{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T07:58:21Z","timestamp":1793260701370,"version":"4.5.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T00:00:00Z","timestamp":1720828800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T00:00:00Z","timestamp":1720828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Schleswig-Holstein - Campus Kiel"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J NeuroEngineering Rehabil"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>How the joints exactly move and interact and how this reflects PD-related gait abnormalities and the response to dopaminergic treatment is poorly understood. A detailed understanding of these kinematics can inform clinical management and treatment decisions. The aim of the study was to investigate the influence of different gait speeds and medication on\/off conditions on inter-joint coordination, as well as kinematic differences throughout the whole gait cycle in well characterized pwPD.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>29 controls and 29 PD patients during medication on, 8 of them also during medication off walked a straight walking path in slow, preferred and fast walking speeds. Gait data was collected using optical motion capture system. Kinematics of the hip and knee and coordinated hip-knee kinematics were evaluated using Statistical Parametric Mapping (SPM) and cyclograms (angle-angle plots). Values derived from cyclograms were compared using repeated-measures ANOVA for within group, and ttest for between group comparisons.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>PD gait differed from controls mainly by lower knee range of motion (ROM). Adaptation to gait speed in PD was mainly achieved by increasing hip ROM. Regularity of gait was worse in PD but only during preferred speed. The ratios of different speed cyclograms were smaller in the PD groups. SPM analyses revealed that PD participants had smaller hip and knee angles during the swing phase, and PD participants reached peak hip flexion later than controls. Withdrawal of medication showed an exacerbation of only a few parameters.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our findings demonstrate the potential of granular kinematic analyses, including\u2009&gt;\u20091 joint, for disease and treatment monitoring in PD. Our approach can be extended to further mobility-limiting conditions and other joint combinations.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>The study is registered in the German Clinical Trials Register (DRKS00022998, registered on 04 Sep 2020).<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12984-024-01416-8","type":"journal-article","created":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T09:01:56Z","timestamp":1720861316000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Inter-joint coordination with and without dopaminergic medication in Parkinson\u2019s disease: a case-control study"],"prefix":"10.1186","volume":"21","author":[{"given":"Karolina","family":"Saegner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robbin","family":"Romijnders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clint","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Holder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Warmerdam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Maetzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,13]]},"reference":[{"key":"1416_CR1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.bspc.2018.01.013","volume":"42","author":"S Viteckova","year":"2018","unstructured":"Viteckova S, Kutilek P, Svoboda Z, Krupicka R, Kauler J, Szabo Z. Gait symmetry measures: a review of current and prospective methods. Biomed Signal Process Control. 2018;42:89\u2013100.","journal-title":"Biomed Signal Process Control"},{"issue":"1","key":"1416_CR2","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.clinbiomech.2012.09.005","volume":"28","author":"RT Roemmich","year":"2013","unstructured":"Roemmich RT, Field AM, Elrod JM, Stegem\u00f6ller EL, Okun MS, Hass CJ. Interlimb coordination is impaired during walking in persons with Parkinson\u2019s disease. Clin Biomech. 