{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:13:50Z","timestamp":1768288430496,"version":"3.49.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virol J"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12985-016-0658-4","type":"journal-article","created":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T10:19:20Z","timestamp":1480501160000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Sequence diversity of dengue virus type 2 in brain and thymus of infected interferon receptor ko mice: implications for dengue virulence"],"prefix":"10.1186","volume":"13","author":[{"given":"Priya","family":"Dhole","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emi E.","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akatsuki","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kriengsak","family":"Limkittikul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supranee","family":"Phanthanawiboon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Shioda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kurosu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,11,30]]},"reference":[{"key":"658_CR1","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1038\/nm1144","volume":"10","author":"JS Mackenzie","year":"2004","unstructured":"Mackenzie JS, Gubler DJ, Petersen LR. Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and dengue viruses. Nat Med. 2004;10:S98\u2013109.","journal-title":"Nat Med"},{"key":"658_CR2","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature02759","volume":"430","author":"DM Morens","year":"2004","unstructured":"Morens DM, Folkers GK, Fauci AS. The challenge of emerging and re-emerging infectious diseases. Nature. 2004;430:242\u20139.","journal-title":"Nature"},{"key":"658_CR3","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.tim.2013.12.011","volume":"22","author":"JP Messina","year":"2014","unstructured":"Messina JP, Brady OJ, Scott TW, Zou C, Pigott DM, Duda KA, Bhatt S, Katzelnick L, Howes RE, Battle KE, et al. Global spread of dengue virus types: mapping the 70\u00a0year history. Trends Microbiol. 2014;22:138\u201346.","journal-title":"Trends Microbiol"},{"key":"658_CR4","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1038\/nrmicro2460","volume":"8","author":"MG Guzman","year":"2010","unstructured":"Guzman MG, Halstead SB, Artsob H, Buchy P, Farrar J, Gubler DJ, Hunsperger E, Kroeger A, Margolis HS, Martinez E, et al. Dengue: a continuing global threat. Nat Rev Microbiol. 2010;8:S7\u201316.","journal-title":"Nat Rev Microbiol"},{"key":"658_CR5","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.mi.44.100190.003245","volume":"44","author":"TJ Chambers","year":"1990","unstructured":"Chambers TJ, Hahn CS, Galler R, Rice CM. Flavivirus genome organization, expression, and replication. Annu Rev Microbiol. 1990;44:649\u201388.","journal-title":"Annu Rev Microbiol"},{"key":"658_CR6","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1056\/NEJMoa0805715","volume":"360","author":"MR Duffy","year":"2009","unstructured":"Duffy MR, Chen TH, Hancock WT, Powers AM, Kool JL, Lanciotti RS, Pretrick M, Marfel M, Holzbauer S, Dubray C, et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med. 2009;360:2536\u201343.","journal-title":"N Engl J Med"},{"key":"658_CR7","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0140-6736(08)60238-X","volume":"371","author":"EA Gould","year":"2008","unstructured":"Gould EA, Solomon T. Pathogenic flaviviruses. Lancet. 2008;371:500\u20139.","journal-title":"Lancet"},{"key":"658_CR8","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","volume":"496","author":"S Bhatt","year":"2013","unstructured":"Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, Drake JM, Brownstein JS, Hoen AG, Sankoh O, et al. The global distribution and burden of dengue. Nature. 2013;496:504\u20137.","journal-title":"Nature"},{"key":"658_CR9","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cimid.2007.05.010","volume":"30","author":"I Kurane","year":"2007","unstructured":"Kurane I. Dengue hemorrhagic fever with special emphasis on immunopathogenesis. Comp Immunol Microbiol Infect Dis. 2007;30:329\u201340.","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"658_CR10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0065-3527(03)59002-9","volume":"59","author":"BD Lindenbach","year":"2003","unstructured":"Lindenbach BD, Rice CM. Molecular biology of flaviviruses. Adv Virus Res. 2003;59:23\u201361.","journal-title":"Adv Virus Res"},{"key":"658_CR11","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.3390\/v3091739","volume":"3","author":"LG Gebhard","year":"2011","unstructured":"Gebhard LG, Filomatori CV, Gamarnik AV. Functional RNA elements in the dengue virus genome. Viruses. 