{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:19:05Z","timestamp":1793330345817,"version":"4.5.0"},"reference-count":184,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400434"],"award-info":[{"award-number":["82400434"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270297"],"award-info":[{"award-number":["82270297"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Grant of Xinxiang Medical University","award":["XYBSKYZZ202151"],"award-info":[{"award-number":["XYBSKYZZ202151"]}]},{"name":"Postgraduate Education Reform and Quality Improvement Project of Henan Province","award":["YJS2026ZM07"],"award-info":[{"award-number":["YJS2026ZM07"]}]},{"name":"Zhongyuan Sci-Tech Innovation Leading Talents","award":["244200510003"],"award-info":[{"award-number":["244200510003"]}]},{"name":"Scientific and Technological Innovative Teams in Universities of Henan Province","award":["23IRTSTHN030"],"award-info":[{"award-number":["23IRTSTHN030"]}]},{"name":"Henan Provincial Joint Fund for Scientific and Technological Research","award":["232301420102"],"award-info":[{"award-number":["232301420102"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Part Fibre Toxicol"],"DOI":"10.1186\/s12989-026-00669-6","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T14:32:48Z","timestamp":1772289168000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Emerging cardiovascular risks of micro- and nanoplastics: toxic effects and mechanistic pathways"],"prefix":"10.1186","volume":"23","author":[{"given":"Gang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuya","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingchen","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiatian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"issue":"Pt 1","key":"669_CR1","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/j.envpol.2017.08.032","volume":"231","author":"J Wilkinson","year":"2017","unstructured":"Wilkinson J, Hooda PS, Barker J, Barton S, Swinden J. Occurrence, fate and transformation of emerging contaminants in water: an overarching review of the field. Environ Pollut. 2017;231(Pt 1):954\u201370. https:\/\/doi.org\/10.1016\/j.envpol.2017.08.032.","journal-title":"Environ Pollut"},{"issue":"8","key":"669_CR2","doi-asserted-by":"publisher","first-page":"4368","DOI":"10.1021\/acs.est.6b06155","volume":"51","author":"YK Song","year":"2017","unstructured":"Song YK, Hong SH, Jang M, Han GM, Jung SW, Shim WJ. Combined effects of UV exposure duration and mechanical abrasion on microplastic fragmentation by polymer type. Environ Sci Technol. 2017;51(8):4368\u201376. https:\/\/doi.org\/10.1021\/acs.est.6b06155.","journal-title":"Environ Sci Technol"},{"key":"669_CR3","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.chemosphere.2015.11.078","volume":"145","author":"S Lambert","year":"2016","unstructured":"Lambert S, Wagner M. Characterisation of nanoplastics during the degradation of polystyrene. Chemosphere. 2016;145:265\u20138. https:\/\/doi.org\/10.1016\/j.chemosphere.2015.11.078.","journal-title":"Chemosphere"},{"key":"669_CR4","doi-asserted-by":"publisher","first-page":"105263","DOI":"10.1016\/j.envint.2019.105263","volume":"137","author":"JJ Guo","year":"2020","unstructured":"Guo JJ, Huang XP, Xiang L, Wang YZ, Li YW, Li H, et al. Source, migration and toxicology of microplastics in soil. Environ Int. 2020;137:105263. https:\/\/doi.org\/10.1016\/j.envint.2019.105263.","journal-title":"Environ Int"},{"key":"669_CR5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.marenvres.2015.10.014","volume":"113","author":"J Wang","year":"2016","unstructured":"Wang J, Tan Z, Peng J, Qiu Q, Li M. The behaviors of microplastics in the marine environment. Mar Environ Res. 2016;113:7\u201317. https:\/\/doi.org\/10.1016\/j.marenvres.2015.10.014.","journal-title":"Mar Environ Res"},{"key":"669_CR6","doi-asserted-by":"publisher","first-page":"107662","DOI":"10.1016\/j.envint.2022.107662","volume":"171","author":"X Zhu","year":"2023","unstructured":"Zhu X, Wang C, Duan X, Liang B, Genbo Xu E, Huang Z. Micro- and nanoplastics: a new cardiovascular risk factor? Environ Int. 2023;171:107662. https:\/\/doi.org\/10.1016\/j.envint.2022.107662.","journal-title":"Environ Int"},{"key":"669_CR7","doi-asserted-by":"publisher","first-page":"108150","DOI":"10.1016\/j.envint.2023.108150","volume":"179","author":"G Zuri","year":"2023","unstructured":"Zuri G, Karanasiou A, Lacorte S, Microplastics. Microplastics: human exposure assessment through air, water, and food. Environ Int. 2023;179:108150. https:\/\/doi.org\/10.1016\/j.envint.2023.108150.","journal-title":"Environ Int"},{"key":"669_CR8","doi-asserted-by":"publisher","first-page":"162954","DOI":"10.1016\/j.scitotenv.2023.162954","volume":"878","author":"K Pelegrini","year":"2023","unstructured":"Pelegrini K, Pereira TCB, Maraschin TG, Teodoro LS, Basso NRS, De Galland GLB, et al. Micro- and nanoplastic toxicity: a review on size, type, source, and test-organism implications. Sci Total Environ. 2023;878:162954. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.162954.","journal-title":"Sci Total Environ"},{"issue":"4","key":"669_CR9","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1038\/s41591-024-03453-1","volume":"31","author":"AJ Nihart","year":"2025","unstructured":"Nihart AJ, Garcia MA, El Hayek E, Liu R, Olewine M, Kingston JD, et al. Bioaccumulation of microplastics in decedent human brains. Nat Med. 2025;31(4):1114\u20139. https:\/\/doi.org\/10.1038\/s41591-024-03453-1.","journal-title":"Nat Med"},{"key":"669_CR10","doi-asserted-by":"publisher","first-page":"104147","DOI":"10.1016\/j.ebiom.2022.104147","volume":"82","author":"T Horvatits","year":"2022","unstructured":"Horvatits T, Tamminga M, Liu B, Sebode M, Carambia A, Fischer L, et al. Microplastics detected in cirrhotic liver tissue. EBioMedicine. 2022;82:104147. https:\/\/doi.org\/10.1016\/j.ebiom.2022.104147.","journal-title":"EBioMedicine"},{"key":"669_CR11","doi-asserted-by":"publisher","first-page":"108444","DOI":"10.1016\/j.envint.2024.108444","volume":"184","author":"S Massardo","year":"2024","unstructured":"Massardo S, Verzola D, Alberti S, Caboni C, Santostefano M, Eugenio Verrina E, et al. MicroRaman spectroscopy detects the presence of microplastics in human urine and kidney tissue. Environ Int. 2024;184:108444. https:\/\/doi.org\/10.1016\/j.envint.2024.108444.","journal-title":"Environ Int"},{"key":"669_CR12","doi-asserted-by":"publisher","first-page":"133855","DOI":"10.1016\/j.jhazmat.2024.133855","volume":"469","author":"S Liu","year":"2024","unstructured":"Liu S, Wang C, Yang Y, Du Z, Li L, Zhang M, et al. Microplastics in three types of human arteries detected by pyrolysis-gas chromatography\/mass spectrometry (Py-GC\/MS). J Hazard Mater. 2024;469:133855. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.133855.","journal-title":"J Hazard Mater"},{"issue":"30","key":"669_CR13","doi-asserted-by":"publisher","first-page":"10911","DOI":"10.1021\/acs.est.2c07179","volume":"57","author":"Y Yang","year":"2023","unstructured":"Yang Y, Xie E, Du Z, Peng Z, Han Z, Li L, et al. Detection of various microplastics in patients undergoing cardiac surgery. Environ Sci Technol. 