2013;28(1):93\u20137.","journal-title":"Clin Biomech"},{"issue":"6","key":"1416_CR3","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1111\/j.1460-9568.2006.05033.x","volume":"24","author":"R Baltadjieva","year":"2006","unstructured":"Baltadjieva R, Giladi N, Gruendlinger L, Peretz C, Hausdorff JM. Marked alterations in the gait timing and rhythmicity of patients with de novo Parkinson\u2019s disease. Eur J Neurosci. 2006;24(6):1815\u201320.","journal-title":"Eur J Neurosci"},{"issue":"3","key":"1416_CR4","first-page":"216","volume":"42","author":"M Rudzi\u0144ska","year":"2008","unstructured":"Rudzi\u0144ska M, Bukowczan S, Banaszkiewicz K, Stozek J, Zajdel K, Szczudlik A. Causes and risk factors of falls in patients with Parkinson\u2019s disease. Neurol Neurochir Pol. 2008;42(3):216\u201322.","journal-title":"Neurol Neurochir Pol"},{"issue":"6","key":"1416_CR5","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1136\/jnnp.72.6.721","volume":"72","author":"BH Wood","year":"2002","unstructured":"Wood BH, Bilclough JA, Bowron A, Walker RW. Incidence and prediction of falls in Parkinson\u2019s disease: a prospective multidisciplinary study. J Neurol Neurosurg Psychiatry. 2002;72(6):721\u20135.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"13","key":"1416_CR6","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1002\/mds.21598","volume":"22","author":"RM Pickering","year":"2007","unstructured":"Pickering RM, Grimbergen YAM, Rigney U, Ashburn A, Mazibrada G, Wood B, et al. A meta-analysis of six prospective studies of falling in Parkinson\u2019s disease. Mov Disord off J Mov Disord Soc. 2007;22(13):1892\u2013900.","journal-title":"Mov Disord off J Mov Disord Soc"},{"issue":"10","key":"1416_CR7","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1002\/mds.26269","volume":"30","author":"C Curtze","year":"2015","unstructured":"Curtze C, Nutt JG, Carlson-Kuhta P, Mancini M, Horak FB. Levodopa is a double-edged Sword for Balance and Gait in People with Parkinson\u2019s Disease. Mov Disord. 2015;30(10):1361\u201370.","journal-title":"Mov Disord"},{"issue":"1","key":"1416_CR8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41531-020-00149-4","volume":"7","author":"E Warmerdam","year":"2021","unstructured":"Warmerdam E, Romijnders R, Hansen C, Elshehabi M, Zimmermann M, Metzger FG, et al. Arm swing responsiveness to dopaminergic medication in Parkinson\u2019s disease depends on task complexity. Npj Park Dis. 2021;7(1):1\u20137.","journal-title":"Npj Park Dis"},{"issue":"6","key":"1416_CR9","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1007\/BF02371451","volume":"12","author":"KN An","year":"1984","unstructured":"An KN, Chao EY. Kinematic analysis of human movement. Ann Biomed Eng. 1984;12(6):585\u201397.","journal-title":"Ann Biomed Eng"},{"key":"1416_CR10","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/s41531-023-00581-2","volume":"9","author":"C Sotirakis","year":"2023","unstructured":"Sotirakis C, Su Z, Brzezicki MA, Conway N, Tarassenko L, FitzGerald JJ, et al. Identification of motor progression in Parkinson\u2019s disease using wearable sensors and machine learning. NPJ Park Dis. 2023;9:142.","journal-title":"NPJ Park Dis"},{"issue":"2","key":"1416_CR11","doi-asserted-by":"publisher","first-page":"e0244842","DOI":"10.1371\/journal.pone.0244842","volume":"16","author":"C Agurto","year":"2021","unstructured":"Agurto C, Heisig S, Abrami A, Ho BK, Caggiano V. Parkinson\u2019s disease medication state and severity assessment based on coordination during walking. PLoS ONE. 2021;16(2):e0244842.","journal-title":"PLoS ONE"},{"issue":"2","key":"1416_CR12","doi-asserted-by":"publisher","first-page":"156","DOI":"10.3390\/bios13020156","volume":"13","author":"C Hansen","year":"2023","unstructured":"Hansen C, Chebil B, Cockroft J, Bianchini E, Romijnders R, Maetzler W. Changes in coordination and its variability with an increase in functional performance of the Lower extremities. Biosensors. 2023;13(2):156.","journal-title":"Biosensors"},{"key":"1416_CR13","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/s12984-023-01252-2","volume":"20","author":"O Dubois","year":"2023","unstructured":"Dubois O, Roby-Brami A, Parry R, Khoramshahi M, Jarrass\u00e9 N. A guide to inter-joint coordination characterization for discrete movements: a comparative study. J Neuroeng Rehabil. 