{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T21:14:27Z","timestamp":1771708467987,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virol J"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12985-019-1197-6","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T14:15:33Z","timestamp":1563891333000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["CIN2+ detection of the HPV DNA Array genotyping assay in comparison with the Cobas 4800 HPV test and cytology"],"prefix":"10.1186","volume":"16","author":[{"given":"Aleksandra","family":"Pesic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amrei","family":"Krings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Hempel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemarie","family":"Preyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimon","family":"Chatzistamatiou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodoros","family":"Agorastos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas M.","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,7,23]]},"reference":[{"key":"1197_CR1","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1136\/jcp.55.4.244","volume":"55","author":"FX Bosch","year":"2002","unstructured":"Bosch FX, Lorincz A, Mu\u00f1oz N, Meijer CJ, Shah KV. The causal relation between human papillomavirus and cervical cancer. J Clin Pathol. 2002;55:244\u201365.","journal-title":"J Clin Pathol"},{"issue":"2","key":"1197_CR2","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1097\/GRF.0b013e31804a8285","volume":"50","author":"TCJ WRIGHT","year":"2007","unstructured":"WRIGHT TCJ. Cervical Cancer screening in the 21st century: is it time to retire the PAP smear? Clin Obstet Gynecol. 2007;50(2):313\u201323.","journal-title":"Clin Obstet Gynecol"},{"issue":"7188","key":"1197_CR3","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1136\/bmj.318.7188.904","volume":"318","author":"M Quinn","year":"1999","unstructured":"Quinn M, Babb P, Jones J, Allen E. Effect of screening on incidence of and mortality from cancer of cervix in England: evaluation based on routinely collected statistics. Bmj. 1999;318(7188):904.","journal-title":"Bmj."},{"issue":"Suppl 10","key":"1197_CR4","doi-asserted-by":"publisher","first-page":"K29","DOI":"10.1016\/j.vaccine.2008.06.019","volume":"26","author":"J Cuzick","year":"2008","unstructured":"Cuzick J, Arbyn M, Sankaranarayanan R, Tsu V, Ronco G, Mayrand MH, et al. Overview of human papillomavirus-based and other novel options for cervical cancer screening in developed and developing countries. Vaccine. 2008;26(Suppl 10):K29\u201341.","journal-title":"Vaccine."},{"key":"1197_CR5","unstructured":"World Health Organizaton. WHO guidelines for screening and treatment of precancerous lesions for cervical cancer prevention. 2013."},{"key":"1197_CR6","volume-title":"FDA approves Roche\u2019s HPV test for first-line primary screening for cervical Cancer","author":"Roche Group Media Relations","year":"2014","unstructured":"Roche Group Media Relations. FDA approves Roche\u2019s HPV test for first-line primary screening for cervical Cancer. 2014."},{"issue":"2","key":"1197_CR7","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1097\/LGT.0000000000000103","volume":"19","author":"WK Huh","year":"2015","unstructured":"Huh WK, Ault KA, Chelmow D, Davey DD, Goulart RA, Garcia FA, et al. Use of primary high-risk human papillomavirus testing for cervical cancer screening: interim clinical guidance. J Low Genit Tract Dis. 2015;19(2):91\u20136.","journal-title":"J Low Genit Tract Dis"},{"issue":"9916","key":"1197_CR8","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/S0140-6736(13)62218-7","volume":"383","author":"G Ronco","year":"2014","unstructured":"Ronco G, Dillner J, Elfstr\u00f6m KM, Tunesi S, Snijders PJF, Arbyn M, et al. Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled trials. The Lancet. 