{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T04:40:05Z","timestamp":1751085605590,"version":"3.41.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Guangdong Provincial Center for Disease Control and Prevention Supports Talent Projects","award":["0720240122"],"award-info":[{"award-number":["0720240122"]}]},{"name":"Guangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease","award":["2023B1212010010"],"award-info":[{"award-number":["2023B1212010010"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virol J"],"DOI":"10.1186\/s12985-025-02827-2","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T04:06:22Z","timestamp":1751083582000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic characterization of type 3 vaccine-derived poliovirus from a patient with hand, foot, and mouth disease in China"],"prefix":"10.1186","volume":"22","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanri","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanying","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuangli","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baisheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,28]]},"reference":[{"issue":"9","key":"2827_CR1","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/j.vaccine.2016.11.017","volume":"35","author":"WH Organization","year":"2017","unstructured":"Organization WH..Polio vaccines: WHO position paper\u2013 March. 2016[J] Vaccine. 2017;35(9):1197\u20139. https:\/\/doi.org\/10.1016\/j.vaccine.2016.11.017.","journal-title":"2016[J] Vaccine"},{"key":"2827_CR2","doi-asserted-by":"publisher","unstructured":"Baicus A. History of polio vaccination. World J Virol. 2012; 1 World J Virol. https:\/\/doi.org\/10.5501\/wjv.v1.i4.108","DOI":"10.5501\/wjv.v1.i4.108"},{"key":"2827_CR3","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1146\/annurev.micro.58.030603.123625","volume":"59","author":"OM Kew","year":"2005","unstructured":"Kew OM, Sutter RW, de Gourville EM, et al. Vaccine-derived polioviruses and the endgame strategy for global polio eradication. Annu Rev Microbiol. 2005;59:587\u2013635. https:\/\/doi.org\/10.1146\/annurev.micro.58.030603.123625.","journal-title":"ANNU REV MICROBIOL"},{"key":"2827_CR4","doi-asserted-by":"publisher","unstructured":"Platt LR, Est\u00edvariz CF, Sutter RW. Vaccine-associated paralytic poliomyelitis: a review of the epidemiology and estimation of the global burden. J Infect Dis. 2014; 210 Suppl 1 J INFECT DIS. https:\/\/doi.org\/10.1093\/infdis\/jiu184","DOI":"10.1093\/infdis\/jiu184"},{"key":"2827_CR5","doi-asserted-by":"publisher","unstructured":"Famulare M, Chang S, Iber J et al. Sabin vaccine reversion in the field: a comprehensive analysis of Sabin-Like poliovirus isolates in Nigeria. J Virol 2016; 90 J Virol. https:\/\/doi.org\/10.1128\/JVI.01532-15","DOI":"10.1128\/JVI.01532-15"},{"key":"2827_CR6","unstructured":"Otelea D, Guillot S, Furione M et al. Genomic modifications in naturally occurring neurovirulent revertants of Sabin 1 polioviruses. Dev Biol Stand. 1993; 78 Dev Biol Stand. PMID: 8099049."},{"key":"2827_CR7","doi-asserted-by":"publisher","unstructured":"Bigouette JP, Henderson E, Traor\u00e9 MA, et al. Update on Vaccine-Derived poliovirus Outbreaks - Worldwide, January 2021-December 2022. MMWR-Morbid Mortal W. 2023;72(MMWR\u2013Morbid Mortal W). https:\/\/doi.org\/10.15585\/mmwr.mm7214a3.","DOI":"10.15585\/mmwr.mm7214a3"},{"key":"2827_CR8","doi-asserted-by":"publisher","unstructured":"Bandyopadhyay AS, Garon J, Seib K et al. Polio vaccination: past, present and future[J].Future microbiology, 2015;10(5):791\u2013808.https:\/\/doi.org\/10.2217\/fmb.15.19","DOI":"10.2217\/fmb.15.19"},{"issue":"3","key":"2827_CR9","doi-asserted-by":"publisher","first-page":"e0152251","DOI":"10.1371\/journal.pone.0152251","volume":"11","author":"KM