2023;20:132.","journal-title":"J Neuroeng Rehabil"},{"issue":"1","key":"1416_CR14","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s00422-005-0582-y","volume":"93","author":"A Forner-Cordero","year":"2005","unstructured":"Forner-Cordero A, Levin O, Li Y, Swinnen SP. Principal component analysis of complex multijoint coordinative movements. Biol Cybern. 2005;93(1):63\u201378.","journal-title":"Biol Cybern"},{"issue":"4","key":"1416_CR15","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1152\/jn.00089.2005","volume":"94","author":"DS Reisman","year":"2005","unstructured":"Reisman DS, Block HJ, Bastian AJ. Interlimb coordination during locomotion: what can be adapted and stored? J Neurophysiol. 2005;94(4):2403\u201315.","journal-title":"J Neurophysiol"},{"issue":"9","key":"1416_CR16","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.1152\/jn.00950.2011","volume":"107","author":"T Krasovsky","year":"2012","unstructured":"Krasovsky T, Bani\u00f1a MC, Hacmon R, Feldman AG, Lamontagne A, Levin MF. Stability of gait and interlimb coordination in older adults. J Neurophysiol. 2012;107(9):2560\u20139.","journal-title":"J Neurophysiol"},{"issue":"9","key":"1416_CR17","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1080\/00207454.2020.1849189","volume":"132","author":"L Ma","year":"2022","unstructured":"Ma L, Mi TM, Jia Q, Han C, Chhetri JK, Chan P. Gait variability is sensitive to detect Parkinson\u2019s disease patients at high fall risk. Int J Neurosci. 2022;132(9):888\u201393.","journal-title":"Int J Neurosci"},{"issue":"5","key":"1416_CR18","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1007\/s00415-020-10355-y","volume":"268","author":"V Sidoroff","year":"2021","unstructured":"Sidoroff V, Raccagni C, Kaindlstorfer C, Eschlboeck S, Fanciulli A, Granata R, et al. Characterization of gait variability in multiple system atrophy and Parkinson\u2019s disease. J Neurol. 2021;268(5):1770\u20139.","journal-title":"J Neurol"},{"issue":"1","key":"1416_CR19","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/ane.12505","volume":"134","author":"MS Bryant","year":"2016","unstructured":"Bryant MS, Rintala DH, Hou JG, Collins RL, Protas EJ. Gait variability in Parkinson\u2019s disease: levodopa and walking direction. Acta Neurol Scand. 2016;134(1):83\u20136.","journal-title":"Acta Neurol Scand"},{"key":"1416_CR20","doi-asserted-by":"publisher","first-page":"1052451","DOI":"10.3389\/fnagi.2022.1052451","volume":"14","author":"P Mukli","year":"2022","unstructured":"Mukli P, Detwiler S, Owens CD, Csipo T, Lipecz A, Pinto CB, et al. Gait variability predicts cognitive impairment in older adults with subclinical cerebral small vessel disease. Front Aging Neurosci. 2022;14:1052451.","journal-title":"Front Aging Neurosci"},{"issue":"2","key":"1416_CR21","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1007\/s00415-013-7199-1","volume":"261","author":"MT Barbe","year":"2014","unstructured":"Barbe MT, Amarell M, Snijders AH, Florin E, Quatuor EL, Sch\u00f6nau E, et al. Gait and upper limb variability in Parkinson\u2019s disease patients with and without freezing of gait. J Neurol. 2014;261(2):330\u201342.","journal-title":"J Neurol"},{"issue":"3","key":"1416_CR22","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3390\/bioengineering9030120","volume":"9","author":"F Arippa","year":"2022","unstructured":"Arippa F, Leban B, Monticone M, Cossu G, Casula C, Pau M. A study on Lower Limb asymmetries in Parkinson\u2019s Disease during Gait assessed through kinematic-derived parameters. Bioengineering. 2022;9(3):120.","journal-title":"Bioengineering"},{"key":"1416_CR23","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3389\/fnhum.2014.00148","volume":"8","author":"L Awai","year":"2014","unstructured":"Awai L, Curt A. Intralimb coordination as a sensitive indicator of motor-control impairment after spinal cord injury. Front Hum Neurosci. 