2023;57(30):10911\u20138. https:\/\/doi.org\/10.1021\/acs.est.2c07179.","journal-title":"Environ Sci Technol"},{"issue":"38","key":"669_CR14","doi-asserted-by":"publisher","first-page":"4099","DOI":"10.1093\/eurheartj\/ehae552","volume":"45","author":"F Prattichizzo","year":"2024","unstructured":"Prattichizzo F, Ceriello A, Pellegrini V, La Grotta R, Graciotti L, Olivieri F, et al. Micro-nanoplastics and cardiovascular diseases: evidence and perspectives. Eur Heart J. 2024;45(38):4099\u2013110. https:\/\/doi.org\/10.1093\/eurheartj\/ehae552.","journal-title":"Eur Heart J"},{"key":"669_CR15","doi-asserted-by":"publisher","first-page":"156727","DOI":"10.1016\/j.scitotenv.2022.156727","volume":"840","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Yin K, Wang D, Wang Y, Lu H, Zhao H, et al. Polystyrene microplastics-induced cardiotoxicity in chickens via the ROS-driven NF-kappaB-NLRP3-GSDMD and AMPK-PGC-1alpha axes. Sci Total Environ. 2022;840:156727. https:\/\/doi.org\/10.1016\/j.scitotenv.2022.156727.","journal-title":"Sci Total Environ"},{"key":"669_CR16","doi-asserted-by":"publisher","first-page":"137410","DOI":"10.1016\/j.jhazmat.2025.137410","volume":"488","author":"X Gu","year":"2025","unstructured":"Gu X, Zhang Z, Zhao L, Lu L, Lu X, Li Y, et al. Exposure to polyethylene terephthalate micro(nano)plastics exacerbates inflammation and fibrosis after myocardial infarction by reprogramming the gut and lung microbiota and metabolome. J Hazard Mater. 2025;488:137410. https:\/\/doi.org\/10.1016\/j.jhazmat.2025.137410.","journal-title":"J Hazard Mater"},{"issue":"11","key":"669_CR17","doi-asserted-by":"publisher","first-page":"5086","DOI":"10.1002\/tox.24387","volume":"39","author":"C Huo","year":"2024","unstructured":"Huo C, Zhu Y, Fang X, Cui J, Ye H, Zhao H, et al. Polystyrene microplastics induce injury to the vascular endothelial through NLRP3-mediated pyroptosis. Environ Toxicol. 2024;39(11):5086\u201398. https:\/\/doi.org\/10.1002\/tox.24387.","journal-title":"Environ Toxicol"},{"key":"669_CR18","doi-asserted-by":"publisher","first-page":"121233","DOI":"10.1016\/j.envpol.2023.121233","volume":"323","author":"F Wang","year":"2023","unstructured":"Wang F, Zhang Q, Cui J, Bao B, Deng X, Liu L, et al. Polystyrene microplastics induce endoplasmic reticulum stress, apoptosis and inflammation by disrupting the gut microbiota in carp intestines. Environ Pollut. 2023;323:121233. https:\/\/doi.org\/10.1016\/j.envpol.2023.121233.","journal-title":"Environ Pollut"},{"key":"669_CR19","doi-asserted-by":"publisher","first-page":"126685","DOI":"10.1016\/j.envpol.2025.126685","volume":"382","author":"H Niu","year":"2025","unstructured":"Niu H, Li W. Exposure of polystyrene nanoplastics led to ferroptosis on cardiomyocytes. Environ Pollut. 2025;382:126685. https:\/\/doi.org\/10.1016\/j.envpol.2025.126685.","journal-title":"Environ Pollut"},{"key":"669_CR20","doi-asserted-by":"publisher","first-page":"169515","DOI":"10.1016\/j.scitotenv.2023.169515","volume":"912","author":"M Zhang","year":"2024","unstructured":"Zhang M, Shi J, Pan H, Zhu J, Wang X, Song L, et al. A novel tiRNA-Glu-CTC induces nanoplastics accelerated vascular smooth muscle cell phenotypic switching and vascular injury through mitochondrial damage. Sci Total Environ. 2024;912:169515. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.169515.","journal-title":"Sci Total Environ"},{"key":"669_CR21","doi-asserted-by":"publisher","first-page":"116983","DOI":"10.1016\/j.ecoenv.2024.116983","volume":"284","author":"Y Zhong","year":"2024","unstructured":"Zhong Y, Feng Y, Huang Y, Wang B, Shi W, Liang B, et al. Polystyrene nanoplastics accelerate atherosclerosis: unraveling the impact on smooth muscle cells through KIF15-mediated migration. Ecotoxicol Environ Saf. 2024;284:116983. https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116983.","journal-title":"Ecotoxicol Environ Saf"},{"issue":"Pt A","key":"669_CR22","doi-asserted-by":"publisher","first-page":"115025","DOI":"10.1016\/j.envpol.2020.115025","volume":"265","author":"Z Li","year":"2020","unstructured":"Li Z, Zhu S, Liu Q, Wei J, Jin Y, Wang X, et al. Polystyrene microplastics cause cardiac fibrosis by activating Wnt\/beta-catenin signaling pathway and promoting cardiomyocyte apoptosis in rats. Environ Pollut. 2020;265(Pt A):115025. https:\/\/doi.org\/10.1016\/j.envpol.2020.115025.","journal-title":"Environ Pollut"},{"issue":"19","key":"669_CR23","doi-asserted-by":"publisher","first-page":"e2205876","DOI":"10.1002\/advs.202205876","volume":"10","author":"B Wang","year":"2023","unstructured":"Wang B, Liang B, Huang Y, Li Z, Zhang B, Du J, et al. Long-chain acyl carnitines aggravate polystyrene nanoplastics-induced atherosclerosis by upregulating MARCO. Adv Sci (Weinh). 2023;10(19):e2205876. https:\/\/doi.org\/10.1002\/advs.202205876.","journal-title":"Adv Sci (Weinh)"},{"key":"669_CR24","doi-asserted-by":"publisher","first-page":"161271","DOI":"10.1016\/j.scitotenv.2022.161271","volume":"865","author":"X Wang","year":"2023","unstructured":"Wang X, Jia Z, Zhou X, Su L, Wang M, Wang T, et al. Nanoplastic-induced vascular endothelial injury and coagulation dysfunction in mice. Sci Total Environ. 2023;865:161271. https:\/\/doi.org\/10.1016\/j.scitotenv.2022.161271.","journal-title":"Sci Total Environ"},{"key":"669_CR25","doi-asserted-by":"publisher","first-page":"133583","DOI":"10.1016\/j.jhazmat.2024.133583","volume":"466","author":"J Wen","year":"2024","unstructured":"Wen J, Sun H, Yang B, Song E, Song Y. Long-term polystyrene nanoplastic exposure disrupt hepatic lipid metabolism and cause atherosclerosis in ApoE(-\/-) mice. J Hazard Mater. 2024;466:133583. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.133583.","journal-title":"J Hazard Mater"},{"issue":"1","key":"669_CR26","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12989-024-00596-4","volume":"21","author":"Y Yang","year":"2024","unstructured":"Yang Y, Zhang F, Jiang Z, Du Z, Liu S, Zhang M, et al. Microplastics are associated with elevated atherosclerotic risk and increased vascular complexity in acute coronary syndrome patients. Part Fibre Toxicol. 2024;21(1):34. https:\/\/doi.org\/10.1186\/s12989-024-00596-4.","journal-title":"Part Fibre Toxicol"},{"key":"669_CR27","doi-asserted-by":"publisher","first-page":"137624","DOI":"10.1016\/j.jhazmat.2025.137624","volume":"489","author":"Y Zhang","year":"2025","unstructured":"Zhang Y, Gao Q, Gao Q, Xu M, Fang N, Mu L, et al. Microplastics and nanoplastics increase major adverse cardiac events in patients with myocardial infarction. J Hazard Mater. 2025;489:137624. https:\/\/doi.org\/10.1016\/j.jhazmat.2025.137624.","journal-title":"J Hazard Mater"},{"key":"669_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.117657","author":"SPS Chia","year":"2025","unstructured":"Chia SPS, Pang JKS, Winanto W, Soh B-S. Nanoplastics induces arrhythmia in human stem-cells derived cardiomyocytes. Ecotoxicol Environ Saf. 2025. https:\/\/doi.org\/10.1016\/j.ecoenv.2024.117657.","journal-title":"Ecotoxicol Environ Saf"},{"issue":"10","key":"669_CR29","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1056\/NEJMoa2309822","volume":"390","author":"R Marfella","year":"2024","unstructured":"Marfella R, Prattichizzo F, Sardu C, Fulgenzi G, Graciotti L, Spadoni T, et al. Microplastics and nanoplastics in atheromas and cardiovascular events. N Engl J Med. 2024;390(10):900\u201310. https:\/\/doi.org\/10.1056\/NEJMoa2309822.","journal-title":"N Engl J Med"},{"key":"669_CR30","doi-asserted-by":"publisher","first-page":"136211","DOI":"10.1016\/j.jhazmat.2024.136211","volume":"480","author":"H Yu","year":"2024","unstructured":"Yu H, Li H, Cui C, Han Y, Xiao Y, Zhang B, et al. Association between blood microplastic levels and severity of extracranial artery stenosis. J Hazard Mater. 2024;480:136211. