{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T10:48:15Z","timestamp":1788691695818,"version":"build-2803163510"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virol J"],"DOI":"10.1186\/s12985-024-02536-2","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T15:01:52Z","timestamp":1729868512000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Adapted Milwaukee protocol for rabies treatment in a Brazilian indigenous child: case report"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2435-7576","authenticated-orcid":false,"given":"Dilceu Silveira Tolentino","family":"J\u00fanior","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryana Santos Vasconcelos","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Carlos","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"2536_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3527(08)00005-5","author":"AS Nadin-Davis","year":"2008","unstructured":"Nadin-Davis AS, Fehlner-Gardiner C. Lyssaviruses: current trends. Adv Virus Res. 2008. https:\/\/doi.org\/10.1016\/S0065-3527(08)00005-5. 71:207\u2009\u2013\u200950.","journal-title":"Adv Virus Res"},{"issue":"2","key":"2536_CR2","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3390\/tropicalmed6020098","volume":"6","author":"M Meske","year":"2021","unstructured":"Meske M, Fanelli A, Rocha F, Awada L, Soto PC, Mapitse N, Tizzani P. Evolution of rabies in South America and Inter-species Dynamics (2009\u20132018). Trop Med Infect Dis. 2021;6(2):98. https:\/\/doi.org\/10.3390\/tropicalmed6020098.","journal-title":"Trop Med Infect Dis"},{"issue":"8","key":"2536_CR3","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1099\/jgv.0.001269","volume":"100","author":"SP Smith","year":"2019","unstructured":"Smith SP, Wu G, Fooks AR, Ma J, Banyard AC. Trying to treat the untreatable: experimental approaches to clear Rabies virus infection from the CNS. J Gen Virol. 2019;100(8):1171\u201386. https:\/\/doi.org\/10.1099\/jgv.0.001269.","journal-title":"J Gen Virol"},{"issue":"4","key":"2536_CR4","first-page":"385","volume":"18","author":"Brazil","year":"2009","unstructured":"Brazil, Ministry of Health (MS). Secretariat of Health Surveillance. Protocol for the treatment of human rabies in Brazil. Epidemiol Serv Saude. 2009;18(4):385\u201394.","journal-title":"Epidemiol Serv Saude"},{"key":"2536_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1590\/0037-8682-0352-2020","volume":"53","author":"LA Ledesma","year":"2020","unstructured":"Ledesma LA, Lemos ERS, Horta MA. Comparing clinical protocols for the treatment of human rabies: the Milwaukee protocol and the Brazilian protocol (Recife). Rev Soc Bras Med Trop. 2020;53:1\u20138.","journal-title":"Rev Soc Bras Med Trop"},{"key":"2536_CR6","doi-asserted-by":"publisher","first-page":"17091","DOI":"10.1038\/nrdp.2017.91","volume":"3","author":"AR Fooks","year":"2017","unstructured":"Fooks AR, Cliquet F, Finke S, Freuling C, Hemachudha T, Mani RS, M\u00fcller T, Nadin-Davis S, Picard-Meyer E, Wilde H, Banyard AC, Rabies. Nat Rev Dis Primers. 2017;3:17091. https:\/\/doi.org\/10.1038\/nrdp.2017.91.","journal-title":"Nat Rev Dis Primers"},{"key":"2536_CR7","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s40249-023-01130-y","volume":"12","author":"DS Tolentino J\u00fanior","year":"2023","unstructured":"Tolentino J\u00fanior DS, Marques MSV, Krummenauer A, et al. Rabies outbreak in Brazil: first case series in children from an indigenous village. Infect Dis Poverty. 2023;12:78. https:\/\/doi.org\/10.1186\/s40249-023-01130-y.","journal-title":"Infect Dis Poverty"},{"key":"2536_CR8","unstructured":"Wiedeman J, Plant J, Glaser C, Messenger S, Wadford D, Sheriff H et al. Recovery of a patient from. Clin Rabies - Calif 2011; MMWR 61(04):61\u20135."},{"key":"2536_CR9","unstructured":"Milwaukee, Protocol. version 6updated November (2018). https:\/\/www.mcw.edu\/-\/media\/MCW\/Departments\/Pediatrics\/Infectious-Diseases\/Milwaukee_protocol.pdf"},{"issue":"1","key":"2536_CR10","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1080\/01652176.2017.1343516","volume":"37","author":"R Singh","year":"2017","unstructured":"Singh R, Singh KP, Cherian S, Saminathan M, Kapoor S, Manjunatha GB, et al. Rabies - epidemiology, pathogenesis, public health concerns and advances in diagnosis and control: a comprehensive review. Vet Q. 2017;37(1):212\u201351.","journal-title":"Vet Q"},{"issue":"24","key":"2536_CR11","doi-asserted-by":"publisher","first-page":"2508","DOI":"10.1056\/NEJMoa050382","volume":"352","author":"RE