{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:30:05Z","timestamp":1788219005544,"version":"build-2803163510"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virol J"],"DOI":"10.1186\/s12985-025-02858-9","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T08:39:09Z","timestamp":1753951149000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Investigating the link between HPV genotypes and cervical abnormality incidence in women with HPV infections: insights from a leading referral centre"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2817-6908","authenticated-orcid":false,"given":"Zahra","family":"Sadeghi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0623-6746","authenticated-orcid":false,"given":"Amir","family":"Aboofazeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0460-0690","authenticated-orcid":false,"given":"Sheida","family":"Sarrafzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naeimeh","family":"Tayebi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3005-909X","authenticated-orcid":false,"given":"Roxana","family":"Tajdini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9882-3360","authenticated-orcid":false,"given":"Fariba","family":"Yarandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mohammad","family":"Jazayeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"2858_CR1","doi-asserted-by":"publisher","first-page":"298","DOI":"10.3390\/pathogens12020298","volume":"12","author":"S Choi","year":"2023","unstructured":"Choi S, Ismail A, Pappas-Gogos G, Boussios S. HPV and cervical cancer: A review of epidemiology and screening uptake in the UK. Pathogens. 2023;12:298.","journal-title":"Pathogens"},{"key":"2858_CR2","doi-asserted-by":"publisher","first-page":"e2400066","DOI":"10.1200\/GO.24.00066","volume":"10","author":"A Fuady","year":"2024","unstructured":"Fuady A, Setiawan D, Man I, et al. Toward a framework to assess the financial and economic burden of cervical Cancer in Low- and Middle-Income countries: A systematic review. JCO Glob Oncol. 2024;10:e2400066.","journal-title":"JCO Glob Oncol"},{"key":"2858_CR3","doi-asserted-by":"publisher","first-page":"1132369","DOI":"10.3389\/fonc.2023.1132369","volume":"13","author":"A Akbari","year":"2023","unstructured":"Akbari A, Khayamzadeh M, Salmanian R, et al. Epidemiology and survival of cervical cancer in Iran based on National cancer registry data (2008\u20132014). Front Oncol. 2023;13:1132369.","journal-title":"Front Oncol"},{"key":"2858_CR4","doi-asserted-by":"crossref","unstructured":"Chan CK, Aimagambetova G, Ukybassova T et al. Human papillomavirus infection and cervical cancer: epidemiology, screening, and vaccination\u2014review of current perspectives. Journal of oncology. 2019; 2019.","DOI":"10.1155\/2019\/3257939"},{"key":"2858_CR5","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1080\/01443615.2019.1634030","volume":"40","author":"KS Okunade","year":"2020","unstructured":"Okunade KS. Human papillomavirus and cervical cancer. J Obstet Gynaecol. 2020;40:602\u201308.","journal-title":"J Obstet Gynaecol"},{"key":"2858_CR6","doi-asserted-by":"crossref","unstructured":"Pratiwi SE, Ysrafil Y, Mardhia M et al. A novel therapeutic multiepitope vaccine based on oncoprotein E6 and E7 of HPV 16 and 18: an in Silico approach. 2024.","DOI":"10.34172\/bi.2024.27846"},{"key":"2858_CR7","doi-asserted-by":"crossref","unstructured":"Adebamowo SN, Famooto A, Dareng EO et al. Clearance of type-specific, low-risk, and high-risk cervical human papillomavirus infections in HIV-negative and HIV-positive women. J Global Oncol. 2018; 4: JGO. 17.00129.","DOI":"10.1200\/JGO.17.00129"},{"key":"2858_CR8","doi-asserted-by":"publisher","first-page":"4053","DOI":"10.1038\/s41598-024-54754-x","volume":"14","author":"E Tesfaye","year":"2024","unstructured":"Tesfaye E, Kumbi B, Mandefro B, et al. Prevalence of human papillomavirus infection and associated factors among women attending cervical cancer screening in setting of addis ababa, Ethiopia. Sci Rep. 2024;14:4053.","journal-title":"Sci Rep"},{"key":"2858_CR9","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.ygyno.2012.11.003","volume":"128","author":"P Luhn","year":"2013","unstructured":"Luhn P, Walker J, Schiffman M, et al. The role of co-factors in the progression from human papillomavirus infection to cervical cancer. Gynecol Oncol. 2013;128:265\u201370.","journal-title":"Gynecol Oncol"},{"key":"2858_CR10","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1002\/ijc.28666","volume":"135","author":"E Roura","year":"2014","unstructured":"Roura E, Castellsague X, Pawlita M, et al. Smoking as a major risk factor for cervical cancer and pre-cancer: results from the EPIC cohort. Int J Cancer. 2014;135:453\u201366.","journal-title":"Int J Cancer"},{"key":"2858_CR11","doi-asserted-by":"publisher","first-page":"235","DOI":"10.3390\/medicina61020235","volume":"61","author":"\u0130 Kayar","year":"2025","unstructured":"Kayar \u0130, Goc G, Cetin F, Birge \u00d6. Impact of smoking on cervical histopathological changes in High-Risk HPV-Positive women: A matched Case\u2013Control study. Medicina. 