{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:37:03Z","timestamp":1789853823011,"version":"4.0.1"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T00:00:00Z","timestamp":1413417600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Part Fibre Toxicol"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/s12989-014-0048-2","type":"journal-article","created":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T12:11:13Z","timestamp":1413375073000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Inhalation of rod-like carbon nanotubes causes unconventional allergic airway inflammation"],"prefix":"10.1186","volume":"11","author":[{"given":"Elina M","family":"Rydman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marit","family":"Ilves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti J","family":"Koivisto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia A S","family":"Kinaret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Fortino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terhi S","family":"Savinko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maili T","family":"Lehto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ville","family":"Pulkkinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minnamari","family":"Vippola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaarle J","family":"H\u00e4meri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sampsa","family":"Matikainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai M","family":"Savolainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Greco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harri","family":"Alenius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,10,16]]},"reference":[{"key":"48_CR1","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1038\/nri2870","volume":"10","author":"CM Lloyd","year":"2010","unstructured":"Lloyd CM, Hessel EM: Functions of T cells in asthma: more than just T(H)2 cells. Nat Rev Immunol 2010, 10: 838\u2013848. 10.1038\/nri2870","journal-title":"Nat Rev Immunol"},{"key":"48_CR2","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/nature07204","volume":"454","author":"SJ Galli","year":"2008","unstructured":"Galli SJ, Tsai M, Piliponsky AM: The development of allergic inflammation. Nature 2008, 454: 445\u2013454. 10.1038\/nature07204","journal-title":"Nature"},{"key":"48_CR3","doi-asserted-by":"publisher","first-page":"797","DOI":"10.3349\/ymj.2010.51.6.797","volume":"51","author":"S Reuter","year":"2010","unstructured":"Reuter S, Stassen M, Taube C: Mast cells in allergic asthma and beyond. Yonsei Med J 2010, 51: 797\u2013807. 10.3349\/ymj.2010.51.6.797","journal-title":"Yonsei Med J"},{"key":"48_CR4","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1056\/NEJMra0804579","volume":"360","author":"CH Fanta","year":"2009","unstructured":"Fanta CH: Asthma. N Engl J Med 2009, 360: 1002\u20131014. 10.1056\/NEJMra0804579","journal-title":"N Engl J Med"},{"key":"48_CR5","doi-asserted-by":"publisher","first-page":"2741","DOI":"10.1172\/JCI60325","volume":"122","author":"MJ Holtzman","year":"2012","unstructured":"Holtzman MJ: Asthma as a chronic disease of the innate and adaptive immune systems responding to viruses and allergens. J Clin Invest 2012, 122: 2741\u20132748. 10.1172\/JCI60325","journal-title":"J Clin Invest"},{"key":"48_CR6","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1476-069X-8-25","volume":"8","author":"DM Stieb","year":"2009","unstructured":"Stieb DM, Szyszkowicz M, Rowe BH, Leech JA: Air pollution and emergency department visits for cardiac and respiratory conditions: a multi-city time-series analysis. Environ Health 2009, 8: 25. 