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.136211.","journal-title":"J Hazard Mater"},{"key":"669_CR31","doi-asserted-by":"publisher","first-page":"120618","DOI":"10.1016\/j.jenvman.2024.120618","volume":"356","author":"Y Arif","year":"2024","unstructured":"Arif Y, Mir AR, Zieli\u0144ski P, Hayat S, Bajguz A. Microplastics and nanoplastics: source, behavior, remediation, and multi-level environmental impact. J Environ Manage. 2024;356:120618. https:\/\/doi.org\/10.1016\/j.jenvman.2024.120618.","journal-title":"J Environ Manage"},{"issue":"7","key":"669_CR32","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1289\/ehp.7339","volume":"113","author":"G Oberdorster","year":"2005","unstructured":"Oberdorster G, Oberdorster E, Oberdorster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect. 2005;113(7):823\u201339. https:\/\/doi.org\/10.1289\/ehp.7339.","journal-title":"Environ Health Perspect"},{"issue":"8","key":"669_CR33","doi-asserted-by":"publisher","first-page":"5484","DOI":"10.1007\/s12010-023-04832-z","volume":"196","author":"Y Wang","year":"2024","unstructured":"Wang Y, Fu Z, Guan D, Zhao J, Zhang Q, Liu Q, et al. Occurrence characteristics and ecotoxic effects of microplastics in environmental media: a mini review. Appl Biochem Biotechnol. 2024;196(8):5484\u2013507. https:\/\/doi.org\/10.1007\/s12010-023-04832-z.","journal-title":"Appl Biochem Biotechnol"},{"key":"669_CR34","doi-asserted-by":"publisher","first-page":"164596","DOI":"10.1016\/j.scitotenv.2023.164596","volume":"891","author":"M Sohail","year":"2023","unstructured":"Sohail M, Urooj Z, Noreen S, Baig M, Zhang X, Li B. Micro- and nanoplastics: contamination routes of food products and critical interpretation of detection strategies. Sci Total Environ. 2023;891:164596. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.164596.","journal-title":"Sci Total Environ"},{"issue":"36","key":"669_CR35","doi-asserted-by":"publisher","first-page":"10450","DOI":"10.1021\/acs.jafc.1c04199","volume":"69","author":"Q Liu","year":"2021","unstructured":"Liu Q, Chen Z, Chen Y, Yang F, Yao W, Xie Y. Microplastics and nanoplastics: emerging contaminants in food. J Agric Food Chem. 2021;69(36):10450\u201368. https:\/\/doi.org\/10.1021\/acs.jafc.1c04199.","journal-title":"J Agric Food Chem"},{"key":"669_CR36","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.watres.2019.02.054","volume":"155","author":"AA Koelmans","year":"2019","unstructured":"Koelmans AA, Mohamed Nor NH, Hermsen E, Kooi M, Mintenig SM, De France J. Microplastics in freshwaters and drinking water: critical review and assessment of data quality. Water Res. 2019;155:410\u201322. https:\/\/doi.org\/10.1016\/j.watres.2019.02.054.","journal-title":"Water Res"},{"key":"669_CR37","doi-asserted-by":"publisher","first-page":"131476","DOI":"10.1016\/j.jhazmat.2023.131476","volume":"454","author":"O Pencik","year":"2023","unstructured":"Pencik O, Durdakova M, Molnarova K, Kucsera A, Klofac D, Kolackova M, et al. Microplastics and nanoplastics toxicity assays: a revision towards to environmental-relevance in water environment. J Hazard Mater. 2023;454:131476. https:\/\/doi.org\/10.1016\/j.jhazmat.2023.131476.","journal-title":"J Hazard Mater"},{"key":"669_CR38","doi-asserted-by":"publisher","first-page":"164531","DOI":"10.1016\/j.scitotenv.2023.164531","volume":"892","author":"SA Siddiqui","year":"2023","unstructured":"Siddiqui SA, Singh S, Bahmid NA, Shyu DJH, Dominguez R, Lorenzo JM, et al. Polystyrene microplastic particles in the food chain: characteristics and toxicity\u2014a review. Sci Total Environ. 2023;892:164531. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.164531.","journal-title":"Sci Total Environ"},{"key":"669_CR39","doi-asserted-by":"publisher","first-page":"140541","DOI":"10.1016\/j.chemosphere.2023.140541","volume":"345","author":"M Wang","year":"2023","unstructured":"Wang M, Wang WX. Infiltration of freshwater food chain by nanoplastics: an examination of trophic transfer and biological impact. Chemosphere. 2023;345:140541. https:\/\/doi.org\/10.1016\/j.chemosphere.2023.140541.","journal-title":"Chemosphere"},{"issue":"1","key":"669_CR40","doi-asserted-by":"publisher","first-page":"8023","DOI":"10.1038\/s41467-023-43788-w","volume":"14","author":"A Porter","year":"2023","unstructured":"Porter A, Godbold JA, Lewis CN, Savage G, Solan M, Galloway TS. Microplastic burden in marine benthic invertebrates depends on species traits and feeding ecology within biogeographical provinces. Nat Commun. 2023;14(1):8023. https:\/\/doi.org\/10.1038\/s41467-023-43788-w.","journal-title":"Nat Commun"},{"key":"669_CR41","doi-asserted-by":"publisher","first-page":"125427","DOI":"10.1016\/j.jenvman.2025.125427","volume":"382","author":"CM Ho","year":"2025","unstructured":"Ho CM, Feng W, Li X, Ngien SK, Yu X, Song F, et al. Microplastic distribution and its implications for human health through marine environments. J Environ Manage. 2025;382:125427. https:\/\/doi.org\/10.1016\/j.jenvman.2025.125427.","journal-title":"J Environ Manage"},{"key":"669_CR42","doi-asserted-by":"publisher","first-page":"147815","DOI":"10.1016\/j.scitotenv.2021.147815","volume":"788","author":"MMA Allouzi","year":"2021","unstructured":"Allouzi MMA, Tang DYY, Chew KW, Rinklebe J, Bolan N, Allouzi SMA, et al. Micro (nano) plastic pollution: the ecological influence on soil-plant system and human health. Sci Total Environ. 2021;788:147815. https:\/\/doi.org\/10.1016\/j.scitotenv.2021.147815.","journal-title":"Sci Total Environ"},{"issue":"2","key":"669_CR43","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41569-024-01068-0","volume":"22","author":"T Munzel","year":"2025","unstructured":"Munzel T, Hahad O, Lelieveld J, Aschner M, Nieuwenhuijsen MJ, Landrigan PJ, et al. Soil and water pollution and cardiovascular disease. Nat Rev Cardiol. 2025;22(2):71\u201389. https:\/\/doi.org\/10.1038\/s41569-024-01068-0.","journal-title":"Nat Rev Cardiol"},{"key":"669_CR44","doi-asserted-by":"publisher","first-page":"125778","DOI":"10.1016\/j.jhazmat.2021.125778","volume":"416","author":"C Dessi","year":"2021","unstructured":"Dessi C, Okoffo ED, O\u2019Brien JW, Gallen M, Samanipour S, Kaserzon S, et al. Plastics contamination of store-bought rice. J Hazard Mater. 2021;416:125778. https:\/\/doi.org\/10.1016\/j.jhazmat.2021.125778.","journal-title":"J Hazard Mater"},{"key":"669_CR45","doi-asserted-by":"publisher","first-page":"109626","DOI":"10.1016\/j.meatsci.2024.109626","volume":"217","author":"E Visentin","year":"2024","unstructured":"Visentin E, Niero G, Benetti F, Perini A, Zanella M, Pozza M, et al. Preliminary characterization of microplastics in beef hamburgers. Meat Sci. 2024;217:109626. https:\/\/doi.org\/10.1016\/j.meatsci.2024.109626.","journal-title":"Meat Sci"},{"issue":"5","key":"669_CR46","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1080\/10408398.2022.2116559","volume":"64","author":"S Wen","year":"2024","unstructured":"Wen S, Zhao Y, Wang M, Yuan H, Xu H. Micro(nano)plastics in food system: potential health impacts on human intestinal system. Crit Rev Food Sci Nutr. 2024;64(5):1429\u201347. https:\/\/doi.org\/10.1080\/10408398.2022.2116559.","journal-title":"Crit Rev Food Sci Nutr"},{"key":"669_CR47","doi-asserted-by":"publisher","first-page":"169228","DOI":"10.1016\/j.scitotenv.2023.169228","volume":"912","author":"R Sun","year":"2024","unstructured":"Sun R, Liu M, Xiong F, Xu K, Huang J, Liu J, et al. Polystyrene micro- and nanoplastics induce gastric toxicity through ROS mediated oxidative stress and P62\/Keap1\/Nrf2 pathway. Sci Total Environ. 