{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:30:49Z","timestamp":1777725049756,"version":"3.51.4"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virol J"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Human parechovirus, a member of the\n                    <jats:italic>Picornaviridae<\/jats:italic>\n                    family (PeVs), can lead to severe infections, including severe meningitis, meningoencephalitis, and sepsis-like syndrome. We report a case of human parechovirus-related encephalitis in a 52-year-old woman diagnosed with glioblastoma multiforme. She underwent surgical resection in June 2022. Unfortunately, her disease recurred, and she underwent a second resection in August 2022, followed by radiation therapy and Temozolomide therapy. She presented to the hospital with acute confusion followed by seizures, necessitating intubation for airway support. A cerebrospinal fluid (CSF) sample was obtained and processed using the Biofire FilmArray, which reported the detection of HSV-1. Despite being on Acyclovir, the patient did not show signs of improvement. Consequently, a second CSF sample was obtained and sent for next-generation sequencing (NGS), which returned a positive result for Parechovirus. In this presented case, the patient exhibited symptoms of an unknown infectious cause. The utilization of NGS and metagenomic analysis helped identify Parechovirus as the primary pathogen present, in addition to previously identified HSV. This comprehensive approach facilitated a thorough assessment of the underlying infection and guided targeted treatment. In conclusion, the application of NGS techniques and metagenomic analysis proved instrumental in identifying the root cause of the infection.\n                  <\/jats:p>","DOI":"10.1186\/s12985-024-02372-4","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T08:02:02Z","timestamp":1714636922000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["First parechovirus reported case in Saudi Arabia in hospitalized immunocompromised adult patient"],"prefix":"10.1186","volume":"21","author":[{"given":"Abdullah","family":"Alshammari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jawaher","family":"Alotaibi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reem","family":"Almaghrabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reema","family":"Bawazeer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar","family":"Althawadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamsa","family":"Tayeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"key":"2372_CR1","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3201\/eid2001.130569","volume":"20","author":"TK Fischer","year":"2014","unstructured":"Fischer TK, Midgley S, Dalgaard C, Nielsen AY. Human parechovirus infection. Denmark Emerg Infect Dis. 2014;20:83\u20137. https:\/\/doi.org\/10.3201\/eid2001.130569.","journal-title":"Denmark Emerg Infect Dis."},{"key":"2372_CR2","doi-asserted-by":"crossref","unstructured":"Harvala H, Griffiths M, Solomon T, Simmonds P. Distinct systemic and central nervous system disease patterns in enterovirus and parechovirus-infected children. J Inf Secur. 2014;69:69\u201374 1016\/j.jinf.2014.02.017.","DOI":"10.1016\/j.jinf.2014.02.017"},{"key":"2372_CR3","doi-asserted-by":"publisher","first-page":"e27735","DOI":"10.1371\/journal.pone.0027735","volume":"7","author":"KM Wylie","year":"2012","unstructured":"Wylie KM, Mihindukulasuriya KA, Sodergren E, et al. Sequence analysis of the human virome in febrile and afebrile children. 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Arch Virol. 2020;165:963\u20136. https:\/\/doi.org\/10.1007\/s00705-020-04547-0.","journal-title":"Arch Virol."},{"key":"2372_CR8","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.3201\/eid1811.111570","volume":"18","author":"K Mizuta","year":"2012","unstructured":"Mizuta K, Kuroda M, Kurimura M, Yahata Y, Sekizuka T, Aoki Y, Ikeda T, Abiko C, Noda M, Kimura H, Mizutani T, Kato T, Kawanami T, Ahiko T. Epidemic myalgia in adults associated with human parechovirus type 3 infection, Yamagata, Japan, 2008. Emerg Infect Dis. 2012;18:1787\u201393. https:\/\/doi.org\/10.3201\/eid1811.111570.","journal-title":"Emerg Infect Dis."},{"key":"2372_CR9","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.3201\/eid2309.161256","volume":"23","author":"KL Kong","year":"2017","unstructured":"Kong KL, Lau JSY, Goh SM, Wilson HL, Catton M, Korman TM. Myocarditis caused by human parechovirus in adult. 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