{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:24:12Z","timestamp":1772166252579,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T00:00:00Z","timestamp":1642204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T00:00:00Z","timestamp":1642204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81541139"],"award-info":[{"award-number":["81541139"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research and development fund of Peking University People\u2019s Hospital","award":["RD 2016-14"],"award-info":[{"award-number":["RD 2016-14"]}]},{"name":"Beijing key clinical specialty construction projects"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virol J"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Compared with immunocompetent patients, immunosuppressed patients have higher morbidity and mortality, a longer duration of viral shedding, more frequent complications, and more antiviral resistance during influenza infections. However, few data on this population in China have been reported. We analysed the clinical characteristics, effects of antiviral therapy, and risk factors for admission to the intensive care unit (ICU) and death in this population after influenza infections and explored the influenza vaccination situation for this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed 111 immunosuppressed inpatients who were infected with influenza virus during the 2015\u20132020 influenza seasons. Medical data were collected through the electronic medical record system and analysed. Univariate analysis and multivariate logistics analysis were used to identify risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The most common cause of immunosuppression was malignancies being treated with chemotherapy (64.0%, 71\/111), followed by haematopoietic stem cell transplantation (HSCT) (23.4%, 26\/111). The most common presenting symptoms were fever and cough. Dyspnoea, gastrointestinal symptoms and altered mental status were more common in HSCT patients than in patients with immunosuppression due to other causes. Approximately 14.4% (16\/111) of patients were admitted to the ICU, and 9.9% (11\/111) of patients died. Combined and double doses of neuraminidase inhibitors did not significantly reduce the risk of admission to the ICU or death. Risk factors for admission to the ICU were dyspnoea, coinfection with other pathogens and no antiviral treatment within 48\u00a0h. The presence of dyspnoea and altered mental status were independently associated with death. Only 2.7% (3\/111) of patients less than 12\u00a0months old had received a seasonal influenza vaccine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Fever and other classic symptoms of influenza may be absent in immunosuppressed recipients, especially in HSCT patients. Conducting influenza virus detection at the first presentation seems to be a good choice for early diagnosis. Clinicians should pay extra attention to immunosuppressed patients with dyspnoea, altered mental status, coinfection with other pathogens and no antiviral treatment within 48\u00a0h because these patients have a high risk of severe illness. Inactivated influenza vaccines are recommended for immunosuppressed patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12985-021-01739-1","type":"journal-article","created":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T04:02:39Z","timestamp":1642219359000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical characteristics, risk factors and antiviral treatments of influenza in immunosuppressed inpatients in Beijing during the 2015\u20132020 influenza seasons"],"prefix":"10.1186","volume":"19","author":[{"given":"Yafen","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Mai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YuanYuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baiyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YiSi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Cong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7282-4530","authenticated-orcid":false,"given":"Yan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,15]]},"reference":[{"key":"1739_CR1","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1016\/S0140-6736(17)33293-2","volume":"391","author":"AD Iuliano","year":"2018","unstructured":"Iuliano AD, Roguski KM, Chang HH, Muscatello DJ, Palekar R, Tempia S, et al. Estimates of global seasonal influenza-associated respiratory mortality: a modelling study. Lancet. 