2024;912:169228. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.169228.","journal-title":"Sci Total Environ"},{"key":"669_CR48","doi-asserted-by":"publisher","first-page":"133412","DOI":"10.1016\/j.jhazmat.2023.133412","volume":"465","author":"D Luo","year":"2024","unstructured":"Luo D, Chu X, Wu Y, Wang Z, Liao Z, Ji X, et al. Micro- and nano-plastics in the atmosphere: a review of occurrence, properties and human health risks. J Hazard Mater. 2024;465:133412. https:\/\/doi.org\/10.1016\/j.jhazmat.2023.133412.","journal-title":"J Hazard Mater"},{"key":"669_CR49","doi-asserted-by":"publisher","first-page":"126007","DOI":"10.1016\/j.jhazmat.2021.126007","volume":"417","author":"Z Liao","year":"2021","unstructured":"Liao Z, Ji X, Ma Y, Lv B, Huang W, Zhu X, et al. Airborne microplastics in indoor and outdoor environments of a coastal city in Eastern China. J Hazard Mater. 2021;417:126007. https:\/\/doi.org\/10.1016\/j.jhazmat.2021.126007.","journal-title":"J Hazard Mater"},{"issue":"19","key":"669_CR50","doi-asserted-by":"publisher","first-page":"12871","DOI":"10.1021\/acs.est.1c03618","volume":"55","author":"X Zhu","year":"2021","unstructured":"Zhu X, Huang W, Fang M, Liao Z, Wang Y, Xu L, et al. Airborne microplastic concentrations in five megacities of Northern and Southeast China. Environ Sci Technol. 2021;55(19):12871\u201381. https:\/\/doi.org\/10.1021\/acs.est.1c03618.","journal-title":"Environ Sci Technol"},{"key":"669_CR51","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.cofs.2021.04.010","volume":"41","author":"M Beaurepaire","year":"2021","unstructured":"Beaurepaire M, Dris R, Gasperi J, Tassin B. Microplastics in the atmospheric compartment: a comprehensive review on methods, results on their occurrence and determining factors. Curr Opin Food Sci. 2021;41:159\u201368. https:\/\/doi.org\/10.1016\/j.cofs.2021.04.010.","journal-title":"Curr Opin Food Sci"},{"key":"669_CR52","doi-asserted-by":"publisher","first-page":"118465","DOI":"10.1016\/j.envpol.2021.118465","volume":"292","author":"Y Chen","year":"2022","unstructured":"Chen Y, Li X, Zhang X, Zhang Y, Gao W, Wang R, et al. Air conditioner filters become sinks and sources of indoor microplastics fibers. Environ Pollut. 2022;292:118465. https:\/\/doi.org\/10.1016\/j.envpol.2021.118465. Pt B):.","journal-title":"Environ Pollut"},{"issue":"32","key":"669_CR53","doi-asserted-by":"publisher","first-page":"e202205713","DOI":"10.1002\/anie.202205713","volume":"61","author":"T Salthammer","year":"2022","unstructured":"Salthammer T. Microplastics and their additives in the indoor environment. Angew Chem Int Ed Engl. 2022;61(32):e202205713. https:\/\/doi.org\/10.1002\/anie.202205713.","journal-title":"Angew Chem Int Ed Engl"},{"issue":"1","key":"669_CR54","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s12989-024-00613-6","volume":"21","author":"Z Gou","year":"2024","unstructured":"Gou Z, Wu H, Li S, Liu Z, Zhang Y. Airborne micro- and nanoplastics: emerging causes of respiratory diseases. Part Fibre Toxicol. 2024;21(1):50. https:\/\/doi.org\/10.1186\/s12989-024-00613-6.","journal-title":"Part Fibre Toxicol"},{"key":"669_CR55","doi-asserted-by":"publisher","first-page":"126124","DOI":"10.1016\/j.jhazmat.2021.126124","volume":"416","author":"LF Amato-Lourenco","year":"2021","unstructured":"Amato-Lourenco LF, Carvalho-Oliveira R, Junior GR, Dos Santos Galvao L, Ando RA, Mauad T. Presence of airborne microplastics in human lung tissue. J Hazard Mater. 2021;416:126124. https:\/\/doi.org\/10.1016\/j.jhazmat.2021.126124.","journal-title":"J Hazard Mater"},{"key":"669_CR56","doi-asserted-by":"publisher","first-page":"126069","DOI":"10.1016\/j.jhazmat.2021.126069","volume":"416","author":"K Lu","year":"2021","unstructured":"Lu K, Lai KP, Stoeger T, Ji S, Lin Z, Lin X, et al. Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology. J Hazard Mater. 2021;416:126069. https:\/\/doi.org\/10.1016\/j.jhazmat.2021.126069.","journal-title":"J Hazard Mater"},{"issue":"1","key":"669_CR57","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s12989-023-00557-3","volume":"20","author":"T Zhang","year":"2023","unstructured":"Zhang T, Yang S, Ge Y, Wan X, Zhu Y, Yang F, et al. Multi-dimensional evaluation of cardiotoxicity in mice following respiratory exposure to polystyrene nanoplastics. Part Fibre Toxicol. 2023;20(1):46. https:\/\/doi.org\/10.1186\/s12989-023-00557-3.","journal-title":"Part Fibre Toxicol"},{"key":"669_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2025.137781","author":"S Chen","year":"2025","unstructured":"Chen S, Fang L, Yang T, Li Z, Zhang M, Wang M, et al. Unveiling the systemic impact of airborne microplastics: Integrating breathomics and machine learning with dual-tissue transcriptomics. J Hazard Mater. 2025. https:\/\/doi.org\/10.1016\/j.jhazmat.2025.137781.","journal-title":"J Hazard Mater"},{"key":"669_CR59","doi-asserted-by":"publisher","first-page":"106367","DOI":"10.1016\/j.envint.2020.106367","volume":"149","author":"T Atugoda","year":"2021","unstructured":"Atugoda T, Vithanage M, Wijesekara H, Bolan N, Sarmah AK, Bank MS, et al. Interactions between microplastics, pharmaceuticals and personal care products: implications for vector transport. Environ Int. 2021;149:106367. https:\/\/doi.org\/10.1016\/j.envint.2020.106367.","journal-title":"Environ Int"},{"issue":"4","key":"669_CR60","doi-asserted-by":"publisher","first-page":"197","DOI":"10.4161\/derm.1.4.9501","volume":"1","author":"M Schneider","year":"2009","unstructured":"Schneider M, Stracke F, Hansen S, Schaefer UF. Nanoparticles and their interactions with the dermal barrier. Dermatoendocrinol. 2009;1(4):197\u2013206. https:\/\/doi.org\/10.4161\/derm.1.4.9501.","journal-title":"Dermatoendocrinol"},{"issue":"4","key":"669_CR61","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1042\/ETLS20220024","volume":"6","author":"S Bastyans","year":"2022","unstructured":"Bastyans S, Jackson S, Fejer G. Micro and nano-plastics, a threat to human health? Emerg Top Life Sci. 2022;6(4):411\u201322. https:\/\/doi.org\/10.1042\/ETLS20220024.","journal-title":"Emerg Top Life Sci"},{"issue":"12","key":"669_CR62","doi-asserted-by":"publisher","first-page":"6634","DOI":"10.1021\/acs.est.7b00423","volume":"51","author":"SL Wright","year":"2017","unstructured":"Wright SL, Kelly FJ. Plastic and human health: a micro issue? Environ Sci Technol. 2017;51(12):6634\u201347. https:\/\/doi.org\/10.1021\/acs.est.7b00423.","journal-title":"Environ Sci Technol"},{"issue":"29","key":"669_CR63","doi-asserted-by":"publisher","first-page":"10554","DOI":"10.1021\/acs.est.3c01894","volume":"57","author":"OA Abafe","year":"2023","unstructured":"Abafe OA, Harrad S, Abdallah MA. Novel insights into the dermal bioaccessibility and human exposure to brominated flame retardant additives in microplastics. Environ Sci Technol. 2023;57(29):10554\u201362. https:\/\/doi.org\/10.1021\/acs.est.3c01894.","journal-title":"Environ Sci Technol"},{"issue":"1","key":"669_CR64","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s12989-021-00428-9","volume":"18","author":"PM Gopinath","year":"2021","unstructured":"Gopinath PM, Twayana KS, Ravanan P, John T, Mukherjee A, Jenkins DF, et al. Prospects on the nano-plastic particles internalization and induction of cellular response in human keratinocytes. Part Fibre Toxicol. 