10.1186\/1476-069X-8-25","journal-title":"Environ Health"},{"key":"48_CR7","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.jaci.2009.10.061","volume":"125","author":"RA Silverman","year":"2010","unstructured":"Silverman RA, Ito K: Age-related association of fine particles and ozone with severe acute asthma in New York City. J Allergy Clin Immunol 2010, 125: 367\u2013373. e365 10.1016\/j.jaci.2009.10.061","journal-title":"J Allergy Clin Immunol"},{"key":"48_CR8","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1126\/science.1222453","volume":"339","author":"MF De Volder","year":"2013","unstructured":"De Volder MF, Tawfick SH, Baughman RH, Hart AJ: Carbon nanotubes: present and future commercial applications. Science 2013, 339: 535\u2013539. 10.1126\/science.1222453","journal-title":"Science"},{"key":"48_CR9","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/nature12502","volume":"501","author":"MM Shulaker","year":"2013","unstructured":"Shulaker MM, Hills G, Patil N, Wei H, Chen HY, Wong HS, Mitra S: Carbon nanotube computer. Nature 2013, 501: 526\u2013530. 10.1038\/nature12502","journal-title":"Nature"},{"key":"48_CR10","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/nnano.2008.111","volume":"3","author":"CA Poland","year":"2008","unstructured":"Poland CA, Duffin R, Kinloch I, Maynard A, Wallace WA, Seaton A, Stone V, Brown S, Macnee W, Donaldson K: Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotechnol 2008, 3: 423\u2013428. 10.1038\/nnano.2008.111","journal-title":"Nat Nanotechnol"},{"key":"48_CR11","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1093\/toxsci\/kfp057","volume":"109","author":"UC Nygaard","year":"2009","unstructured":"Nygaard UC, Hansen JS, Samuelsen M, Alberg T, Marioara CD, Lovik M: Single-walled and multi-walled carbon nanotubes promote allergic immune responses in mice. Toxicol Sci 2009, 109: 113\u2013123. 10.1093\/toxsci\/kfp057","journal-title":"Toxicol Sci"},{"key":"48_CR12","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.taap.2009.04.003","volume":"237","author":"K Inoue","year":"2009","unstructured":"Inoue K, Koike E, Yanagisawa R, Hirano S, Nishikawa M, Takano H: Effects of multi-walled carbon nanotubes on a murine allergic airway inflammation model. Toxicol Appl Pharmacol 2009, 237: 306\u2013316. 10.1016\/j.taap.2009.04.003","journal-title":"Toxicol Appl Pharmacol"},{"key":"48_CR13","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1165\/rcmb.2008-0276OC","volume":"40","author":"JP Ryman-Rasmussen","year":"2009","unstructured":"Ryman-Rasmussen JP, Tewksbury EW, Moss OR, Cesta MF, Wong BA, Bonner JC: Inhaled multiwalled carbon nanotubes potentiate airway fibrosis in murine allergic asthma. Am J Respir Cell Mol Biol 2009, 40: 349\u2013358. 10.1165\/rcmb.2008-0276OC","journal-title":"Am J Respir Cell Mol Biol"},{"key":"48_CR14","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1159\/000199715","volume":"149","author":"CL Van Hove","year":"2009","unstructured":"Van Hove CL, Maes T, Cataldo DD, Gueders MM, Palmans E, Joos GF, Tournoy KG: Comparison of acute inflammatory and chronic structural asthma-like responses between C57BL\/6 and BALB\/c mice. Int Arch Allergy Immunol 2009, 149: 195\u2013207. 10.1159\/000199715","journal-title":"Int Arch Allergy Immunol"},{"key":"48_CR15","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s00204-013-1116-3","volume":"88","author":"C Ronzani","year":"2014","unstructured":"Ronzani C, Casset A, Pons F: Exposure to multi-walled carbon nanotubes results in aggravation of airway inflammation and remodeling and in increased production of epithelium-derived innate cytokines in a mouse model of asthma. Arch Toxicol 2014, 88: 489\u2013499. 10.1007\/s00204-013-1116-3","journal-title":"Arch Toxicol"},{"key":"48_CR16","doi-asserted-by":"publisher","first-page":"476010","DOI":"10.1155\/2013\/476010","volume":"2013","author":"UC Nygaard","year":"2013","unstructured":"Nygaard UC, Samuelsen M, Marioara CD, Lovik M: Carbon nanofibers have IgE adjuvant capacity but are less potent than nanotubes in promoting allergic airway responses. Biomed Res Int 2013, 2013: 476010. 