2018;391:1285\u2013300.","journal-title":"Lancet"},{"key":"1739_CR2","doi-asserted-by":"publisher","first-page":"e473","DOI":"10.1016\/S2468-2667(19)30163-X","volume":"4","author":"L Li","year":"2019","unstructured":"Li L, Liu Y, Wu P, Peng Z, Wang X, Chen T, et al. Influenza-associated excess respiratory mortality in China, 2010\u201315: a population-based study. Lancet Public Health. 2019;4:e473\u201381.","journal-title":"Lancet Public Health"},{"key":"1739_CR3","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/S1473-3099(09)70175-6","volume":"9","author":"KM Kunisaki","year":"2009","unstructured":"Kunisaki KM, Janoff EN. Influenza in immunosuppressed populations: a review of infection frequency, morbidity, mortality, and vaccine responses. Lancet Infect Dis. 2009;9:493\u2013504.","journal-title":"Lancet Infect Dis"},{"key":"1739_CR4","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1093\/cid\/ciy723","volume":"68","author":"MF Di Pasquale","year":"2019","unstructured":"Di Pasquale MF, Sotgiu G, Gramegna A, Radovanovic D, Terraneo S, Reyes LF, et al. Prevalence and etiology of community-acquired pneumonia in immunocompromised patients. Clin Infect Dis. 2019;68:1482\u201393.","journal-title":"Clin Infect Dis"},{"key":"1739_CR5","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1093\/cid\/cit725","volume":"58","author":"MJ Memoli","year":"2014","unstructured":"Memoli MJ, Athota R, Reed S, Czajkowski L, Bristol T, Proudfoot K, et al. The natural history of influenza infection in the severely immunocompromised vs nonimmunocompromised hosts. Clin Infect Dis. 2014;58:214\u201324.","journal-title":"Clin Infect Dis"},{"issue":"Suppl 3","key":"1739_CR6","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/irv.12170","volume":"7","author":"MG Ison","year":"2013","unstructured":"Ison MG. Influenza prevention and treatment in transplant recipients and immunecompromised hosts. Influenza Other Respir Viruses. 2013;7(Suppl 3):60\u20136.","journal-title":"Influenza Other Respir Viruses"},{"key":"1739_CR7","doi-asserted-by":"publisher","first-page":"7188","DOI":"10.1128\/AAC.03667-14","volume":"58","author":"A Eshaghi","year":"2014","unstructured":"Eshaghi A, Shalhoub S, Rosenfeld P, Li A, Higgins RR, Stogios PJ, et al. Multiple influenza A (H3N2) mutations conferring resistance to neuraminidase inhibitors in a bone marrow transplant recipient. Antimicrob Agents Chemother. 2014;58:7188\u201397.","journal-title":"Antimicrob Agents Chemother"},{"key":"1739_CR8","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1056\/NEJM200302273480923","volume":"348","author":"DM Weinstock","year":"2003","unstructured":"Weinstock DM, Gubareva LV, Zuccotti G. Prolonged shedding of multidrug-resistant influenza A virus in an immunocompromised patient. N Engl J Med. 2003;348:867\u20138.","journal-title":"N Engl J Med"},{"key":"1739_CR9","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1086\/425004","volume":"39","author":"WG Nichols","year":"2004","unstructured":"Nichols WG, Guthrie KA, Corey L, Boeckh M. Influenza infections after hematopoietic stem cell transplantation: risk factors, mortality, and the effect of antiviral therapy. Clin Infect Dis. 2004;39:1300\u20136.","journal-title":"Clin Infect Dis"},{"key":"1739_CR10","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/tid.12116","volume":"15","author":"G Reid","year":"2013","unstructured":"Reid G, Huprikar S, Patel G, Razonable RR, Mossad S, Levi M, et al. A multicenter evaluation of pandemic influenza A\/H1N1 in hematopoietic stem cell transplant recipients. Transpl Infect Dis. 2013;15:487\u201392.","journal-title":"Transpl Infect Dis"},{"key":"1739_CR11","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S1473-3099(10)70133-X","volume":"10","author":"D Kumar","year":"2010","unstructured":"Kumar D, Michaels MG, Morris MI, Green M, Avery RK, Liu C, et al. Outcomes from pandemic influenza A H1N1 infection in recipients of solid-organ transplants: a multicentre cohort study. Lancet Infect Dis. 2010;10:521\u20136.","journal-title":"Lancet Infect Dis"},{"key":"1739_CR12","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/j.1600-6143.2009.02960.x","volume":"10","author":"D Kumar","year":"2010","unstructured":"Kumar D, Morris MI, Kotton CN, Fischer SA, Michaels MG, Allen U, et al. Guidance on novel influenza A\/H1N1 in solid organ transplant recipients. Am J Transplant. 