Willoughby","year":"2005","unstructured":"Willoughby RE, Tieves KS, Hoffman GM, Ghanayem NS, Amlie-Lefond CM, Schwabe MJ, et al. Survival after treatment of rabies with induction of coma. N Engl J Med. 2005;352(24):2508\u201314.","journal-title":"N Engl J Med"},{"issue":"27","key":"2536_CR12","doi-asserted-by":"publisher","first-page":"11300","DOI":"10.1073\/pnas.0905640106","volume":"106","author":"M Faber","year":"2009","unstructured":"Faber M, Li J, Kean RB, Hooper DC, Alugupalli KR, Dietzschold B. Effective preexposure and postexposure prophylaxis of rabies with a highly attenuated recombinant rabies virus. Proc Natl Acad Sci U S A. 2009;106(27):11300\u20135. https:\/\/doi.org\/10.1073\/pnas.0905640106.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"2536_CR13","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/S1474-4422(13)70038-3","volume":"12","author":"T Hemachudha","year":"2013","unstructured":"Hemachudha T, Ugolini G, Wacharapluesadee S, Sungkarat W, Shuangshoti S, Laothamatas J. Human rabies: neuropathogenesis, diagnosis, and management. Lancet Neurol. 2013;12(5):498\u2013513.","journal-title":"Lancet Neurol"},{"issue":"1","key":"2536_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3851\/IMP2851","volume":"20","author":"CM Appolinario","year":"2015","unstructured":"Appolinario CM, Jackson AC. Antiviral therapy for human rabies. Antivir Ther. 2015;20(1):1\u201310.","journal-title":"Antivir Ther"},{"key":"2536_CR15","doi-asserted-by":"publisher","first-page":"3312","DOI":"10.1523\/JNEUROSCI.4262-04.2005","volume":"25","author":"TA Blanpied","year":"2005","unstructured":"Blanpied TA, Clarke RJ, Johnson JW. Amantadine inhibits NMDA receptors by accelerating channel closure during channel block. J Neurosci. 2005;25:3312\u201322.","journal-title":"J Neurosci"},{"issue":"1","key":"2536_CR16","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ijvsm.2018.05.001","volume":"6","author":"A El-Sayed","year":"2018","unstructured":"El-Sayed A. Advances in rabies prophylaxis and treatment with emphasis on immunoresponse mechanisms. Int J Vet Sci Med. 2018;6(1):8\u201315.","journal-title":"Int J Vet Sci Med"},{"key":"2536_CR17","unstructured":"Hutz MH. Geneticista Diz que Imunidade De ind\u00edgenas \u00e0 Covid-19 \u00e9 menor. 2021. https:\/\/ds.saudeindigena.icict.fiocruz.br\/bitstream\/bvs\/4143\/1\/Azevedo%20-%202021%20%20Geneticista%20diz%20que%20imunidade%20de%20ind%C3%ADgenas%20%C3%A0%20Covid.pdf"},{"key":"2536_CR18","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/S1473-3099(02)00287-6","volume":"2","author":"CE Rupprecht","year":"2002","unstructured":"Rupprecht CE, Hanlon CA, Hemachudha T, Rabies Re-Examined. Lancet. 2002;2:327\u201343. https:\/\/doi.org\/10.1016\/S1473-3099(02)00287-6.","journal-title":"Lancet"},{"key":"2536_CR19","doi-asserted-by":"crossref","unstructured":"Jackson AC. Therapy of human rabies. In: Jackson AC, editor. Rabies: scientific basis of the disease and its management, Third Edition. Oxford, UK: Elsevier Academic Press, 2013; 573\u2013587.","DOI":"10.1016\/B978-0-12-396547-9.00016-X"}],"container-title":["Virology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12985-024-02536-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12985-024-02536-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12985-024-02536-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T15:03:07Z","timestamp":1729868587000},"score":1,"resource":{"primary":{"URL":"https:\/\/virologyj.biomedcentral.com\/articles\/10.1186\/s12985-024-02536-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,25]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2536"],"URL":"https:\/\/doi.org\/10.1186\/s12985-024-02536-2","relation":{},"ISSN":["1743-422X"],"issn-type":[{"value":"1743-422X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,25]]},"assertion":[{"value":"25 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research used only secondary data from the Technical Report of the Special Indigenous Health District of Minas Gerais and Esp\u00edrito Santo, without the need for referral to the National Research Ethics Commission (CONEP), according to Item 4 of Resolution 466\/2012 of the National Health Council and Technical Note n\u00ba 16\/2020- COGASI\/DASI\/ SESAI\/MS, added to the supervisory action provided for in Federal Law 8,080\/1990.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2018s next of kin for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"265"}}