2021;18(1):35. https:\/\/doi.org\/10.1186\/s12989-021-00428-9.","journal-title":"Part Fibre Toxicol"},{"issue":"1","key":"669_CR65","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s12989-024-00583-9","volume":"21","author":"L Martin","year":"2024","unstructured":"Martin L, Simpson K, Brzezinski M, Watt J, Xu W. Cellular response of keratinocytes to the entry and accumulation of nanoplastic particles. Part Fibre Toxicol. 2024;21(1):22. https:\/\/doi.org\/10.1186\/s12989-024-00583-9.","journal-title":"Part Fibre Toxicol"},{"key":"669_CR66","doi-asserted-by":"publisher","first-page":"135054","DOI":"10.1016\/j.jhazmat.2024.135054","volume":"476","author":"S Liu","year":"2024","unstructured":"Liu S, Yang Y, Du Z, Wang C, Li L, Zhang M, et al. Percutaneous coronary intervention leads to microplastics entering the blood: interventional devices are a major source. J Hazard Mater. 2024;476:135054. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.135054.","journal-title":"J Hazard Mater"},{"key":"669_CR67","doi-asserted-by":"publisher","first-page":"176468","DOI":"10.1016\/j.scitotenv.2024.176468","volume":"954","author":"Z Liu","year":"2024","unstructured":"Liu Z, Wang D, Liu Z, Xu C, Zhang Y, Liu P. Microplastic injection? Identification and quantification of plastic particles in medical injections. Sci Total Environ. 2024;954:176468. https:\/\/doi.org\/10.1016\/j.scitotenv.2024.176468.","journal-title":"Sci Total Environ"},{"issue":"12","key":"669_CR68","doi-asserted-by":"publisher","first-page":"108454","DOI":"10.1016\/j.isci.2023.108454","volume":"26","author":"P Li","year":"2023","unstructured":"Li P, Li Q, Lai Y, Yang S, Yu S, Liu R, et al. Direct entry of micro(nano)plastics into human blood circulatory system by intravenous infusion. iScience. 2023;26(12):108454. https:\/\/doi.org\/10.1016\/j.isci.2023.108454.","journal-title":"iScience"},{"key":"669_CR69","doi-asserted-by":"publisher","first-page":"133559","DOI":"10.1016\/j.jhazmat.2024.133559","volume":"466","author":"Y Shi","year":"2024","unstructured":"Shi Y, Li D, Hill C, Yang L, Sheerin ED, Pilliadugula R, et al. Micro and nano plastics release from a single absorbable suture into simulated body fluid. J Hazard Mater. 2024;466:133559. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.133559.","journal-title":"J Hazard Mater"},{"key":"669_CR70","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.actbio.2015.05.016","volume":"23","author":"A Liu","year":"2015","unstructured":"Liu A, Richards L, Bladen CL, Ingham E, Fisher J, Tipper JL. The biological response to nanometre-sized polymer particles. Acta Biomater. 2015;23:38\u201351. https:\/\/doi.org\/10.1016\/j.actbio.2015.05.016.","journal-title":"Acta Biomater"},{"issue":"2","key":"669_CR71","doi-asserted-by":"publisher","first-page":"e24355","DOI":"10.1016\/j.heliyon.2024.e24355","volume":"10","author":"SC Saha","year":"2024","unstructured":"Saha SC, Saha G. Effect of microplastics deposition on human lung airways: a review with computational benefits and challenges. Heliyon. 2024;10(2):e24355. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e24355.","journal-title":"Heliyon"},{"key":"669_CR72","doi-asserted-by":"publisher","first-page":"106654","DOI":"10.1016\/j.envint.2021.106654","volume":"154","author":"J Fern\u00e1ndez-Arribas","year":"2021","unstructured":"Fern\u00e1ndez-Arribas J, Moreno T, Bartrol\u00ed R, Eljarrat E. COVID-19 face masks: a new source of human and environmental exposure to organophosphate esters. Environ Int. 2021;154:106654. https:\/\/doi.org\/10.1016\/j.envint.2021.106654.","journal-title":"Environ Int"},{"key":"669_CR73","doi-asserted-by":"publisher","first-page":"134219","DOI":"10.1016\/j.jhazmat.2024.134219","volume":"470","author":"Y Weng","year":"2024","unstructured":"Weng Y, Yan H, Nan X, Sun H, Shi Y, Zhang Y, et al. Potential health risks of microplastic fibres release from disposable surgical masks: impact of repeated wearing and handling. J Hazard Mater. 2024;470:134219. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.134219.","journal-title":"J Hazard Mater"},{"issue":"2","key":"669_CR74","doi-asserted-by":"publisher","first-page":"e0280594","DOI":"10.1371\/journal.pone.0280594","volume":"18","author":"JM Rotchell","year":"2023","unstructured":"Rotchell JM, Jenner LC, Chapman E, Bennett RT, Bolanle IO, Loubani M, et al. Detection of microplastics in human saphenous vein tissue using muFTIR: a pilot study. PLoS ONE. 2023;18(2):e0280594. https:\/\/doi.org\/10.1371\/journal.pone.0280594.","journal-title":"PLoS ONE"},{"key":"669_CR75","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.scitotenv.2011.11.078","volume":"416","author":"JP Harrison","year":"2012","unstructured":"Harrison JP, Ojeda JJ, Romero-Gonzalez ME. The applicability of reflectance micro-Fourier-transform infrared spectroscopy for the detection of synthetic microplastics in marine sediments. Sci Total Environ. 2012;416:455\u201363. https:\/\/doi.org\/10.1016\/j.scitotenv.2011.11.078.","journal-title":"Sci Total Environ"},{"key":"669_CR76","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.marpolbul.2017.12.061","volume":"127","author":"MR Jung","year":"2018","unstructured":"Jung MR, Horgen FD, Orski SV, Rodriguez CV, Beers KL, Balazs GH, et al. Validation of ATR FT-IR to identify polymers of plastic marine debris, including those ingested by marine organisms. Mar Pollut Bull. 2018;127:704\u201316. https:\/\/doi.org\/10.1016\/j.marpolbul.2017.12.061.","journal-title":"Mar Pollut Bull"},{"key":"669_CR77","doi-asserted-by":"publisher","first-page":"154907","DOI":"10.1016\/j.scitotenv.2022.154907","volume":"831","author":"LC Jenner","year":"2022","unstructured":"Jenner LC, Rotchell JM, Bennett RT, Cowen M, Tentzeris V, Sadofsky LR. Detection of microplastics in human lung tissue using muFTIR spectroscopy. Sci Total Environ. 2022;831:154907. https:\/\/doi.org\/10.1016\/j.scitotenv.2022.154907.","journal-title":"Sci Total Environ"},{"key":"669_CR78","doi-asserted-by":"publisher","first-page":"04179","DOI":"10.7189\/jogh.14.04179","volume":"14","author":"NS Roslan","year":"2024","unstructured":"Roslan NS, Lee YY, Ibrahim YS, Tuan Anuar S, Yusof K, Lai LA, et al. Detection of microplastics in human tissues and organs: a scoping review. J Glob Health. 2024;14:04179. https:\/\/doi.org\/10.7189\/jogh.14.04179.","journal-title":"J Glob Health"},{"key":"669_CR79","doi-asserted-by":"publisher","DOI":"10.3390\/foods14030536","author":"F Zhang","year":"2025","unstructured":"Zhang F, Yu X, Li L, Song W, Dong D, Yue X, et al. Research on rapid and non-destructive detection of coffee powder adulteration based on portable near-infrared spectroscopy technology. Foods. 2025. https:\/\/doi.org\/10.3390\/foods14030536.","journal-title":"Foods"},{"key":"669_CR80","doi-asserted-by":"publisher","DOI":"10.3390\/w13192736","author":"H Park","year":"2021","unstructured":"Park H, Park B. Review of microplastic distribution, toxicity, analysis methods, and removal technologies. Water. 