Cassemiro","year":"2016","unstructured":"Cassemiro KM, Burlandy FM, Barbosa MR, et al. Molecular and phenotypic characterization of a highly evolved type 2 Vaccine-Derived poliovirus isolated from seawater in brazil, 2014. PLoS ONE. 2016;11(3):e0152251. https:\/\/doi.org\/10.1371\/journal.pone.0152251.","journal-title":"PLoS ONE"},{"issue":"5566","key":"2827_CR10","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1126\/science.1068284","volume":"296","author":"O Kew","year":"2002","unstructured":"Kew O, Morris-Glasgow V, Landaverde M, et al. Outbreak of poliomyelitis in Hispaniola associated with Circulating type 1 vaccine-derived poliovirus. Science. 2002;296(5566):356\u20139. https:\/\/doi.org\/10.1126\/science.1068284.","journal-title":"Science"},{"key":"2827_CR11","doi-asserted-by":"publisher","unstructured":"Quarleri J. Poliomyelitis is a current challenge: long-term sequelae and Circulating vaccine-derived poliovirus. Geroscience. 2023;45(Geroscience). https:\/\/doi.org\/10.1007\/s11357-022-00672-7.","DOI":"10.1007\/s11357-022-00672-7"},{"key":"2827_CR12","doi-asserted-by":"publisher","unstructured":"Mbani CJ, Nekoua MP, Moukassa D, et al. The fight against poliovirus is not over. Microorganisms. 2023;11(5). https:\/\/doi.org\/10.3390\/microorganisms11051323.","DOI":"10.3390\/microorganisms11051323"},{"key":"2827_CR13","unstructured":"World health Organization. Polio endgame strategy 2019\u20132023: eradication, integration,certification and containment.[EB\/OL](2018-12-31)[2023-12-09]. https:\/\/www.who.int\/publications\/i\/item\/polio-endgame-strategy-2019-2023-eradication-integration-certification-and-containment"},{"key":"2827_CR14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0255795","author":"H Sun","year":"2021","unstructured":"Sun H, Harrington C, Gerloff N, et al. Validation of a redesigned pan-poliovirus assay and real-time PCR platforms for the global poliovirus laboratory network. PLoS ONE. 2021. https:\/\/doi.org\/10.1371\/journal.pone.0255795. 16 PLoS One.","journal-title":"PLoS ONE"},{"key":"2827_CR15","unstructured":"Expanding contributions of the global laboratory network for poliomyelitis eradication, 2000\u20132001. Wkly Epidemiol Rec. 2002;77(17):133-7. PMID: 12033163."},{"key":"2827_CR16","doi-asserted-by":"publisher","unstructured":"Rezapkin GV, Douthitt M, Dragunsky E et al. Reevaluation of nucleotide sequences of wild-type and attenuated polioviruses of type 3. Virus Res. 1999;65 Virus Res. https:\/\/doi.org\/10.1016\/s0168-1702(99)00108-2","DOI":"10.1016\/s0168-1702(99)00108-2"},{"key":"2827_CR17","unstructured":"Levenbook I, Nomura T. Development of a neurovirulent testing system for oral poliovirus vaccine with transgenic mice. Lab Anim Sci. 1997;47 Lab Anim Sci. PMID: 9150487."},{"issue":"8","key":"2827_CR18","doi-asserted-by":"publisher","first-page":"4972","DOI":"10.1128\/JVI.69.8.4972-4978.1995","volume":"69","author":"MJ Bouchard","year":"1995","unstructured":"Bouchard MJ, Lam DH, Racaniello VR. Determinants of Attenuation and temperature sensitivity in the type 1 poliovirus Sabin vaccine. J Virol. 1995;69(8):4972\u20138. https:\/\/doi.org\/10.1128\/JVI.69.8.4972-4978.1995.","journal-title":"J VIROL"},{"issue":"3","key":"2827_CR19","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1128\/JVI.63.3.1338-1344.1989","volume":"63","author":"GD Westrop","year":"1989","unstructured":"Westrop GD, Wareham KA, Evans DM, et al. Genetic basis of Attenuation of the Sabin type 3 oral poliovirus vaccine. J Virol. 