{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:08:59Z","timestamp":1768284539468,"version":"3.49.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["8581"],"award-info":[{"award-number":["8581"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virol J"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Human cytomegalovirus (CMV) can establish a latent infection with periodic or sporadic reactivation after the first infection happens. Primary and recurrent infection, results in different problems in patients with impaired or immature immune systems, such as kidney transplant recipients (KTRs). MicroRNAs (miRNAs, miRs) are important regulatory molecules in the outcome of CMV-infected KTRs. Therefore, in this study the expression level of CMV miRNAs were evaluated in active vs. latent CMV infected KTRs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Expression of viral miRNAs were studied in 61 KTRs which were divided into 30 active CMV and 31 latent CMV infected individuals. In order to study the expression level of selected miRNAs, SYBR Green Real-time PCR technique was exploited. Also, mature miRNAs expression level that were produced from one precursor, studied both in active and latent situations.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among studied miRNAs\u2019 expression level, CMV miR-UL112-3p\/5p, -UL22A-3p\/5p, -US25-1-5p, -US25-2-3p\/5p, -UL36-3p\/5p and -UL70-3p showed significant increase in active CMV infected KTRs in comparison to latent ones. The ROC curve analysis results for miR-UL112-3p, -UL22A-3p, -US25-2-3p, -UL36-3p and -UL70-3p showed significant difference between two studied patient groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This study revealed an extremely high expression level in CMV miR-UL112-3p\/5p, -UL22A-3p\/5p, -US25-1-5p, -US25-2-3p\/5p, -UL36-3p\/5p and -UL70-3p in active CMV infected KTRs in comparison to latent ones. Further studies might help in finding the capability of miRNAs to differentiate active from latent stage of CMV infection in KTRs.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12985-022-01880-5","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T08:02:51Z","timestamp":1662969771000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cytomegalovirus microRNAs level determination in kidney recipients post transplantation"],"prefix":"10.1186","volume":"19","author":[{"given":"Afsoon","family":"Afshari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramin","family":"Yaghobi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Golshan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"key":"1880_CR1","doi-asserted-by":"publisher","first-page":"260","DOI":"10.3947\/ic.2013.45.3.260","volume":"45","author":"P Ramanan","year":"2013","unstructured":"Ramanan P, Razonable RR. Cytomegalovirus infections in solid organ transplantation: a review. Infect Chemother. 2013;45:260\u201371. https:\/\/doi.org\/10.3947\/ic.2013.45.3.260.","journal-title":"Infect Chemother"},{"key":"1880_CR2","doi-asserted-by":"publisher","first-page":"515","DOI":"10.6061\/clinics\/2015(07)09","volume":"70","author":"LS Azevedo","year":"2015","unstructured":"Azevedo LS, Pierrotti LC, Abdala E, Costa SF, Strabelli TMV, Campos SV, et al. Cytomegalovirus infection in transplant recipients. Clinics. 2015;70:515\u201323. https:\/\/doi.org\/10.6061\/clinics\/2015(07)09.","journal-title":"Clinics"},{"key":"1880_CR3","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1053\/j.ajkd.2011.04.010","volume":"58","author":"K De Keyzer","year":"2011","unstructured":"De Keyzer K, Van Laecke S, Peeters P, Vanholder R. Human cytomegalovirus and kidney transplantation: a clinician\u2019s update. Am J Kidney Dis. 2011;58:118\u201326. https:\/\/doi.org\/10.1053\/j.ajkd.2011.04.010.","journal-title":"Am J Kidney Dis"},{"key":"1880_CR4","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1097\/TP.0b013e318235c7fc","volume":"92","author":"PA Andrews","year":"2011","unstructured":"Andrews PA, Emery VC, Newstead C. Summary of the British transplantation society guidelines for the prevention and management of CMV disease after solid organ transplantation. Transplantation. 