{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:12:39Z","timestamp":1784099559004,"version":"3.55.0"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":77,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the National Natural Science Foundation of China CDC","award":["IVDC-202402"],"award-info":[{"award-number":["IVDC-202402"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virol J"],"DOI":"10.1186\/s12985-026-03164-8","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:55:33Z","timestamp":1777449333000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MG132-mediated inhibition of rabies virus replication via the Nrf2\/SQSTM1\/PINK1\/Parkin autophagy pathway"],"prefix":"10.1186","volume":"23","author":[{"given":"Ying Lin","family":"Chi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu Qing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu Yang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"issue":"2","key":"3164_CR1","doi-asserted-by":"publisher","first-page":"569","DOI":"10.20506\/rst.37.2.2825","volume":"37","author":"AC Jackson","year":"2018","unstructured":"Jackson AC. Rabies: a medical perspective. Rev Sci Tech. 2018;37(2):569\u201380.","journal-title":"Rev Sci Tech"},{"key":"3164_CR2","unstructured":"Swinkels HM, Koury R, Warrington SJ. Rabies. 2025 Mar 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan."},{"issue":"11","key":"3164_CR3","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.medcli.2023.11.017","volume":"162","author":"M Arsuaga","year":"2024","unstructured":"Arsuaga M, de Miguel Buckley R, Diaz-Menendez M. Rabies: Epidemiological update and pre- and post-exposure management. Med Clin (Barc). 2024;162(11):542\u20138.","journal-title":"Med Clin (Barc)"},{"issue":"1","key":"3164_CR4","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/j.1743-7563.2012.01535.x","volume":"9","author":"N Guo","year":"2013","unstructured":"Guo N, Peng Z. MG132, a proteasome inhibitor, induces apoptosis in tumor cells. Asia Pac J Clin Oncol. 2013;9(1):6\u201311.","journal-title":"Asia Pac J Clin Oncol"},{"key":"3164_CR5","doi-asserted-by":"publisher","first-page":"852","DOI":"10.3389\/fmicb.2020.00852","volume":"11","author":"Y Chen","year":"2020","unstructured":"Chen Y, Fan S, Zhao M, Wu K, Zhu E, Ma S, He W, Deng S, Xu H, Zhang J, et al. MG132 Attenuates the Replication of Classical Swine Fever Virus in vitro. Front Microbiol. 2020;11:852.","journal-title":"Front Microbiol"},{"issue":"1","key":"3164_CR6","doi-asserted-by":"publisher","first-page":"6671","DOI":"10.1038\/s41598-020-63438-1","volume":"10","author":"H Ishimaru","year":"2020","unstructured":"Ishimaru H, Hosokawa K, Sugimoto A, Tanaka R, Watanabe T, Fujimuro M. MG132 exerts anti-viral activity against HSV-1 by overcoming virus-mediated suppression of the ERK signaling pathway. Sci Rep. 2020;10(1):6671.","journal-title":"Sci Rep"},{"issue":"124","key":"3164_CR7","first-page":"837","volume":"60","author":"Y Wang","year":"2013","unstructured":"Wang Y, Li XL, Yu YS, Tang ZH, Zang GQ. Inhibition of hepatitis B virus production in vitro by proteasome inhibitor MG132. Hepatogastroenterology. 2013;60(124):837\u201341.","journal-title":"Hepatogastroenterology"},{"key":"3164_CR8","doi-asserted-by":"publisher","first-page":"3671751","DOI":"10.1155\/2017\/3671751","volume":"2017","author":"L Kong","year":"2017","unstructured":"Kong L, Wang Y, Luo M, Tan Y, Cui W, Miao L. Prevention of Streptozotocin-Induced Diabetic Nephropathy by MG132: Possible Roles of Nrf2 and IkappaB. Oxid Med Cell Longev. 