{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T05:19:28Z","timestamp":1794287968256,"version":"4.9.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,10,21]],"date-time":"2014-10-21T00:00:00Z","timestamp":1413849600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Part Fibre Toxicol"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/s12989-014-0055-3","type":"journal-article","created":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T20:25:08Z","timestamp":1413836708000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Biokinetics and effects of barium sulfate nanoparticles"],"prefix":"10.1186","volume":"11","author":[{"given":"Nagarjun","family":"Konduru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Ma-Hock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibylle","family":"Gr\u00f6ters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Landsiedel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C","family":"Donaghey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D","family":"Brain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendel","family":"Wohlleben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon M","family":"Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,10,21]]},"reference":[{"key":"55_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2217\/nnm.09.99","volume":"5","author":"R Gillani","year":"2010","unstructured":"Gillani R, Ercan R, Qiao A, Webster TJ: Nanofunctionalized zirconia and barium sulfate particles as bone cement additives. Int J Nanomed 2010, 5: 1\u201311. 10.2217\/nnm.09.99","journal-title":"Int J Nanomed"},{"key":"55_CR2","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1080\/17453670710015349","volume":"79","author":"AH Gomoll","year":"2008","unstructured":"Gomoll AH, Fitz W, Scott RD, Thornhill TS, Bellare A: Nanoparticulate fillers improve the mechanical strength of bone cement. Acta Orthop 2008, 79: 421\u2013427. 10.1080\/17453670710015349","journal-title":"Acta Orthop"},{"key":"55_CR3","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/j.1365-2591.2009.01660.x","volume":"43","author":"D Mohn","year":"2010","unstructured":"Mohn D, Zehnder M, Imfeld T, Stark WJ: Radio-opaque nanosized bioactive glass for potential root canal application: evaluation of radiopacity, bioactivity and alkaline capacity. Int Endod J 2010, 43: 210\u2013217. 10.1111\/j.1365-2591.2009.01660.x","journal-title":"Int Endod J"},{"key":"55_CR4","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s00216-011-5069-1","volume":"401","author":"R Noreen","year":"2011","unstructured":"Noreen R, Pineau R, Chien CC, Cestelli-Guidi M, Hwu Y, Marcelli A, Moenner M, Petibois C: Functional histology of glioma vasculature by FTIR imaging. Anal Bioanal Chem 2011, 401: 795\u2013801. 10.1007\/s00216-011-5069-1","journal-title":"Anal Bioanal Chem"},{"key":"55_CR5","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.ejpb.2004.11.002","volume":"60","author":"JR Villalobos-Hernandez","year":"2005","unstructured":"Villalobos-Hernandez JR, Muller-Goymann CC: Novel nanoparticulate carrier system based on carnauba wax and decyl oleate for the dispersion of inorganic sunscreens in aqueous media. Eur J Pharm Biopharm 2005, 60: 113\u2013122. 10.1016\/j.ejpb.2004.11.002","journal-title":"Eur J Pharm Biopharm"},{"key":"55_CR6","first-page":"1197","volume":"8","author":"GE Aninwene 2nd","year":"2013","unstructured":"Aninwene GE 2nd, Stout D, Yang Z, Webster TJ: Nano-BaSO\n                    4\n                  : a novel antimicrobial additive to pellethane. Int J Nanomed 2013, 8: 1197\u20131205.","journal-title":"Int J Nanomed"},{"key":"55_CR7","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1136\/thx.31.1.30","volume":"31","author":"AT Doig","year":"1976","unstructured":"Doig AT: Baritosis: a benign pneumoconiosis. Thorax 1976, 31: 30\u201339. 