2011;92:1181\u20137. https:\/\/doi.org\/10.1097\/TP.0b013e318235c7fc.","journal-title":"Transplantation"},{"key":"1880_CR5","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1111\/j.1462-5822.2005.00598.x","volume":"7","author":"W Dunn","year":"2005","unstructured":"Dunn W, Trang P, Zhong Q, Yang E, van Belle C, Liu F. Human cytomegalovirus expresses novel microRNAs during productive viral infection. Cell Microbiol. 2005;7:1684\u201395. https:\/\/doi.org\/10.1111\/j.1462-5822.2005.00598.x.","journal-title":"Cell Microbiol"},{"key":"1880_CR6","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1371\/journal.ppat.0030163","volume":"3","author":"F Grey","year":"2007","unstructured":"Grey F, Meyers H, White EA, Spector DH, Nelson J. A human cytomegalovirus-encoded microRNA regulates expression of multiple viral genes involved in replication. PLoS Pathog. 2007;3:1593\u2013602. https:\/\/doi.org\/10.1371\/journal.ppat.0030163.","journal-title":"PLoS Pathog"},{"key":"1880_CR7","doi-asserted-by":"publisher","first-page":"985","DOI":"10.4252\/WJSC.V13.I8.985","volume":"13","author":"A Afshari","year":"2021","unstructured":"Afshari A, Yaghobi R, Rezaei G. Inter-regulatory role of microRNAs in interaction between viruses and stem cells. World J Stem Cells. 2021;13:985. https:\/\/doi.org\/10.4252\/WJSC.V13.I8.985.","journal-title":"World J Stem Cells"},{"key":"1880_CR8","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1111\/j.1462-5822.2004.00425.x","volume":"6","author":"ES Mocarski","year":"2004","unstructured":"Mocarski ES. Immune escape and exploitation strategies of cytomegaloviruses: Impact on and imitation of the major histocompatibility system. Cell Microbiol. 2004;6:707\u201317. https:\/\/doi.org\/10.1111\/j.1462-5822.2004.00425.x.","journal-title":"Cell Microbiol"},{"key":"1880_CR9","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/nmeth746","volume":"2","author":"S Pfeffer","year":"2005","unstructured":"Pfeffer S, Sewer A, Lagos-Quintana M, Sheridan R, Sander C, Gr\u00e4sser FA, et al. Identification of microRNAs of the herpesvirus family. Nat Methods. 2005;2:269\u201376. https:\/\/doi.org\/10.1038\/nmeth746.","journal-title":"Nat Methods"},{"key":"1880_CR10","doi-asserted-by":"publisher","first-page":"S25","DOI":"10.1038\/ng1793","volume":"38","author":"BR Cullen","year":"2006","unstructured":"Cullen BR. Viruses and micrornas. Nat Genet. 2006;38:S25-30. https:\/\/doi.org\/10.1038\/ng1793.","journal-title":"Nat Genet"},{"key":"1880_CR11","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.chom.2008.05.002","volume":"3","author":"E Gottwein","year":"2008","unstructured":"Gottwein E, Cullen BR. Viral and cellular microRNAs as determinants of viral pathogenesis and immunity. Cell Host Microbe. 2008;3:375\u201387. https:\/\/doi.org\/10.1016\/j.chom.2008.05.002.","journal-title":"Cell Host Microbe"},{"key":"1880_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088531","author":"ZZ Shen","year":"2014","unstructured":"Shen ZZ, Pan X, Miao LF, Ye HQ, Chavanas S, Davrinche C, et al. Comprehensive analysis of human cytomegalovirus microRNA expression during lytic and quiescent infection. PLoS ONE. 2014. https:\/\/doi.org\/10.1371\/journal.pone.0088531.","journal-title":"PLoS ONE"},{"key":"1880_CR13","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.coviro.2016.07.005","volume":"19","author":"MH Powdrill","year":"2016","unstructured":"Powdrill MH, Desrochers GF, Singaravelu R, Pezacki JP. The role of microRNAs in metabolic interactions between viruses and their hosts. Curr Opin Virol. 2016;19:71\u20136. https:\/\/doi.org\/10.1016\/j.coviro.2016.07.005.","journal-title":"Curr Opin Virol"},{"key":"1880_CR14","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1007\/S11262-018-1532-9","volume":"54","author":"K Shen","year":"2018","unstructured":"Shen K, Xu L, Chen D, Tang W, Huang Y. Human cytomegalovirus-encoded miR-UL112 contributes to HCMV-mediated vascular diseases by inducing vascular endothelial cell dysfunction. Virus Genes. 