2017;2017:3671751.","journal-title":"Oxid Med Cell Longev"},{"key":"3164_CR9","doi-asserted-by":"crossref","unstructured":"Kiflu AB. The Immune Escape Strategy of Rabies Virus and Its Pathogenicity Mechanisms. Viruses. 2024 Nov 14;16(11):1774.","DOI":"10.3390\/v16111774"},{"key":"3164_CR10","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.freeradbiomed.2024.05.034","volume":"221","author":"M Ribeiro","year":"2024","unstructured":"Ribeiro M, Alvarenga L, Coutinho-Wolino KS, Nakao LS, Cardozo LF, Mafra D. Sulforaphane upregulates the mRNA expression of NRF2 and NQO1 in non-dialysis patients with chronic kidney disease. Free Radic Biol Med. 2024;221:181\u20137.","journal-title":"Free Radic Biol Med"},{"key":"3164_CR11","doi-asserted-by":"publisher","first-page":"1457010","DOI":"10.3389\/fimmu.2024.1457010","volume":"15","author":"SA O\u2019Rourke","year":"2024","unstructured":"O\u2019Rourke SA, Shanley LC, Dunne A. The Nrf2-HO-1 system and inflammaging. Front Immunol. 2024;15:1457010.","journal-title":"Front Immunol"},{"key":"3164_CR12","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.neulet.2017.06.014","volume":"656","author":"T Tominaga","year":"2017","unstructured":"Tominaga T, Goto M, Onoue T, Mizoguchi A, Sugiyama M, Tsunekawa T, Hagiwara D, Morishita Y, Ito Y, Iwama S, et al. Sequestosome 1 (SQSTM1\/p62) maintains protein folding capacity under endoplasmic reticulum stress in mouse hypothalamic organotypic culture. Neurosci Lett. 2017;656:103\u20137.","journal-title":"Neurosci Lett"},{"issue":"6","key":"3164_CR13","doi-asserted-by":"publisher","first-page":"355","DOI":"10.2131\/jts.48.355","volume":"48","author":"Y Takanezawa","year":"2023","unstructured":"Takanezawa Y, Nakamura R, Ohshiro Y, Uraguchi S, Kiyono M. Proteasome and p62\/SQSTM1 are involved in methylmercury toxicity mitigation in mouse embryonic fibroblast cells. J Toxicol Sci. 2023;48(6):355\u201361.","journal-title":"J Toxicol Sci"},{"issue":"1","key":"3164_CR14","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1186\/s12985-023-02213-w","volume":"20","author":"YL Chi","year":"2023","unstructured":"Chi YL, Xie Y, Liu SQ, Zhu WY. Bardoxolone methyl inhibits the infection of rabies virus via Nrf2 pathway activation in vitro. Virol J. 2023;20(1):258.","journal-title":"Virol J"},{"issue":"3","key":"3164_CR15","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1093\/carcin\/bgab116","volume":"43","author":"MS Gilardini Montani","year":"2022","unstructured":"Gilardini Montani MS, Tarquini G, Santarelli R, Gonnella R, Romeo MA, Benedetti R, Arena A, Faggioni A, Cirone M. p62\/SQSTM1 promotes mitophagy and activates the NRF2-mediated antioxidant and anti-inflammatory response restraining EBV-driven B lymphocyte proliferation. Carcinogenesis. 2022;43(3):277\u201387.","journal-title":"Carcinogenesis"},{"issue":"3","key":"3164_CR16","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/ncb2021","volume":"12","author":"M Komatsu","year":"2010","unstructured":"Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, et al. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol. 2010;12(3):213\u201323.","journal-title":"Nat Cell Biol"},{"issue":"2","key":"3164_CR17","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.freeradbiomed.2006.10.043","volume":"42","author":"E Warabi","year":"2007","unstructured":"Warabi E, Takabe W, Minami T, Inoue K, Itoh K, Yamamoto M, Ishii T, Kodama T, Noguchi N. Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: role of reactive oxygen\/nitrogen species. Free Radic Biol Med. 2007;42(2):260\u20139.","journal-title":"Free Radic Biol Med"},{"issue":"21","key":"3164_CR18","doi-asserted-by":"publisher","first-page":"16023","DOI":"10.1074\/jbc.275.21.16023","volume":"275","author":"T Ishii","year":"2000","unstructured":"Ishii T, Itoh K, Takahashi S, Sato H, Yanagawa T, Katoh Y, Bannai S, Yamamoto M. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem. 2000;275(21):16023\u20139.","journal-title":"J Biol Chem"},{"issue":"34","key":"3164_CR19","doi-asserted-by":"publisher","first-page":"13561","DOI":"10.1073\/pnas.1121572109","volume":"109","author":"K Taguchi","year":"2012","unstructured":"Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H, Yamamoto M. Keap1 degradation by autophagy for the maintenance of redox homeostasis. Proc Natl Acad Sci U S A. 2012;109(34):13561\u20136.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"3164_CR20","doi-asserted-by":"publisher","first-page":"8022","DOI":"10.1096\/fj.201900133R","volume":"33","author":"M Yamada","year":"2019","unstructured":"Yamada M, Iwata M, Warabi E, Oishi H, Lira VA, Okutsu M. p62\/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle. FASEB J. 2019;33(7):8022\u201332.","journal-title":"FASEB J"},{"issue":"10","key":"3164_CR21","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/j.ajpath.2023.02.015","volume":"193","author":"H Qian","year":"2023","unstructured":"Qian H, Ding WX. SQSTM1\/p62 and Hepatic Mallory-Denk Body Formation in Alcohol-Associated Liver Disease. Am J Pathol. 2023;193(10):1415\u201326.","journal-title":"Am J Pathol"},{"issue":"8","key":"3164_CR22","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1080\/15548627.2024.2338575","volume":"20","author":"Y Yuan","year":"2024","unstructured":"Yuan Y, Fang A, Wang Z, Chen H, Fu ZF, Zhou M, Zhao L. The matrix protein of lyssavirus hijacks autophagosome for efficient egress by recruiting NEDD4 through its PPxY motif. Autophagy. 2024;20(8):1723\u201340.","journal-title":"Autophagy"},{"issue":"6","key":"3164_CR23","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1089\/ars.2018.7649","volume":"31","author":"SJ Jeong","year":"2019","unstructured":"Jeong SJ, Zhang X, Rodriguez-Velez A, Evans TD, Razani B. p62\/SQSTM1 and Selective Autophagy in Cardiometabolic Diseases. Antioxid Redox Signal. 2019;31(6):458\u201371.","journal-title":"Antioxid Redox Signal"},{"issue":"5","key":"3164_CR24","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1089\/dna.2012.1915","volume":"32","author":"X Lin","year":"2013","unstructured":"Lin X, Li S, Zhao Y, Ma X, Zhang K, He X, Wang Z. Interaction domains of p62: a bridge between p62 and selective autophagy. DNA Cell Biol. 2013;32(5):220\u20137.","journal-title":"DNA Cell Biol"},{"issue":"1","key":"3164_CR25","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/s41467-022-28171-5","volume":"13","author":"K Miyakawa","year":"2022","unstructured":"Miyakawa K, Nishi M, Ogawa M, Matsunaga S, Sugiyama M, Nishitsuji H, Kimura H, Ohnishi M, Watashi K, Shimotohno K, et al. Galectin-9 restricts hepatitis B virus replication via p62\/SQSTM1-mediated selective autophagy of viral core proteins. Nat Commun. 2022;13(1):531.","journal-title":"Nat Commun"},{"issue":"10","key":"3164_CR26","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1080\/15548627.2016.1196315","volume":"12","author":"J Peng","year":"2016","unstructured":"Peng J, Zhu S, Hu L, Ye P, Wang Y, Tian Q, Mei M, Chen H, Guo X. Wild-type rabies virus induces autophagy in human and mouse neuroblastoma cell lines. Autophagy. 