10.1136\/thx.31.1.30","journal-title":"Thorax"},{"key":"55_CR8","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S0003-4975(02)04496-X","volume":"76","author":"T Dosios","year":"2003","unstructured":"Dosios T, Karydas AG: Baritosis of the mediastinal lymph nodes. Ann Thorac Surg 2003, 76: 297. 10.1016\/S0003-4975(02)04496-X","journal-title":"Ann Thorac Surg"},{"key":"55_CR9","first-page":"443","volume":"20","author":"P Levi-Valensi","year":"1966","unstructured":"Levi-Valensi P, Drif M, Dat A, Hadjadj G: Apropos of 57 cases of pulmonary baritosis. (Results of a systematic investigation in a baryta factory). J Fr Med Chir Thorac 1966, 20: 443\u2013455.","journal-title":"J Fr Med Chir Thorac"},{"key":"55_CR10","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/s11051-005-6770-9","volume":"7","author":"AD Maynard","year":"2005","unstructured":"Maynard AD, Kuempel ED: Airborne nanostructured particles and occupational health. J Nanopart Res 2005, 7: 587\u2013614. 10.1007\/s11051-005-6770-9","journal-title":"J Nanopart Res"},{"key":"55_CR11","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1080\/089583701753338622","volume":"14","author":"G Oberdorster","year":"2002","unstructured":"Oberdorster G: Toxicokinetics and effects of fibrous and nonfibrous particles. Inhal Toxicol 2002, 14: 29\u201356. 10.1080\/089583701753338622","journal-title":"Inhal Toxicol"},{"key":"55_CR12","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1080\/08958378.2000.11463252","volume":"12","author":"CL Tran","year":"2000","unstructured":"Tran CL, Buchanan D, Cullen RT, Searl A, Jones AD, Donaldson K: Inhalation of poorly soluble particles. II. Influence of particle surface area on inflammation and clearance. Inhal Toxicol 2000, 12: 1113\u20131126. 10.1080\/08958370050166796","journal-title":"Inhal Toxicol"},{"key":"55_CR13","doi-asserted-by":"publisher","first-page":"285103","DOI":"10.1088\/0957-4484\/21\/28\/285103","volume":"21","author":"X He","year":"2010","unstructured":"He X, Zhang H, Ma Y, Bai W, Zhang Z, Lu K, Ding Y, Zhao Y, Chai Z: Lung deposition and extrapulmonary translocation of nano-ceria after intratracheal instillation. Nanotechnology 2010, 21: 285103. 10.1088\/0957-4484\/21\/28\/285103","journal-title":"Nanotechnology"},{"key":"55_CR14","doi-asserted-by":"publisher","first-page":"79","DOI":"10.5487\/TR.2009.25.2.079","volume":"25","author":"E-J Park","year":"2009","unstructured":"Park E-J, Park Y-K, Park K: Acute toxicity and tissue distribution of cerium oxide nanoparticles by a single oral administration in rats. Toxicol Res 2009, 25: 79\u201384. 10.5487\/TR.2009.25.2.079","journal-title":"Toxicol Res"},{"key":"55_CR15","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1743-8977-10-15","volume":"10","author":"H Shi","year":"2013","unstructured":"Shi H, Magaye R, Castranova V, Zhao J: Titanium dioxide nanoparticles: a review of current toxicological data. Part Fibre Toxicol 2013, 10: 15. 10.1186\/1743-8977-10-15","journal-title":"Part Fibre Toxicol"},{"key":"55_CR16","doi-asserted-by":"publisher","first-page":"MR17","DOI":"10.1116\/1.2815690","volume":"2","author":"C Buzea","year":"2007","unstructured":"Buzea C, Pacheco II, Robbie K: Nanomaterials and nanoparticles: sources and toxicity. Biointerphases 2007, 2: MR17-MR71. 10.1116\/1.2815690","journal-title":"Biointerphases"},{"key":"55_CR17","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1080\/08958370050166787","volume":"12","author":"RT Cullen","year":"2000","unstructured":"Cullen RT, Tran CL, Buchanan D, Davis JM, Searl A, Jones AD, Donaldson K: Inhalation of poorly soluble particles. I. Differences in inflammatory response and clearance during exposure. Inhal Toxicol 2000, 12: 1089\u20131111. 