1989;63(3):1338\u201344. https:\/\/doi.org\/10.1128\/JVI.63.3.1338-1344.1989.","journal-title":"J VIROL"},{"issue":"12","key":"2827_CR20","doi-asserted-by":"publisher","first-page":"7601","DOI":"10.1128\/JVI.69.12.7601-7605.1995","volume":"69","author":"A McGoldrick","year":"1995","unstructured":"McGoldrick A, Macadam AJ, Dunn G, et al. Role of mutations G-480 and C-6203 in the Attenuation phenotype of Sabin type 1 poliovirus. J Virol. 1995;69(12):7601\u20135. https:\/\/doi.org\/10.1128\/JVI.69.12.7601-7605.1995.","journal-title":"J VIROL"},{"issue":"1","key":"2827_CR21","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1006\/viro.2000.0354","volume":"272","author":"AV Paul","year":"2000","unstructured":"Paul AV, Mugavero J, Yin J, et al. Studies on the Attenuation phenotype of polio vaccines: poliovirus RNA polymerase derived from Sabin type 1 sequence is temperature sensitive in the uridylylation of VPg. Virology. 2000;272(1):72\u201384. https:\/\/doi.org\/10.1006\/viro.2000.0354.","journal-title":"Virology"},{"issue":"9","key":"2827_CR22","doi-asserted-by":"publisher","first-page":"5278","DOI":"10.1128\/JVI.69.9.5278-5286.1995","volume":"69","author":"MM Georgescu","year":"1995","unstructured":"Georgescu MM, Tardy-Panit M, Guillot S, et al. Mapping of mutations contributing to the temperature sensitivity of the Sabin 1 vaccine strain of poliovirus. J Virol. 1995;69(9):5278\u201386. https:\/\/doi.org\/10.1128\/JVI.69.9.5278-5286.1995.","journal-title":"J VIROL"},{"issue":"9","key":"2827_CR23","doi-asserted-by":"publisher","first-page":"4429","DOI":"10.1128\/JVI.02354-07","volume":"82","author":"J Jorba","year":"2008","unstructured":"Jorba J, Campagnoli R, De L, et al. Calibration of multiple poliovirus molecular clocks covering an extended evolutionary range. J Virol. 2008;82(9):4429\u201340. https:\/\/doi.org\/10.1128\/JVI.02354-07.","journal-title":"J VIROL"},{"key":"2827_CR24","doi-asserted-by":"publisher","unstructured":"China CDCW, Recommendations. Childhood Immunization Schedule for National Immunization Program Vaccines-China (Version 2021).[EB\/OL].[2025-04-28]. https:\/\/weekly.Chinacdc.cn\/en\/article\/doi\/https:\/\/doi.org\/10.46234\/ccdcw2021.270","DOI":"10.46234\/ccdcw2021.270"},{"key":"2827_CR25","unstructured":"China National Institutes for Drug Control. [EB\/OL].[2025-04-28]. https:\/\/bio.nifdc.org.cn\/pqf\/search.do?formAction=listGsxq%26parameter1=1%26parameter2=%25E7%2594%259F%25E7%2589%25A9%25E5%2588%25B6%25E5%2593%2581%25E6%2589%25B9%25E7%25AD%25BE%25E5%258F%2591%25E4%25BA%25A7%25E5%2593%2581%25E6%2583%2585%25E5%2586%25B5%25E6%25B1%2587%25E6%2580%25BB%25EF%25BC%2588%25E5%2585%25AC%25E7%25A4%25BA%25EF%25BC%2589%25E8%25A1%25A8%2B%2528%25E7%25AD%25BE%25E5%258F%2591%25E6%2597%25A5%25E6%259C%259F%253A2018%25E5%25B9%25B42%25E6%259C%258826%25E6%2597%25A5%25E8%2587%25B32018%25E5%25B9%25B43%25E6%259C%25884%25E6%2597%25A5%25EF%25BC%2589"},{"key":"2827_CR26","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1146\/annurev.micro.51.1.151","volume":"51","author":"E Domingo","year":"1997","unstructured":"Domingo E, Holland JJ. RNA virus mutations and fitness for survival. Annu Rev Microbiol. 1997;51:151\u201378. https:\/\/doi.org\/10.1146\/annurev.micro.51.1.151.","journal-title":"ANNU REV MICROBIOL"},{"key":"2827_CR27","doi-asserted-by":"publisher","unstructured":"Duggal R, Wimmer E. Genetic recombination of poliovirus in vitro and in vivo: temperature-dependent alteration of crossover sites. Virology. 1999;258(VIROLOGY). https:\/\/doi.org\/10.1006\/viro.1999.9703.","DOI":"10.1006\/viro.1999.9703"},{"key":"2827_CR28","doi-asserted-by":"crossref","unstructured":"Alejska M, Kurzy\u0144ska-Kokorniak A, Broda M et al. How RNA viruses exchange their genetic material. ACTA BIOCHIM POL. 2001; 48 Acta Biochim Pol. PMID: 11732610.","DOI":"10.18388\/abp.2001_3924"},{"key":"2827_CR29","doi-asserted-by":"publisher","unstructured":"Jegouic S, Joffret ML, Blanchard C et al. Recombination between polioviruses and co-circulating Coxsackie A viruses: role in the emergence of pathogenic vaccine-derived polioviruses. Plos Pathog. 