{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:24:40Z","timestamp":1782977080568,"version":"3.54.5"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"FIBElx (10\/08)","award":["FIBElx (10\/08)"],"award-info":[{"award-number":["FIBElx (10\/08)"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virol J"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12985-017-0885-3","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T12:35:40Z","timestamp":1510058140000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Lack of cytomegalovirus detection in human glioma"],"prefix":"10.1186","volume":"14","author":[{"given":"Araceli","family":"Garcia-Martinez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Alenda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esperanza","family":"Irles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Ochoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Quintanar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Rodriguez-Lescure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L.","family":"Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor M.","family":"Barbera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,7]]},"reference":[{"issue":"5","key":"885_CR1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00401-010-0736-4","volume":"120","author":"M Riemenschneider","year":"2010","unstructured":"Riemenschneider M. Molecular diagnostics of gliomas: state of the art. Acta Neuropathol. 2010;120(5):567\u201384.","journal-title":"Acta Neuropathol"},{"issue":"12","key":"885_CR2","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1111\/j.1349-7006.2009.01308.x","volume":"100","author":"H Ohgaki","year":"2009","unstructured":"Ohgaki H, Kleihues P. Genetic alterations and signaling pathways in the evolution of gliomas. Cancer Sci. 2009;100(12):2235\u201341.","journal-title":"Cancer Sci"},{"key":"885_CR3","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1182\/asheducation-2011.1.305","volume":"2011","author":"M Boeckh","year":"2011","unstructured":"Boeckh M. Complications, diagnosis, management, and prevention of CMV infections: current and future. Hematology Am Soc Hematol Educ Program. 2011;2011:305\u20139.","journal-title":"Hematology Am Soc Hematol Educ Program"},{"issue":"5-6","key":"885_CR4","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1159\/000150503","volume":"39","author":"ES Mocarski Jr","year":"1996","unstructured":"Mocarski ES Jr, Kemble GW. Recombinant cytomegaloviruses for study of replication and pathogenesis. Intervirology. 1996;39(5-6):320\u201330.","journal-title":"Intervirology"},{"key":"885_CR5","first-page":"417","volume":"325","author":"W Britt","year":"2008","unstructured":"Britt W. Manifestations of human cytomegalovirus infection: proposed mechanisms of acute and chronic disease. Curr Top Microbiol Immunol. 2008;325:417\u201370.","journal-title":"Curr Top Microbiol Immunol"},{"issue":"12","key":"885_CR6","first-page":"3347","volume":"62","author":"CS Cobbs","year":"2002","unstructured":"Cobbs CS, et al. Human cytomegalovirus infection and expression in human malignant glioma. Cancer Res. 2002;62(12):3347\u201350.","journal-title":"Cancer Res"},{"issue":"1","key":"885_CR7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00401-008-0359-1","volume":"116","author":"ME Scheurer","year":"2008","unstructured":"Scheurer ME, et al. Detection of human cytomegalovirus in different histological types of gliomas. Acta Neuropathol. 2008;116(1):79\u201386.","journal-title":"Acta Neuropathol"},{"issue":"12","key":"885_CR8","doi-asserted-by":"crossref","first-page":"6815","DOI":"10.1128\/JVI.00015-12","volume":"86","author":"B Bhattacharjee","year":"2012","unstructured":"Bhattacharjee B, Renzette N, Kowalik TF. Genetic analysis of cytomegalovirus in malignant gliomas. J Virol. 2012;86(12):6815\u201324.","journal-title":"J Virol"},{"issue":"11","key":"885_CR9","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1097\/NEN.0000000000000125","volume":"73","author":"IH Solomon","year":"2014","unstructured":"Solomon IH, et al. Cytomegalovirus and glioblastoma: a review of evidence for their association and indications for testing and treatment. J Neuropathol Exp Neurol. 