10.1080\/08958370050166787","journal-title":"Inhal Toxicol"},{"key":"55_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/17435390802578595","volume":"3","author":"A Dhawan","year":"2008","unstructured":"Dhawan A, Sharma V, Parmar D: Nanomaterials: A challenge for toxicologists. Nanotoxicology 2008, 3: 1\u20139. 10.1080\/17435390802578595","journal-title":"Nanotoxicology"},{"key":"55_CR19","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s12989-014-0044-6","volume":"11","author":"NV Konduru","year":"2014","unstructured":"Konduru NV, Murdaugh KM, Sotiriou GA, Donaghey TC, Demokritou P, Brain JD, Molina RM: Bioavailability, distribution and clearance of tracheally-instilled and gavaged uncoated or silica-coated zinc oxide nanoparticles. Part Fibre Toxicol 2014, 11: 44. 10.1186\/s12989-014-0044-6","journal-title":"Part Fibre Toxicol"},{"key":"55_CR20","first-page":"628","volume":"12","author":"H Cember","year":"1955","unstructured":"Cember H, Hatch TF, Watson JA, Grucci T: Pulmonary effects from radioactive barium sulfate dust. AMA Arch Ind Health 1955, 12: 628\u2013634.","journal-title":"AMA Arch Ind Health"},{"key":"55_CR21","first-page":"170","volume":"13","author":"H Cember","year":"1956","unstructured":"Cember H, Hatch TF, Watson JA, Grucci T, Bell P: The elimination of radioactive barium sulfate particles from the lung. AMA Arch Ind Health 1956, 13: 170\u2013176.","journal-title":"AMA Arch Ind Health"},{"key":"55_CR22","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.polymdegradstab.2009.02.005","volume":"94","author":"L Reijnders","year":"2009","unstructured":"Reijnders L: The release of TiO\n                    2\n                   and SiO\n                    2\n                   nanoparticles from nanocomposites. Polym Degrad Stab 2009, 94: 873\u2013876. 10.1016\/j.polymdegradstab.2009.02.005","journal-title":"Polym Degrad Stab"},{"key":"55_CR23","doi-asserted-by":"publisher","first-page":"4281","DOI":"10.1002\/adfm.201203317","volume":"23","author":"G Song","year":"2013","unstructured":"Song G, Wang Q, Wang Y, Lv G, Li C, Zou R, Chen Z, Qin Z, Huo K, Hu R, Hu J: A low-toxic multifunctional nanoplatform based on Cu\n                    9\n                  S\n                    5\n                  @mSiO\n                    2\n                   core-shell nanocomposites: combining photothermal- and chemotherapies with infrared thermal imaging for cancer treatment. Ad Func Mat 2013, 23: 4281\u20134292. 10.1002\/adfm.201203317","journal-title":"Ad Func Mat"},{"key":"55_CR24","volume-title":"Toxic Combustion of Products from Fire Retarded Nanocomposite Polymers","author":"AA Stec","year":"2007","unstructured":"Stec AA, Hull TR: Toxic Combustion of Products from Fire Retarded Nanocomposite Polymers. Proceedings of the 5th International Seminar on Fire and Explosion Hazards, Edinburgh, UK; 2007."},{"key":"55_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/10408444.2012.738187","volume":"43","author":"H Johnston","year":"2013","unstructured":"Johnston H, Pojana G, Zuin S, Jacobsen NR, Moller P, Loft S, Semmler-Behnke M, McGuiness C, Balharry D, Marcomini A, Wallin H, Kreyling W, Donaldson K, Tran L, Stone V: Engineered nanomaterial risk. Lessons learnt from completed nanotoxicology studies: potential solutions to current and future challenges. Crit Rev Toxicol 2013, 43: 1\u201320. 10.3109\/10408444.2012.738187","journal-title":"Crit Rev Toxicol"},{"key":"55_CR26","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.1002\/adma.200902658","volume":"22","author":"R Landsiedel","year":"2010","unstructured":"Landsiedel R, Ma-Hock L, Kroll A, Hahn D, Schnekenburger J, Wiench K, Wohlleben W: Testing metal-oxide nanomaterials for human safety. Adv Mater 2010, 22: 2601\u20132627. 