2016;12(10):1704\u201320.","journal-title":"Autophagy"},{"key":"3164_CR27","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.virol.2023.05.012","volume":"585","author":"Y Xie","year":"2023","unstructured":"Xie Y, Chi YL, Liu SQ, Zhu WY. BCX4430 inhibits the replication of rabies virus by suppressing mTOR-dependent autophagy invitro. Virology. 2023;585:21\u201331.","journal-title":"Virology"},{"key":"3164_CR28","doi-asserted-by":"crossref","unstructured":"Tu Z, Gong W, Zhang Y, Feng Y, Liu Y, Tu C. Inhibition of Rabies Virus by 1,2,3,4,6-Penta-O-galloyl-beta-d-Glucose Involves mTOR-Dependent Autophagy. Viruses 2018, 10(4).","DOI":"10.3390\/v10040201"},{"issue":"4","key":"3164_CR29","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1007\/s13365-015-0320-8","volume":"21","author":"W Kammouni","year":"2015","unstructured":"Kammouni W, Wood H, Saleh A, Appolinario CM, Fernyhough P, Jackson AC. Rabies virus phosphoprotein interacts with mitochondrial Complex I and induces mitochondrial dysfunction and oxidative stress. J Neurovirol. 2015;21(4):370\u201382.","journal-title":"J Neurovirol"},{"issue":"2","key":"3164_CR30","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/ncb2012","volume":"12","author":"S Geisler","year":"2010","unstructured":"Geisler S, Holmstrom KM, Skujat D, Fiesel FC, Rothfuss OC, Kahle PJ, Springer W. PINK1\/Parkin-mediated mitophagy is dependent on VDAC1 and p62\/SQSTM1. Nat Cell Biol. 2010;12(2):119\u201331.","journal-title":"Nat Cell Biol"},{"issue":"5674","key":"3164_CR31","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1126\/science.1096284","volume":"304","author":"EM Valente","year":"2004","unstructured":"Valente EM, Abou-Sleiman PM, Caputo V, Muqit MM, Harvey K, Gispert S, Ali Z, Del Turco D, Bentivoglio AR, Healy DG, et al. Hereditary early-onset Parkinson\u2019s disease caused by mutations in PINK1. Science. 2004;304(5674):1158\u201360.","journal-title":"Science"},{"issue":"6676","key":"3164_CR32","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/33416","volume":"392","author":"T Kitada","year":"1998","unstructured":"Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Y, Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature. 1998;392(6676):605\u20138.","journal-title":"Nature"},{"key":"3164_CR33","doi-asserted-by":"crossref","unstructured":"Mohanty S, Suklabaidya S, Mnatsakanyan N, Jacobson S, Harhaj EW. HTLV-1 Tax induces PINK1-Parkin-dependent mitophagy to mitigate activation of the cGAS-STING pathway. bioRxiv 2025.","DOI":"10.1101\/2025.03.15.643451"},{"issue":"6","key":"3164_CR34","doi-asserted-by":"publisher","first-page":"e0148023","DOI":"10.1128\/mbio.01480-23","volume":"14","author":"J Cheng","year":"2023","unstructured":"Cheng J, Wang Y, Yin L, Liang W, Zhang J, Ma C, Zhang Y, Liu B, Wang J, Zhao W, et al. The nonstructural protein 1 of respiratory syncytial virus hijacks host mitophagy as a novel mitophagy receptor to evade the type I IFN response in HEp-2 cells. mBio. 2023;14(6):e0148023.","journal-title":"mBio"},{"issue":"7","key":"3164_CR35","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1080\/15548627.2021.1990515","volume":"18","author":"Y Gong","year":"2022","unstructured":"Gong Y, Tang N, Liu P, Sun Y, Lu S, Liu W, Tan L, Song C, Qiu X, Liao Y, et al. Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells. Autophagy. 