2014;8:148.","journal-title":"Front Hum Neurosci"},{"key":"1416_CR24","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.clinbiomech.2018.12.024","volume":"62","author":"PA Pincheira","year":"2019","unstructured":"Pincheira PA, De La Maza E, Silvestre R, Guzm\u00e1n-Venegas R, Becerra M. Comparison of total hip arthroplasty surgical approaches by statistical Parametric Mapping. Clin Biomech Bristol Avon. 2019;62:7\u201314.","journal-title":"Clin Biomech Bristol Avon"},{"issue":"14","key":"1416_CR25","doi-asserted-by":"publisher","first-page":"2394","DOI":"10.1016\/j.jbiomech.2013.07.031","volume":"46","author":"TC Pataky","year":"2013","unstructured":"Pataky TC, Robinson MA, Vanrenterghem J. Vector field statistical analysis of kinematic and force trajectories. J Biomech. 2013;46(14):2394\u2013401.","journal-title":"J Biomech"},{"key":"1416_CR26","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.clinbiomech.2016.11.008","volume":"41","author":"CJ Donnelly","year":"2017","unstructured":"Donnelly CJ, Alexander C, Pataky TC, Stannage K, Reid S, Robinson MA. Vector-field statistics for the analysis of time varying clinical gait data. Clin Biomech. 2017;41:87\u201391.","journal-title":"Clin Biomech"},{"key":"1416_CR27","doi-asserted-by":"publisher","first-page":"81","DOI":"10.12688\/hrbopenres.13647.2","volume":"5","author":"R O\u2019Sullivan","year":"2023","unstructured":"O\u2019Sullivan R, French H, Horgan F. A prospective assessment of gait kinematics and related clinical examination measures in cerebral palsy crouch gait. HRB Open Res. 2023;5:81.","journal-title":"HRB Open Res"},{"issue":"18","key":"1416_CR28","doi-asserted-by":"publisher","first-page":"7671","DOI":"10.3390\/s23187671","volume":"23","author":"D Fern\u00e1ndez-V\u00e1zquez","year":"2023","unstructured":"Fern\u00e1ndez-V\u00e1zquez D, Calvo-Mal\u00f3n G, Molina-Rueda F, L\u00f3pez-Gonz\u00e1lez R, Carratal\u00e1-Tejada M, Navarro-L\u00f3pez V, et al. Kinematic Gait Analysis in people with mild-disability multiple sclerosis using statistical Parametric Mapping: a cross-sectional study. Sensors. 2023;23(18):7671.","journal-title":"Sensors"},{"key":"1416_CR29","doi-asserted-by":"publisher","first-page":"6746010","DOI":"10.1155\/2016\/6746010","volume":"2016","author":"N Ribeiro Artigas","year":"2016","unstructured":"Ribeiro Artigas N, Eltz GD, do Pinho AS, Torman VBL, Hilbig A, Rieder CRM. Evaluation of knee proprioception and factors related to Parkinson\u2019s Disease. Neurosci J. 2016;2016:6746010.","journal-title":"Neurosci J"},{"issue":"11","key":"1416_CR30","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1002\/mds.20187","volume":"19","author":"R Djaldetti","year":"2004","unstructured":"Djaldetti R, Hellmann M, Melamed E. Bent knees and tiptoeing: late manifestations of end-stage Parkinson\u2019s disease. Mov Disord. 2004;19(11):1325\u20138.","journal-title":"Mov Disord"},{"issue":"1","key":"1416_CR31","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.expneurol.2007.07.002","volume":"208","author":"WG Wright","year":"2007","unstructured":"Wright WG, Gurfinkel VS, Nutt J, Horak FB, Cordo PJ. Axial hypertonicity in Parkinson\u2019s disease: direct measurements of trunk and hip torque. Exp Neurol. 2007;208(1):38\u201346.","journal-title":"Exp Neurol"},{"issue":"17","key":"1416_CR32","doi-asserted-by":"publisher","first-page":"5833","DOI":"10.3390\/s21175833","volume":"21","author":"E Warmerdam","year":"2021","unstructured":"Warmerdam E, Romijnders R, Geritz J, Elshehabi M, Maetzler C, Otto JC, et al. Proposed mobility assessments with Simultaneous Full-Body Inertial Measurement Units and Optical Motion capture in healthy adults and neurological patients for future validation studies: study protocol. Sensors. 2021;21(17):5833.","journal-title":"Sensors"},{"issue":"2","key":"1416_CR33","first-page":"197","volume":"13","author":"F von der Recke","year":"2023","unstructured":"von der Recke F, Warmerdam E, Hansen C, Romijnders R, Maetzler W. Reduced range of Gait Speed: a Parkinson\u2019s Disease-Specific Symptom? J Park Dis. 2023;13(2):197\u2013202.","journal-title":"J Park Dis"},{"issue":"1","key":"1416_CR34","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1097\/NPT.0000000000000112","volume":"40","author":"CC Lin","year":"2016","unstructured":"Lin CC, Creath RA, Rogers MW. Variability of anticipatory postural adjustments during gait initiation in individuals with Parkinson Disease. J Neurol Phys Ther JNPT. 2016;40(1):40\u20136.","journal-title":"J Neurol Phys Ther JNPT"},{"key":"1416_CR35","unstructured":"Poldrack RA, Markiewicz CJ, Appelhoff S, Ashar YK, Auer T, Baillet S et al. The Past, Present, and Future of the Brain Imaging Data Structure (BIDS). ArXiv. 