10.1155\/2013\/476010","journal-title":"Biomed Res Int"},{"key":"48_CR17","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nrd3838","volume":"12","author":"PC Fulkerson","year":"2013","unstructured":"Fulkerson PC, Rothenberg ME: Targeting eosinophils in allergy, inflammation and beyond. Nat Rev Drug Discov 2013, 12: 117\u2013129. 10.1038\/nrd3838","journal-title":"Nat Rev Drug Discov"},{"key":"48_CR18","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1067\/mai.2000.105712","volume":"105","author":"GJ Gleich","year":"2000","unstructured":"Gleich GJ: Mechanisms of eosinophil-associated inflammation. J Allergy Clin Immunol 2000, 105: 651\u2013663. 10.1067\/mai.2000.105712","journal-title":"J Allergy Clin Immunol"},{"key":"48_CR19","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.tox.2009.02.009","volume":"259","author":"EJ Park","year":"2009","unstructured":"Park EJ, Cho WS, Jeong J, Yi J, Choi K, Park K: Pro-inflammatory and potential allergic responses resulting from B cell activation in mice treated with multi-walled carbon nanotubes by intratracheal instillation. Toxicology 2009, 259: 113\u2013121. 10.1016\/j.tox.2009.02.009","journal-title":"Toxicology"},{"issue":"6","key":"48_CR20","doi-asserted-by":"publisher","first-page":"587","DOI":"10.3109\/17435390.2011.594912","volume":"6","author":"Y Morimoto","year":"2012","unstructured":"Morimoto Y, Hirohashi M, Ogami A, Oyabu T, Myojo T, Todoroki M, Yamamoto M, Hashiba M, Mizuguchi Y, Lee BW, Kuroda E, Shimada M, Wang WN, Yamamoto K, Fujita K, Endoh S, Uchida K, Kobayashi N, Mizuno K, Inada M, Tao H, Nakazato T, Nakanishi J, Tanaka I: Pulmonary toxicity of well-dispersed multi-wall carbon nanotubes following inhalation and intratracheal instillation. Nanotoxicology 2012,6(6):587\u2013599. 10.3109\/17435390.2011.594912","journal-title":"Nanotoxicology"},{"key":"48_CR21","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.3109\/17435390.2012.702230","volume":"7","author":"CA Beamer","year":"2013","unstructured":"Beamer CA, Girtsman TA, Seaver BP, Finsaas KJ, Migliaccio CT, Perry VK, Rottman JB, Smith DE, Holian A: IL-33 mediates multi-walled carbon nanotube (MWCNT)-induced airway hyper-reactivity via the mobilization of innate helper cells in the lung. Nanotoxicology 2013, 7: 1070\u20131081. 10.3109\/17435390.2012.702230","journal-title":"Nanotoxicology"},{"key":"48_CR22","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/1743-8977-8-24","volume":"8","author":"X Wang","year":"2011","unstructured":"Wang X, Katwa P, Podila R, Chen P, Ke PC, Rao AM, Walters DM, Wingard CJ, Brown JM: Multi-walled carbon nanotube instillation impairs pulmonary function in C57BL\/6 mice. Part Fibre Toxicol 2011, 8: 24. 10.1186\/1743-8977-8-24","journal-title":"Part Fibre Toxicol"},{"key":"48_CR23","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1093\/toxsci\/kfp146","volume":"112","author":"L Ma-Hock","year":"2009","unstructured":"Ma-Hock L, Treumann S, Strauss V, Brill S, Luizi F, Mertler M, Wiench K, Gamer AO, van Ravenzwaay B, Landsiedel R: Inhalation toxicity of multiwall carbon nanotubes in rats exposed for 3 months. Toxicol Sci 2009, 112: 468\u2013481. 10.1093\/toxsci\/kfp146","journal-title":"Toxicol Sci"},{"key":"48_CR24","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.3109\/17435390.2012.719649","volume":"7","author":"DW Porter","year":"2013","unstructured":"Porter DW, Hubbs AF, Chen BT, McKinney W, Mercer RR, Wolfarth MG, Battelli L, Wu N, Sriram K, Leonard S, Andrew M, Willard P, Tsuruoka S, Endo M, Tsukada T, Munekane F, Frazer DG, Castranova V: Acute pulmonary dose-responses to inhaled multi-walled carbon nanotubes. Nanotoxicology 2013, 7: 1179\u20131194. 