2018;54:172\u201381. https:\/\/doi.org\/10.1007\/S11262-018-1532-9.","journal-title":"Virus Genes"},{"key":"1880_CR15","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0113740","author":"AA Mohammad","year":"2014","unstructured":"Mohammad AA, Rahbar A, Lui WO, Davoudi B, Catrina A, Stragliotto G, et al. Detection of circulating hcmv-miR-UL112-3p in patients with glioblastoma, rheumatoid arthritis, diabetes mellitus and healthy controls. PLoS ONE. 2014. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0113740.","journal-title":"PLoS ONE"},{"key":"1880_CR16","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.1080\/15476286.2021.1930757\/FORMAT\/EPUB","volume":"18","author":"R Fern\u00e1ndez-Moreno","year":"2021","unstructured":"Fern\u00e1ndez-Moreno R, Torre-Cisneros J, Cantis\u00e1n S. Human cytomegalovirus (HCMV)-encoded microRNAs: potential biomarkers and clinical applications. RNA Biol. 2021;18:2194\u2013202. https:\/\/doi.org\/10.1080\/15476286.2021.1930757\/FORMAT\/EPUB.","journal-title":"RNA Biol"},{"key":"1880_CR17","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.3389\/FIMMU.2019.01155\/BIBTEX","volume":"10","author":"ARK Patro","year":"2019","unstructured":"Patro ARK. Subversion of immune response by human cytomegalovirus. Front Immunol. 2019;10:1155. https:\/\/doi.org\/10.3389\/FIMMU.2019.01155\/BIBTEX.","journal-title":"Front Immunol"},{"key":"1880_CR18","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1128\/jvi.05903-11","volume":"86","author":"TJ Stark","year":"2012","unstructured":"Stark TJ, Arnold JD, Spector DH, Yeo GW. High-resolution profiling and analysis of viral and host small RNAs during human cytomegalovirus infection. J Virol. 2012;86:226\u201335. https:\/\/doi.org\/10.1128\/jvi.05903-11.","journal-title":"J Virol"},{"key":"1880_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S41544-019-0029-6","volume":"1","author":"C Wang","year":"2019","unstructured":"Wang C, Wang J-J, Zhang C. Altered human cytomegalovirus-encoded miRNAs in host circulation: novel disease biomarkers and potential aetiological agents. ExRNA. 2019;1:1\u201313. https:\/\/doi.org\/10.1186\/S41544-019-0029-6.","journal-title":"ExRNA"},{"key":"1880_CR20","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1161\/CIRCULATIONAHA.110.012237","volume":"124","author":"S Li","year":"2011","unstructured":"Li S, Zhu J, Zhang W, Chen Y, Zhang K, Popescu LM, et al. Signature microRNA expression profile of essential hypertension and its novel link to human cytomegalovirus infection. Circulation. 2011;124:175\u201384. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.110.012237.","journal-title":"Circulation"},{"key":"1880_CR21","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1590\/S1679-45082015RW3175","volume":"13","author":"LR Requi\u00e3o-Moura","year":"2015","unstructured":"Requi\u00e3o-Moura LR, deMatos ACC, Pacheco-Silva A. Cytomegalovirus infection in renal transplantation: clinical aspects, management and the perspectives. Einstein (S\u00e3o Paulo, Brazil). 2015;13:142\u20138. https:\/\/doi.org\/10.1590\/S1679-45082015RW3175.","journal-title":"Einstein (S\u00e3o Paulo, Brazil)"},{"key":"1880_CR22","first-page":"27","volume":"11","author":"A Afshari","year":"2020","unstructured":"Afshari A, Yaghobi R, Karimi MH, Azarpira N, Geramizadeh B, Darbouy M, et al. Association between interleukin-21, 23 and 27 expression and protein level with cytomegalovirus infection in liver transplant recipients. Int J Organ Transplant Med. 2020;11:27\u201334.","journal-title":"Int J Organ Transplant Med"},{"key":"1880_CR23","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1093\/infdis\/jiw596","volume":"215","author":"SH Han","year":"2017","unstructured":"Han SH, Kumar D, Ferreira VH, Egli A, Hirsch HH, Weisser M, et al. Human microRNA responses predict cytomegalovirus replication following solid organ. Transplantation. 