2022;18(7):1503\u201321.","journal-title":"Autophagy"},{"issue":"6","key":"3164_CR36","first-page":"790","volume":"32","author":"P Yu","year":"2016","unstructured":"Yu P, Tao X, Wang L, Tang Q, Liu S, Zhu W. [Preparation and Preliminary Application of a Virus Library for the Neutralizing Activity of a Monoclonal Antibody Against the Rabies Virus]. Bing Du Xue Bao. 2016;32(6):790\u20135.","journal-title":"Bing Du Xue Bao"},{"key":"3164_CR37","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/s12974-014-0146-y","volume":"11","author":"Y Huang","year":"2014","unstructured":"Huang Y, Jiao S, Tao X, Tang Q, Jiao W, Xiao J, Xu X, Zhang Y, Liang G, Wang H. Met-CCL5 represents an immunotherapy strategy to ameliorate rabies virus infection. J Neuroinflammation. 2014;11:146.","journal-title":"J Neuroinflammation"},{"key":"3164_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.antiviral.2018.03.011","volume":"154","author":"PD Anindita","year":"2018","unstructured":"Anindita PD, Sasaki M, Okada K, Ito N, Sugiyama M, Saito-Tarashima N, Minakawa N, Shuto S, Otsuguro S, Ichikawa S, et al. Ribavirin-related compounds exert in vitro inhibitory effects toward rabies virus. Antiviral Res. 2018;154:1\u20139.","journal-title":"Antiviral Res"},{"key":"3164_CR39","doi-asserted-by":"crossref","unstructured":"Smith TG, Jackson FR, Morgan CN, Carson WC, Martin BE, Gallardo-Romero N, Ellison JA, Greenberg L, Hodge T, Squiquera L, Sulley J, Olson VA, Hutson CL. Antiviral Ranpirnase TMR-001 Inhibits Rabies Virus Release and Cell-to-Cell Infection In Vitro. Viruses. 2020 Feb 5;12(2):177.","DOI":"10.3390\/v12020177"},{"key":"3164_CR40","doi-asserted-by":"crossref","unstructured":"Smith TG, Gilbert AT. Comparison of a Micro-Neutralization Test with the Rapid Fluorescent Focus Inhibition Test for Measuring Rabies Virus Neutralizing Antibodies. Trop Med Infect Dis. 2017;2(3):24.","DOI":"10.3390\/tropicalmed2030024"},{"issue":"29","key":"3164_CR41","doi-asserted-by":"publisher","first-page":"17195","DOI":"10.1073\/pnas.2006560117","volume":"117","author":"UK Shigdel","year":"2020","unstructured":"Shigdel UK, Lee SJ, Sowa ME, Bowman BR, Robison K, Zhou M, Pua KH, Stiles DT, Blodgett JAV, Udwary DW, et al. Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface. Proc Natl Acad Sci U S A. 2020;117(29):17195\u2013203.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3164_CR42","doi-asserted-by":"crossref","unstructured":"Pasquereau S, Nehme Z, Haidar Ahmad S, Daouad F, Van Assche J, Wallet C, Schwartz C, Rohr O, Morot-Bizot S, Herbein G. Resveratrol Inhibits HCoV-229E and SARS-CoV-2 Coronavirus Replication In Vitro. Viruses. 2021 Feb 23;13(2):354.","DOI":"10.3390\/v13020354"},{"issue":"1","key":"3164_CR43","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s12985-020-01429-4","volume":"17","author":"SQ Liu","year":"2020","unstructured":"Liu SQ, Xie Y, Gao X, Wang Q, Zhu WY. Inflammatory response and MAPK and NF-kappaB pathway activation induced by natural street rabies virus infection in the brain tissues of dogs and humans. Virol J. 2020;17(1):157.","journal-title":"Virol J"},{"issue":"1","key":"3164_CR44","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/s41541-024-00925-w","volume":"9","author":"J Li","year":"2024","unstructured":"Li J, Yu P, Liu Q, Xu L, Chen Y, Li Y, Zhang F, Zhu W, Peng Y. Safety and efficacy assessment of an mRNA rabies vaccine in dogs, rodents, and cynomolgus macaques. NPJ Vaccines. 2024;9(1):130.","journal-title":"NPJ Vaccines"},{"key":"3164_CR45","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.molimm.2020.06.011","volume":"125","author":"SQ Liu","year":"2020","unstructured":"Liu SQ, Gao X, Xie Y, Wang Q, Zhu WY. Rabies viruses of different virulence regulates inflammatory responses both in vivo and in vitro via MAPK and NF-kappaB pathway. Mol Immunol. 