{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:33:11Z","timestamp":1793899991871,"version":"4.8.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"The First Affiliated Hospital of Dalian Medical University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virol J"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Human herpesvirus 7 (HHV-7) is a common virus that infects children early and is accompanied by lifelong latency in cells, which is easy to reactivate in immunodeficient adults, but the underlying pathological mechanism is uncertain in immunocompetent adults without peculiar past medical history. Even though the clinical manifestation of the encephalitis caused by HHV-7 is uncommon in immunocompetent adults, the HHV-7 infection should not be neglected for encephalitis for unknown reasons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We reported here a case of HHV-7 encephalitis with epileptic seizures. While the brain computer tomography was standard, electroencephalography displayed slow waves in the temporal and bilateral frontal areas, then HHV-7 DNA was detected in the metagenomic next-generation sequencing of cerebrospinal fluid. Fortunately, the patient recovered after treatment and was discharged 2\u00a0months later. We also collected the related cases and explored a better way to illuminate the underlying mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The case indicates clinicians should memorize HHV-7 as an unusual etiology of encephalitis to make an early diagnosis and therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12985-022-01925-9","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T09:05:06Z","timestamp":1669712706000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Human herpesvirus 7 encephalitis in an immunocompetent adult and a literature review"],"prefix":"10.1186","volume":"19","author":[{"given":"Yi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhao","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuming","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianyao","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"issue":"11","key":"1925_CR1","doi-asserted-by":"publisher","first-page":"6260","DOI":"10.1128\/jvi.65.11.6260-6265.1991","volume":"65","author":"LS Wyatt","year":"1991","unstructured":"Wyatt LS, Rodriguez WJ, Balachandran N, Frenkel N. Human herpesvirus 7: antigenic properties and prevalence in children and adults. J Virol. 1991;65(11):6260\u20135.","journal-title":"J Virol"},{"issue":"3","key":"1925_CR2","first-page":"173","volume":"30","author":"E Caselli","year":"2007","unstructured":"Caselli E, Di Luca D. Molecular biology and clinical associations of Roseoloviruses human herpesvirus 6 and human herpesvirus 7. New Microbiol. 2007;30(3):173\u201387.","journal-title":"New Microbiol"},{"issue":"Suppl 6","key":"1925_CR3","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/j.1528-1167.2008.01751.x","volume":"49","author":"UK Misra","year":"2008","unstructured":"Misra UK, Tan CT, Kalita J. Viral encephalitis and epilepsy. Epilepsia. 2008;49(Suppl 6):13\u20138.","journal-title":"Epilepsia"},{"key":"1925_CR4","doi-asserted-by":"publisher","first-page":"799454","DOI":"10.3389\/fimmu.2022.799454","volume":"13","author":"S Li","year":"2022","unstructured":"Li S, Wang M, Li H, Wang J, Zhang Q, Zhou D, Li J. Case report: overlapping syndrome of anti-NMDAR encephalitis and MOG inflammatory demyelinating disease in a patient with human herpesviruses 7 infection. Front Immunol. 2022;13:799454.","journal-title":"Front Immunol"},{"issue":"3","key":"1925_CR5","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s13365-018-0618-4","volume":"24","author":"\u00cd Corral","year":"2018","unstructured":"Corral \u00cd, de la Maza SS, Rodr\u00edguez M, Kawiorski MM, L\u00f3pez-Mart\u00ednez MJ, Gal\u00e1n JC. Molecular detection of human herpesvirus 7 DNA in cerebrospinal fluid from adult patients with neurological disorders. J Neurovirol. 2018;24(3):333\u20138.","journal-title":"J Neurovirol"},{"issue":"1","key":"1925_CR6","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s12985-017-0764-y","volume":"14","author":"M Parra","year":"2017","unstructured":"Parra M, Alcala A, Amoros C, Baeza A, Galiana A, Tarrag\u00f3 D, Garc\u00eda-Quesada M\u00c1, S\u00e1nchez-Hell\u00edn V. Encephalitis associated with human herpesvirus-7 infection in an immunocompetent adult. Virol J. 2017;14(1):97.","journal-title":"Virol J"},{"issue":"14","key":"1925_CR7","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.2169\/internalmedicine.56.8185","volume":"56","author":"Y Aburakawa","year":"2017","unstructured":"Aburakawa Y, Katayama T, Saito T, Sawada J, Suzutani T, Aizawa H, Hasebe N. Limbic encephalitis associated with human herpesvirus-7 (HHV-7) in an immunocompetent adult: the first reported case in Japan. Intern Med. 2017;56(14):1919\u201323.","journal-title":"Intern Med"},{"issue":"11","key":"1925_CR8","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1002\/jmv.23683","volume":"85","author":"MH Martikainen","year":"2013","unstructured":"Martikainen MH, Gr\u00f6nroos JO, Vuorinen T. Detection of human herpesvirus 7 DNA from the CSF in association with neurosarcoidosis. 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