2011;3:1739\u201356.","journal-title":"Viruses"},{"key":"658_CR12","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1128\/CMR.3.4.376","volume":"3","author":"EA Henchal","year":"1990","unstructured":"Henchal EA, Putnak JR. The dengue viruses. Clin Microbiol Rev. 1990;3:376\u201396.","journal-title":"Clin Microbiol Rev"},{"key":"658_CR13","doi-asserted-by":"crossref","first-page":"11418","DOI":"10.1128\/JVI.01257-06","volume":"80","author":"K Clyde","year":"2006","unstructured":"Clyde K, Kyle JL, Harris E. Recent advances in deciphering viral and host determinants of dengue virus replication and pathogenesis. J Virol. 2006;80:11418\u201331.","journal-title":"J Virol"},{"key":"658_CR14","first-page":"99","volume":"48","author":"E Domingo","year":"1997","unstructured":"Domingo E, Menendez-Arias L, Quinones-Mateu ME, Holguin A, Gutierrez-Rivas M, Martinez MA, Quer J, Novella IS, Holland JJ. Viral quasispecies and the problem of vaccine-escape and drug-resistant mutants. Prog Drug Res. 1997;48:99\u2013128.","journal-title":"Prog Drug Res"},{"key":"658_CR15","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature04388","volume":"439","author":"M Vignuzzi","year":"2006","unstructured":"Vignuzzi M, Stone JK, Arnold JJ, Cameron CE, Andino R. Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population. Nature. 2006;439:344\u20138.","journal-title":"Nature"},{"key":"658_CR16","doi-asserted-by":"crossref","first-page":"12717","DOI":"10.1128\/JVI.78.22.12717-12721.2004","volume":"78","author":"SR Lin","year":"2004","unstructured":"Lin SR, Hsieh SC, Yueh YY, Lin TH, Chao DY, Chen WJ, King CC, Wang WK. Study of sequence variation of dengue type 3 virus in naturally infected mosquitoes and human hosts: implications for transmission and evolution. J Virol. 2004;78:12717\u201321.","journal-title":"J Virol"},{"key":"658_CR17","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nri3014","volume":"11","author":"AL Rothman","year":"2011","unstructured":"Rothman AL. Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms. Nat Rev Immunol. 2011;11:532\u201343.","journal-title":"Nat Rev Immunol"},{"key":"658_CR18","doi-asserted-by":"crossref","first-page":"7221","DOI":"10.1016\/j.vaccine.2011.07.022","volume":"29","author":"J Whitehorn","year":"2011","unstructured":"Whitehorn J, Simmons CP. The pathogenesis of dengue. Vaccine. 2011;29:7221\u20138.","journal-title":"Vaccine"},{"key":"658_CR19","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.cell.2015.07.005","volume":"162","author":"MS Diamond","year":"2015","unstructured":"Diamond MS, Pierson TC. Molecular insight into dengue virus pathogenesis and its implications for disease control. Cell. 2015;162:488\u201392.","journal-title":"Cell"},{"key":"658_CR20","doi-asserted-by":"crossref","first-page":"10208","DOI":"10.1128\/JVI.00062-06","volume":"80","author":"S Shresta","year":"2006","unstructured":"Shresta S, Sharar KL, Prigozhin DM, Beatty PR, Harris E. Murine model for dengue virus-induced lethal disease with increased vascular permeability. J Virol. 2006;80:10208\u201317.","journal-title":"J Virol"},{"key":"658_CR21","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1128\/JVI.73.1.783-786.1999","volume":"73","author":"AJ Johnson","year":"1999","unstructured":"Johnson AJ, Roehrig JT. New mouse model for dengue virus vaccine testing. J Virol. 1999;73:783\u20136.","journal-title":"J Virol"},{"key":"658_CR22","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1086\/511310","volume":"195","author":"W Schul","year":"2007","unstructured":"Schul W, Liu W, Xu HY, Flamand M, Vasudevan SG. A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs. J Infect Dis. 2007;195:665\u201374.","journal-title":"J Infect Dis"},{"issue":"Suppl 1","key":"658_CR23","doi-asserted-by":"crossref","first-page":"E12","DOI":"10.1111\/j.1749-6632.2009.05057.x","volume":"1171","author":"KL Williams","year":"2009","unstructured":"Williams KL, Zompi S, Beatty PR, Harris E. A mouse model for studying dengue virus pathogenesis and immune response. Ann N Y Acad Sci. 2009;1171 Suppl 1:E12\u201323.","journal-title":"Ann N Y Acad Sci"},{"key":"658_CR24","doi-asserted-by":"crossref","first-page":"e0148564","DOI":"10.1371\/journal.pone.0148564","volume":"11","author":"S Phanthanawiboon","year":"2016","unstructured":"Phanthanawiboon S, Limkittikul K, Sakai Y, Takakura N, Saijo M, Kurosu T. Acute systemic infection with dengue virus leads to vascular leakage and death through tumor necrosis factor-alpha and Tie2\/angiopoietin signaling in mice lacking type I and II interferon receptors. PLoS One. 2016;11:e0148564.","journal-title":"PLoS One"},{"key":"658_CR25","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.bbrc.2010.02.181","volume":"394","author":"T Kurosu","year":"2010","unstructured":"Kurosu T, Khamlert C, Phanthanawiboon S, Ikuta K, Anantapreecha S. Highly efficient rescue of dengue virus using a co-culture system with mosquito\/mammalian cells. Biochem Biophys Res Commun. 