2023;arXiv:2309.05768v1."},{"issue":"3","key":"1416_CR36","doi-asserted-by":"publisher","first-page":"e0152616","DOI":"10.1371\/journal.pone.0152616","volume":"11","author":"\u00d8 Gl\u00f8ersen","year":"2016","unstructured":"Gl\u00f8ersen \u00d8, Federolf P. Predicting missing marker trajectories in human Motion Data using marker intercorrelations. PLoS ONE. 2016;11(3):e0152616.","journal-title":"PLoS ONE"},{"issue":"10","key":"1416_CR37","doi-asserted-by":"publisher","first-page":"3859","DOI":"10.3390\/s22103859","volume":"22","author":"R Romijnders","year":"2022","unstructured":"Romijnders R, Warmerdam E, Hansen C, Schmidt G, Maetzler W. A Deep Learning Approach for Gait Event detection from a single Shank-worn IMU: validation in healthy and neurological cohorts. Sensors. 2022;22(10):3859.","journal-title":"Sensors"},{"key":"1416_CR38","unstructured":"Saegner K, Romijnders R. Joint Angle extration [Internet]. 2023. https:\/\/github.com\/neurogeriatricskiel\/MocapJointAngles"},{"key":"1416_CR39","unstructured":"Pataky T. spm1d [Internet]. 2023. https:\/\/spm1d.org\/"},{"key":"1416_CR40","first-page":"1","volume":"PP","author":"G Cicirelli","year":"2021","unstructured":"Cicirelli G, Impedovo D, Dentamaro V, Marani R, Pirlo G, D\u2019Orazio T. Human gait analysis in neurodegenerative diseases: a review. IEEE J Biomed Health Inf. 2021;PP:1\u20131.","journal-title":"IEEE J Biomed Health Inf"},{"issue":"43","key":"1416_CR41","first-page":"A6400","volume":"157","author":"SAE Peters","year":"2013","unstructured":"Peters SAE, Groenwold RHH, Bots ML. [Intermediate endpoints in clinical research]. Ned Tijdschr Geneeskd. 2013;157(43):A6400.","journal-title":"Ned Tijdschr Geneeskd"},{"key":"1416_CR42","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.gaitpost.2018.06.162","volume":"65","author":"BF Mentiplay","year":"2018","unstructured":"Mentiplay BF, Banky M, Clark RA, Kahn MB, Williams G. Lower limb angular velocity during walking at various speeds. Gait Posture. 2018;65:190\u20136.","journal-title":"Gait Posture"},{"key":"1416_CR43","doi-asserted-by":"crossref","unstructured":"de ShidaTKF CEN, da Silva Fragoso D, Los Angeles E, Bernardo C, dos, Santos de Oliveira L et al. Effect of freezing of gait and dopaminergic medication in the biomechanics of lower limbs in the gait of patients with Parkinson\u2019s disease compared to neurologically healthy. Neurosci Lett. 2023;806:137250.","DOI":"10.1016\/j.neulet.2023.137250"},{"issue":"1","key":"1416_CR44","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/0022-510X(91)90283-D","volume":"103","author":"O Blin","year":"1991","unstructured":"Blin O, Ferrandez AM, Pailhous J, Serratrice G. Dopa-sensitive and dopa-resistant gait parameters in Parkinson\u2019s disease. J Neurol Sci. 1991;103(1):51\u20134.","journal-title":"J Neurol Sci"},{"key":"1416_CR45","doi-asserted-by":"publisher","first-page":"105322","DOI":"10.1016\/j.parkreldis.2023.105322","volume":"108","author":"M Ohara","year":"2023","unstructured":"Ohara M, Hirata K, Hallett M, Matsubayashi T, Chen Q, Kina S, et al. Long-term levodopa ameliorates sequence effect in simple, but not complex walking in early Parkinson\u2019s disease patients. Parkinsonism Relat Disord. 2023;108:105322.","journal-title":"Parkinsonism Relat Disord"},{"key":"1416_CR46","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s40035-023-00347-z","volume":"12","author":"A Tosserams","year":"2023","unstructured":"Tosserams A, Bloem BR, Ehgoetz Martens KA, Helmich RC, Kessels RPC, Shine JM, et al. Modulating arousal to overcome gait impairments in Parkinson\u2019s disease: how the noradrenergic system may act as a double-edged sword. Transl Neurodegener. 2023;12:15.","journal-title":"Transl Neurodegener"},{"issue":"12","key":"1416_CR47","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1016\/S0003-9993(03)00433-7","volume":"84","author":"M Pohl","year":"2003","unstructured":"Pohl M, Rockstroh G, R\u00fcckriem S, Mrass G, Mehrholz J. Immediate effects of speed-dependent treadmill training on gait parameters in early Parkinson\u2019s disease1. Arch Phys Med Rehabil. 