10.1002\/adma.200902658","journal-title":"Adv Mater"},{"key":"55_CR27","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1007\/s00204-012-0834-2","volume":"86","author":"CL Klein","year":"2012","unstructured":"Klein CL, Wiench K, Wiemann M, Ma-Hock L, Van Ravenzwaay B, Landsiedel R: Hazard identification of inhaled nanomaterials: making use of short-term inhalation studies. Arch Toxicol 2012, 86: 1137\u20131151. 10.1007\/s00204-012-0834-2","journal-title":"Arch Toxicol"},{"key":"55_CR28","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1743-8977-11-16","volume":"11","author":"R Landsiedel","year":"2014","unstructured":"Landsiedel R, Ma-Hock L, Hofmann T, Wiemann M, Strauss V, Treumann S, Wohlleben W, Groters S, Wiench K, van Ravenzwaay B: Application of short-term inhalation studies to assess the inhalation toxicity of nanomaterials. Part Fibre Toxicol 2014, 11: 16. 10.1186\/1743-8977-11-16","journal-title":"Part Fibre Toxicol"},{"key":"55_CR29","first-page":"93","volume":"4","author":"W Wohlleben","year":"2013","unstructured":"Wohlleben W, Ma-Hock L, Boyko V, Cox G, Egenolf H, Freiberger H, Hinrichsen B, Hirth S, Landsiedel R: Nanospecific guidance in REACH: a comparative physical-chemical characterization of 15 materials with methodical correlations. J Ceram Sci Tech 2013, 4: 93\u2013104.","journal-title":"J Ceram Sci Tech"},{"key":"55_CR30","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.tiv.2004.08.001","volume":"19","author":"AB Stefaniak","year":"2005","unstructured":"Stefaniak AB, Guilmette RA, Day GA, Hoover MD, Breysse PN, Scripsick RC: Characterization of phagolysosomal simulant fluid for study of beryllium aerosol particle dissolution. Toxicol In Vitro 2005, 19: 123\u2013134. 10.1016\/j.tiv.2004.08.001","journal-title":"Toxicol In Vitro"},{"key":"55_CR31","first-page":"L146","volume":"276","author":"JD Brain","year":"1999","unstructured":"Brain JD, Molina RM, DeCamp MM, Warner AE: Pulmonary intravascular macrophages: their contribution to the mononuclear phagocyte system in 13 species. Am J Physiol 1999, 276: L146-L154.","journal-title":"Am J Physiol"},{"key":"55_CR32","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1743-8977-11-5","volume":"11","author":"BL Baisch","year":"2014","unstructured":"Baisch BL, Corson NM, Wade-Mercer P, Gelein R, Kennell AJ, Oberdorster G, Elder A: Equivalent titanium dioxide nanoparticle deposition by intratracheal instillation and whole body inhalation: the effect of dose rate on acute respiratory tract inflammation. Part Fibre Toxicol 2014, 11: 5. 10.1186\/1743-8977-11-5","journal-title":"Part Fibre Toxicol"},{"key":"55_CR33","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1006\/faat.1997.2390","volume":"40","author":"M Osier","year":"1997","unstructured":"Osier M, Oberdorster G: Intratracheal inhalation vs intratracheal instillation: differences in particle effects. Fundam Appl Toxicol 1997, 40: 220\u2013227. 10.1006\/faat.1997.2390","journal-title":"Fundam Appl Toxicol"},{"key":"55_CR34","doi-asserted-by":"crossref","unstructured":"Keller J, Wohlleben W, Ma-Hock L, Strauss V, Groters S, Kuttler K, Wiench K, Herden C, Oberdorster G, van Ravenzwaay B, Landsiedel R: Time course of lung retention and toxicity of inhaled particles: short-term exposure to nano-Ceria. Arch Toxicol 2014, doi:10.1007\/s00204\u2013014\u20131349\u20139.","DOI":"10.1007\/s00204-014-1349-9"},{"key":"55_CR35","doi-asserted-by":"publisher","first-page":"376","DOI":"10.2307\/3571587","volume":"21","author":"W Moore Jr","year":"1964","unstructured":"Moore W Jr: Comparative metabolism of barium-133 and calcium-45 by embryonic bone grown in vitro. Radiat Res 1964, 21: 376\u2013382. 10.2307\/3571587","journal-title":"Radiat Res"},{"key":"55_CR36","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1080\/00028896109344129","volume":"22","author":"H Cember","year":"1961","unstructured":"Cember H, Watson JA, Novak ME: The influence of radioactivity and lung burden on the pulmonary clearance rate of barium sulfate. Am Ind Hyg Assoc J 1961, 22: 27\u201332. 