2009; 5 PLOS PATHOG. https:\/\/doi.org\/10.1371\/journal.ppat.1000412","DOI":"10.1371\/journal.ppat.1000412"},{"issue":"4","key":"2827_CR30","doi-asserted-by":"publisher","first-page":"e0007335","DOI":"10.1371\/journal.pntd.0007335","volume":"13","author":"SA Sadeuh-Mba","year":"2019","unstructured":"Sadeuh-Mba SA, Kavunga-Membo H, Joffret ML, et al. Genetic landscape and macro-evolution of co-circulating coxsackieviruses A and Vaccine-derived polioviruses in the Democratic Republic of congo, 2008\u20132013. PLoS Negl Trop Dis. 2019;13(4):e0007335. https:\/\/doi.org\/10.1371\/journal.pntd.0007335.","journal-title":"PLoS Negl Trop Dis"},{"key":"2827_CR31","doi-asserted-by":"publisher","unstructured":"Combelas N, Holmblat B, Joffret ML et al. Recombination between poliovirus and coxsackie A viruses of species C: a model of viral genetic plasticity and emergence. Viruses. 2011; 3 Viruses. https:\/\/doi.org\/10.3390\/v3081460","DOI":"10.3390\/v3081460"},{"issue":"8","key":"2827_CR32","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.3390\/v3081460","volume":"3","author":"N Combelas","year":"2011","unstructured":"Combelas N, Holmblat B, Joffret ML, et al. Recombination between poliovirus and Coxsackie A viruses of species C: a model of viral genetic plasticity and emergence. Viruses. 2011;3(8):1460\u201384. https:\/\/doi.org\/10.3390\/v3081460.","journal-title":"Viruses"},{"issue":"9","key":"2827_CR33","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1093\/infdis\/jis204","volume":"205","author":"ML Joffret","year":"2012","unstructured":"Joffret ML, J\u00e9gouic S, Bessaud M, et al. Common and diverse features of cocirculating type 2 and 3 Recombinant vaccine-derived polioviruses isolated from patients with poliomyelitis and healthy children. J Infect Dis. 2012;205(9):1363\u201373. https:\/\/doi.org\/10.1093\/infdis\/jis204.","journal-title":"J INFECT DIS"},{"issue":"12","key":"2827_CR34","doi-asserted-by":"publisher","first-page":"e191","DOI":"10.1371\/journal.ppat.0030191","volume":"3","author":"M Rakoto-Andrianarivelo","year":"2007","unstructured":"Rakoto-Andrianarivelo M, Guillot S, Iber J, et al. Co-circulation and evolution of polioviruses and species C enteroviruses in a district of Madagascar. Plos Pathog. 2007;3(12):e191. https:\/\/doi.org\/10.1371\/journal.ppat.0030191.","journal-title":"PLOS PATHOG"},{"key":"2827_CR35","doi-asserted-by":"publisher","first-page":"l6201","DOI":"10.1136\/bmj.l6201","volume":"367","author":"O Dyer","year":"2019","unstructured":"Dyer O, Polio. WHO declares type 3 poliovirus eradicated after 31 year campaign. BMJ. 2019;367:l6201. https:\/\/doi.org\/10.1136\/bmj.l6201.","journal-title":"BMJ"},{"key":"2827_CR36","doi-asserted-by":"publisher","unstructured":"Mohanty A, Rohilla R, Zaman K et al. Vaccine Derived Poliovirus (VDPV). Infez Med. 2023; 31 Infez Med. https:\/\/doi.org\/10.53854\/liim-3102-5","DOI":"10.53854\/liim-3102-5"},{"key":"2827_CR37","doi-asserted-by":"publisher","unstructured":"Knowlson S, Burlison J, Giles E, et al. New strains intended for the production of inactivated polio vaccine at Low-Containment after eradication. Plos Pathog. 2015;11(PLOS PATHOG). https:\/\/doi.org\/10.1371\/journal.ppat.1005316.","DOI":"10.1371\/journal.ppat.1005316"},{"issue":"5","key":"2827_CR38","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.chom.2020.04.003","volume":"27","author":"MT Yeh","year":"2020","unstructured":"Yeh MT, Bujaki E, Dolan PT, et al. Engineering the Live-Attenuated polio vaccine to prevent reversion to virulence. Cell Host Microbe. 