{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:35:54Z","timestamp":1791272154121,"version":"4.1.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virol J"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12985-015-0330-4","type":"journal-article","created":{"date-parts":[[2015,7,13]],"date-time":"2015-07-13T13:37:40Z","timestamp":1436794660000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["In vitro characterisation of a pleconaril\/pirodavir-like compound with potent activity against rhinoviruses"],"prefix":"10.1186","volume":"12","author":[{"given":"C\u00e9line","family":"Lacroix","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuela","family":"Laconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Angius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Coluccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romano","family":"Silvestri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaello","family":"Pompei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Neyts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Leyssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"330_CR1","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.bcp.2011.08.016","volume":"83","author":"HJ Thibaut","year":"2012","unstructured":"Thibaut HJ, De Palma AM, Neyts J. Combating enterovirus replication: state-of-the-art on antiviral research. Biochem Pharmacol. 2012;83:185\u201392.","journal-title":"Biochem Pharmacol"},{"key":"330_CR2","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/j.jaci.2010.04.021","volume":"125","author":"DJ Jackson","year":"2010","unstructured":"Jackson DJ, Johnston SL. The role of viruses in acute exacerbations of asthma. J Allergy Clin Immunol. 2010;125:1178\u201387.","journal-title":"J Allergy Clin Immunol"},{"key":"330_CR3","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1164\/rccm.201006-0833OC","volume":"183","author":"P Mallia","year":"2011","unstructured":"Mallia P, Message SD, Gielen V, Contoli M, Gray K, Kebadze T, et al. Experimental rhinovirus infection as a human model of chronic obstructive pulmonary disease exacerbation. Am J Respir Crit Care Med. 2011;183:734\u201342.","journal-title":"Am J Respir Crit Care Med"},{"key":"330_CR4","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/S1473-3099(02)00277-3","volume":"2","author":"K Senior","year":"2002","unstructured":"Senior K. FDA panel rejects common cold treatment. Lancet Infect Dis. 2002;2:264.","journal-title":"Lancet Infect Dis"},{"key":"330_CR5","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1021\/jm00383a010","volume":"28","author":"GD Diana","year":"1985","unstructured":"Diana GD, McKinlay MA, Brisson CJ, Zalay ES, Miralles JV, Salvador UJ. Isoxazoles with antipicornavirus activity. J Med Chem. 1985;28:748\u201352.","journal-title":"J Med Chem"},{"key":"330_CR6","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1128\/AAC.36.1.100","volume":"36","author":"K Andries","year":"1992","unstructured":"Andries K, Dewindt B, Snoeks J, Willebrords R, Van EK, Stokbroekx R, et al. In vitro activity of pirodavir (R 77975), a substituted phenoxy-pyridazinamine with broad-spectrum antipicornaviral activity. Antimicrob Agents Chemother. 1992;36:100\u20137.","journal-title":"Antimicrob Agents Chemother"},{"key":"330_CR7","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1128\/AAC.36.4.727","volume":"36","author":"FG Hayden","year":"1992","unstructured":"Hayden FG, Andries K, Janssen PA. Safety and efficacy of intranasal pirodavir (R77975) in experimental rhinovirus infection. Antimicrob Agents Chemother. 1992;36:727\u201332.","journal-title":"Antimicrob Agents Chemother"},{"key":"330_CR8","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1128\/AAC.39.2.290","volume":"39","author":"FG Hayden","year":"1995","unstructured":"Hayden FG, Hipskind GJ, Woerner DH, Eisen GF, Janssens M, Janssen PA, et al. Intranasal pirodavir (R77,975) treatment of rhinovirus colds. Antimicrob Agents Chemother. 1995;39:290\u20134.","journal-title":"Antimicrob Agents Chemother"},{"key":"330_CR9","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1021\/ml2002955","volume":"3","author":"SC Feil","year":"2012","unstructured":"Feil SC, Hamilton S, Krippner GY, Lin B, Luttick A, McConnell DB, et al. An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus. ACS Med Chem Lett. 2012;3:303\u20137.","journal-title":"ACS Med Chem Lett"},{"key":"330_CR10","doi-asserted-by":"publisher","first-page":"3479","DOI":"10.3390\/molecules16053479","volume":"16","author":"S Laconi","year":"2011","unstructured":"Laconi S, Madeddu MA, Pompei R. Study of the biological activity of novel synthetic compounds with antiviral properties against human rhinoviruses. Molecules. 2011;16:3479\u201387.","journal-title":"Molecules"},{"key":"330_CR11","doi-asserted-by":"publisher","first-page":"4061","DOI":"10.1016\/j.bmc.2014.05.066","volume":"22","author":"AM Bernard","year":"2014","unstructured":"Bernard AM, Cabiddu MG, De MS, Mura R, Pompei R. Synthesis of new compounds with promising antiviral properties against group A and B Human Rhinoviruses. Bioorg Med Chem. 2014;22:4061\u20136.","journal-title":"Bioorg Med Chem"},{"key":"330_CR12","doi-asserted-by":"publisher","first-page":"2723","DOI":"10.1093\/jac\/dku200","volume":"69","author":"C Lacroix","year":"2014","unstructured":"Lacroix C, Querol-Audi J, Roche M, Franco D, Froeyen M, Guerra P, et al. A novel benzonitrile analogue inhibits rhinovirus replication. J Antimicrob Chemother. 2014;69:2723\u201332.","journal-title":"J Antimicrob Chemother"},{"key":"330_CR13","doi-asserted-by":"publisher","first-page":"11061","DOI":"10.1128\/JVI.78.20.11061-11069.2004","volume":"78","author":"Y Zhang","year":"2004","unstructured":"Zhang Y, Simpson AA, Ledford RM, Bator CM, Chakravarty S, Skochko GA, et al. Structural and virological studies of the stages of virus replication that are affected by antirhinovirus compounds. J Virol. 2004;78:11061\u20139.","journal-title":"J Virol"},{"key":"330_CR14","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1021\/ci800298z","volume":"49","author":"O Korb","year":"2009","unstructured":"Korb O, Stutzle T, Exner TE. Empirical scoring functions for advanced protein-ligand docking with PLANTS. J Chem Inf Model. 2009;49:84\u201396.","journal-title":"J Chem Inf Model"},{"key":"330_CR15","doi-asserted-by":"publisher","first-page":"3663","DOI":"10.1128\/JVI.78.7.3663-3674.2004","volume":"78","author":"RM Ledford","year":"2004","unstructured":"Ledford RM, Patel NR, Demenczuk TM, Watanyar A, Herbertz T, Collett MS, et al. VP1 sequencing of all human rhinovirus serotypes: insights into genus phylogeny and susceptibility to antiviral capsid-binding compounds. J Virol. 2004;78:3663\u201374.","journal-title":"J Virol"}],"container-title":["Virology Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12985-015-0330-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12985-015-0330-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12985-015-0330-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12985-015-0330-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T16:38:09Z","timestamp":1630600689000},"score":1,"resource":{"primary":{"URL":"https:\/\/virologyj.biomedcentral.com\/articles\/10.1186\/s12985-015-0330-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,14]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["330"],"URL":"https:\/\/doi.org\/10.1186\/s12985-015-0330-4","relation":{},"ISSN":["1743-422X"],"issn-type":[{"value":"1743-422X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,14]]},"assertion":[{"value":"30 March 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"106"}}