10.1080\/00028896109344129","journal-title":"Am Ind Hyg Assoc J"},{"key":"55_CR37","volume-title":"Part Fibre Toxicol","author":"RM Molina","year":"2014","unstructured":"Molina RM, Konduru NV, Jimenez RJ, Pyrgiotakis G, Demokritou P, Wohlleben W, Brai JD: Bioavailability, distribution and clearance of tracheally instilled, gavaged or injected cerium dioxide nanoparticles and ionic cerium. Part Fibre Toxicol 2014."},{"key":"55_CR38","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nnano.2013.158","volume":"8","author":"DA Walker","year":"2013","unstructured":"Walker DA, Leitsch EK, Nap RJ, Szleifer I, Grzybowski BA: Geometric curvature controls the chemical patchiness and self-assembly of nanoparticles. Nat Nanotechnol 2013, 8: 676\u2013681. 10.1038\/nnano.2013.158","journal-title":"Nat Nanotechnol"},{"key":"55_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2011\/450912","volume":"2011","author":"MY Wani","year":"2011","unstructured":"Wani MY, Hashim MA, Nabi F, Malik MA: Nanotoxicity: dimensional and morphological concerns. Adv Phys Chem 2011, 2011: 1\u201315. 10.1155\/2011\/450912","journal-title":"Adv Phys Chem"},{"key":"55_CR40","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1021\/tx900369x","volume":"23","author":"M Ghiazza","year":"2010","unstructured":"Ghiazza M, Polimeni M, Fenoglio I, Gazzano E, Ghigo D, Fubini B: Does vitreous silica contradict the toxicity of the crystalline silica paradigm? Chem Res Toxicol 2010, 23: 620\u2013629. 10.1021\/tx900369x","journal-title":"Chem Res Toxicol"},{"key":"55_CR41","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1038\/nbt.1696","volume":"28","author":"HS Choi","year":"2010","unstructured":"Choi HS, Ashitate Y, Lee JH, Kim SH, Matsui A, Insin N, Bawendi MG, Semmler-Behnke M, Frangioni JV, Tsuda A: Rapid translocation of nanoparticles from the lung airspaces to the body. Nat Biotechnol 2010, 28: 1300\u20131303. 10.1038\/nbt.1696","journal-title":"Nat Biotechnol"},{"key":"55_CR42","doi-asserted-by":"publisher","first-page":"417","DOI":"10.3109\/17435390.2012.666576","volume":"7","author":"J Cohen","year":"2013","unstructured":"Cohen J, Deloid G, Pyrgiotakis G, Demokritou P: Interactions of engineered nanomaterials in physiological media and implications for in vitro dosimetry. Nanotoxicology 2013, 7: 417\u2013431. 10.3109\/17435390.2012.666576","journal-title":"Nanotoxicology"},{"key":"55_CR43","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/0013-9351(76)90107-9","volume":"11","author":"JD Brain","year":"1976","unstructured":"Brain JD, Knudson DE, Sorokin SP, Davis MA: Pulmonary distribution of particles given by intratracheal instillation or by aerosol inhalation. Environ Res 1976, 11: 13\u201333. 10.1016\/0013-9351(76)90107-9","journal-title":"Environ Res"},{"key":"55_CR44","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1177\/074823379701300401","volume":"13","author":"RP Brown","year":"1997","unstructured":"Brown RP, Delp MD, Lindstedt SL, Rhomberg LR, Beliles RP: Physiological parameter values for physiologically based pharmacokinetic models. Toxicol Ind Health 1997, 13: 407\u2013484. 10.1177\/074823379701300401","journal-title":"Toxicol Ind Health"},{"key":"55_CR45","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1080\/009841099157917","volume":"56","author":"DJ Schoeffner","year":"1999","unstructured":"Schoeffner DJ, Warren DA, Muralidara S, Bruckner JV, Simmons JE: Organ weights and fat volume in rats as a function of strain and age. J Toxicol Environ Health A 1999, 56: 449\u2013462. 