2020;125:70\u201382.","journal-title":"Mol Immunol"},{"key":"3164_CR46","doi-asserted-by":"crossref","unstructured":"Gureev AP, Sadovnikova IS, Starkov NN, Starkov AA, Popov VN. p62-Nrf2-p62 Mitophagy Regulatory Loop as a Target for Preventive Therapy of Neurodegenerative Diseases. Brain Sci. 2020 Nov 12;10(11):847.","DOI":"10.3390\/brainsci10110847"},{"key":"3164_CR47","doi-asserted-by":"publisher","first-page":"110260","DOI":"10.1016\/j.vetmic.2024.110260","volume":"298","author":"J Zhao","year":"2024","unstructured":"Zhao J, Wang Q, Liu Z, Sun M, Zhou R, Fu ZF, Zhao L, Zhou M. Z-Ligustilide restricts rabies virus replication by inducing ferroptosis through the ACSL4-LPCAT3-POR pathway. Vet Microbiol. 2024;298:110260.","journal-title":"Vet Microbiol"},{"key":"3164_CR48","doi-asserted-by":"publisher","first-page":"105977","DOI":"10.1016\/j.antiviral.2024.105977","volume":"229","author":"K Konishi","year":"2024","unstructured":"Konishi K, Kusakabe S, Kawaguchi N, Shishido T, Ito N, Harada M, Inoue S, Maeda K, Hall WW, Orba Y, et al. : beta-d-N(4)-hydroxycytidine, a metabolite of molnupiravir, exhibits in vitro antiviral activity against rabies virus. Antiviral Res. 2024;229:105977.","journal-title":"Antiviral Res"},{"issue":"10","key":"3164_CR49","doi-asserted-by":"publisher","first-page":"e0140586","DOI":"10.1371\/journal.pone.0140586","volume":"10","author":"Z Luo","year":"2015","unstructured":"Luo Z, Tian D, Zhou M, Xiao W, Zhang Y, Li M, Sui B, Wang W, Guan H, Chen H, et al. lambda-Carrageenan P32 Is a Potent Inhibitor of Rabies Virus Infection. PLoS ONE. 2015;10(10):e0140586.","journal-title":"PLoS ONE"},{"issue":"3","key":"3164_CR50","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1080\/01480545.2022.2066116","volume":"46","author":"A Kara","year":"2023","unstructured":"Kara A, Yakut S, Caglayan C, Atcali T, Ulucan A, Kandemir FM. Evaluation of the toxicological effects of favipiravir (T-705) on liver and kidney in rats: biochemical and histopathological approach. Drug Chem Toxicol. 2023;46(3):546\u201356.","journal-title":"Drug Chem Toxicol"},{"issue":"2","key":"3164_CR51","first-page":"e4012","volume":"11","author":"N Butt","year":"2019","unstructured":"Butt N, Akbar A, Abbasi A, Reema S, Baqar JB, Shaikh QH. Safety and Efficacy of Sofosbuvir with Ribavirin(R) in Hepatitis C, Genotype 3 Patients with Cirrhosis: A Real-world Experience. Cureus. 2019;11(2):e4012.","journal-title":"Cureus"},{"issue":"9","key":"3164_CR52","doi-asserted-by":"publisher","first-page":"5219","DOI":"10.1128\/JVI.02643-12","volume":"87","author":"R Wang","year":"2013","unstructured":"Wang R, Nan Y, Yu Y, Zhang YJ. Porcine reproductive and respiratory syndrome virus Nsp1beta inhibits interferon-activated JAK\/STAT signal transduction by inducing karyopherin-alpha1 degradation. J Virol. 2013;87(9):5219\u201328.","journal-title":"J Virol"},{"issue":"4","key":"3164_CR53","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3851\/IMP1479","volume":"20","author":"S Ujino","year":"2010","unstructured":"Ujino S, Yamaguchi S, Shimotohno K, Takaku H. Combination therapy for hepatitis C virus with heat-shock protein 90 inhibitor 17-AAG and proteasome inhibitor MG132. Antivir Chem Chemother. 2010;20(4):161\u20137.","journal-title":"Antivir Chem Chemother"},{"issue":"1","key":"3164_CR54","doi-asserted-by":"publisher","first-page":"E87","DOI":"10.1152\/ajpendo.00430.2012","volume":"304","author":"W Cui","year":"2013","unstructured":"Cui W, Li B, Bai Y, Miao X, Chen Q, Sun W, Tan Y, Luo P, Zhang C, Zheng S, et al. Potential role for Nrf2 activation in the therapeutic effect of MG132 on diabetic nephropathy in OVE26 diabetic mice. Am J Physiol Endocrinol Metab. 