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We aim to describe the clinical and laboratory features, epidemiological characteristics, and HAdV species and\/or types of inpatients with HAdV respiratory infections.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Respiratory samples were gathered from inpatients diagnosed ARIs in Children\u2019s Hospital, Zhejiang University School of Medicine, and were detected by using Direct Immunofluorescence Assay from 2018 to 2019. PCR amplification and sequencing of the hypervariable zone of <jats:italic>hexon<\/jats:italic> gene were used for genotyping. The clinical and laboratory features, and HAdV genotyping, and epidemiological characteristic analysis were retrospectively performed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of 7072 samples collected, 488 were identified as HAdV-positive. The overall detection rate was 6.9%. The peaked detection rate was 14.1% in January 2019. HAdV-positive cases with ARIs mainly appeared in winter. The detection rate was highest among children between 6\u00a0months and 2\u00a0years (8.7%, 123\/1408). Clinical diagnosis included pneumonia (70.3%, 343\/488), bronchitis (7.0%, 34\/488) and acute upper respiratory tract infection (22.7%, 111\/488). The common clinical manifestations were fever (93.4%, 456\/488), cough (94.7%, 462\/488), wheezing (26.2%, 128\/488), and shortness of breath (14.8%, 72\/488). 213 (43.6%) cases had co-infection and 138 (28.3%) cases had extrapulmonary symptoms. 96(19.7%) cases had intrapulmonary and intrathoracic complications.78 (16.0%) had an underlying condition, most of which were congenital heart diseases (20.5%, 16\/78). The proportions of hyperpyrexia, duration of fever\u2009&gt;\u200910\u00a0days, severe pneumonia, and wheezing in the co-infection group were remarkably higher than those in HAdV single-infection group (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The proportions of duration of hospitalization, duration of fever\u2009&gt;\u200910\u00a0days, wheezing, shortness of breath, change in level of consciousness, serosal fluids, extrapulmonary symptoms, co-infections and underlying diseases were significantly higher in severe pneumonia group than those in the mild pneumonia group (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Four HAdV species were successfully identified in 155 cases and presented by 8 genotypes. HAdV-B3 (56.1%, 87\/155) and HAdV -B7 (31.0%, 48\/155) were the most predominant detected types and occurred commonly in different severity groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.000), while, HAdV-B55 was detected only in the severe group. HAdV-B7\u2019s detection rate in the severe pneumonia group was significantly higher than the non-severe pneumonia group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>HAdV detection rate is related to age and season. Bronchopneumonia accounts for about 70% HAdV-positive inpatients. The common clinical manifestations include hyperpyrexia, cough, wheezing, and shortness of breath. HAdV-B3 and HAdV-B7 are the most common types in children diagnosed with respiration infections.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12985-021-01705-x","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T12:02:49Z","timestamp":1638187369000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Clinical features and epidemiological analysis of respiratory human adenovirus infection in hospitalized children: a cross-sectional study in Zhejiang"],"prefix":"10.1186","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0932-3650","authenticated-orcid":false,"given":"Caiyun","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juanjuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumei","family":"Mi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinghu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,29]]},"reference":[{"issue":"11","key":"1705_CR1","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1002\/jmv.24544","volume":"88","author":"M Finianos","year":"2016","unstructured":"Finianos M, Issa R, Curran MD, et al. 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