2017;215:537\u201383. https:\/\/doi.org\/10.1093\/infdis\/jiw596.","journal-title":"Transplantation"},{"key":"1880_CR24","doi-asserted-by":"publisher","first-page":"2266","DOI":"10.1016\/j.febslet.2013.05.057","volume":"587","author":"M Qi","year":"2013","unstructured":"Qi M, Qi Y, Ma Y, He R, Ji Y, Sun Z, et al. Over-expression of human cytomegalovirus miR-US25-2-3p downregulates eIF4A1 and inhibits HCMV replication. FEBS Lett. 2013;587:2266\u201371. https:\/\/doi.org\/10.1016\/j.febslet.2013.05.057.","journal-title":"FEBS Lett"},{"key":"1880_CR25","doi-asserted-by":"publisher","first-page":"10684","DOI":"10.1128\/jvi.01292-09","volume":"83","author":"N Stern-Ginossar","year":"2009","unstructured":"Stern-Ginossar N, Saleh N, Goldberg MD, Prichard M, Wolf DG, Mandelboim O. Analysis of human cytomegalovirus-encoded microRNA activity during infection. J Virol. 2009;83:10684\u201393. https:\/\/doi.org\/10.1128\/jvi.01292-09.","journal-title":"J Virol"},{"key":"1880_CR26","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1111\/AJT.13222","volume":"15","author":"LF Lisboa","year":"2015","unstructured":"Lisboa LF, Egli A, O\u2019Shea D, \u00c5sberg A, Hartmann A, Rollag H, et al. Hcmv-miR-UL22A-5p: a biomarker in transplantation with broad impact on host gene expression and potential immunological implications. Am J Transplant. 2015;15:1893\u2013902. https:\/\/doi.org\/10.1111\/AJT.13222.","journal-title":"Am J Transplant"},{"key":"1880_CR27","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.chom.2015.05.014","volume":"17","author":"S Kim","year":"2015","unstructured":"Kim S, Seo D, Kim D, Hong Y, Chang H, Baek D, et al. Temporal landscape of microRNA-mediated host-virus crosstalk during productive human cytomegalovirus infection. Cell Host Microbe. 2015;17:838\u201351. https:\/\/doi.org\/10.1016\/j.chom.2015.05.014.","journal-title":"Cell Host Microbe"},{"key":"1880_CR28","doi-asserted-by":"publisher","first-page":"7829","DOI":"10.1073\/PNAS.141108798","volume":"98","author":"A Skaletskaya","year":"2001","unstructured":"Skaletskaya A, Bartle LM, Chittenden T, McCormick AL, Mocarski ES, Goldmacher VS. A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation. Proc Natl Acad Sci. 2001;98:7829\u201334. https:\/\/doi.org\/10.1073\/PNAS.141108798.","journal-title":"Proc Natl Acad Sci"},{"key":"1880_CR29","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/J.CHOM.2019.11.013","volume":"27","author":"MH Hancock","year":"2020","unstructured":"Hancock MH, Crawford LB, Pham AH, Mitchell J, Struthers HM, Yurochko AD, et al. Human cytomegalovirus miRNAs regulate TGF-\u03b2 to mediate myelosuppression while maintaining viral latency in CD34+ hematopoietic progenitor cells. Cell Host Microbe. 2020;27:104. https:\/\/doi.org\/10.1016\/J.CHOM.2019.11.013.","journal-title":"Cell Host Microbe"},{"key":"1880_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/srep31205","author":"B Lau","year":"2016","unstructured":"Lau B, Poole E, Krishna B, Sellart I, Wills MR, Murphy E, et al. The expression of human cytomegalovirus microRNA MIR-UL148D during latent infection in primary myeloid cells inhibits activin a-triggered secretion of IL-6. Sci Rep. 2016. https:\/\/doi.org\/10.1038\/srep31205.","journal-title":"Sci Rep"},{"key":"1880_CR31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000967","author":"F Grey","year":"2010","unstructured":"Grey F, Tirabassi R, Meyers H, Wu G, McWeeney S, Hook L, et al. A viral microRNA down-regulates multiple cell cycle genes through mRNA 59\u2032UTRs. PLoS Pathog. 2010. https:\/\/doi.org\/10.1371\/journal.ppat.1000967.","journal-title":"PLoS Pathog"},{"key":"1880_CR32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002577","author":"Y Kim","year":"2012","unstructured":"Kim Y, Lee S, Kim S, Kim D, Ahn JH, Ahn K. Human cytomegalovirus clinical strain-specific microRNA miR-UL148D targets the human chemokine RANTES during infection. PLoS Pathog. 2012. https:\/\/doi.org\/10.1371\/journal.ppat.1002577.","journal-title":"PLoS Pathog"},{"key":"1880_CR33","doi-asserted-by":"publisher","first-page":"959","DOI":"10.3892\/ijmm.2013.1271","volume":"31","author":"YP Wang","year":"2013","unstructured":"Wang YP, Qi Y, Huang YJ, Qi ML, Ma YP, He R, et al. Identification of immediate early gene X-1 as a cellular target gene of hcmv-mir-UL148D. Int J Mol Med. 2013;31:959\u201366. https:\/\/doi.org\/10.3892\/ijmm.2013.1271.","journal-title":"Int J Mol Med"},{"key":"1880_CR34","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PPAT.1006007","author":"C Pan","year":"2016","unstructured":"Pan C, Zhu D, Wang Y, Li L, Li D, Liu F, et al. Human cytomegalovirus miR-UL148D facilitates latent viral infection by targeting host cell immediate early response gene 5. PLoS Pathog. 