sciences. Ayder referral Hospital. https:\/\/ayder.info\/index.php\/about-us. Accessed 11 Feb 2020."},{"key":"635_CR4","unstructured":"2014 World Health Organization. Guidelines on Post Exposure Prophylaxis for HIV and the Use of Co-Trimoxazole Prophylaxis for HIV-Related Infections Among Adults, Adolescents and Children: Recommendations for a Public Health Approach: December 2014 supplement to the 2013 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. Geneva: WHO, Dec. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK298964\/. Accessed 5 Jun 2023."},{"key":"635_CR5","doi-asserted-by":"publisher","unstructured":"Mehta S, Moore RD, Graham NM. Potential factors affecting adherence with HIV therapy. AIDS. 1997;11(14):1665-70. https:\/\/doi.org\/10.1097\/00002030-199714000-00002. PMID: 9386800.","DOI":"10.1097\/00002030-199714000-00002"},{"key":"635_CR6","doi-asserted-by":"publisher","first-page":"881","DOI":"10.2147\/PPA.S252805","volume":"14","author":"GB Mekonnen","year":"2020","unstructured":"Mekonnen GB, Addis SA. Factors affecting adherence to Co-Trimoxazole preventive therapy in HIV\/AIDS patients attending an antiretroviral therapy clinic in Ethiopia University Hospital: a cross-sectional study. Patient Prefer Adherence. 2020;14:881\u201390. PMID: 32546982; PMCID: PMC7250296.","journal-title":"Patient Prefer Adherence"},{"key":"635_CR7","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/2050-6511-15-4","volume":"15","author":"B Geresu","year":"2014","unstructured":"Geresu B, Misganaw D, Beyene Y. Retrospective evaluation of cotrimoxazole use as preventive therapy in people living with HIV\/AIDS in Boru Meda Hospital. BMC Pharmacol Toxicol. 2014;15:4. https:\/\/doi.org\/10.1186\/2050-6511-15-4. PMID: 24507658; PMCID: PMC3923568.","journal-title":"BMC Pharmacol Toxicol"},{"key":"635_CR8","unstructured":"Nigatu D. Cotrimoxazole Prophylaxis Treatment Adherence and Challenges in Implementation among HIV Exposed Children in the Public Hospital in Ilubabor Zone, South West Ethiopia. AAU institutional repository, 2018. http:\/\/etd.aau.edu.et\/handle\/123456789\/13660. Accessed 10 Jun 2023."}],"container-title":["AIDS Research and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12981-024-00635-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12981-024-00635-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12981-024-00635-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T15:06:57Z","timestamp":1722870417000},"score":1,"resource":{"primary":{"URL":"https:\/\/aidsrestherapy.biomedcentral.com\/articles\/10.1186\/s12981-024-00635-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,5]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["635"],"URL":"https:\/\/doi.org\/10.1186\/s12981-024-00635-2","relation":{},"ISSN":["1742-6405"],"issn-type":[{"value":"1742-6405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,5]]},"assertion":[{"value":"11 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declerations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was approved by the Health Research Ethics Review Committee of the School of Pharmacy of College of Health Sciences, Mekelle University (approval number CHS\/559\/phar-12). All participants were interviewed, and their medical records were reviewed after obtaining verbal consent from them self or from their parents. Prior to obtaining consent, the study aims and the benefits and risks of participating in the study were discussed with each participant. Participants were also assured of the confidentiality of their data. All methods included in this study were in accordance with the ethical standards of the institutional and\/or national research committee and with the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and informed Consent"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}],"article-number":"50"}}