{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:38:36Z","timestamp":1791437916191,"version":"4.3.3"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/100010276","name":"Rollins College","doi-asserted-by":"crossref","award":["none"],"award-info":[{"award-number":["none"]}],"id":[{"id":"10.13039\/100010276","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virol J"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12985-016-0602-7","type":"journal-article","created":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T13:12:23Z","timestamp":1472217143000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Epstein-Barr viral microRNAs target caspase 3"],"prefix":"10.1186","volume":"13","author":[{"given":"Cecelia","family":"Harold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Cox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasandra J.","family":"Riley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,26]]},"reference":[{"issue":"2","key":"602_CR1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/rmv.1816","volume":"25","author":"CJ Houldcroft","year":"2015","unstructured":"Houldcroft CJ, Kellam P. Host genetics of Epstein-Barr virus infection, latency and disease. Rev Med Virol. 2015;25(2):71\u201384.","journal-title":"Rev Med Virol"},{"key":"602_CR2","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1126\/science.1096781","volume":"304","author":"S Pfeffer","year":"2004","unstructured":"Pfeffer S, Zavolan M, Gr\u00e4sser FA, Chien M, Russo JJ, Ju J, John B, Enright AJ, Marks D, Sander C, Tuschl T. Identification of virus-encoded microRNAs. Science. 2004;304:734\u20136.","journal-title":"Science"},{"key":"602_CR3","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1371\/journal.ppat.0020023","volume":"2","author":"X Cai","year":"2006","unstructured":"Cai X, Sch\u00e4fer A, Lu S, Bilello JP, Desrosiers RC, Edwards R, Raab-Traub N, Cullen BR. Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed. PLoS Pathog. 2006;2:e23.","journal-title":"PLoS Pathog"},{"key":"602_CR4","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.virol.2011.01.002","volume":"411","author":"A Grundhoff","year":"2011","unstructured":"Grundhoff A, Sullivan CS. Virus-encoded microRNAs. Virology. 2011;411:325\u201343.","journal-title":"Virology"},{"key":"602_CR5","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jviromet.2012.05.005","volume":"184","author":"JP Nourse","year":"2012","unstructured":"Nourse JP, Crooks P, Keane C, Nguyen-Van D, Mujaj S, Ross N, Jones K, Vari F, Han E, Trappe R, Fink S, Gandhi MK. Expression profiling of Epstein-Barr virus-encoded microRNAs from paraffin-embedded formalin-fixed primary Epstein-Barr virus-positive B-cell lymphoma samples. J Virol Methods. 2012;184:46\u201354.","journal-title":"J Virol Methods"},{"key":"602_CR6","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1186\/1743-422X-10-314","volume":"10","author":"H-J Yang","year":"2013","unstructured":"Yang H-J, Huang T-J, Yang C-F, Peng L-XL-X, Liu R-Y, Yang G-D, Chu Q-Q, Huang J-L, Liu N, Huang H-B, Zhu Z-Y, Qian C-N, Huang B-J. Comprehensive profiling of Epstein-Barr virus-encoded miRNA species associated with specific latency types in tumor cells. Virol J. 2013;10:314.","journal-title":"Virol J"},{"key":"602_CR7","doi-asserted-by":"crossref","first-page":"10432","DOI":"10.3748\/wjg.v20.i30.10432","volume":"20","author":"VY Shin","year":"2014","unstructured":"Shin VY, Chu K-M. MiRNA as potential biomarkers and therapeutic targets for gastric cancer. World J Gastroenterol. 2014;20:10432\u20139.","journal-title":"World J Gastroenterol"},{"key":"602_CR8","doi-asserted-by":"crossref","first-page":"5581","DOI":"10.1128\/JVI.03639-14","volume":"89","author":"A Shinozaki-Ushiku","year":"2015","unstructured":"Shinozaki-Ushiku A, Kunita A, Isogai M, Hibiya T, Ushiku T, Takada K, Fukayama M. Profiling of virus-Encoded MicroRNAs in Epstein-Barr virus-associated gastric carcinoma and their roles in gastric carcinogenesis. J Virol. 