{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:22:40Z","timestamp":1768551760404,"version":"3.49.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Science Platform of Zhejiang, China","award":["2017KY290"],"award-info":[{"award-number":["2017KY290"]}]},{"name":"Medical Science Platform of Zhejiang, China","award":["2017KY035"],"award-info":[{"award-number":["2017KY035"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672060"],"award-info":[{"award-number":["81672060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virol J"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever that was first described in China in 2011. We report a patient who died of <jats:italic>Severe fever with thrombocytopenia syndrome virus<\/jats:italic> (SFTSV) infection, with a rapidly progressive central nervous system (CNS) disturbance, in Dongyang, Zhejiang Province, China, in 2017.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>A 64-year-old man was admitted to hospital after 4\u2009days of fever. SFTSV was detected 1\u2009day after the patient was admitted to hospital. The patient presented with CNS disturbance and died 4\u2009days after admission. Detailed clinical and epidemiological investigations and laboratory tests were conducted. Reduced platelet, white blood cell, lymphocyte, and neutrophil counts, elevated lactate dehydrogenase, creatine kinase, aspartate aminotransferaseand alanine aminotransferase concentrations, and an increased activated partial thromboplastin time were observed. In a phylogenetic analysis, the isolate clustered close to a strain derived from South Korea.<\/jats:p>\n<jats:p>Conclusions: This is the first case of SFTSV infection with CNS disturbance in Dongyang, Zhejiang Province, China. The surveillance of suspected cases of SFTS is important in SFTSV endemic regions.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12985-019-1230-9","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T09:04:41Z","timestamp":1573117481000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Patient with severe fever with thrombocytopenia syndrome virus infection and central nervous system disturbance in Dongyang, Zhejiang Province, China, 2017"],"prefix":"10.1186","volume":"16","author":[{"given":"Yi","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai Lan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen Wu","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Hang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai Yan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4070-6844","authenticated-orcid":false,"given":"Yan Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,11,7]]},"reference":[{"key":"1230_CR1","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1056\/NEJMoa1010095","volume":"364","author":"XJ Yu","year":"2011","unstructured":"Yu XJ, Liang MF, Zhang SY, Liu Y, Li JD, Sun YL, et al. Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med. 2011;364:1523\u201332.","journal-title":"N Engl J Med"},{"key":"1230_CR2","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.3201\/eid1911.130792","volume":"19","author":"KH Kim","year":"2013","unstructured":"Kim KH, Yi J, Kim G, Choi SJ, Jun KI, Kim NH, et al. Sever fever with thrombocytopenia syndrome, South Korea, 2012. Emerg Infect Dis. 2013;19:1892\u20134.","journal-title":"Emerg Infect Dis"},{"key":"1230_CR3","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.micinf.2014.12.002","volume":"17","author":"XY Lei","year":"2015","unstructured":"Lei XY, Liu MM, Yu XJ. Sever fever with thrombocytopenia syndrome and its pathogen SFTSV. Microbes Infect. 2015;17:149\u201354.","journal-title":"Microbes Infect"},{"key":"1230_CR4","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.ijid.2014.02.022","volume":"25","author":"JM Sun","year":"2014","unstructured":"Sun JM, Chai CL, Lv HK, Lin JF, Wang CW, Chen EF, et al. Epidemiological characteristics of sever fever with thrombocytopenia syndrome in Zhejiang Province. China Int J Infect Dis. 2014;25:180\u20135.","journal-title":"China Int J Infect Dis"},{"key":"1230_CR5","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1093\/cid\/cit530","volume":"57","author":"W Liu","year":"2013","unstructured":"Liu W, Lu QB, Cui N, Li H, Wang LY, Liu MK, et al. Case-fatality ratio and effectiveness of ribavirin therapy among hospitalized patients in China who had sever fever with thrombocytopenia syndrome. Clin Infect Dis. 2013;57:1292\u20139.","journal-title":"Clin Infect Dis"},{"key":"1230_CR6","first-page":"52","volume":"70","author":"N Cui","year":"2015","unstructured":"Cui N, Liu R, Lu QR, Wang LY, Qin SL, Yang ZD, et al. Severe fever with thrombocytopenia syndrome bunyavirus-related human encephalitis. J Inf Secur. 