2014;73(11):994\u20138.","journal-title":"J Neuropathol Exp Neurol"},{"issue":"1","key":"885_CR10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1215\/15228517-2007-035","volume":"10","author":"DA Mitchell","year":"2008","unstructured":"Mitchell DA, et al. Sensitive detection of human cytomegalovirus in tumors and peripheral blood of patients diagnosed with glioblastoma. Neuro-Oncology. 2008;10(1):10\u20138.","journal-title":"Neuro-Oncology"},{"key":"885_CR11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2042-4280-3-3","volume":"3","author":"A Rahbar","year":"2012","unstructured":"Rahbar A, et al. Low levels of human cytomegalovirus infection in Glioblastoma multiforme associates with patient survival; \u2212a case-control study. Herpesviridae. 2012;3:3.","journal-title":"Herpesviridae"},{"issue":"9","key":"885_CR12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0108861","volume":"9","author":"S Libard","year":"2014","unstructured":"Libard S, et al. Human cytomegalovirus tegument protein pp65 is detected in all intra- and extra-axial brain tumours independent of the tumour type or grade. PLoS One. 2014;9(9):e108861.","journal-title":"PLoS One"},{"issue":"4","key":"885_CR13","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/sj.bjc.6602339","volume":"92","author":"J Sabatier","year":"2005","unstructured":"Sabatier J, et al. Detection of human cytomegalovirus genome and gene products in central nervous system tumours. Br J Cancer. 2005;92(4):747\u201350.","journal-title":"Br J Cancer"},{"issue":"2","key":"885_CR14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s11060-010-0383-6","volume":"103","author":"KG Lucas","year":"2011","unstructured":"Lucas KG, et al. The detection of CMV pp65 and IE1 in glioblastoma multiforme. J Neuro-Oncol. 2011;103(2):231\u20138.","journal-title":"J Neuro-Oncol"},{"issue":"7","key":"885_CR15","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1590\/S0074-02762012000700020","volume":"107","author":"RF Fonseca","year":"2012","unstructured":"Fonseca RF, et al. The prevalence of human cytomegalovirus DNA in gliomas of Brazilian patients. Mem Inst Oswaldo Cruz. 2012;107(7):953\u20134.","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"3","key":"885_CR16","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s11060-013-1350-9","volume":"116","author":"D Ding","year":"2014","unstructured":"Ding D, et al. Does the existence of HCMV components predict poor prognosis in glioma? J Neuro-Oncol. 2014;116(3):515\u201322.","journal-title":"J Neuro-Oncol"},{"issue":"6","key":"885_CR17","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/modpathol.3800352","volume":"18","author":"SK Lau","year":"2005","unstructured":"Lau SK, et al. Lack of association of cytomegalovirus with human brain tumors. Mod Pathol. 2005;18(6):838\u201343.","journal-title":"Mod Pathol"},{"issue":"2","key":"885_CR18","first-page":"90","volume":"12","author":"S Poltermann","year":"2006","unstructured":"Poltermann S, et al. Lack of association of herpesviruses with brain tumors. J Neuro-Oncol. 2006;12(2):90\u20139.","journal-title":"J Neuro-Oncol"},{"issue":"7","key":"885_CR19","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/modpathol.2013.219","volume":"27","author":"Y Yamashita","year":"2014","unstructured":"Yamashita Y, et al. Lack of presence of the human cytomegalovirus in human glioblastoma. Mod Pathol. 2014;27(7):922\u20139.","journal-title":"Mod Pathol"},{"issue":"11","key":"885_CR20","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1093\/neuonc\/nou167","volume":"16","author":"P Baumgarten","year":"2014","unstructured":"Baumgarten P, et al. Human cytomegalovirus infection in tumor cells of the nervous system is not detectable with standardized pathologico-virological diagnostics. Neuro-Oncology. 