2015;89:5581\u201391.","journal-title":"J Virol"},{"key":"602_CR9","doi-asserted-by":"crossref","first-page":"11670","DOI":"10.1128\/JVI.01248-10","volume":"84","author":"SD Linnstaedt","year":"2010","unstructured":"Linnstaedt SD, Gottwein E, Skalsky RL, Luftig M a, Cullen BR. Virally induced cellular microRNA miR-155 plays a key role in B-cell immortalization by Epstein-Barr virus. J Virol. 2010;84:11670\u20138.","journal-title":"J Virol"},{"key":"602_CR10","doi-asserted-by":"crossref","first-page":"e1004561","DOI":"10.1371\/journal.ppat.1004561","volume":"11","author":"J Qiu","year":"2015","unstructured":"Qiu J, Smith P, Leahy L, Thorley-Lawson DA. The Epstein-Barr Virus Encoded BART miRNAs potentiate tumor growth In Vivo. PLOS Pathog. 2015;11:e1004561.","journal-title":"PLOS Pathog"},{"key":"602_CR11","doi-asserted-by":"crossref","first-page":"e1004979","DOI":"10.1371\/journal.ppat.1004979","volume":"11","author":"D Kang","year":"2015","unstructured":"Kang D, Skalsky RL, Cullen BR. EBV BART MicroRNAs target multiple pro-apoptotic cellular genes to promote epithelial cell survival. PLOS Pathog. 2015;11:e1004979.","journal-title":"PLOS Pathog"},{"key":"602_CR12","doi-asserted-by":"crossref","first-page":"e1001063","DOI":"10.1371\/journal.ppat.1001063","volume":"6","author":"E Seto","year":"2010","unstructured":"Seto E, Moosmann A, Gr\u00f6mminger S, Walz N, Grundhoff A, Hammerschmidt W. Micro RNAs of Epstein-Barr virus promote cell cycle progression and prevent apoptosis of primary human B cells. PLoS Pathog. 2010;6:e1001063.","journal-title":"PLoS Pathog"},{"key":"602_CR13","doi-asserted-by":"crossref","unstructured":"Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;281\u2013297.","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"602_CR14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.molcel.2007.06.017","volume":"27","author":"A Grimson","year":"2007","unstructured":"Grimson A, Farh KK-H, Johnston WK, Garrett-Engele P, Lim LP, Bartel DP. MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell. 2007;27:91\u2013105.","journal-title":"Mol Cell"},{"key":"602_CR15","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1126\/science.1258040","volume":"346","author":"NT Schirle","year":"2014","unstructured":"Schirle NT, Sheu-Gruttadauria J, MacRae IJ. Structural basis for microRNA targeting. Science. 2014;346:608\u201313.","journal-title":"Science"},{"key":"602_CR16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","volume":"136","author":"DP Bartel","year":"2009","unstructured":"Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009;136:215\u201333.","journal-title":"Cell"},{"key":"602_CR17","doi-asserted-by":"crossref","first-page":"e1002484","DOI":"10.1371\/journal.ppat.1002484","volume":"8","author":"RL Skalsky","year":"2012","unstructured":"Skalsky RL, Corcoran DL, Gottwein E, Frank CL, Kang D, Hafner M, Nusbaum JD, Feederle R, Delecluse H-J, Luftig MA, Tuschl T, Ohler U, Cullen BR. The Viral and Cellular MicroRNA Targetome in lymphoblastoid cell lines. PLoS Pathog. 2012;8:e1002484.","journal-title":"PLoS Pathog"},{"key":"602_CR18","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1038\/emboj.2012.63","volume":"31","author":"KJ Riley","year":"2012","unstructured":"Riley KJ, Rabinowitz GS, Yario TA, Luna JM, Darnell RB, Steitz JA. EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency. EMBO J. 2012;31:2207\u201321.","journal-title":"EMBO J"},{"key":"602_CR19","doi-asserted-by":"crossref","first-page":"e1005405","DOI":"10.1371\/journal.ppat.1005405","volume":"12","author":"K Bernhardt","year":"2016","unstructured":"Bernhardt K, Haar J, Tsai M-H, Poirey R, Feederle R, Delecluse H-J. A Viral microRNA cluster regulates the expression of PTEN, p27 and of a bcl-2 Homolog. PLoS Pathog. 