2010;394:398\u2013404.","journal-title":"Biochem Biophys Res Commun"},{"key":"658_CR26","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1128\/JCM.41.6.2408-2416.2003","volume":"41","author":"PY Shu","year":"2003","unstructured":"Shu PY, Chang SF, Kuo YC, Yueh YY, Chien LJ, Sue CL, Lin TH, Huang JH. Development of group- and serotype-specific one-step SYBR green I-based real-time reverse transcription-PCR assay for dengue virus. J Clin Microbiol. 2003;41:2408\u201316.","journal-title":"J Clin Microbiol"},{"key":"658_CR27","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1007\/s00705-013-1645-3","volume":"158","author":"MG Guzman","year":"2013","unstructured":"Guzman MG, Alvarez M, Halstead SB. Secondary infection as a risk factor for dengue hemorrhagic fever\/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection. Arch Virol. 2013;158:1445\u201359.","journal-title":"Arch Virol"},{"key":"658_CR28","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri2206","volume":"8","author":"F Nimmerjahn","year":"2008","unstructured":"Nimmerjahn F, Ravetch JV. Fcgamma receptors as regulators of immune responses. Nat Rev Immunol. 2008;8:34\u201347.","journal-title":"Nat Rev Immunol"},{"key":"658_CR29","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/379346a0","volume":"379","author":"T Takai","year":"1996","unstructured":"Takai T, Ono M, Hikida M, Ohmori H, Ravetch JV. Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature. 1996;379:346\u20139.","journal-title":"Nature"},{"key":"658_CR30","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1084\/jem.189.1.179","volume":"189","author":"R Clynes","year":"1999","unstructured":"Clynes R, Maizes JS, Guinamard R, Ono M, Takai T, Ravetch JV. Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors. J Exp Med. 1999;189:179\u201385.","journal-title":"J Exp Med"},{"key":"658_CR31","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1084\/jem.191.9.1611","volume":"191","author":"S Kleinau","year":"2000","unstructured":"Kleinau S, Martinsson P, Heyman B. Induction and suppression of collagen-induced arthritis is dependent on distinct fcgamma receptors. J Exp Med. 2000;191:1611\u20136.","journal-title":"J Exp Med"},{"key":"658_CR32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1084\/jem.189.1.187","volume":"189","author":"T Yuasa","year":"1999","unstructured":"Yuasa T, Kubo S, Yoshino T, Ujike A, Matsumura K, Ono M, Ravetch JV, Takai T. Deletion of fcgamma receptor IIB renders H-2(b) mice susceptible to collagen-induced arthritis. J Exp Med. 1999;189:187\u201394.","journal-title":"J Exp Med"},{"key":"658_CR33","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1084\/jem.191.5.899","volume":"191","author":"A Nakamura","year":"2000","unstructured":"Nakamura A, Yuasa T, Ujike A, Ono M, Nukiwa T, Ravetch JV, Takai T. Fcgamma receptor IIB-deficient mice develop Goodpasture\u2019s syndrome upon immunization with type IV collagen: a novel murine model for autoimmune glomerular basement membrane disease. J Exp Med. 2000;191:899\u2013906.","journal-title":"J Exp Med"},{"key":"658_CR34","doi-asserted-by":"crossref","first-page":"12479","DOI":"10.1073\/pnas.1106568108","volume":"108","author":"KR Chan","year":"2011","unstructured":"Chan KR, Zhang SL, Tan HC, Chan YK, Chow A, Lim AP, Vasudevan SG, Hanson BJ, Ooi EE. Ligation of Fc gamma receptor IIB inhibits antibody-dependent enhancement of dengue virus infection. Proc Natl Acad Sci U S A. 2011;108:12479\u201384.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"658_CR35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10875-005-0353-8","volume":"25","author":"T Takai","year":"2005","unstructured":"Takai T. Fc receptors and their role in immune regulation and autoimmunity. J Clin Immunol. 2005;25:1\u201318.","journal-title":"J Clin Immunol"},{"key":"658_CR36","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0065-3527(03)60008-4","volume":"60","author":"TJ Chambers","year":"2003","unstructured":"Chambers TJ, Diamond MS. Pathogenesis of flavivirus encephalitis. Adv Virus Res. 2003;60:273\u2013342.","journal-title":"Adv Virus Res"},{"key":"658_CR37","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0165-0270(00)00296-X","volume":"103","author":"RM Kelly","year":"2000","unstructured":"Kelly RM, Strick PL. Rabies as a transneuronal tracer of circuits in the central nervous system. J Neurosci Methods. 2000;103:63\u201371.","journal-title":"J Neurosci Methods"}],"container-title":["Virology Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12985-016-0658-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T16:26:57Z","timestamp":1601224017000},"score":1,"resource":{"primary":{"URL":"http:\/\/virologyj.biomedcentral.com\/articles\/10.1186\/s12985-016-0658-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,30]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["658"],"URL":"https:\/\/doi.org\/10.1186\/s12985-016-0658-4","relation":{},"ISSN":["1743-422X"],"issn-type":[{"value":"1743-422X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,30]]},"article-number":"199"}}