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Because of the emergence of multidrug-resistant\n                      <jats:italic>V. parahaemolyticus<\/jats:italic>\n                      strains, bacteriophages are considered promising agents for their biocontrol as an alternative or supplement to antibiotics. In this study, a lytic vibriophage, vB_VpaM_R16F (R16F), infecting\n                      <jats:italic>V. parahaemolyticus<\/jats:italic>\n                      1.1997\n                      <jats:sup>T<\/jats:sup>\n                      was isolated, characterized and evaluated for its biocontrol potential.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A vibriophage R16F was isolated from sewage from a seafood market with the double-layer agar method. R16F was studied by transmission electron microscopy, host range, sensitivity of phage particles to chloroform, one-step growth curve and lytic activity. The phage genome was sequenced and in-depth characterized, including phylogenetic and taxonomic analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      R16F belongs to the myovirus morphotype and infects\n                      <jats:italic>V. parahaemolyticus<\/jats:italic>\n                      , but not nine other\n                      <jats:italic>Vibrio<\/jats:italic>\n                      spp. As characterized by determining its host range, one-step growth curve, and lytic activity, phage R16F was found to highly effective in lysing host cells with a short latent period (&lt;\u200910\u00a0min) and a small burst size (13 plaque-forming units). R16F has a linear double-stranded DNA with genome size 139,011\u00a0bp and a G\u2009+\u2009C content of 35.21%. Phylogenetic and intergenomic nucleotide sequence similarity analysis revealed that R16F is distinct from currently known vibriophages and belongs to a novel genus. Several genes (e.g., encoding ultraviolet damage endonuclease and endolysin) that may enhance environmental competitiveness were found in the genome of R16F, while no antibiotic resistance- or virulence factor-related gene was detected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In consideration of its biological and genetic properties, this newly discovered phage R16F belongs to a novel genus and may be a potential alternate biocontrol agent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12985-023-02036-9","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T11:11:40Z","timestamp":1682939500000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Isolation and characterization of a novel phage belonging to a new genus against Vibrio parahaemolyticus"],"prefix":"10.1186","volume":"20","author":[{"given":"Yubing","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keming","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,1]]},"reference":[{"issue":"1","key":"2036_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/aah.10045","volume":"31","author":"MY Ina-Salwany","year":"2019","unstructured":"Ina-Salwany MY, Al-saari N, Mohamad A, Mursidi FA, Mohd-Aris A, Amal MNA, et al. 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