2021. https:\/\/doi.org\/10.3390\/w13192736.","journal-title":"Water"},{"key":"669_CR81","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.aca.2019.05.021","volume":"1077","author":"Z Sobhani","year":"2019","unstructured":"Sobhani Z, Al Amin M, Naidu R, Megharaj M, Fang C. Identification and visualisation of microplastics by Raman mapping. Anal Chim Acta. 2019;1077:191\u20139. https:\/\/doi.org\/10.1016\/j.aca.2019.05.021.","journal-title":"Anal Chim Acta"},{"key":"669_CR82","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.watres.2018.05.060","volume":"142","author":"CF Araujo","year":"2018","unstructured":"Araujo CF, Nolasco MM, Ribeiro AMP, Ribeiro-Claro PJA. Identification of microplastics using Raman spectroscopy: latest developments and future prospects. Water Res. 2018;142:426\u201340. https:\/\/doi.org\/10.1016\/j.watres.2018.05.060.","journal-title":"Water Res"},{"issue":"29","key":"669_CR83","doi-asserted-by":"publisher","first-page":"8377","DOI":"10.1007\/s00216-016-9956-3","volume":"408","author":"A Kappler","year":"2016","unstructured":"Kappler A, Fischer D, Oberbeckmann S, Schernewski G, Labrenz M, Eichhorn KJ, et al. Analysis of environmental microplastics by vibrational microspectroscopy: FTIR, Raman or both? Anal Bioanal Chem. 2016;408(29):8377\u201391. https:\/\/doi.org\/10.1007\/s00216-016-9956-3.","journal-title":"Anal Bioanal Chem"},{"key":"669_CR84","doi-asserted-by":"publisher","first-page":"135271","DOI":"10.1016\/j.jhazmat.2024.135271","volume":"477","author":"X Yun","year":"2024","unstructured":"Yun X, Liang L, Tian J, Li N, Chen Z, Zheng Y, et al. Raman-guided exploration of placental microplastic exposure: unraveling the polymeric tapestry and assessing developmental implications. J Hazard Mater. 2024;477:135271. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.135271.","journal-title":"J Hazard Mater"},{"key":"669_CR85","doi-asserted-by":"publisher","DOI":"10.3390\/nano14141179","author":"S Vohl","year":"2024","unstructured":"Vohl S, Kristl M, Stergar J. Harnessing magnetic nanoparticles for the effective removal of micro- and nanoplastics: a critical review. Nanomaterials (Basel). 2024. https:\/\/doi.org\/10.3390\/nano14141179.","journal-title":"Nanomaterials (Basel)"},{"issue":"12","key":"669_CR86","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1039\/d4va00244j","volume":"3","author":"M Huang","year":"2024","unstructured":"Huang M, Si C, Qiu C, Wang G. Microplastics analysis: from qualitative to quantitative. Environ Science: Adv. 2024;3(12):1652\u201368. https:\/\/doi.org\/10.1039\/d4va00244j.","journal-title":"Environ Science: Adv"},{"issue":"9","key":"669_CR87","doi-asserted-by":"publisher","first-page":"5052","DOI":"10.1021\/acs.est.6b06362","volume":"51","author":"M Fischer","year":"2017","unstructured":"Fischer M, Scholz-Bottcher BM. Simultaneous trace identification and quantification of common types of microplastics in environmental samples by pyrolysis-gas chromatography-mass spectrometry. Environ Sci Technol. 2017;51(9):5052\u201360. https:\/\/doi.org\/10.1021\/acs.est.6b06362.","journal-title":"Environ Sci Technol"},{"issue":"1","key":"669_CR88","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s43591-025-00152-7","volume":"5","author":"F Nardella","year":"2025","unstructured":"Nardella F, Brits M, van Velzen MJM, Scibetta L, Durkin A, Vermeulen R, et al. Advancing pyrolysis-gas chromatography-mass spectrometry for the accurate quantification of micro- and nanoplastics in human blood. Microplast nanoplast. 2025;5(1):48. https:\/\/doi.org\/10.1186\/s43591-025-00152-7.","journal-title":"Microplast nanoplast"},{"issue":"2","key":"669_CR89","doi-asserted-by":"publisher","first-page":"13","DOI":"10.24200\/amecj.v2.i2.57","volume":"2","author":"AwirnkorV Christian Ebere","year":"2019","unstructured":"Christian Ebere AwirnkorV, Evelyn Ngozi E. Microplastics, an emerging concern: a review of analytical techniques for detecting and quantifying microplatics. Anal Methods Environ Chem J. 2019;2(2):13\u201330. https:\/\/doi.org\/10.24200\/amecj.v2.i2.57.","journal-title":"Anal Methods Environ Chem J"},{"key":"669_CR90","doi-asserted-by":"publisher","first-page":"107199","DOI":"10.1016\/j.envint.2022.107199","volume":"163","author":"HA Leslie","year":"2022","unstructured":"Leslie HA, van Velzen MJM, Brandsma SH, Vethaak AD, Garcia-Vallejo JJ, Lamoree MH. Discovery and quantification of plastic particle pollution in human blood. Environ Int. 2022;163:107199. https:\/\/doi.org\/10.1016\/j.envint.2022.107199.","journal-title":"Environ Int"},{"issue":"4","key":"669_CR91","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.1021\/acs.est.4c12599","volume":"59","author":"C Rauert","year":"2025","unstructured":"Rauert C, Charlton N, Bagley A, Dunlop SA, Symeonides C, Thomas KV. Assessing the efficacy of pyrolysis-gas chromatography-mass spectrometry for nanoplastic and microplastic analysis in human blood. Environ Sci Technol. 2025;59(4):1984\u201394. https:\/\/doi.org\/10.1021\/acs.est.4c12599.","journal-title":"Environ Sci Technol"},{"key":"669_CR92","doi-asserted-by":"publisher","first-page":"108751","DOI":"10.1016\/j.envint.2024.108751","volume":"188","author":"SVLL Liddle","year":"2024","unstructured":"Liddle SVLL, Atherall CR, Chapman CA, Watkins E. Microplastics in human blood: polymer types, concentrations and characterisation using \u00b5FTIR. Environ Int. 2024;188:108751. https:\/\/doi.org\/10.1016\/j.envint.2024.108751.","journal-title":"Environ Int"},{"key":"669_CR93","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.jare.2022.09.004","volume":"49","author":"D Wu","year":"2023","unstructured":"Wu D, Feng Y, Wang R, Jiang J, Guan Q, Yang X, et al. Pigment microparticles and microplastics found in human thrombi based on Raman spectral evidence. J Adv Res. 2023;49:141\u201350. https:\/\/doi.org\/10.1016\/j.jare.2022.09.004.","journal-title":"J Adv Res"},{"issue":"1","key":"669_CR94","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12989-022-00500-y","volume":"19","author":"EH Kim","year":"2022","unstructured":"Kim EH, Choi S, Kim D, Park HJ, Bian Y, Choi SH, et al. Amine-modified nanoplastics promote the procoagulant activation of isolated human red blood cells and thrombus formation in rats. Part Fibre Toxicol. 2022;19(1):60. https:\/\/doi.org\/10.1186\/s12989-022-00500-y.","journal-title":"Part Fibre Toxicol"},{"issue":"3","key":"669_CR95","doi-asserted-by":"publisher","first-page":"356","DOI":"10.3109\/17435390.2014.933902","volume":"9","author":"E Smyth","year":"2015","unstructured":"Smyth E, Solomon A, Vydyanath A, Luther PK, Pitchford S, Tetley TD, et al. Induction and enhancement of platelet aggregation in vitro and in vivo by model polystyrene nanoparticles. Nanotoxicology. 2015;9(3):356\u201364. https:\/\/doi.org\/10.3109\/17435390.2014.933902.","journal-title":"Nanotoxicology"},{"key":"669_CR96","doi-asserted-by":"publisher","DOI":"10.3390\/cells13211788","author":"F Mahmud","year":"2024","unstructured":"Mahmud F, Sarker DB, Jocelyn JA, Sang QA. Molecular and cellular effects of microplastics and nanoplastics: focus on inflammation and senescence. Cells. 2024. https:\/\/doi.org\/10.3390\/cells13211788.","journal-title":"Cells"},{"key":"669_CR97","doi-asserted-by":"publisher","first-page":"136100","DOI":"10.1016\/j.jhazmat.2024.136100","volume":"480","author":"KM Park","year":"2024","unstructured":"Park KM, Kim B, Woo W, Kim LK, Hyun YM. Polystyrene microplastics induce activation and cell death of neutrophils through strong adherence and engulfment. J Hazard Mater. 2024;480:136100. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.136100.","journal-title":"J Hazard Mater"},{"key":"669_CR98","doi-asserted-by":"publisher","first-page":"129805","DOI":"10.1016\/j.chemosphere.2021.129805","volume":"272","author":"H \u00c7obano\u011flu","year":"2021","unstructured":"\u00c7obano\u011flu H, Belivermi\u015f M, S\u0131kdokur E, K\u0131l\u0131\u00e7 \u00d6, \u00c7ay\u0131r A. Genotoxic and cytotoxic effects of polyethylene microplastics on human peripheral blood lymphocytes. Chemosphere. 