2016;12:e1005405.","journal-title":"PLoS Pathog"},{"key":"602_CR20","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.virol.2011.01.028","volume":"412","author":"AR Marquitz","year":"2011","unstructured":"Marquitz AR, Mathur A, Nam CS, Raab-Traub N. The Epstein-Barr virus BART microRNAs target the pro-apoptotic protein Bim. Virology. 2011;412:392\u2013400.","journal-title":"Virology"},{"key":"602_CR21","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1084\/jem.20072581","volume":"205","author":"EY-W Choy","year":"2008","unstructured":"Choy EY-W, Siu K-L, Kok K-H, Lung RW-M, Tsang CM, To K-F, Kwong DL-W, Tsao SW, Jin D-Y. An Epstein-Barr virus-encoded microRNA targets PUMA to promote host cell survival. J Exp Med. 2008;205:2551\u201360.","journal-title":"J Exp Med"},{"key":"602_CR22","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1128\/JVI.02794-15","volume":"90","author":"H Kim","year":"2015","unstructured":"Kim H, Choi H, Lee SK. Epstein-Barr Virus MicroRNA miR-BART20-5p Suppresses Lytic induction by inhibiting BAD-Mediated caspase-3-dependent apoptosis. J Virol. 2015;90:1359\u201368.","journal-title":"J Virol"},{"key":"602_CR23","doi-asserted-by":"crossref","first-page":"a006080","DOI":"10.1101\/cshperspect.a006080","volume":"7","author":"DR Green","year":"2015","unstructured":"Green DR, Llambi F. Cell death signaling. Cold Spring Harb Perspect Biol. 2015;7:a006080.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"602_CR24","doi-asserted-by":"crossref","first-page":"e1005344","DOI":"10.1371\/journal.ppat.1005344","volume":"11","author":"X Lin","year":"2015","unstructured":"Lin X, Tsai M-H, Shumilov A, Poirey R, Bannert H, Middeldorp JM, Feederle R, Delecluse H-J. The Epstein-Barr Virus BART miRNA cluster of the M81 strain modulates multiple functions in primary B cells. PLoS Pathog. 2015;11:e1005344.","journal-title":"PLoS Pathog"},{"key":"602_CR25","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/onc.2013.71","volume":"33","author":"DT Vereide","year":"2014","unstructured":"Vereide DT, Seto E, Chiu Y-F, Hayes M, Tagawa T, Grundhoff A, Hammerschmidt W, Sugden B. Epstein-Barr virus maintains lymphomas via its miRNAs. Oncogene. 2014;33:1258\u201364.","journal-title":"Oncogene"},{"key":"602_CR26","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.cell.2006.07.031","volume":"126","author":"KC Miranda","year":"2006","unstructured":"Miranda KC, Huynh T, Tay Y, Ang Y-S, Tam W-L, Thomson AM, Lim B, Rigoutsos I. A Pattern-based Method for the Identification of MicroRNA binding sites and their corresponding Heteroduplexes. Cell. 2006;126:1203\u201317.","journal-title":"Cell"},{"key":"602_CR27","doi-asserted-by":"crossref","unstructured":"Agarwal V, Bell GW, Nam J-W, Bartel DP. Predicting effective microRNA target sites in mammalian mRNAs. Elife. 2015;4.","DOI":"10.7554\/eLife.05005"},{"issue":"Database issue","key":"602_CR28","doi-asserted-by":"crossref","first-page":"D68","DOI":"10.1093\/nar\/gkt1181","volume":"42","author":"A Kozomara","year":"2014","unstructured":"Kozomara A, Griffiths-Jones S. miRBase: annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res. 2014;42(Database issue):D68\u201373.","journal-title":"Nucleic Acids Res"},{"key":"602_CR29","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.molcel.2014.03.025","volume":"54","author":"YE Guo","year":"2014","unstructured":"Guo YE, Riley KJ, Iwasaki A, Steitz JA. Alternative capture of Noncoding RNAs or protein-coding genes by Herpesviruses to alter host T cell function. Mol Cell. 2014;54:67\u201379.","journal-title":"Mol Cell"},{"key":"602_CR30","doi-asserted-by":"crossref","unstructured":"Tuschl T. Annealing siRNAs to produce siRNA duplexes. CSH Protoc. 