2016. https:\/\/doi.org\/10.1371\/JOURNAL.PPAT.1006007.","journal-title":"PLoS Pathog"},{"key":"1880_CR35","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3390\/cancers7010070","volume":"7","author":"HA Loomans","year":"2014","unstructured":"Loomans HA, Andl CD, Andl CD, Andl CD, Andl CD, Andl CD. Intertwining of activin a and TGF\u03b2 signaling: Dual roles in cancer progression and cancer cell invasion. Cancers (Basel). 2014;7:70\u201391. https:\/\/doi.org\/10.3390\/cancers7010070.","journal-title":"Cancers (Basel)"},{"key":"1880_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/SREP23007","author":"Y Pan","year":"2016","unstructured":"Pan Y, Wang N, Zhou Z, Liang H, Pan C, Zhu D, et al. Circulating human cytomegalovirus-encoded HCMV-miR-US4-1 as an indicator for predicting the efficacy of IFN\u03b1 treatment in chronic hepatitis B patients. Sci Rep. 2016. https:\/\/doi.org\/10.1038\/SREP23007.","journal-title":"Sci Rep"},{"key":"1880_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S12967-017-1222-8\/FIGURES\/5","volume":"15","author":"M Ding","year":"2017","unstructured":"Ding M, Wang X, Wang C, Liu X, Zen K, Wang W, et al. Distinct expression profile of HCMV encoded miRNAs in plasma from oral lichen planus patients. J Transl Med. 2017;15:1\u201312. https:\/\/doi.org\/10.1186\/S12967-017-1222-8\/FIGURES\/5.","journal-title":"J Transl Med"},{"key":"1880_CR38","first-page":"46","volume":"12","author":"M Golshan","year":"2021","unstructured":"Golshan M, Yaghobi R, Geramizadeh B, Afshari A, Roozbeh J, Malek-Hosseini SA. Importance of miR-UL-148D expression pattern in cytomegalovirus infected transplant patients. Int J Organ Transplant Med. 2021;12:46\u201354.","journal-title":"Int J Organ Transplant Med"},{"key":"1880_CR39","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-013-9353-4","author":"Y Huang","year":"2013","unstructured":"Huang Y, Sun Z, Ruan Q. Down-regulation of human cytomegalovirus UL138, a novel latency-associated determinant, by hcmv-miR-UL36. J Biosci. 2013. https:\/\/doi.org\/10.1007\/s12038-013-9353-4.","journal-title":"J Biosci"},{"key":"1880_CR40","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1007\/s00705-015-2498-8","volume":"160","author":"X Guo","year":"2015","unstructured":"Guo X, Huang Y, Qi Y, Liu Z, Ma Y, Shao Y, et al. Human cytomegalovirus miR-UL36-5p inhibits apoptosis via downregulation of adenine nucleotide translocator 3 in cultured cells. Adv Virol. 2015;160:2483\u201390. https:\/\/doi.org\/10.1007\/s00705-015-2498-8.","journal-title":"Adv Virol"}],"container-title":["Virology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12985-022-01880-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12985-022-01880-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12985-022-01880-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T08:11:07Z","timestamp":1662970267000},"score":1,"resource":{"primary":{"URL":"https:\/\/virologyj.biomedcentral.com\/articles\/10.1186\/s12985-022-01880-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,12]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["1880"],"URL":"https:\/\/doi.org\/10.1186\/s12985-022-01880-5","relation":{},"ISSN":["1743-422X"],"issn-type":[{"value":"1743-422X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,12]]},"assertion":[{"value":"13 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All applied protocols in this study, were in complete agreement with the Helsinki Declaration and its later amendment. The local Ethics committee of Shiraz University of Medical Sciences approved every step of this study. After explaining the study objectives, written informed consent was obtained from each patient.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication was obtained.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"147"}}