10.1080\/009841099157917","journal-title":"J Toxicol Environ Health A"},{"key":"55_CR46","unstructured":"Organization for Economic Cooperation and Development (OECD): OECD Principles on Good Laboratory Practice (as revised in 1997). ENV\/MC\/CHEM(98)17, Guidance Manual for the testing of manufactured nanomaterials. Paris: OECD; 1998."},{"key":"55_CR47","unstructured":"OECD Guidelines for Testing of Chemicals, Section 4: Health Effects, No.412, \"Repeated Dose Inhalation Toxicity: 28day or 14day Study\". OECD, Paris; 2009."},{"key":"55_CR48","unstructured":"OECD Guidelines for the Testing of Chemicals, Section 4, Test No. 453: Combined Chronic Toxicity\/Carcinogenicity Studies. OECD, Paris; 2009."},{"key":"55_CR49","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1080\/08958370701479190","volume":"19","author":"L Ma-Hock","year":"2007","unstructured":"Ma-Hock L, Gamer AO, Landsiedel R, Leibold E, Frechen T, Sens B, Linsenbuehler M, Van Ravenzwaay B: Generation and characterization of test atmospheres with nanomaterials. Inhal Toxicol 2007, 19: 833\u2013848. 10.1080\/08958370701479190","journal-title":"Inhal Toxicol"},{"key":"55_CR50","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1080\/08958370802361057","volume":"21","author":"L Ma-Hock","year":"2009","unstructured":"Ma-Hock L, Burkhardt S, Strauss V, Gamer AO, Wiench K, Van Ravenzwaay B, Landsiedel R: Development of a short-term inhalation test in the rat using nano-titanium dioxide as a model substance. Inhal Toxicol 2009, 21: 102\u2013118. 10.1080\/08958370802361057","journal-title":"Inhal Toxicol"},{"key":"55_CR51","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1078\/0940-2993-00349","volume":"55","author":"B Kittel","year":"2004","unstructured":"Kittel B, Ruehl-Fehlert C, Morawietz G, Klapwijk J, Elwell MR, Lenz B, O'Sullivan MG, Roth DR, Wadsworth PF: Revised guides for organ sampling and trimming in rats and mice\u2013part 2. A joint publication of the RITA and NACAD groups. Exp Toxicol Pathol 2004, 55: 413\u2013431. 10.1078\/0940-2993-00349","journal-title":"Exp Toxicol Pathol"},{"key":"55_CR52","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1078\/0940-2993-00350","volume":"55","author":"G Morawietz","year":"2004","unstructured":"Morawietz G, Ruehl-Fehlert C, Kittel B, Bube A, Keane K, Halm S, Heuser A, Hellmann J: Revised guides for organ sampling and trimming in rats and mice\u2013part 3. A joint publication of the RITA and NACAD groups. Exp Toxicol Pathol 2004, 55: 433\u2013449. 10.1078\/0940-2993-00350","journal-title":"Exp Toxicol Pathol"},{"key":"55_CR53","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1078\/0940-2993-00311","volume":"55","author":"C Ruehl-Fehlert","year":"2003","unstructured":"Ruehl-Fehlert C, Kittel B, Morawietz G, Deslex P, Keenan C, Mahrt CR, Nolte T, Robinson M, Stuart BP, Deschl U: Revised guides for organ sampling and trimming in rats and mice\u2013part 1. Exp Toxicol Pathol 2003, 55: 91\u2013106. 10.1078\/0940-2993-00311","journal-title":"Exp Toxicol Pathol"}],"container-title":["Particle and Fibre Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12989-014-0055-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12989-014-0055-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12989-014-0055-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12989-014-0055-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T06:04:01Z","timestamp":1630562641000},"score":1,"resource":{"primary":{"URL":"https:\/\/particleandfibretoxicology.biomedcentral.com\/articles\/10.1186\/s12989-014-0055-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,21]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["55"],"URL":"https:\/\/doi.org\/10.1186\/s12989-014-0055-3","relation":{},"ISSN":["1743-8977"],"issn-type":[{"value":"1743-8977","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,21]]},"assertion":[{"value":"7 August 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"55"}}