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We aimed to determine whether women with COVID-19 diagnosis had adverse pregnancy outcomes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A two-sample Mendelian randomization (MR) analysis in this study was used to evaluate the casual relationships between COVID-19 infection and obstetric-related diseases based on genome-wide association studies (GWAS) dataset. Inverse-variance weighted (IVW), MR-Egger and MR-PRESSO were used to infer the connection and estimate the pleiotropy respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The significant connection was observed between COVID-19 and placental disorders with beta<jats:sub>IVW<\/jats:sub> of 1.57 and odds ratio\u00a0(OR) of 4.81 (95% confidence interval [CI]: 1.05\u201322.05, <jats:italic>p<\/jats:italic>\u2009=\u20090.04). However, there were no associations between COVID-19 infection and gestational diabetes mellitus (GDM) (OR\u2009=\u20091.12; 95% CI: 0.85\u20131.45, <jats:italic>p<\/jats:italic>\u2009=\u20090.41), other disorders of amniotic fluid and membranes (OR\u2009=\u20090.90; 95% CI: 0.61\u20131.32, <jats:italic>p<\/jats:italic>\u2009=\u20090.59), Intrahepatic Cholestasis of Pregnancy (ICP) (OR\u2009=\u20091.42; 95% CI: 0.85\u20132.36, <jats:italic>p<\/jats:italic>\u2009=\u20090.18), birth weight (OR\u2009=\u20091.02; 95% CI: 0.99\u20131.05, <jats:italic>p<\/jats:italic>\u2009=\u20090.19), gestational hypertension (OR\u2009=\u20091.00; 95% CI: 1.00\u20131.00, <jats:italic>p<\/jats:italic>\u2009=\u20090.85), spontaneous miscarriages (OR\u2009=\u20091.00; 95% CI: 0.96\u20131.04, <jats:italic>p<\/jats:italic>\u2009=\u20090.90) and stillbirth (OR\u2009=\u20091.00; 95% CI: 0.98\u20131.01, <jats:italic>p<\/jats:italic>\u2009=\u20090.62).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>There was no direct causal relationship between COVID-19 infection and maternal and neonatal poor outcomes. Our study could alleviate the anxiety of pregnant women under the COVID-19 pandemic conditions partly.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12985-024-02348-4","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T14:01:30Z","timestamp":1711375290000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mendelian randomization analysis reveals causal relationship between obstetric-related diseases and COVID-19"],"prefix":"10.1186","volume":"21","author":[{"given":"Yan","family":"Fang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dajun","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,25]]},"reference":[{"issue":"3","key":"2348_CR1","first-page":"e00228","volume":"34","author":"SH SafiabadiTali","year":"2021","unstructured":"SafiabadiTali SH, et al. 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