10.3109\/17435390.2012.719649","journal-title":"Nanotoxicology"},{"key":"48_CR25","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1743-8977-3-15","volume":"3","author":"J Mangum","year":"2006","unstructured":"Mangum J, Turpin E, Antao-Menezes A, Cesta M, Bermudez E, Bonner J: Single-Walled Carbon Nanotube (SWCNT)-induced interstitial fibrosis in the lungs of rats is associated with increased levels of PDGF mRNA and the formation of unique intercellular carbon structures that bridge alveolar macrophages In Situ. Particle Fibre Toxicol 2006, 3: 15. 10.1186\/1743-8977-3-15","journal-title":"Particle Fibre Toxicol"},{"key":"48_CR26","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.tcb.2009.07.005","volume":"19","author":"L Helming","year":"2009","unstructured":"Helming L, Gordon S: Molecular mediators of macrophage fusion. Trends Cell Biol 2009, 19: 514\u2013522. 10.1016\/j.tcb.2009.07.005","journal-title":"Trends Cell Biol"},{"key":"48_CR27","first-page":"975","volume":"149","author":"AK McNally","year":"1996","unstructured":"McNally AK, DeFife KM, Anderson JM: Interleukin-4-induced macrophage fusion is prevented by inhibitors of mannose receptor activity. Am J Pathol 1996, 149: 975\u2013985.","journal-title":"Am J Pathol"},{"key":"48_CR28","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.4049\/jimmunol.158.7.3385","volume":"158","author":"KM DeFife","year":"1997","unstructured":"DeFife KM, Jenney CR, McNally AK, Colton E, Anderson JM: Interleukin-13 induces human monocyte\/macrophage fusion and macrophage mannose receptor expression. J Immunol 1997, 158: 3385\u20133390.","journal-title":"J Immunol"},{"key":"48_CR29","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1159\/000336025","volume":"4","author":"P Dasgupta","year":"2012","unstructured":"Dasgupta P, Keegan AD: Contribution of alternatively activated macrophages to allergic lung inflammation: a tale of mice and men. J Innate Immun 2012, 4: 478\u2013488. 10.1159\/000336025","journal-title":"J Innate Immun"},{"key":"48_CR30","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1378\/chest.88.3.376","volume":"88","author":"SM Brooks","year":"1985","unstructured":"Brooks SM, Weiss MA, Bernstein IL: REactive airways dysfunction syndrome (rads). persistent asthma syndrome after high level irritant exposures. Chest J 1985, 88: 376\u2013384. 10.1378\/chest.88.3.376","journal-title":"Chest J"},{"key":"48_CR31","first-page":"1","volume":"14","author":"S Tarlo","year":"2013","unstructured":"Tarlo S: Irritant-induced asthma in the workplace. Curr Allergy Asthma Rep 2013, 14: 1\u20136.","journal-title":"Curr Allergy Asthma Rep"},{"key":"48_CR32","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1093\/occmed\/kqn013","volume":"58","author":"MS Shakeri","year":"2008","unstructured":"Shakeri MS, Dick FD, Ayres JG: Which agents cause reactive airways dysfunction syndrome (RADS)? A systematic review. Occup Med 2008, 58: 205\u2013211. 10.1093\/occmed\/kqn013","journal-title":"Occup Med"},{"key":"48_CR33","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1097\/00130832-200104000-00008","volume":"1","author":"DE Banks","year":"2001","unstructured":"Banks DE: Workplace irritant exposures: do they produce true occupational asthma? Curr Opin Allergy Clin Immunol 2001, 1: 163\u2013168. 10.1097\/01.all.0000011002.72912.c8","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"48_CR34","doi-asserted-by":"publisher","first-page":"87","DOI":"10.2147\/JAA.S19107","volume":"4","author":"VA Varney","year":"2011","unstructured":"Varney VA, Evans J, Bansal AS: Successful treatment of reactive airways dysfunction syndrome by high-dose vitamin D. J Asthma Allergy 2011, 4: 87\u201391. 10.2147\/JAA.S19107","journal-title":"J Asthma Allergy"},{"key":"48_CR35","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/nri2327","volume":"8","author":"SJ Galli","year":"2008","unstructured":"Galli SJ, Grimbaldeston M, Tsai M: Immunomodulatory mast cells: negative, as well as positive, regulators of immunity. Nat Rev Immunol 2008, 8: 478\u2013486. 