2014;16(11):1469\u201377.","journal-title":"Neuro-Oncology"},{"issue":"4","key":"885_CR21","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/ijc.29042","volume":"136","author":"KW Tang","year":"2015","unstructured":"Tang KW, Hellstrand K, Larsson E. Absence of cytomegalovirus in high-coverage DNA sequencing of human glioblastoma multiforme. Int J Cancer. 2015;136(4):977\u201381.","journal-title":"Int J Cancer"},{"issue":"14","key":"885_CR22","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1158\/1078-0432.CCR-11-0992","volume":"17","author":"JH Sampson","year":"2011","unstructured":"Sampson JH, Mitchell DA. Is cytomegalovirus a therapeutic target in glioblastoma? Clin Cancer Res. 2011;17(14):4619\u201321.","journal-title":"Clin Cancer Res"},{"issue":"12","key":"885_CR23","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1158\/1078-0432.CCR-16-1490","volume":"23","author":"M Holdhoff","year":"2017","unstructured":"Holdhoff M, et al. Absence of cytomegalovirus in Glioblastoma and other high-grade Gliomas by real-time PCR, Immunohistochemistry, and <em>in situ<\/em> hybridization. Clin Cancer Res. 2017;23(12):3150\u20137.","journal-title":"Clin Cancer Res"},{"issue":"1","key":"885_CR24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00430-010-0177-7","volume":"200","author":"M Michaelis","year":"2011","unstructured":"Michaelis M, et al. Oncomodulation by human cytomegalovirus: novel clinical findings open new roads. Med Microbiol Immunol. 2011;200(1):1\u20135.","journal-title":"Med Microbiol Immunol"},{"key":"885_CR25","doi-asserted-by":"crossref","unstructured":"Cinatl, J., Jr., et al., Modulatory effects of human cytomegalovirus infection on malignant properties of cancer cells. Intervirology, 1996. 39(4): p. 259-269.","DOI":"10.1159\/000150527"},{"issue":"3","key":"885_CR26","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1365-2796.2006.01618.x","volume":"259","author":"C Soderberg-Naucler","year":"2006","unstructured":"Soderberg-Naucler C. Does cytomegalovirus play a causative role in the development of various inflammatory diseases and cancer? J Intern Med. 2006;259(3):219\u201346.","journal-title":"J Intern Med"},{"issue":"2","key":"885_CR27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00430-009-0107-8","volume":"198","author":"M Michaelis","year":"2009","unstructured":"Michaelis M, Doerr HW, Cinatl J Jr. Oncomodulation by human cytomegalovirus: evidence becomes stronger. Med Microbiol Immunol. 2009;198(2):79\u201381.","journal-title":"Med Microbiol Immunol"},{"issue":"1","key":"885_CR28","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/2042-4280-2-10","volume":"2","author":"CS Cobbs","year":"2011","unstructured":"Cobbs CS. Evolving evidence implicates cytomegalovirus as a promoter of malignant glioma pathogenesis. Herpesviridae. 2011;2(1):10.","journal-title":"Herpesviridae"},{"issue":"3","key":"885_CR29","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s11060-015-1734-0","volume":"123","author":"SE Lawler","year":"2015","unstructured":"Lawler SE. Cytomegalovirus and glioblastoma; controversies and opportunities. J Neuro-Oncol. 2015;123(3):465\u201371.","journal-title":"J Neuro-Oncol"},{"issue":"23","key":"885_CR30","doi-asserted-by":"crossref","first-page":"6473","DOI":"10.1158\/1078-0432.CCR-13-1121","volume":"19","author":"P Hadaczek","year":"2013","unstructured":"Hadaczek P, et al. Cidofovir: a novel antitumor agent for glioblastoma. Clin Cancer Res. 2013;19(23):6473\u201383.","journal-title":"Clin Cancer Res"}],"container-title":["Virology Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12985-017-0885-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,5]],"date-time":"2019-10-05T19:12:37Z","timestamp":1570302757000},"score":1,"resource":{"primary":{"URL":"https:\/\/virologyj.biomedcentral.com\/articles\/10.1186\/s12985-017-0885-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,7]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["885"],"URL":"https:\/\/doi.org\/10.1186\/s12985-017-0885-3","relation":{},"ISSN":["1743-422X"],"issn-type":[{"value":"1743-422X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,7]]},"article-number":"216"}}