2003;84(12):1760\u20136.","journal-title":"Arch Phys Med Rehabil"},{"issue":"2","key":"1416_CR48","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1001\/jamaneurol.2013.646","volume":"70","author":"LM Shulman","year":"2013","unstructured":"Shulman LM, Katzel LI, Ivey FM, Sorkin JD, Favors K, Anderson KE, et al. Randomized Clinical Trial of 3 types of Physical Exercise for patients with Parkinson Disease. JAMA Neurol. 2013;70(2):183\u201390.","journal-title":"JAMA Neurol"},{"issue":"3","key":"1416_CR49","doi-asserted-by":"publisher","first-page":"183","DOI":"10.3233\/NRE-2005-20305","volume":"20","author":"EJ Protas","year":"2005","unstructured":"Protas EJ, Mitchell K, Williams A, Qureshy H, Caroline K, Lai EC. Gait and step training to reduce falls in Parkinson\u2019s disease. NeuroRehabilitation. 2005;20(3):183\u201390.","journal-title":"NeuroRehabilitation"},{"issue":"1","key":"1416_CR50","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1097\/00002060-200101000-00011","volume":"80","author":"TA Scandalis","year":"2001","unstructured":"Scandalis TA, Bosak A, Berliner JC, Helman LL, Wells MR. Resistance Training and gait function in patients with Parkinson\u2019s Disease. Am J Phys Med Rehabil. 2001;80(1):38.","journal-title":"Am J Phys Med Rehabil"},{"issue":"5","key":"1416_CR51","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.apmr.2004.08.012","volume":"86","author":"O Sofuwa","year":"2005","unstructured":"Sofuwa O, Nieuwboer A, Desloovere K, Willems AM, Chavret F, Jonkers I. Quantitative gait analysis in Parkinson\u2019s disease: comparison with a healthy control group. Arch Phys Med Rehabil. 2005;86(5):1007\u201313.","journal-title":"Arch Phys Med Rehabil"},{"key":"1416_CR52","doi-asserted-by":"publisher","first-page":"1247532","DOI":"10.3389\/fneur.2023.1247532","volume":"14","author":"R Romijnders","year":"2023","unstructured":"Romijnders R, Salis F, Hansen C, K\u00fcderle A, Paraschiv-Ionescu A, Cereatti A, et al. Ecological validity of a deep learning algorithm to detect gait events from real-life walking bouts in mobility-limiting diseases. Front Neurol. 2023;14:1247532.","journal-title":"Front Neurol"},{"key":"1416_CR53","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.gaitpost.2016.08.012","volume":"50","author":"FA Storm","year":"2016","unstructured":"Storm FA, Buckley CJ, Mazz\u00e0 C. Gait event detection in laboratory and real life settings: accuracy of ankle and waist sensor based methods. Gait Posture. 2016;50:42\u20136.","journal-title":"Gait Posture"},{"issue":"10","key":"1416_CR54","doi-asserted-by":"publisher","first-page":"136","DOI":"10.3390\/data7100136","volume":"7","author":"E Warmerdam","year":"2022","unstructured":"Warmerdam E, Hansen C, Romijnders R, Hobert MA, Welzel J, Maetzler W. Full-body mobility data to Validate Inertial Measurement Unit Algorithms in healthy and neurological cohorts. Data. 2022;7(10):136.","journal-title":"Data"}],"container-title":["Journal of NeuroEngineering and Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12984-024-01416-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12984-024-01416-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12984-024-01416-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T09:04:30Z","timestamp":1720861470000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneuroengrehab.biomedcentral.com\/articles\/10.1186\/s12984-024-01416-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,13]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1416"],"URL":"https:\/\/doi.org\/10.1186\/s12984-024-01416-8","relation":{},"ISSN":["1743-0003"],"issn-type":[{"value":"1743-0003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,13]]},"assertion":[{"value":"27 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the ethics committee of the Medical Faculty of Kiel University (D438\/18) and was conducted in accordance with the principles of the Declaration of Helsinki. The study is registered in the German Clinical Trials Register (DRKS00022998, registered on 04 Sep 2020). All study participants have read and signed an informed consent prior to the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"118"}}