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Various physical, transport and immune properties tightly regulate molecule movement between the blood and the brain to maintain brain homeostasis. A recent study utilizing a pan-endothelial, constitutive\n                    <jats:italic>Tie2-Cre<\/jats:italic>\n                    showed that paracellular passage of blood proteins into the brain is governed by endocytic and cell signaling protein low-density lipoprotein receptor\u2013related protein 1 (LRP1). Taking advantage of conditional\n                    <jats:italic>Slco1c1-CreER<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>T2<\/jats:italic>\n                    <\/jats:sup>\n                    specific to CNS endothelial cells and choroid plexus epithelial cells we now supplement previous results and show that brain endothelial\n                    <jats:italic>Lrp1<\/jats:italic>\n                    ablation results in protease-mediated tight junction degradation, P-glycoprotein (P-gp) reduction and a loss of BBB integrity.\n                  <\/jats:p>","DOI":"10.1186\/s12987-021-00260-5","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T08:02:29Z","timestamp":1624089749000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Brain endothelial LRP1 maintains blood\u2013brain barrier integrity"],"prefix":"10.1186","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6965-2264","authenticated-orcid":false,"given":"Steffen E.","family":"Storck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Kurtyka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1202-5489","authenticated-orcid":false,"given":"Claus U.","family":"Pietrzik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,19]]},"reference":[{"key":"260_CR1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190062","author":"CP Profaci","year":"2020","unstructured":"Profaci CP, Munji RN, Pulido RS, Daneman R. 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