2025;61:235.","journal-title":"Medicina"},{"key":"2858_CR12","doi-asserted-by":"crossref","unstructured":"Makuza JD, Nsanzimana S, Muhimpundu MA et al. Prevalence and risk factors for cervical cancer and pre-cancerous lesions in Rwanda. Pan Afr Med J. 2015; 22.","DOI":"10.11604\/pamj.2015.22.26.7116"},{"key":"2858_CR13","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1080\/14737140.2021.1888719","volume":"21","author":"G Nagelhout","year":"2021","unstructured":"Nagelhout G, Van Der Ebisch RM, et al. Is smoking an independent risk factor for developing cervical intra-epithelial neoplasia and cervical cancer? A systematic review and meta-analysis. Expert Rev Anticancer Ther. 2021;21:781\u201394.","journal-title":"Expert Rev Anticancer Ther"},{"key":"2858_CR14","doi-asserted-by":"publisher","first-page":"45","DOI":"10.4103\/0970-9371.93222","volume":"29","author":"MS Bal","year":"2012","unstructured":"Bal MS, Goyal R, Suri AK, Mohi MK. Detection of abnormal cervical cytology in Papanicolaou smears. J Cytology\/Indian Acad Cytologists. 2012;29:45.","journal-title":"J Cytology\/Indian Acad Cytologists"},{"key":"2858_CR15","doi-asserted-by":"publisher","first-page":"337","DOI":"10.4103\/apjon.apjon_15_18","volume":"5","author":"PL Sachan","year":"2018","unstructured":"Sachan PL, Singh M, Patel ML, Sachan R. A study on cervical cancer screening using pap smear test and clinical correlation. Asia-Pacific J Oncol Nurs. 2018;5:337\u201341.","journal-title":"Asia-Pacific J Oncol Nurs"},{"key":"2858_CR16","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.sxmr.2019.09.005","volume":"8","author":"SL Bedell","year":"2020","unstructured":"Bedell SL, Goldstein LS, Goldstein AR, Goldstein AT. Cervical cancer screening: past, present, and future. Sex Med Reviews. 2020;8:28\u201337.","journal-title":"Sex Med Reviews"},{"key":"2858_CR17","first-page":"39","volume":"102","author":"JV Burness","year":"2020","unstructured":"Burness JV, Schroeder JM, Warren JB. Cervical colposcopy: indications and risk assessment. Am Family Phys. 2020;102:39\u201348.","journal-title":"Am Family Phys"},{"key":"2858_CR18","first-page":"e195","volume":"25","author":"M S\u00e1nchez-Siles","year":"2020","unstructured":"S\u00e1nchez-Siles M, Remezal-Solano M, L\u00f3pez-L\u00f3pez AM, Camacho-Alonso F. Prevalence of human papillomavirus in the saliva of sexually active women with cervical intraepithelial neoplasias. Med Oral Patol Oral Cir Bucal. 2020;25:e195\u2013204.","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"2858_CR19","doi-asserted-by":"publisher","first-page":"e0264498","DOI":"10.1371\/journal.pone.0264498","volume":"17","author":"ZZA Mbulawa","year":"2022","unstructured":"Mbulawa ZZA, Phohlo K, Garcia-Jardon M, et al. High human papillomavirus (HPV)-35 prevalence among South African women with cervical intraepithelial neoplasia warrants attention. PLoS ONE. 2022;17:e0264498.","journal-title":"PLoS ONE"},{"key":"2858_CR20","doi-asserted-by":"publisher","first-page":"107327482211033","DOI":"10.1177\/10732748221103331","volume":"29","author":"LDC Alarc\u00f3n-Romero","year":"2022","unstructured":"Alarc\u00f3n-Romero LDC, Organista-Nava J, G\u00f3mez-G\u00f3mez Y, et al. Prevalence and distribution of human papillomavirus genotypes (1997\u20132019) and their association with cervical Cancer and precursor lesions in women from Southern Mexico. Cancer Control. 2022;29:10732748221103331.","journal-title":"Cancer Control"},{"key":"2858_CR21","doi-asserted-by":"publisher","first-page":"e32728","DOI":"10.5812\/jjm.32728","volume":"9","author":"A Piroozmand","year":"2016","unstructured":"Piroozmand A, Mostafavi Zadeh SM, Madani A, et al. The association of high risk human papillomaviruses in patients with cervical cancer: an evidence based study on patients with squamous cell dysplasia or carcinoma for evaluation of 23 human papilloma virus genotypes. Jundishapur J Microbiol. 2016;9:e32728.","journal-title":"Jundishapur J Microbiol"}],"container-title":["Virology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12985-025-02858-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12985-025-02858-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12985-025-02858-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T08:54:03Z","timestamp":1757321643000},"score":1,"resource":{"primary":{"URL":"https:\/\/virologyj.biomedcentral.com\/articles\/10.1186\/s12985-025-02858-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,31]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2858"],"URL":"https:\/\/doi.org\/10.1186\/s12985-025-02858-9","relation":{},"ISSN":["1743-422X"],"issn-type":[{"value":"1743-422X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,31]]},"assertion":[{"value":"28 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Ethics Committees of Tehran University of Medical Sciences, Iran (IR.TUMS.SPH.REC.1403.046) approved this study. A consent letter was obtained from all patients involved in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Guidelines"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"264"}}