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This study was designed to test the hypotheses that pyrotechnic firework displays introduce significant amounts of toxic metals into the atmosphere and are hazardous to human health. Size-selective emissions from 10 different fireworks displays were collected during particle generation in a dynamic, stainless steel chamber and tested for toxicity in cells. A subset of 2 particle types were tested in vivo in mice. At doses that did not produce cytotoxicity in an LDH assay, in vitro reactive oxygen species (ROS) formation was measured in bronchial epithelial airway (BEAS-2B) and human pulmonary microvascular endothelial (HPMEC-ST1.6R) cell lines treated with size-fractionated particles from the emissions of fireworks.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Significant increases in ROS, in both cell types, were dependent upon the type of firework but not particle size. The in vitro ROS activity was correlated with lung inflammation produced in groups of mice treated by oropharyngeal aspiration with 0, 50, or 100\u2009\u03bcg fireworks PM<jats:sub>10<\/jats:sub>\/mouse. Trace metal analyses of the PM<jats:sub>10<\/jats:sub> samples showed significant differences in metal content among fireworks type. Interestingly, the PM<jats:sub>10<\/jats:sub> sample for the fireworks type producing the greatest in vitro ROS response in BEAS-2B cells contained ~\u200940,000 and\u2009~\u200912,000\u2009ppm of lead and copper, respectively. This sample also produced the greatest inflammatory response (i.e., increased neutrophils in bronchoalveolar lavage fluid) in mice.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>These findings demonstrate that pyrotechnic display particles can produce adverse effects in mammalian cells and lungs, thus suggesting that further research is needed to expand our understanding of the contribution of metal content to the adverse health effects of fireworks particles. This information will lead to the manufacture of safer fireworks.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12989-020-00360-4","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T23:26:08Z","timestamp":1593645968000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Toxicity of particles emitted by fireworks"],"prefix":"10.1186","volume":"17","author":[{"given":"Christina","family":"Hickey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Galdanes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Blaustein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori","family":"Horton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Chillrud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Ross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lital","family":"Yinon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lung Chi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,2]]},"reference":[{"key":"360_CR1","unstructured":"US Today. 2016. https:\/\/www.usatoday.com\/story\/news\/nation-now\/2016\/07\/03\/how-america-celebrates-4th-july-numbers\/86602246\/."},{"key":"360_CR2","unstructured":"APA (American Pyrotechnics Association). 2019. https:\/\/www.americanpyro.com\/industry-facts-figures."},{"issue":"1","key":"360_CR3","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.jss.2014.03.066","volume":"190","author":"JK Canner","year":"2014","unstructured":"Canner JK, Haider AH, Selvarajah S, Hui X, Wang H, Efron DT, Haut ER, Velopulos CG, Schwartz DA, Chi A, Schneider EB. 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