2021;272:129805. https:\/\/doi.org\/10.1016\/j.chemosphere.2021.129805.","journal-title":"Chemosphere"},{"key":"669_CR99","doi-asserted-by":"publisher","first-page":"100393","DOI":"10.1016\/j.jvssci.2025.100393","volume":"6","author":"PL Massie","year":"2025","unstructured":"Massie PL, Garcia MA, Gallego D, Schlosser C, Decker A, Liu R, et al. Micro- and nanoplastics are elevated in femoral atherosclerotic plaques compared with undiseased arteries. JVS Vasc Sci. 2025;6:100393. https:\/\/doi.org\/10.1016\/j.jvssci.2025.100393.","journal-title":"JVS Vasc Sci"},{"key":"669_CR100","doi-asserted-by":"publisher","first-page":"105118","DOI":"10.1016\/j.ebiom.2024.105118","volume":"103","author":"T Wang","year":"2024","unstructured":"Wang T, Yi Z, Liu X, Cai Y, Huang X, Fang J, et al. Multimodal detection and analysis of microplastics in human thrombi from multiple anatomically distinct sites. EBioMedicine. 2024;103:105118. https:\/\/doi.org\/10.1016\/j.ebiom.2024.105118.","journal-title":"EBioMedicine"},{"issue":"3","key":"669_CR101","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s12012-024-09837-6","volume":"24","author":"T Lu","year":"2024","unstructured":"Lu T, Li D, Yuan X, Wang Z, Shao Z, Feng X, et al. Potential effects of orally ingesting polyethylene terephthalate microplastics on the mouse heart. Cardiovasc Toxicol. 2024;24(3):291\u2013301. https:\/\/doi.org\/10.1007\/s12012-024-09837-6.","journal-title":"Cardiovasc Toxicol"},{"key":"669_CR102","doi-asserted-by":"publisher","first-page":"117712","DOI":"10.1016\/j.ecoenv.2025.117712","volume":"290","author":"Z Xiong","year":"2025","unstructured":"Xiong Z, Kong Q, Hua J, Chen Q, Wang D. Cardiotoxicity of polystyrene nanoplastics and associated mechanism of myocardial cell injury in mice. Ecotoxicol Environ Saf. 2025;290:117712. https:\/\/doi.org\/10.1016\/j.ecoenv.2025.117712.","journal-title":"Ecotoxicol Environ Saf"},{"key":"669_CR103","doi-asserted-by":"publisher","first-page":"k3310","DOI":"10.1136\/bmj.k3310","volume":"362","author":"R Chowdhury","year":"2018","unstructured":"Chowdhury R, Ramond A, O\u2019Keeffe LM, Shahzad S, Kunutsor SK, Muka T, et al. Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis. BMJ. 2018;362:k3310. https:\/\/doi.org\/10.1136\/bmj.k3310.","journal-title":"BMJ"},{"issue":"5","key":"669_CR104","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/s41576-022-00569-3","volume":"24","author":"H Wu","year":"2023","unstructured":"Wu H, Eckhardt CM, Baccarelli AA. Molecular mechanisms of environmental exposures and human disease. Nat Rev Genet. 2023;24(5):332\u201344. https:\/\/doi.org\/10.1038\/s41576-022-00569-3.","journal-title":"Nat Rev Genet"},{"issue":"1","key":"669_CR105","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s40779-023-00452-0","volume":"10","author":"QY Guo","year":"2023","unstructured":"Guo QY, Yang JQ, Feng XX, Zhou YJ. Regeneration of the heart: from molecular mechanisms to clinical therapeutics. Mil Med Res. 2023;10(1):18. https:\/\/doi.org\/10.1186\/s40779-023-00452-0.","journal-title":"Mil Med Res"},{"issue":"1","key":"669_CR106","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1093\/clinchem\/hvaa281","volume":"67","author":"IA Katrukha","year":"2021","unstructured":"Katrukha IA, Katrukha AG. Myocardial injury and the release of troponins I and T in the blood of patients. Clin Chem. 2021;67(1):124\u201330. https:\/\/doi.org\/10.1093\/clinchem\/hvaa281.","journal-title":"Clin Chem"},{"key":"669_CR107","doi-asserted-by":"publisher","first-page":"110353","DOI":"10.1016\/j.cbpc.2025.110353","volume":"299","author":"Q Liu","year":"2026","unstructured":"Liu Q, Yan F, Liu H, Zhang J, Zhang J. Toxic effects of polystyrene and polyethylene microplastics on the zebrafish cardiovascular system and their differential mechanisms. Comp Biochem Physiol C Toxicol Pharmacol. 2026;299:110353. https:\/\/doi.org\/10.1016\/j.cbpc.2025.110353.","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"669_CR108","doi-asserted-by":"publisher","first-page":"123713","DOI":"10.1016\/j.envpol.2024.123713","volume":"347","author":"J Ye","year":"2024","unstructured":"Ye J, Qiu W, Pang X, Su Y, Zhang X, Huang J, et al. Polystyrene nanoplastics and cadmium co-exposure aggravated cardiomyocyte damage in mice by regulating PANoptosis pathway. Environ Pollut. 2024;347:123713. https:\/\/doi.org\/10.1016\/j.envpol.2024.123713.","journal-title":"Environ Pollut"},{"key":"669_CR109","doi-asserted-by":"publisher","first-page":"153338","DOI":"10.1016\/j.tox.2022.153338","volume":"480","author":"P Lin","year":"2022","unstructured":"Lin P, Tong X, Xue F, Qianru C, Xinyu T, Zhe L, et al. Polystyrene nanoplastics exacerbate lipopolysaccharide-induced myocardial fibrosis and autophagy in mice via ROS\/TGF-\u03b21\/Smad. Toxicology. 2022;480:153338. https:\/\/doi.org\/10.1016\/j.tox.2022.153338.","journal-title":"Toxicology"},{"key":"669_CR110","doi-asserted-by":"publisher","first-page":"108171","DOI":"10.1016\/j.envint.2023.108171","volume":"179","author":"Y Zhou","year":"2023","unstructured":"Zhou Y, Wu Q, Li Y, Feng Y, Wang Y, Cheng W. Low-dose of polystyrene microplastics induce cardiotoxicity in mice and human-originated cardiac organoids. Environ Int. 2023;179:108171. https:\/\/doi.org\/10.1016\/j.envint.2023.108171.","journal-title":"Environ Int"},{"issue":"12","key":"669_CR111","doi-asserted-by":"publisher","first-page":"5371","DOI":"10.1002\/tox.24411","volume":"39","author":"T Lu","year":"2024","unstructured":"Lu T, Yuan X, Sui C, Yang C, Li D, Liu H, et al. Exposure to Polypropylene Microplastics Causes Cardiomyocyte Apoptosis Through Oxidative Stress and Activation of the MAPK-Nrf2 Signaling Pathway. Environ Toxicol. 2024;39(12):5371\u201381. https:\/\/doi.org\/10.1002\/tox.24411.","journal-title":"Environ Toxicol"},{"issue":"2","key":"669_CR112","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/ejhf.696","volume":"19","author":"M Gy\u00f6ngy\u00f6si","year":"2017","unstructured":"Gy\u00f6ngy\u00f6si M, Winkler J, Ramos I, Do QT, Firat H, McDonald K, et al. Myocardial fibrosis: biomedical research from bench to bedside. Eur J Heart Fail. 2017;19(2):177\u201391. https:\/\/doi.org\/10.1002\/ejhf.696.","journal-title":"Eur J Heart Fail"},{"key":"669_CR113","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.matbio.2024.08.008","volume":"134","author":"IG Lunde","year":"2024","unstructured":"Lunde IG, Rypdal KB, Van Linthout S, Diez J, Gonz\u00e1lez A. Myocardial fibrosis from the perspective of the extracellular matrix: mechanisms to clinical impact. Matrix Biol. 2024;134:1\u201322. https:\/\/doi.org\/10.1016\/j.matbio.2024.08.008.","journal-title":"Matrix Biol"},{"issue":"5","key":"669_CR114","doi-asserted-by":"publisher","first-page":"e70245","DOI":"10.1002\/jbt.70245","volume":"39","author":"L Xiong","year":"2025","unstructured":"Xiong L, Xiong Z, Hua J, Chen Q, Wang D. Mechanism of nano-microplastics exposure-induced myocardial fibrosis: DKK3-mediated mitophagy dysfunction and pyroptosis. J Biochem Mol Toxicol. 