2015;70:52\u20139.","journal-title":"J Inf Secur"},{"key":"1230_CR7","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.jiac.2017.10.016","volume":"24","author":"M Kaneko","year":"2018","unstructured":"Kaneko M, Shikata H, Matsukage S, Maruta M, Shinomiya H, Suzuki T, et al. A patient with severe fever with thrombocytopenia syndrome and hemophagocytic lymphohistiocytosis-associated involvement of the central nervous system. J Infect Chemother. 2018;24:292\u20137.","journal-title":"J Infect Chemother"},{"key":"1230_CR8","first-page":"256","volume":"27","author":"YH Xie","year":"2012","unstructured":"Xie YH, Yang JT, Tan Y, Lin M, Bi FY, Wu XH, et al. Clinical features and evaluation of clinical diagnosis of viral encephalitis. Dis Surveill. 2012;27:256\u201362.","journal-title":"Dis Surveill"},{"key":"1230_CR9","doi-asserted-by":"publisher","first-page":"e137","DOI":"10.1016\/j.ijid.2012.07.007","volume":"17","author":"L Zhang","year":"2012","unstructured":"Zhang L, Wang XY, Zhang YJ, Zhang YL, Wang HL, Wang CW, et al. Sever fever with thrombocytopenia syndrome bunyavirus (SFTSV) infections in Zhejiang Province China. Int J Infect Dis. 2012;17:e137\u20138.","journal-title":"Int J Infect Dis"},{"key":"1230_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.epidem.2012.09.002","volume":"5","author":"TT Lam","year":"2013","unstructured":"Lam TT, Liu W, Bowden TA, Cui N, Zhuang L, Liu K, et al. Evolutionary and molecular analysis of the emergent severe fever with thrombocytopenia syndrome virus. Epidemic. 2013;5:1\u201310.","journal-title":"Epidemic"},{"key":"1230_CR11","doi-asserted-by":"publisher","first-page":"19563","DOI":"10.1038\/srep19563","volume":"6","author":"YF Fu","year":"2016","unstructured":"Fu YF, Li SB, Zhang Z, Man SQ, Li XP, Zhang WH, et al. Phylogeographic analysis of severe fever with thrombocytopenia syndrome virus from Zhoushan islands China: implication for transmission across the ocean. Sci Rep. 2016;6:19563.","journal-title":"Sci Rep"},{"key":"1230_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151677","volume":"11","author":"JW Liu","year":"2016","unstructured":"Liu JW, Zhao L, Luo LM, Liu MM, Sun Y, Su X, et al. Molecular evolution and spatial transmission of sever fever with thrombocytopenia syndrome virus based on complete genome sequences. PLoS One. 2016;11:e0151677.","journal-title":"PLoS One"},{"key":"1230_CR13","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1093\/bioinformatics\/14.9.817","volume":"14","author":"D Posada","year":"1998","unstructured":"Posada D, Crandall KA. Modeltest testing the model of DNA substitution. Bioinformatics. 1998;14:817\u20138.","journal-title":"Bioinformatics"},{"key":"1230_CR14","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.1093\/bioinformatics\/btq467","volume":"26","author":"DP Martin","year":"2010","unstructured":"Martin DP, Lemey P, Lott M, Moulton V, Posada D, Lefeuvre P. RDP3: a flexible and fast computer program for analyzing recombination. Bioinformatics. 2010;26:2462\u20133.","journal-title":"Bioinformatics"},{"key":"1230_CR15","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.meegid.2016.11.015","volume":"47","author":"JM Shi","year":"2017","unstructured":"Shi JM, Hu S, Liu XP, Yang J, Liu D, Wu L, et al. Migration recombination and reassortment are involved in the evolution of sever fever with thrombocytopenia syndrome bunyavirus. Infect Genet Evol. 2017;47:109\u201317.","journal-title":"Infect Genet Evol"},{"key":"1230_CR16","doi-asserted-by":"publisher","first-page":"89","DOI":"10.2220\/biomedres.38.89","volume":"38","author":"Y Tsuda","year":"2017","unstructured":"Tsuda Y, Igarashi M, Ito R, Nishio S, Shimizu K, Yoshimatsu K, et al. The amino acid at position 624 in the glycoprotein of SFTSV (severe fever with thrombocytopenia virus) plays a critical role in low-pH-dependent cell fusion activity. Biomed Res. 