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Within this framework, we designed and adapted different manual dexterity tests in extended reality (XR), using immersive virtual reality (VR) with controllers (BBT-VR-C), immersive VR with hand-tracking (BBT-VR-HT), and mixed-reality (MD-MR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study primarily aimed to assess and compare the validity of the BBT-VR-C, BBT-VR-HT and MD-MR to assess post-stroke manual dexterity. Secondary objectives were to evaluate reliability, usability and to define arm kinematics measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A sample of 21 healthy control participants (HCP) and 21 stroke individuals with hemiparesis (IHP) completed three trials of the traditional BBT, the BBT-VR-C, BBT-VR-HT and MD-MR. Content validity of the different tests were evaluated by asking five healthcare professionals to rate the difficulty of performing each test in comparison to the traditional BBT. Convergent validity was evaluated through correlations between the scores of the traditional BBT and the XR tests. Test-retest reliability was assessed through correlations between the second and third trial and usability was assessed using the System Usability Scale (SUS). Lastly, upper limb movement smoothness (SPARC) was compared between IHP and HCP for both BBT-VR test versions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      For content validity, healthcare professionals rated the BBT-VR-HT (0[0\u20131]) and BBT-MR (0[0\u20131]) as equally difficult to the traditional BBT, whereas they rated BBT-VR-C as more difficult than the traditional BBT (1[0\u20132]). For IHP convergent validity, the Pearson tests demonstrated larger correlations between the scores of BBT and BBT-VR-HT (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.94;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and BBT and MD-MR (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.95;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) than BBT and BBT-VR-C (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.65;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). BBT-VR-HT and MD-MR usability were both rated as excellent, with median SUS scores of 83[57.5\u201391.3] and 83[53.8\u201392.5] respectively. Excellent reliability was found for the BBT-VR-C (ICC\u2009=\u20090.96;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), BBT-VR-HT (ICC\u2009=\u20090.96;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and BBT-MR (ICC\u2009=\u20090.99;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The usability of the BBT-VR-C was rated as good with a median SUS of 70[43.8\u201383.8]. Upper limb movements of HCP were significantly smoother than for IHP when completing either the BBT-VR-C (t\u2009=\u20092.05;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043) and the BBT-VR-HT (t\u2009=\u20095.21;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The different XR manual tests are valid, short-term reliable and usable tools to assess post-stroke manual dexterity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04694833\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04694833<\/jats:ext-link>\n                      ; Unique identifier: NCT04694833, Date of registration: 11\/24\/2020.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12984-024-01332-x","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T03:01:27Z","timestamp":1710471687000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Extended reality to assess post-stroke manual dexterity: contrasts between the classic box and block test, immersive virtual reality with controllers, with hand-tracking, and mixed-reality tests"],"prefix":"10.1186","volume":"21","author":[{"given":"Gauthier","family":"Everard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Burton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Van de Sype","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Th\u00e9r\u00e8se Ntabuhashe","family":"Bibentyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Auvinet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin Gareth","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles Sebiyo","family":"Batcho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Lejeune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"issue":"5","key":"1332_CR1","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1161\/01.STR.30.5.949","volume":"30","author":"A Sunderland","year":"1999","unstructured":"Sunderland A, Bowers MP, Sluman SM, Wilcock DJ, Ardron ME. 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