2014;383(9916):524\u201332.","journal-title":"The Lancet"},{"key":"1197_CR9","doi-asserted-by":"publisher","first-page":"g130","DOI":"10.1136\/bmj.g130","volume":"348","author":"KM Elfstrom","year":"2014","unstructured":"Elfstrom KM, Smelov V, Johansson AL, Eklund C, Naucler P, Arnheim-Dahlstrom L, et al. Long term duration of protective effect for HPV negative women: follow-up of primary HPV screening randomised controlled trial. Bmj. 2014;348:g130.","journal-title":"Bmj."},{"key":"1197_CR10","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1038\/sj.bjc.6602541","volume":"92","author":"NWJ Bulkmans","year":"2005","unstructured":"Bulkmans NWJ, Rozendaal L, Voorhorst FJ, Snijders PJF, Meijer CJLM. Long-term protective effect of high-risk human papillomavirus testing in population-based cervical screening. Br J Cancer. 2005;92:1800.","journal-title":"Br J Cancer"},{"issue":"6","key":"1197_CR11","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1054\/bjoc.2000.1689","volume":"84","author":"MAE Nobbenhuis","year":"2001","unstructured":"Nobbenhuis MAE, Meijer CJLM, AJCvd B, Rozendaal L, Voorhorst FJ, EKJ R, et al. Addition of high-risk HPV testing improves the current guidelines on follow-up after treatment for cervical intraepithelial neoplasia. Br J Cancer. 2001;84(6):796\u2013801.","journal-title":"Br J Cancer"},{"issue":"3","key":"1197_CR12","doi-asserted-by":"publisher","first-page":"264 e1","DOI":"10.1016\/j.ajog.2016.10.042","volume":"216","author":"K Elfgren","year":"2017","unstructured":"Elfgren K, Elfstrom KM, Naucler P, Arnheim-Dahlstrom L, Dillner J. Management of women with human papillomavirus persistence: long-term follow-up of a randomized clinical trial. Am J Obstet Gynecol. 2017;216(3):264 e1\u20137.","journal-title":"Am J Obstet Gynecol"},{"issue":"13","key":"1197_CR13","doi-asserted-by":"publisher","first-page":"4717","DOI":"10.1158\/1078-0432.CCR-04-2599","volume":"11","author":"CL Trimble","year":"2005","unstructured":"Trimble CL, Piantadosi S, Gravitt P, Ronnett B, Pizer E, Elko A, et al. Spontaneous regression of high-grade cervical dysplasia: effects of human papillomavirus type and HLA phenotype. Clin Cancer Res. 2005;11(13):4717\u201323.","journal-title":"Clin Cancer Res"},{"issue":"7","key":"1197_CR14","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1158\/1055-9965.EPI-06-0129","volume":"15","author":"H Trottier","year":"2006","unstructured":"Trottier H, Mahmud S, Costa MC, Sobrinho JP, Duarte-Franco E, Rohan TE, et al. Human Papillomavirus Infections with Multiple Types and Risk of Cervical Neoplasia. Cancer Epidemiol Biomarkers Prev. 2006;15(7):1274.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"3","key":"1197_CR15","doi-asserted-by":"publisher","first-page":"e0119755","DOI":"10.1371\/journal.pone.0119755","volume":"10","author":"T Agorastos","year":"2015","unstructured":"Agorastos T, Chatzistamatiou K, Katsamagkas T, Koliopoulos G, Daponte A, Constantinidis T, et al. Primary screening for cervical cancer based on high-risk human papillomavirus (HPV) detection and HPV 16 and HPV 18 genotyping, in comparison to cytology. PLoS One. 2015;10(3):e0119755.","journal-title":"PLoS One"},{"issue":"10","key":"1197_CR16","doi-asserted-by":"publisher","first-page":"3344","DOI":"10.1128\/JCM.00725-09","volume":"47","author":"PE Castle","year":"2009","unstructured":"Castle PE, Sadorra M, Lau T, Aldrich C, Garcia FA, Kornegay J. Evaluation of a prototype real-time PCR assay for carcinogenic human papillomavirus (HPV) detection and simultaneous HPV genotype 16 (HPV16) and HPV18 genotyping. J Clin Microbiol. 2009;47(10):3344\u20137.","journal-title":"J Clin Microbiol"},{"issue":"16","key":"1197_CR17","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1001\/jama.287.16.2114","volume":"287","author":"D Solomon","year":"2002","unstructured":"Solomon D, Davey D, Kurman R, et al. The 2001 Bethesda system: terminology for reporting results of cervical cytology. JAMA. 2002;287(16):2114\u20139.","journal-title":"JAMA."},{"key":"1197_CR18","unstructured":"Altman DG. Practical statistics for medical research: chapman\\& hall\/CRC; 2006."