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As key mediators of cytotoxic immunity, CD8 T cells play a crucial and multifaceted role in ZIKV pathogenesis. While essential for controlling viral replication, their infiltration into the central nervous system (CNS)\u2014an immune-privileged site\u2014raises potential concerns regarding immunopathology. This review explores the dual roles of CD8 T cells during ZIKV infection, emphasizing both their antiviral functions and their potential to drive neuroinflammation. We examine how ZIKV infection and chemokine-mediated signals facilitate immune cell trafficking across the blood\u2013brain barrier, drawing parallels with other neurotropic flaviviruses. We also explore how therapeutic agents, such as the S1P receptor modulator FTY720, influence lymphocyte trafficking and CNS immune regulation. Finally, we review emerging interventions\u2014including vaccines, antivirals, immunomodulators, and passive immunotherapies\u2014that aim to achieve effective viral control while minimizing neural damage. A balanced understanding of immune cell responses in flavivirus infections is essential for guiding future therapeutic strategies against ZIKV and related neurotropic viruses.<\/jats:p>","DOI":"10.1186\/s12985-025-02866-9","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T07:04:05Z","timestamp":1752563045000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["CD8 T cell dynamics and immune cell trafficking in ZIKV infection: implications for neuroinflammation and therapy"],"prefix":"10.1186","volume":"22","author":[{"given":"Sungjun","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"issue":"12 Suppl","key":"2866_CR1","doi-asserted-by":"publisher","first-page":"S98","DOI":"10.1038\/nm1144","volume":"10","author":"JS Mackenzie","year":"2004","unstructured":"Mackenzie JS, Gubler DJ, Petersen LR. 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