2010;10:18\u201325.","journal-title":"Am J Transplant"},{"key":"1739_CR13","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1093\/cid\/ciy874","volume":"68","author":"TM Uyeki","year":"2019","unstructured":"Uyeki TM, Bernstein HH, Bradley JS, Englund JA, File TM, Fry AM, et al. Clinical practice guidelines by the infectious diseases society of America: 2018 update on diagnosis, treatment, chemoprophylaxis, and institutional outbreak management of seasonal influenzaa. Clin Infect Dis. 2019;68:895\u2013902.","journal-title":"Clin Infect Dis"},{"key":"1739_CR14","doi-asserted-by":"crossref","unstructured":"Hermann B, Lehners N, Brodhun M, Boden K, Hochhaus A, Kochanek M, et al. Influenza virus infections in patients with malignancies\u2014characteristics and outcome of the season 2014\/15. A survey conducted by the Infectious Diseases Working Party (AGIHO) of the German Society of Haematology and Medical Oncology (DGHO). Eur J Clin Microbiol Infect Dis. 2017; 36: 565\u201373.","DOI":"10.1007\/s10096-016-2833-3"},{"key":"1739_CR15","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1093\/cid\/ciz638","volume":"70","author":"JP Collins","year":"2020","unstructured":"Collins JP, Campbell AP, Openo K, Farley MM, Cummings CN, Hill M, et al. Outcomes of immunocompromised adults hospitalized with laboratory-confirmed influenza in the United States, 2011\u20132015. Clin Infect Dis. 2020;70:2121\u201330.","journal-title":"Clin Infect Dis"},{"key":"1739_CR16","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.3201\/eid1607.091691","volume":"16","author":"AR Tramontana","year":"2010","unstructured":"Tramontana AR, George B, Hurt AC, Doyle JS, Langan K, Reid AB, et al. Oseltamivir resistance in adult oncology and hematology patients infected with pandemic (H1N1) 2009 virus. Australia Emerg Infect Dis. 2010;16:1068\u201375.","journal-title":"Australia Emerg Infect Dis"},{"key":"1739_CR17","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.3324\/haematol.2011.041913","volume":"96","author":"P Ljungman","year":"2011","unstructured":"Ljungman P, de la Camara R, Perez-Bercoff L, Abecasis M, Nieto Campuzano JB, Cannata-Ortiz MJ, et al. Outcome of pandemic H1N1 infections in hematopoietic stem cell transplant recipients. Haematologica. 2011;96:1231\u20135.","journal-title":"Haematologica"},{"key":"1739_CR18","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1093\/cid\/ciz316","volume":"69","author":"A Dunbar","year":"2019","unstructured":"Dunbar A, Schauwvlieghe A, Rijnders BJA. Influenza and invasive aspergillosis in immunocompromised patients. Clin Infect Dis. 2019;69:2037.","journal-title":"Clin Infect Dis"},{"key":"1739_CR19","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1365-2141.2008.07295.x","volume":"143","author":"M Boeckh","year":"2008","unstructured":"Boeckh M. The challenge of respiratory virus infections in hematopoietic cell transplant recipients. Br J Haematol. 2008;143:455\u201367.","journal-title":"Br J Haematol"},{"key":"1739_CR20","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1097\/01.md.0000232560.22098.4e","volume":"85","author":"RF Chemaly","year":"2006","unstructured":"Chemaly RF, Ghosh S, Bodey GP, Rohatgi N, Safdar A, Keating MJ, et al. Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major cancer center. Medicine (Baltimore). 2006;85:278\u201387.","journal-title":"Medicine (Baltimore)"},{"key":"1739_CR21","doi-asserted-by":"publisher","first-page":"ofu050","DOI":"10.1093\/ofid\/ofu050","volume":"1","author":"S Apewokin","year":"2014","unstructured":"Apewokin S, Vyas K, Lester LK, Grazzuitti M, Haselow DT, Wolfe F, et al. Influenza a outbreak in an ambulatory stem cell transplant center. Open Forum Infect Dis. 2014;1:ofu050.","journal-title":"Open Forum Infect Dis"},{"key":"1739_CR22","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.ccm.2017.07.012","volume":"38","author":"GC Paulsen","year":"2017","unstructured":"Paulsen GC, Danziger-Isakov L. Respiratory viral infections in solid organ and hematopoietic stem cell transplantation. Clin Chest Med. 2017;38:707\u201326.","journal-title":"Clin Chest Med"},{"key":"1739_CR23","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.bbmt.2015.11.015","volume":"22","author":"J Kmeid","year":"2016","unstructured":"Kmeid J, Vanichanan J, Shah DP, El Chaer F, Azzi J, Ariza-Heredia EJ, et al. Outcomes of influenza infections in hematopoietic cell transplant recipients: application of an immunodeficiency scoring index. Biol Blood Marrow Transplant. 