10.1038\/nri2327","journal-title":"Nat Rev Immunol"},{"key":"48_CR36","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1146\/annurev.immunol.21.120601.141025","volume":"23","author":"SJ Galli","year":"2005","unstructured":"Galli SJ, Kalesnikoff J, Grimbaldeston MA, Piliponsky AM, Williams CM, Tsai M: Mast cells as \u201ctunable\u201d effector and immunoregulatory cells: recent advances. Annu Rev Immunol 2005, 23: 749\u2013786. 10.1146\/annurev.immunol.21.120601.141025","journal-title":"Annu Rev Immunol"},{"key":"48_CR37","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/nri2692","volume":"10","author":"FY Liew","year":"2010","unstructured":"Liew FY, Pitman NI, McInnes IB: Disease-associated functions of IL-33: the new kid in the IL-1 family. Nat Rev Immunol 2010, 10: 103\u2013110. 10.1038\/nri2692","journal-title":"Nat Rev Immunol"},{"key":"48_CR38","doi-asserted-by":"publisher","first-page":"13","DOI":"10.2332\/allergolint.13-RAI-0538","volume":"62","author":"S Nakae","year":"2013","unstructured":"Nakae S, Morita H, Ohno T, Arae K, Matsumoto K, Saito H: Role of interleukin-33 in innate-type immune cells in allergy. Allergol Int 2013, 62: 13\u201320. 10.2332\/allergolint.13-RAI-0538","journal-title":"Allergol Int"},{"key":"48_CR39","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1172\/JCI7613","volume":"104","author":"C Vestergaard","year":"1999","unstructured":"Vestergaard C, Yoneyama H, Murai M, Nakamura K, Tamaki K, Terashima Y, Imai T, Yoshie O, Irimura T, Mizutani H, Matsushima K: Overproduction of Th2-specific chemokines in NC\/Nga mice exhibiting atopic dermatitis-like lesions. J Clin Invest 1999, 104: 1097\u20131105. 10.1172\/JCI7613","journal-title":"J Clin Invest"},{"key":"48_CR40","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1016\/j.jaci.2012.07.023","volume":"130","author":"KJ Staples","year":"2012","unstructured":"Staples KJ, Hinks TS, Ward JA, Gunn V, Smith C, Djukanovic R: Phenotypic characterization of lung macrophages in asthmatic patients: overexpression of CCL17. J Allergy Clin Immunol 2012, 130: 1404\u20131412. e1407 10.1016\/j.jaci.2012.07.023","journal-title":"J Allergy Clin Immunol"},{"key":"48_CR41","doi-asserted-by":"publisher","first-page":"2904","DOI":"10.1002\/smll.201200873","volume":"8","author":"P Katwa","year":"2012","unstructured":"Katwa P, Wang X, Urankar RN, Podila R, Hilderbrand SC, Fick RB, Rao AM, Ke PC, Wingard CJ, Brown JM: A carbon nanotube toxicity paradigm driven by mast cells and the IL-(3)(3)\/ST(2) axis. Small 2012, 8: 2904\u20132912. 10.1002\/smll.201200873","journal-title":"Small"},{"issue":"3","key":"48_CR42","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/ni.2208","volume":"13","author":"SH Wong","year":"2012","unstructured":"Wong SH, Walker JA, Jolin HE, Drynan LF, Hams E, Camelo A, Barlow JL, Neill DR, Panova V, Koch U, Radtke F, Hardman CS, Hwang YY, Fallon PG, McKenzie AN: Transcription factor RORalpha is critical for nuocyte development. Nat Immunol 2012,13(3):229\u2013236. 10.1038\/ni.2208","journal-title":"Nat Immunol"},{"key":"48_CR43","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/ni.2617","volume":"14","author":"P Licona-Limon","year":"2013","unstructured":"Licona-Limon P, Kim LK, Palm NW, Flavell RA: TH2, allergy and group 2 innate lymphoid cells. Nat Immunol 2013, 14: 536\u2013542. 10.1038\/ni.2617","journal-title":"Nat Immunol"},{"key":"48_CR44","doi-asserted-by":"publisher","first-page":"665","DOI":"10.4049\/jimmunol.179.1.665","volume":"179","author":"JJ Ryan","year":"2007","unstructured":"Ryan JJ, Bateman HR, Stover A, Gomez G, Norton SK, Zhao W, Schwartz LB, Lenk R, Kepley CL: Fullerene nanomaterials inhibit the allergic response. J Immunol 2007, 179: 665\u2013672. 10.4049\/jimmunol.179.1.665","journal-title":"J Immunol"},{"issue":"1","key":"48_CR45","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1080\/0002889778507709","volume":"39","author":"VA Marple","year":"1978","unstructured":"Marple VA, Liu BY, Rubow KL: A dust generator for laboratory use. Am Ind Hyg Assoc J 1978,39(1):26\u201332. 