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Chronic use of low-dose aspirin is associated with the occurrence of gastric ulcer. The aim of this study was to investigate the healing potential of <jats:italic>Lycium barbarum<\/jats:italic> polysaccharides (LBP) from Chinese Goji berry and C-phycocyanin (CPC) from <jats:italic>Spirulina platensis<\/jats:italic> on gastric ulcer in rats.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Male Sprague\u2013Dawley rats were divided into five groups: normal, aspirin (700\u00a0mg\/kg bw), LBP (aspirin\u2009+\u2009100\u00a0mg\/kg bw\/d LBP), CPC (aspirin\u2009+\u200950\u00a0mg\/kg bw\/d CPC), and MIX (aspirin\u2009+\u200950\u00a0mg\/kg bw\/d LBP\u2009+\u200925\u00a0mg\/kg bw\/d CPC) groups. Gastric ulcer was developed by daily oral feeding of aspirin for 8\u00a0weeks. Treatments were given orally a week before ulcer induction for 9\u00a0weeks.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The MIX group elevated gastric cyclooxygenase-1, prostaglandin E<jats:sub>2<\/jats:sub>, and total nitrite and nitrate levels by 139%, 86%, and 66%, respectively, compared with the aspirin group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Moreover, the MIX group reduced lipid peroxides malondialdehyde levels by 78% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The treatment of LBP and\/or CPC increased gastric <jats:italic>Bifidobacterium<\/jats:italic> relative abundance by 2.5\u20134.0 times compared with the aspirin group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>We conclude that combined LBP and CPC enhance gastroprotective factors, inhibit lipid peroxidation, and increase gastric <jats:italic>Bifidobacterium<\/jats:italic> relative abundance. Combined LBP and CPC have protective potential against gastric ulcer caused by aspirin in rats.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12986-020-00538-9","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T22:03:49Z","timestamp":1609970629000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Combined Lycium barbarum polysaccharides and C-phycocyanin increase gastric Bifidobacterium relative abundance and protect against gastric ulcer caused by aspirin in rats"],"prefix":"10.1186","volume":"18","author":[{"given":"Shu-Yu","family":"Hsieh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Zhi","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Hsuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey A.","family":"Tinkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatoly V.","family":"Skalny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3610-9580","authenticated-orcid":false,"given":"Jane C.-J.","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,6]]},"reference":[{"key":"538_CR1","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0140-6736(02)11030-0","volume":"360","author":"FK Chan","year":"2002","unstructured":"Chan FK, Leung WK. 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