2016;22:542\u20138.","journal-title":"Biol Blood Marrow Transplant"},{"key":"1739_CR24","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1093\/cid\/ciy860","volume":"69","author":"J Katzen","year":"2019","unstructured":"Katzen J, Kohn R, Houk JL, Ison MG. Early oseltamivir after hospital admission is associated with shortened hospitalization: a 5-year analysis of oseltamivir timing and clinical outcomes. Clin Infect Dis. 2019;69:52\u20138.","journal-title":"Clin Infect Dis"},{"issue":"Suppl 5","key":"1739_CR25","doi-asserted-by":"publisher","first-page":"S344","DOI":"10.1093\/cid\/ciu623","volume":"59","author":"RF Chemaly","year":"2014","unstructured":"Chemaly RF, Shah DP, Boeckh MJ. Management of respiratory viral infections in hematopoietic cell transplant recipients and patients with hematologic malignancies. Clin Infect Dis. 2014;59(Suppl 5):S344\u201351.","journal-title":"Clin Infect Dis"},{"key":"1739_CR26","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1056\/NEJMc0803120","volume":"359","author":"E van der Vries","year":"2008","unstructured":"van der Vries E, van den Berg B, Schutten M. Fatal oseltamivir-resistant influenza virus infection. N Engl J Med. 2008;359:1074\u20136.","journal-title":"N Engl J Med"},{"key":"1739_CR27","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1001\/jama.2009.297","volume":"301","author":"J Gooskens","year":"2009","unstructured":"Gooskens J, Jonges M, Claas EC, Meijer A, van den Broek PJ, Kroes AM. Morbidity and mortality associated with nosocomial transmission of oseltamivir-resistant influenza A(H1N1) virus. JAMA. 2009;301:1042\u20136.","journal-title":"JAMA"},{"key":"1739_CR28","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1093\/cid\/cit597","volume":"57","author":"N Lee","year":"2013","unstructured":"Lee N, Hui DS, Zuo Z, Ngai KL, Lui GC, Wo SK, et al. A prospective intervention study on higher-dose oseltamivir treatment in adults hospitalized with influenza a and B infections[J]. Clin Infect Dis. 2013;57:1511\u20139.","journal-title":"Clin Infect Dis"},{"key":"1739_CR29","doi-asserted-by":"crossref","unstructured":"Effect of double dose oseltamivir on clinical and virological outcomes in children and adults admitted to hospital with severe influenza: double blind randomised controlled trial. Bmj. 2013;346:f3039.","DOI":"10.1136\/bmj.f3039"},{"key":"1739_CR30","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s00134-019-05868-8","volume":"46","author":"A Torres","year":"2020","unstructured":"Torres A, Loeches I-M, Sligl W, Lee N, et al. Severe flu management: a point of view. Intensive Care Med. 2020;46:153\u201362.","journal-title":"Intensive Care Med"},{"key":"1739_CR31","doi-asserted-by":"publisher","first-page":"e172","DOI":"10.1093\/cid\/ciu632","volume":"59","author":"MD De Jong","year":"2014","unstructured":"De Jong MD, Ison MG, Monto AS, Metev H, Clark C, O\u2019Neil B, et al. Evaluation of intravenous peramivir for treatment of influenza in hospitalized patients. Clin Infect Dis. 2014;59:e172\u201385.","journal-title":"Clin Infect Dis"},{"key":"1739_CR32","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1097\/QCO.0b013e3283480440","volume":"24","author":"C Renaud","year":"2011","unstructured":"Renaud C, Campbell AP. Changing epidemiology of respiratory viral infections in hematopoietic cell transplant recipients and solid organ transplant recipients. Curr Opin Infect Dis. 2011;24:333\u201343.","journal-title":"Curr Opin Infect Dis"},{"key":"1739_CR33","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1055\/s-0031-1283286","volume":"32","author":"SS Weigt","year":"2011","unstructured":"Weigt SS, Gregson AL, Deng JC, Lynch JP, Belperio JA. Respiratory viral infections in hematopoietic stem cell and solid organ transplant recipients. Semin Respir Crit Care Med. 2011;32:471\u201393.","journal-title":"Semin Respir Crit Care Med"},{"key":"1739_CR34","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/tid.12054","volume":"15","author":"D Engelhard","year":"2013","unstructured":"Engelhard D, Mohty B, de la Camara R, Cordonnier C, Ljungman P. European guidelines for prevention and management of influenza in hematopoietic stem cell transplantation and leukemia patients: summary of ECIL-4 (2011), on behalf of ECIL, a joint venture of EBMT, EORTC, ICHS, and ELN. Transpl Infect Dis. 2013;15:219\u201332.","journal-title":"Transpl Infect Dis"},{"key":"1739_CR35","doi-asserted-by":"publisher","first-page":"5050","DOI":"10.1182\/blood-2010-11-319186","volume":"117","author":"SM Choi","year":"2011","unstructured":"Choi SM, Boudreault AA, Xie H, Englund JA, Corey L, Boeckh M. Differences in clinical outcomes after 2009 influenza A\/H1N1 and seasonal influenza among hematopoietic cell transplant recipients. Blood. 