10.1080\/0002889778507709","journal-title":"Am Ind Hyg Assoc J"},{"key":"48_CR46","first-page":"542","volume":"56","author":"MM Dahm","year":"2012","unstructured":"Dahm MM, Evans DE, Schubauer-Berigan MK, Birch ME, Fernback JE: Occupational exposure assessment in carbon nanotube and nanofiber primary and secondary manufacturers. Ann Occup Hyg 2012, 56: 542\u2013556.","journal-title":"Ann Occup Hyg"},{"issue":"1","key":"48_CR47","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/1743-8977-10-53","volume":"10","author":"A Erdely","year":"2013","unstructured":"Erdely A, Dahm M, Chen BT, Zeidler-Erdely PC, Fernback JE, Birch ME, Evans DE, Kashon ML, Deddens JA, Hulderman T, Bilgesu SA, Battelli L, Schwegler-Berry D, Leonard HD, McKinney W, Frazer DG, Antonini JM, Porter DW, Castranova V, Schubauer-Berigan MK: Carbon nanotube dosimetry: from workplace exposure assessment to inhalation toxicology. Part Fibre Toxicol 2013,10(1):53. 10.1186\/1743-8977-10-53","journal-title":"Part Fibre Toxicol"},{"key":"48_CR48","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1164\/ajrccm.156.3.9606031","volume":"156","author":"E Hamelmann","year":"1997","unstructured":"Hamelmann E, Schwarze J, Takeda K, Oshiba A, Larsen GL, Irvin CG, Gelfand EW: Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med 1997, 156: 766\u2013775. 10.1164\/ajrccm.156.3.9606031","journal-title":"Am J Respir Crit Care Med"},{"key":"48_CR49","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/nar\/30.1.207","volume":"30","author":"R Edgar","year":"2002","unstructured":"Edgar R, Domrachev M, Lash AE: Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 2002, 30: 207\u2013210. 10.1093\/nar\/30.1.207","journal-title":"Nucleic Acids Res"},{"key":"48_CR50","unstructured":"R Core Team: R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria; 2012. ISBN 3-900051-07-0 URL: http:\/\/www.R-project.org\/."},{"key":"48_CR51","volume-title":"In","author":"GK Smyth","year":"2005","unstructured":"Smyth GK: Limma: Linear models for microarray data. In 2005."},{"issue":"6","key":"48_CR52","doi-asserted-by":"publisher","first-page":"2941","DOI":"10.4049\/jimmunol.1200935","volume":"189","author":"C Procaccini","year":"2012","unstructured":"Procaccini C, De Rosa V, Galgani M, Carbone F, Cassano S, Greco D, Qian K, Auvinen P, Cali G, Stallone G, Formisano L, La Cava A, Matarese G: Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses. J Immunol 2012,189(6):2941\u20132953. 10.4049\/jimmunol.1200935","journal-title":"J Immunol"},{"key":"48_CR53","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1194\/jlr.M030650","volume":"54","author":"L Kilpinen","year":"2013","unstructured":"Kilpinen L, Tigistu-Sahle F, Oja S, Greco D, Parmar A, Saavalainen P, Nikkila J, Korhonen M, Lehenkari P, Kakela R, Laitinen S: Aging bone marrow mesenchymal stromal cells have altered membrane glycerophospholipid composition and functionality. J Lipid Res 2013, 54: 622\u2013635. 10.1194\/jlr.M030650","journal-title":"J Lipid Res"},{"key":"48_CR54","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/1471-2164-13-134","volume":"13","author":"M Palgi","year":"2012","unstructured":"Palgi M, Greco D, Lindstrom R, Auvinen P, Heino TI: Gene expression analysis of Drosophilaa Manf mutants reveals perturbations in membrane traffic and major metabolic changes. BMC Genomics 2012, 13: 134. 10.1186\/1471-2164-13-134","journal-title":"BMC Genomics"},{"key":"48_CR55","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/1471-2105-14-165","volume":"14","author":"GK Smyth","year":"2013","unstructured":"Smyth GK, Altman NS: Separate-channel analysis of two-channel microarrays: recovering inter-spot information. BMC Bioinformatics 2013, 14: 165. 