2006;2006.","DOI":"10.1101\/pdb.prot4340"},{"key":"602_CR31","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.molcel.2013.01.030","volume":"49","author":"KJ Riley","year":"2013","unstructured":"Riley KJ, Steitz JA. The \u201cObserver Effect\u201d in genome-wide surveys of protein-RNA interactions. Mol Cell. 2013;49:601\u20134.","journal-title":"Mol Cell"},{"key":"602_CR32","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1261\/rna.034934.112","volume":"18","author":"KJ Riley","year":"2012","unstructured":"Riley KJ, Yario TA, Steitz JA. Association of argonaute proteins and microRNAs can occur after cell lysis. RNA. 2012;18:1581\u20135.","journal-title":"RNA"},{"key":"602_CR33","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1128\/JVI.03189-14","volume":"89","author":"T Kanda","year":"2015","unstructured":"Kanda T, Miyata M, Kano M, Kondo S, Yoshizaki T, Iizasa H. Clustered microRNAs of the Epstein-Barr virus cooperatively downregulate an epithelial cell-specific metastasis suppressor. J Virol. 2015;89:2684\u201397.","journal-title":"J Virol"},{"key":"602_CR34","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.yexcr.2016.05.011","volume":"345","author":"B Wang","year":"2016","unstructured":"Wang B, Wang D, Yan T, Yuan H. MiR-138-5p promotes TNF-\u03b1-induced apoptosis in human intervertebral disc degeneration by targeting SIRT1 through PTEN\/PI3K\/Akt signaling. Exp Cell Res. 2016;345:199\u2013205.","journal-title":"Exp Cell Res"},{"key":"602_CR35","doi-asserted-by":"crossref","first-page":"375","DOI":"10.14348\/molcells.2016.0013","volume":"39","author":"H Seok","year":"2016","unstructured":"Seok H, Ham J, Jang E-S, Chi SW. MicroRNA target recognition: insights from Transcriptome-wide non-canonical interactions. Mol Cells. 2016;39:375\u201381.","journal-title":"Mol Cells"},{"key":"602_CR36","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.molcel.2012.10.002","volume":"48","author":"GB Loeb","year":"2012","unstructured":"Loeb GB, Khan AA, Canner D, Hiatt JB, Shendure J, Darnell RB, Leslie CS, Rudensky AY. Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting. Mol Cell. 2012;48:760\u201370.","journal-title":"Mol Cell"},{"key":"602_CR37","doi-asserted-by":"crossref","first-page":"e1002884","DOI":"10.1371\/journal.ppat.1002884","volume":"8","author":"I Haecker","year":"2012","unstructured":"Haecker I, Gay LA, Yang Y, Hu J, Morse AM, McIntyre LM, Renne R. Ago HITS-CLIP expands understanding of Kaposi\u2019s sarcoma-associated herpesvirus miRNA function in primary effusion lymphomas. PLoS Pathog. 2012;8:e1002884.","journal-title":"PLoS Pathog"},{"key":"602_CR38","doi-asserted-by":"crossref","first-page":"e1002405","DOI":"10.1371\/journal.ppat.1002405","volume":"7","author":"G Suffert","year":"2011","unstructured":"Suffert G, Malterer G, Hausser J, Viili\u00e4inen J, Fender A, Contrant M, Ivacevic T, Benes V, Gros F, Voinnet O, Zavolan M, Ojala PM, Haas JG, Pfeffer S. Kaposi\u2019s Sarcoma Herpesvirus microRNAs target Caspase 3 and regulate apoptosis. PLoS Pathog. 2011;7:e1002405.","journal-title":"PLoS Pathog"},{"key":"602_CR39","doi-asserted-by":"crossref","first-page":"e1003018","DOI":"10.1371\/journal.ppat.1003018","volume":"8","author":"RP Kincaid","year":"2012","unstructured":"Kincaid RP, Sullivan CS. Virus-encoded microRNAs: an overview and a look to the future. PLoS Pathog. 2012;8:e1003018.","journal-title":"PLoS Pathog"},{"key":"602_CR40","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.tim.2009.09.002","volume":"17","author":"IW Boss","year":"2009","unstructured":"Boss IW, Plaisance KB, Renne R. Role of virus-encoded microRNAs in herpesvirus biology. Trends Microbiol. 2009;17:544\u201353.","journal-title":"Trends Microbiol"}],"container-title":["Virology Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12985-016-0602-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T00:19:20Z","timestamp":1568333960000},"score":1,"resource":{"primary":{"URL":"http:\/\/virologyj.biomedcentral.com\/articles\/10.1186\/s12985-016-0602-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,26]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["602"],"URL":"https:\/\/doi.org\/10.1186\/s12985-016-0602-7","relation":{},"ISSN":["1743-422X"],"issn-type":[{"value":"1743-422X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,26]]},"article-number":"145"}}