2011;117:5050\u20136.","journal-title":"Blood"},{"key":"1739_CR36","doi-asserted-by":"publisher","first-page":"3294","DOI":"10.3389\/fmicb.2018.03294","volume":"9","author":"C Pochon","year":"2019","unstructured":"Pochon C, Voigt S. Respiratory virus infections in hematopoietic cell transplant recipients. Front Microbiol. 2019;9:3294.","journal-title":"Front Microbiol"},{"issue":"9","key":"1739_CR37","doi-asserted-by":"publisher","first-page":"e436","DOI":"10.1016\/S2468-2667(19)30158-6","volume":"4","author":"X Huo","year":"2019","unstructured":"Huo X, Zhu F-C. Influenza surveillance in China: a big jump, but further to go. The Lancet Public Health. 2019;4(9):e436\u20137.","journal-title":"The Lancet Public Health"},{"key":"1739_CR38","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1086\/431304","volume":"41","author":"CM Machado","year":"2005","unstructured":"Machado CM. Influenza infections after hematopoietic stem cell transplantation. Clin Infect Dis. 2005;41:273\u20134.","journal-title":"Clin Infect Dis"},{"key":"1739_CR39","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/S1473-3099(10)70136-5","volume":"10","author":"P Ljungman","year":"2010","unstructured":"Ljungman P. Solid-organ transplants and the risks of pandemic influenza. Lancet Infect Dis. 2010;10:506\u20137.","journal-title":"Lancet Infect Dis"},{"key":"1739_CR40","doi-asserted-by":"crossref","unstructured":"Danzinger-Isakov L, Kumar D; AST Infectious Diseases Community of Practice. Guidelines for vaccination of solid organ transplant candidates and recipients. Am J Transplant. 2009;9 Suppl 4:S258\u201362.","DOI":"10.1111\/j.1600-6143.2009.02917.x"},{"key":"1739_CR41","doi-asserted-by":"crossref","unstructured":"Cordonnier C, Einarsdottir S, Cesaro S, Di Blasi R, Mikulska M, Rieger C, et al. Vaccination of haemopoietic stem cell transplant recipients: guidelines of the 2017 European Conference on Infections in Leukaemia (ECIL 7). Lancet Infect Dis. 2019;19:e200-e212.","DOI":"10.1016\/S1473-3099(18)30600-5"},{"key":"1739_CR42","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1093\/cid\/cix1081","volume":"66","author":"PP Chong","year":"2018","unstructured":"Chong PP, Handler L, Weber DJ. A systematic review of safety and immunogenicity of influenza vaccination strategies in solid organ transplant recipients. Clin Infect Dis. 2018;66:1802\u201311.","journal-title":"Clin Infect Dis"}],"container-title":["Virology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12985-021-01739-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12985-021-01739-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12985-021-01739-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T16:43:30Z","timestamp":1700066610000},"score":1,"resource":{"primary":{"URL":"https:\/\/virologyj.biomedcentral.com\/articles\/10.1186\/s12985-021-01739-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,15]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["1739"],"URL":"https:\/\/doi.org\/10.1186\/s12985-021-01739-1","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-910455\/v1","asserted-by":"object"}]},"ISSN":["1743-422X"],"issn-type":[{"value":"1743-422X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,15]]},"assertion":[{"value":"18 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was in accordance with the guidelines of the Declaration of Helsinki and was approved by the ethics committees of the Peking University People\u2019s Hospital (PKUPH, IRB No. 2016PHB100-01). We explained the details of our study to each participant, and written informed consent was obtained from all participants prior to their inclusion in the study. Nasal samples and medical data were collected and analysed anonymously.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"11"}}