10.1186\/1471-2105-14-165","journal-title":"BMC Bioinformatics"},{"key":"48_CR56","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/1471-2105-8-142","volume":"8","author":"M Zahurak","year":"2007","unstructured":"Zahurak M, Parmigiani G, Yu W, Scharpf RB, Berman D, Schaeffer E, Shabbeer S, Cope L: Pre-processing Agilent microarray data. BMC Bioinformatics 2007, 8: 142. 10.1186\/1471-2105-8-142","journal-title":"BMC Bioinformatics"},{"key":"48_CR57","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y: Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Statist Soc B 1995, 57: 289\u2013300.","journal-title":"J R Statist Soc B"},{"key":"48_CR58","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1093\/biostatistics\/kxj037","volume":"8","author":"WE Johnson","year":"2007","unstructured":"Johnson WE, Li C, Rabinovic A: Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics 2007, 8: 118\u2013127. 10.1093\/biostatistics\/kxj037","journal-title":"Biostatistics"},{"key":"48_CR59","volume-title":"Sva: Surrogate Variable Analysis","author":"JT Leek","year":"2013","unstructured":"Leek JT, Johnson E, Parker HS, Jaffe AE, Storey JD: Sva: Surrogate Variable Analysis. 2013."},{"key":"48_CR60","doi-asserted-by":"publisher","first-page":"D8","DOI":"10.1093\/nar\/gks1189","volume":"41","author":"NCBI Research Coordinators","year":"2013","unstructured":"Database resources of the National Center for Biotechnology Information Nucleic Acids Res 2013, 41: D8-D20. 10.1093\/nar\/gks1189","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"48_CR61","doi-asserted-by":"crossref","first-page":"Article 3","DOI":"10.2202\/1544-6115.1027","volume":"3","author":"GK Smyth","year":"2004","unstructured":"Smyth GK: Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004,3(1):Article 3.","journal-title":"Stat Appl Genet Mol Biol"},{"issue":"1","key":"48_CR62","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"DW Huang","year":"2009","unstructured":"Huang DW, Sherman BT, Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009,4(1):44\u201357. 10.1038\/nprot.2008.211","journal-title":"Nat Protoc"},{"issue":"12","key":"48_CR63","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1007\/s00011-009-0054-2","volume":"58","author":"MM Gueders","year":"2009","unstructured":"Gueders MM, Paulissen G, Crahay C, Quesada-Calvo F, Hacha J, Van Hove C, Tournoy K, Louis R, Foidart JM, Noel A, Cataldo DD: Mouse models of asthma: a comparison between C57BL\/6 and BALB\/c strains regarding bronchial responsiveness, inflammation, and cytokine production. Inflamm Res 2009,58(12):845\u2013854. 10.1007\/s00011-009-0054-2","journal-title":"Inflamm Res"},{"issue":"5","key":"48_CR64","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1097\/01.shk.0000142249.08135.e9","volume":"22","author":"H Watanabe","year":"2004","unstructured":"Watanabe H, Numata K, Ito T, Takagi K, Matsukawa A: Innate immune response in Th1- and Th2-dominant mouse strains. Shock 2004,22(5):460\u2013466. 10.1097\/01.shk.0000142249.08135.e9","journal-title":"Shock"}],"container-title":["Particle and Fibre Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12989-014-0048-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12989-014-0048-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12989-014-0048-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12989-014-0048-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T19:17:07Z","timestamp":1717442227000},"score":1,"resource":{"primary":{"URL":"https:\/\/particleandfibretoxicology.biomedcentral.com\/articles\/10.1186\/s12989-014-0048-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,16]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["48"],"URL":"https:\/\/doi.org\/10.1186\/s12989-014-0048-2","relation":{},"ISSN":["1743-8977"],"issn-type":[{"value":"1743-8977","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,16]]},"assertion":[{"value":"17 April 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"48"}}