2017;38:89\u201397.","journal-title":"Biomed Res"},{"key":"1230_CR17","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1093\/infdis\/jis472","volume":"206","author":"ZT Gai","year":"2012","unstructured":"Gai ZT, Zhang Y, Liang MF, Jin C, Zhang S, Zhu CB, et al. Clinical progress and risk factors for death in severe fever with thrombocytopenia syndrome patients. J Infect Dis. 2012;206:1095\u2013102.","journal-title":"J Infect Dis"},{"key":"1230_CR18","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jcv.2013.10.024","volume":"59","author":"N Cui","year":"2014","unstructured":"Cui N, Bao XL, Yang ZD, Lu QB, Hu CY, Wang LY, et al. Clinical progression and predictors of death in patients with severe fever with thrombocytopenia syndrome in China. J Clin Virol. 2014;59:12\u20137.","journal-title":"J Clin Virol"},{"key":"1230_CR19","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.jiac.2017.11.004","volume":"24","author":"S Nakamura","year":"2018","unstructured":"Nakamura S, Azuma M, Maruhashi T, Sogabe K, Sumitani R, Uemura M, et al. Steroid pulse therapy in patients with encephalopathy associated with severe fever with thrombocytopenia syndrome. J Infect Chemother. 2018;24:389\u201392.","journal-title":"J Infect Chemother"},{"key":"1230_CR20","doi-asserted-by":"publisher","first-page":"10053","DOI":"10.1073\/pnas.1120246109","volume":"109","author":"C Jin","year":"2012","unstructured":"Jin C, Liang MF, Ning JY, Gu W, Jiang H, Wu W, et al. Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57\/BL6 mouse model. Proc Natl Acad Sci U S A. 2012;109:10053\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1230_CR21","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1093\/cid\/cir804","volume":"54","author":"YZ Zhang","year":"2012","unstructured":"Zhang YZ, He YW, Dai YA, Xiong Y, Zheng H, Zhou DJ, et al. Hemorrhagic fever caused by a novel Bunyavirus in China: pathogenesis and correlates of fatal outcome. Clin Infect Dis. 2012;54:527\u201333.","journal-title":"Clin Infect Dis"},{"key":"1230_CR22","first-page":"70718","volume":"14","author":"Q Liu","year":"2014","unstructured":"Liu Q, He B, Huang SY, Wei F, Zhu XQ. Severe fever with thrombocytopenia syndrome, an emerging tick-borne zoonosis. Lancet Infect Dis. 2014;14:70718.","journal-title":"Lancet Infect Dis"},{"key":"1230_CR23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003237","volume":"8","author":"X Huang","year":"2014","unstructured":"Huang X, Liu L, Du Y, Wu W, Wang H, Su J, et al. The evolutionary history and spatiotemporal dynamics of the fever thrombocytopenia and leukocytopenia syndrome virus (FTLSV) in China. PLoS Negl Trop Dis. 2014;8:e3237.","journal-title":"PLoS Negl Trop Dis"},{"key":"1230_CR24","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.3201\/eid2008.131796","volume":"20","author":"L Zhang","year":"2014","unstructured":"Zhang L, Sun JM, Yan J, Lv HK, Chai CL, Sun Y, et al. Antibodies against sever fever with thrombocytopenia syndrome virus in healthy persons China 2013. Emerg Infect Dis. 2014;20:1355\u20137.","journal-title":"Emerg Infect Dis"}],"container-title":["Virology Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12985-019-1230-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12985-019-1230-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12985-019-1230-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:18:42Z","timestamp":1604621922000},"score":1,"resource":{"primary":{"URL":"https:\/\/virologyj.biomedcentral.com\/articles\/10.1186\/s12985-019-1230-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,7]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1230"],"URL":"https:\/\/doi.org\/10.1186\/s12985-019-1230-9","relation":{},"ISSN":["1743-422X"],"issn-type":[{"value":"1743-422X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,7]]},"assertion":[{"value":"21 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the ethics committee of the Zhejiang Provincial Center for Disease Control and Prevention (ZJCDC), China. Written informed consent was obtained from the patient. All methods were carried out in accordance with the principles of the Declaration of Helsinki.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from the patient for publication of this case report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"129"}}