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Mirror Therapy, wherein patients observe a mirror reflection of their intact limb, has demonstrated efficacy in alleviating PLP. However, its unilateral and seated nature presents limitations. To address these constraints while still reducing PLP, and evaluating the impact of different virtual limb representations (anthropomorphic vs. non-anthropomorphic) on the user\u2019s sense of ownership, agency, and embodiment, PhantomAR was developed. Leveraging wearable first-person augmented reality (AR) technology, PhantomAR extends traditional Mirror Therapy by enabling users to move freely and engage in bimanual tasks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The assistive mixed reality game application PhantomAR was deployed on the Microsoft HoloLens 2 and augmented the user\u2019s residual limb by superimposing a virtual arm or tentacle that was controlled via residual muscles on their stump using an EMG electrode array. This setup allowed patients to engage in a first-person perspective and manipulate virtual objects with both the healthy and augmented limbs, free from the confines of a seated position. The study enrolled 10 able-bodied individuals and 8 individuals with unilateral, transradial amputation. All amputees experienced PLP. The usability of the PhantomAR application was evaluated using the System Usability Scale (SUS) and a user-centric survey. Additionally, the Game Experience was assessed on a 5-point Likert questionnaire (GEQ). Participants rated their phantom sensations using the Numerical Rating Scale and McGill Pain Questionnaire before, during, and after interaction with PhantomAR. The embodiment and agency of the virtual superimposed arm were evaluated with an altered Prosthesis Embodiment Scale. The study protocol included two sessions of 30 min each, during which participants experienced PhantomAR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants (n\u2009=\u200918) rated PhantomAR highly usable (SUS m\u2009=\u200990.8%, SD\u2009=\u20096.88). Feedback on the Game Experience Questionnaire was overwhelmingly positive, showing high immersion (m\u2009=\u20094.46, SD\u2009=\u20090.08) and positive affect (m\u2009=\u20094.97, SD\u2009=\u20090.05). PLP (n\u2009=\u20098) significantly decreased post-intervention (NRS and McGill Pain Questionnaire, p\u2009&lt;\u2009.001). Skin temperature in the residual limb increased significantly post-intervention (p\u2009&lt;\u2009.01) but did not correlate with PLP (r\u2009=\u2009\u2212\u00a00.08, p\u2009=\u20090.83). Tentacle overlay yielded mixed ownership but high agency ratings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PhantomAR leverages mixed reality to significantly reduce Phantom Limb Pain, enhance user engagement, and alter perceptions of ownership and agency of their augmented limb through bi-manual, dynamic, full-body interactions.<\/jats:p>\n                    <jats:p>\n                      <jats:italic>Trial registration<\/jats:italic>\n                      DRKS00033208 (Jan. 5th 2024)\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12984-025-01554-7","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T14:50:21Z","timestamp":1738680621000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["PhantomAR: gamified mixed reality system for alleviating phantom limb pain in upper limb amputees\u2014design, implementation, and clinical usability evaluation"],"prefix":"10.1186","volume":"22","clinical-trial-number":[{"clinical-trial-number":"drks00033208","registry":"10.18810\/drks"}],"author":[{"given":"Cosima","family":"Prahm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korbinian","family":"Eckstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bressler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashige","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Daigeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Kolbenschlag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Kuzuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"1554_CR1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01402796","author":"TS Jensen","year":"1983","unstructured":"Jensen TS, Krebs B, Nielsen J, Rasmussen P. 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