2013;304(1):E87\u201399.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"3164_CR55","doi-asserted-by":"publisher","first-page":"101279","DOI":"10.1016\/j.mam.2024.101279","volume":"97","author":"K Muzammil","year":"2024","unstructured":"Muzammil K, Sabah Ghnim Z, Saeed Gataa I, Fawzi Al-Hussainy A, Ali Soud N, Adil M, Ali Shallan M, Yasamineh S. NRF2-mediated regulation of lipid pathways in viral infection. Mol Aspects Med. 2024;97:101279.","journal-title":"Mol Aspects Med"},{"issue":"12","key":"3164_CR56","doi-asserted-by":"publisher","first-page":"4062","DOI":"10.1080\/15548627.2021.1900498","volume":"17","author":"J Li","year":"2021","unstructured":"Li J, Tian M, Hua T, Wang H, Yang M, Li W, Zhang X, Yuan H. Combination of autophagy and NFE2L2\/NRF2 activation as a treatment approach for neuropathic pain. Autophagy. 2021;17(12):4062\u201382.","journal-title":"Autophagy"},{"issue":"11","key":"3164_CR57","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1080\/15548627.2020.1712108","volume":"16","author":"DH Lee","year":"2020","unstructured":"Lee DH, Park JS, Lee YS, Han J, Lee DK, Kwon SW, Han DH, Lee YH, Bae SH. SQSTM1\/p62 activates NFE2L2\/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity. Autophagy. 2020;16(11):1949\u201373.","journal-title":"Autophagy"},{"issue":"1","key":"3164_CR58","doi-asserted-by":"publisher","first-page":"796","DOI":"10.3892\/mmr.2015.4599","volume":"13","author":"W Bao","year":"2016","unstructured":"Bao W, Gu Y, Ta L, Wang K, Xu Z. Induction of autophagy by the MG\u2013132 proteasome inhibitor is associated with endoplasmic reticulum stress in MCF\u20137 cells. Mol Med Rep. 2016;13(1):796\u2013804.","journal-title":"Mol Med Rep"},{"issue":"2","key":"3164_CR59","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.bbrc.2008.07.031","volume":"374","author":"WK Wu","year":"2008","unstructured":"Wu WK, Wu YC, Yu L, Li ZJ, Sung JJ, Cho CH. Induction of autophagy by proteasome inhibitor is associated with proliferative arrest in colon cancer cells. Biochem Biophys Res Commun. 2008;374(2):258\u201363.","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"3164_CR60","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.bbrc.2016.09.151","volume":"479","author":"MM Ji","year":"2016","unstructured":"Ji MM, Lee JM, Mon H, Xu J, Tatsuke T, Kusakabe T. Proteasome inhibitor MG132 impairs autophagic flux through compromising formation of autophagosomes in Bombyx cells. Biochem Biophys Res Commun. 2016;479(4):690\u20136.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"3164_CR61","doi-asserted-by":"publisher","first-page":"3720","DOI":"10.1038\/s41467-022-31213-7","volume":"13","author":"HWS Tan","year":"2022","unstructured":"Tan HWS, Lu G, Dong H, Cho YL, Natalia A, Wang L, Chan C, Kappei D, Taneja R, Ling SC, et al. A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery. Nat Commun. 2022;13(1):3720.","journal-title":"Nat Commun"},{"issue":"9","key":"3164_CR62","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1093\/hmg\/ddr048","volume":"20","author":"NC Chan","year":"2011","unstructured":"Chan NC, Salazar AM, Pham AH, Sweredoski MJ, Kolawa NJ, Graham RL, Hess S, Chan DC. Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy. Hum Mol Genet. 2011;20(9):1726\u201337.","journal-title":"Hum Mol Genet"},{"issue":"7","key":"3164_CR63","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1083\/jcb.201007013","volume":"191","author":"A Tanaka","year":"2010","unstructured":"Tanaka A, Cleland MM, Xu S, Narendra DP, Suen DF, Karbowski M, Youle RJ. Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. J Cell Biol. 2010;191(7):1367\u201380.","journal-title":"J Cell Biol"},{"issue":"11","key":"3164_CR64","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1080\/15548627.2019.1643185","volume":"15","author":"T Yamada","year":"2019","unstructured":"Yamada T, Dawson TM, Yanagawa T, Iijima M, Sesaki H. SQSTM1\/p62 promotes mitochondrial ubiquitination independently of PINK1 and PRKN\/parkin in mitophagy. Autophagy. 2019;15(11):2012\u20138.","journal-title":"Autophagy"},{"issue":"3","key":"3164_CR65","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1128\/JVI.02177-12","volume":"87","author":"R Mateo","year":"2013","unstructured":"Mateo R, Nagamine CM, Spagnolo J, Mendez E, Rahe M, Gale M Jr., Yuan J, Kirkegaard K. Inhibition of cellular autophagy deranges dengue virion maturation. J Virol. 2013;87(3):1312\u201321.","journal-title":"J Virol"},{"key":"3164_CR66","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.gde.2017.01.016","volume":"44","author":"AJ Whitworth","year":"2017","unstructured":"Whitworth AJ, Pallanck LJ. PINK1\/Parkin mitophagy and neurodegeneration-what do we really know in vivo? Curr Opin Genet Dev. 2017;44:47\u201353.","journal-title":"Curr Opin Genet Dev"},{"key":"3164_CR67","doi-asserted-by":"publisher","first-page":"1460286","DOI":"10.3389\/fimmu.2024.1460286","volume":"15","author":"Y Zhu","year":"2024","unstructured":"Zhu Y, Zhang J, Deng Q, Chen X. Mitophagy-associated programmed neuronal death and neuroinflammation. Front Immunol. 2024;15:1460286.","journal-title":"Front Immunol"},{"issue":"8","key":"3164_CR68","doi-asserted-by":"publisher","first-page":"10856","DOI":"10.1007\/s12035-025-04936-z","volume":"62","author":"J Tian","year":"2025","unstructured":"Tian J, Mao Y, Liu D, Li T, Wang Y, Zhu C. Mitophagy in Brain Injuries: Mechanisms, Roles, and Therapeutic Potential. Mol Neurobiol. 2025;62(8):10856\u201368.","journal-title":"Mol Neurobiol"}],"container-title":["Virology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12985-026-03164-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12985-026-03164-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12985-026-03164-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:02:45Z","timestamp":1784098965000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12985-026-03164-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,29]]},"references-count":68,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3164"],"URL":"https:\/\/doi.org\/10.1186\/s12985-026-03164-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-8283741\/v1","asserted-by":"object"}]},"ISSN":["1743-422X"],"issn-type":[{"value":"1743-422X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,29]]},"assertion":[{"value":"5 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All experiments with mice were performed at the Animal Experiment Center of the Chinese Center for Disease Control and Prevention in accordance with institutional guidelines for the care and use of laboratory animals, upon approval by the Animal Ethics Committee of the National Institute for Viral Disease Control and Prevention, China CDC (approval number: bdbs20250331045) (Title: Inhibitory effects of small-molecule inhibitors on rabies virus) (Date of approval: 31\/03\/2025).","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the authors give their consent for publication in Virology Journal.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"176"}}