},{"issue":"7","key":"1197_CR19","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1136\/jclinpath-2014-202851","volume":"68","author":"GA Stanczuk","year":"2015","unstructured":"Stanczuk GA, Currie H, Baxter G, Foster A, Gibson L, Graham C, et al. Cobas 4800 HPV detection in the cervical, vaginal and urine samples of women with high-grade CIN before and after treatment. J Clin Pathol. 2015;68(7):567.","journal-title":"J Clin Pathol"},{"issue":"2","key":"1197_CR20","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.ygyno.2014.11.076","volume":"136","author":"TC Wright","year":"2015","unstructured":"Wright TC, Stoler MH, Behrens CM, Sharma A, Zhang G, Wright TL. Primary cervical cancer screening with human papillomavirus: end of study results from the ATHENA study using HPV as the first-line screening test. Gynecol Oncol. 2015;136(2):189\u201397.","journal-title":"Gynecol Oncol"},{"issue":"1","key":"1197_CR21","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.ygyno.2006.08.053","volume":"104","author":"G Koliopoulos","year":"2007","unstructured":"Koliopoulos G, Arbyn M, Martin-Hirsch P, Kyrgiou M, Prendiville W, Paraskevaidis E. Diagnostic accuracy of human papillomavirus testing in primary cervical screening: a systematic review and meta-analysis of non-randomized studies. Gynecol Oncol. 2007;104(1):232\u201346.","journal-title":"Gynecol Oncol"},{"issue":"Suppl 3","key":"1197_CR22","first-page":"S3\/26","volume":"24","author":"G Clifford","year":"2006","unstructured":"Clifford G, Franceschi S, Diaz M, Munoz N, Villa LL. Chapter 3: HPV type-distribution in women with and without cervical neoplastic diseases. Vaccine. 2006;24(Suppl 3):S3\/26\u201334.","journal-title":"Vaccine."},{"issue":"3","key":"1197_CR23","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1002\/ijc.24010","volume":"124","author":"CJ Meijer","year":"2009","unstructured":"Meijer CJ, Berkhof J, Castle PE, Hesselink AT, Franco EL, Ronco G, et al. Guidelines for human papillomavirus DNA test requirements for primary cervical cancer screening in women 30 years and older. Int J Cancer. 2009;124(3):516\u201320.","journal-title":"Int J Cancer"},{"issue":"1","key":"1197_CR24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086835","volume":"9","author":"M Rebolj","year":"2014","unstructured":"Rebolj M, Preisler S, Ejegod DM, Rygaard C, Lynge E, Bonde J. Disagreement between human papillomavirus assays: an unexpected challenge for the choice of an assay in primary cervical screening. PLoS One. 2014;9(1):e86835.","journal-title":"PLoS One"}],"container-title":["Virology Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12985-019-1197-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12985-019-1197-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12985-019-1197-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T23:15:38Z","timestamp":1595373338000},"score":1,"resource":{"primary":{"URL":"https:\/\/virologyj.biomedcentral.com\/articles\/10.1186\/s12985-019-1197-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,23]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1197"],"URL":"https:\/\/doi.org\/10.1186\/s12985-019-1197-6","relation":{},"ISSN":["1743-422X"],"issn-type":[{"value":"1743-422X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,23]]},"assertion":[{"value":"4 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Patients consented to use residual material for research (Protocol number A13719\/31.08.2010 approved by the Ethical Committee of the Aristotle University of Thessaloniki).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"AP received travel grants from AID\/GeinID. MH and RP are employed at AID\/GenID. KC and TA had their travel expenses and Conference fees covered by Roche Diagnostics. AID\/GenID provided the necessary kits free of charge. They had no role in study design, data collection and analysis.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"92"}}