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The blood-CSF-barrier (BCSFB) in choroid-plexus (CP) has long been hypothesized to be a main entry-point for intravenous-GBCAs into CSF. Most existing studies on this topic were performed in animals and human patients with various diseases. Results in\n                      <jats:italic>healthy<\/jats:italic>\n                      human subjects are limited. Besides, most studies were performed using MRI methods with limited temporal resolution and significant partial-volume effects from blood and CSF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study employs the recently developed dynamic-susceptibility-contrast-in-the-CSF (cDSC) MRI approach to measure GBCA-distribution in the CSF immediately and 4\u00a0h after intravenous-GBCA administration in healthy subjects. With a temporal resolution of 10\u00a0s, cDSC MRI can track GBCA-induced CSF signal changes during the bolus phase, which has not been investigated previously. It employs a long echo-time (TE\u2009=\u20091347\u00a0ms) to suppress tissue and blood signals so that pure CSF signal is detected with minimal partial-volume effects. GBCA concentration in the CSF can be estimated from cDSC MRI. In this study, cDSC and FLAIR MRI were performed immediately and 4\u00a0h after intravenous GBCA administration in 25 healthy volunteers (age 48.9\u2009\u00b1\u200919.5\u00a0years; 14 females). Paired t-tests were used to compare pre-GBCA and post-GBCA signal changes, and their correlations with age were evaluated using Pearson-correlation-coefficients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At\u2009~\u200920\u00a0s post-GBCA, GBCA-induced cDSC signal changes were detected in the CSF around CP (\u0394S\/S\u2009=\u2009\u2212\u00a02.40\u2009\u00b1\u20090.30%; P\u2009&lt;\u2009.001) but not in the rest of lateral ventricle (LV). At 4\u00a0h, significant GBCA-induced cDSC signal changes were observed in the entire LV (\u0394S\/S\u2009=\u2009\u2212\u00a07.58\u2009\u00b1\u20093.90%; P\u2009=\u2009.002). FLAIR MRI showed a similar trend. GBCA-induced CSF signal changes did not correlate with age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These results provided direct imaging evidence that GBCAs can pass the BCSFB in the CP and enter ventricular CSF\n                      <jats:italic>immediately<\/jats:italic>\n                      after\n                      <jats:italic>intravenous<\/jats:italic>\n                      administration in\n                      <jats:italic>healthy<\/jats:italic>\n                      human brains. Besides, our results in healthy subjects established a basis for clinical studies in brain diseases exploiting GBCA-enhanced MRI to detect BCSFB dysfunction.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12987-024-00571-3","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T04:04:09Z","timestamp":1726459449000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Rapid imaging of intravenous gadolinium-based contrast agent (GBCA) entering ventricular cerebrospinal fluid (CSF) through the choroid plexus in healthy human subjects"],"prefix":"10.1186","volume":"21","author":[{"given":"Yuanqi","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay J.","family":"Pillai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Paez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunming","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob M.","family":"Pogson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Knutsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"Barker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C. 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