2020;27(5):736\u2013e7518. https:\/\/doi.org\/10.1016\/j.chom.2020.04.003.","journal-title":"CELL HOST MICROBE"},{"key":"2827_CR39","doi-asserted-by":"publisher","unstructured":"Yeh MT, Smith M, Carlyle S et al. Genetic stabilization of attenuated oral vaccines against poliovirus types 1 and 3. Nature. 2023; 619 NATURE. https:\/\/doi.org\/10.1038\/s41586-023-06212-3","DOI":"10.1038\/s41586-023-06212-3"},{"issue":"1","key":"2827_CR40","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/s40249-022-01028-1","volume":"11","author":"M Zhang","year":"2022","unstructured":"Zhang M, Yang J, Bai Y, et al. Epidemiological survey and genetic characterization of type 3 vaccine-derived poliovirus isolated from a patient with four doses of inactivated polio vaccine in Henan province, China. Infect Dis Poverty. 2022;11(1):124. https:\/\/doi.org\/10.1186\/s40249-022-01028-1.","journal-title":"INFECT DIS POVERTY"},{"key":"2827_CR41","unstructured":"Deshpande J, Ram M, Durrani S et al. Detecting polio through surveillance for acute flaccid paralysis (AFP). J Indian Med Assoc. 2005; 103 J Indian Med Assoc. PMID: 16821661."},{"issue":"1","key":"2827_CR42","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1186\/s12879-018-3070-4","volume":"18","author":"KM O\u2019Reilly","year":"2018","unstructured":"O\u2019Reilly KM, Verity R, Durry E, et al. Population sensitivity of acute flaccid paralysis and environmental surveillance for serotype 1 poliovirus in pakistan: an observational study. BMC Infect Dis. 2018;18(1):176. https:\/\/doi.org\/10.1186\/s12879-018-3070-4.","journal-title":"BMC Infect Dis"},{"key":"2827_CR43","unstructured":"Chen C, Xie H, Cui M et al. [An investigation on a case of hand-foot-mouth disease caused by coxsackie-virus A6 associated with a vaccine-derived poliovirus co-infection]. Zhonghua Liu Xing Bing Xue Za Zhi. 2014; 35 Zhonghua Liu Xing Bing Xue Za Zhi. PMID: 24685040."},{"key":"2827_CR44","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jcv.2015.08.017","volume":"72","author":"S Ma","year":"2015","unstructured":"Ma S, Du Z, Feng M, et al., et al. A severe case of co-infection with enterovirus 71 and vaccine-derived poliovirus type 1I. J Clin Virol. 2015;72:25\u20139. https:\/\/doi.org\/10.1016\/j.jcv.2015.08.017.","journal-title":"J CLIN VIROL"}],"container-title":["Virology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12985-025-02827-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12985-025-02827-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12985-025-02827-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T04:06:24Z","timestamp":1751083584000},"score":1,"resource":{"primary":{"URL":"https:\/\/virologyj.biomedcentral.com\/articles\/10.1186\/s12985-025-02827-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,28]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2827"],"URL":"https:\/\/doi.org\/10.1186\/s12985-025-02827-2","relation":{},"ISSN":["1743-422X"],"issn-type":[{"value":"1743-422X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,28]]},"assertion":[{"value":"21 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted for public health surveillance and was approved by The Medical Research Ethics Review Committee, Guangdong Provincial Center for Disease Control and Prevention.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"This manuscript has not been published or presented elsewhere in part or in entirety, and is not under consideration by another journal. All the authors have approved the manuscript and agree with submission to your esteemed journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"208"}}