2025;39(5):e70245. https:\/\/doi.org\/10.1002\/jbt.70245.","journal-title":"J Biochem Mol Toxicol"},{"key":"669_CR115","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.mam.2018.07.001","volume":"65","author":"NG Frangogiannis","year":"2019","unstructured":"Frangogiannis NG. Cardiac fibrosis: cell biological mechanisms, molecular pathways and therapeutic opportunities. Mol Aspects Med. 2019;65:70\u201399. https:\/\/doi.org\/10.1016\/j.mam.2018.07.001.","journal-title":"Mol Aspects Med"},{"issue":"2","key":"669_CR116","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/path.2277","volume":"214","author":"TA Wynn","year":"2008","unstructured":"Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol. 2008;214(2):199\u2013210. https:\/\/doi.org\/10.1002\/path.2277.","journal-title":"J Pathol"},{"issue":"2","key":"669_CR117","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s40572-023-00391-x","volume":"10","author":"EA Medley","year":"2023","unstructured":"Medley EA, Spratlen MJ, Yan B, Herbstman JB, Deyssenroth MA. A systematic review of the placental translocation of micro- and nanoplastics. Curr Environ Health Rep. 2023;10(2):99\u2013111. https:\/\/doi.org\/10.1007\/s40572-023-00391-x.","journal-title":"Curr Environ Health Rep"},{"issue":"3","key":"669_CR118","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1039\/d4em00642a","volume":"27","author":"X Li","year":"2025","unstructured":"Li X, Cao H, Yang Q, Yu S, Huang L, Liu Q, et al. Sex differences in cardiac fibrosis induced by gestational exposure to polystyrene nanoplastics in mice offspring. Environ Sci Process Impacts. 2025;27(3):694\u2013705. https:\/\/doi.org\/10.1039\/d4em00642a.","journal-title":"Environ Sci Process Impacts"},{"issue":"2","key":"669_CR119","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1161\/01.atv.0000051384.43104.fc","volume":"23","author":"PO Bonetti","year":"2003","unstructured":"Bonetti PO, Lerman LO, Lerman A. Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol. 2003;23(2):168\u201375. https:\/\/doi.org\/10.1161\/01.atv.0000051384.43104.fc.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"12","key":"669_CR120","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.1016\/j.bbadis.2013.08.006","volume":"1832","author":"CM Sena","year":"2013","unstructured":"Sena CM, Pereira AM, Sei\u00e7a R. Endothelial dysfunction\u2014a major mediator of diabetic vascular disease. Biochim Biophys Acta. 2013;1832(12):2216\u201331. https:\/\/doi.org\/10.1016\/j.bbadis.2013.08.006.","journal-title":"Biochim Biophys Acta"},{"issue":"9299","key":"669_CR121","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.1016\/s0140-6736(01)07229-4","volume":"358","author":"P Vallance","year":"2001","unstructured":"Vallance P. Importance of asymmetrical dimethylarginine in cardiovascular risk. Lancet. 2001;358(9299):2096\u20137. https:\/\/doi.org\/10.1016\/s0140-6736(01)07229-4.","journal-title":"Lancet"},{"key":"669_CR122","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.vph.2017.05.005","volume":"100","author":"MA Incalza","year":"2018","unstructured":"Incalza MA, D\u2019Oria R, Natalicchio A, Perrini S, Laviola L, Giorgino F. Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases. Vascul Pharmacol. 2018;100:1\u201319. https:\/\/doi.org\/10.1016\/j.vph.2017.05.005.","journal-title":"Vascul Pharmacol"},{"key":"669_CR123","doi-asserted-by":"publisher","first-page":"137582","DOI":"10.1016\/j.chemosphere.2022.137582","volume":"313","author":"YC Chen","year":"2023","unstructured":"Chen YC, Chen KF, Andrew Lin KY, Su HP, Wu DN, Lin CH. Evaluation of toxicity of polystyrene microplastics under realistic exposure levels in human vascular endothelial EA.hy926 cells. Chemosphere. 2023;313:137582. https:\/\/doi.org\/10.1016\/j.chemosphere.2022.137582.","journal-title":"Chemosphere"},{"key":"669_CR124","doi-asserted-by":"publisher","first-page":"1587759","DOI":"10.3389\/fmed.2025.1587759","volume":"12","author":"JH Yun","year":"2025","unstructured":"Yun JH. Polystyrene microplastics impair the function of human retinal microvascular endothelial cells and pericytes and increase vascular permeability in vitro. Front Med (Lausanne). 2025;12:1587759. https:\/\/doi.org\/10.3389\/fmed.2025.1587759.","journal-title":"Front Med (Lausanne)"},{"key":"669_CR125","doi-asserted-by":"publisher","first-page":"109420","DOI":"10.1016\/j.envint.2025.109420","volume":"198","author":"J Zheng","year":"2025","unstructured":"Zheng J, He L, Shi Q, Wang M, Ma Y, Yu W, et al. In vivo and In vitro assessment of the retinal toxicity of polystyrene nanoplastics. Environ Int. 2025;198:109420. https:\/\/doi.org\/10.1016\/j.envint.2025.109420.","journal-title":"Environ Int"},{"key":"669_CR126","doi-asserted-by":"publisher","first-page":"137114","DOI":"10.1016\/j.jhazmat.2025.137114","volume":"486","author":"J Lv","year":"2025","unstructured":"Lv J, Tan Z, An Z, Xu R, Zhang H, Guo M, et al. Co-exposure to polystyrene nanoplastics and F-53B induces vascular endothelial cell pyroptosis through the NF-\u03baB\/NLRP3 pathway. J Hazard Mater. 2025;486:137114. https:\/\/doi.org\/10.1016\/j.jhazmat.2025.137114.","journal-title":"J Hazard Mater"},{"issue":"1","key":"669_CR127","doi-asserted-by":"publisher","first-page":"6256","DOI":"10.1038\/s41598-023-33086-2","volume":"13","author":"B Dhakal","year":"2023","unstructured":"Dhakal B, Shiwakoti S, Park EY, Kang KW, Schini-Kerth VB, Park SH, et al. SGLT2 inhibition ameliorates nano plastics-induced premature endothelial senescence and dysfunction. Sci Rep. 2023;13(1):6256. https:\/\/doi.org\/10.1038\/s41598-023-33086-2.","journal-title":"Sci Rep"},{"key":"669_CR128","doi-asserted-by":"publisher","first-page":"107248","DOI":"10.1016\/j.envint.2022.107248","volume":"164","author":"S Shiwakoti","year":"2022","unstructured":"Shiwakoti S, Ko JY, Gong D, Dhakal B, Lee JH, Adhikari R, et al. Effects of polystyrene nanoplastics on endothelium senescence and its underlying mechanism. Environ Int. 2022;164:107248. https:\/\/doi.org\/10.1016\/j.envint.2022.107248.","journal-title":"Environ Int"},{"issue":"20","key":"669_CR129","doi-asserted-by":"publisher","first-page":"e031121","DOI":"10.1161\/jaha.123.031121","volume":"12","author":"R Chen","year":"2023","unstructured":"Chen R, McVey DG, Shen D, Huang X, Ye S. Phenotypic switching of vascular smooth muscle cells in atherosclerosis. J Am Heart Assoc. 2023;12(20):e031121. https:\/\/doi.org\/10.1161\/jaha.123.031121.","journal-title":"J Am Heart Assoc"},{"issue":"3","key":"669_CR130","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1152\/physrev.1995.75.3.487","volume":"75","author":"GK Owens","year":"1995","unstructured":"Owens GK. Regulation of differentiation of vascular smooth muscle cells. Physiol Rev. 1995;75(3):487\u2013517. https:\/\/doi.org\/10.1152\/physrev.1995.75.3.487.","journal-title":"Physiol Rev"},{"key":"669_CR131","doi-asserted-by":"publisher","first-page":"116695","DOI":"10.1016\/j.ecoenv.2024.116695","volume":"282","author":"T Lomonaco","year":"2024","unstructured":"Lomonaco T, Persiani E, Biagini D, Gisone I, Ceccherini E, Cecchettini A, et al. Type-specific inflammatory responses of vascular cells activated by interaction with virgin and aged microplastics. Ecotoxicol Environ Saf. 2024;282:116695. https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116695.","journal-title":"Ecotoxicol Environ Saf"},{"key":"669_CR132","doi-asserted-by":"publisher","first-page":"134854","DOI":"10.1016\/j.jhazmat.2024.134854","volume":"475","author":"X Xie","year":"2024","unstructured":"Xie X, Wang K, Shen X, Li X, Wang S, Yuan S, et al. Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead. J Hazard Mater. 2024;475:134854. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.134854.","journal-title":"J Hazard Mater"},{"key":"669_CR133","doi-asserted-by":"publisher","first-page":"167215","DOI":"10.1016\/j.scitotenv.2023.167215","volume":"905","author":"J Yan","year":"2023","unstructured":"Yan J, Pan Y, He J, Pang X, Shao W, Wang C, et al. Toxic vascular effects of polystyrene microplastic exposure. Sci Total Environ. 2023;905:167215. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.167215.","journal-title":"Sci Total Environ"},{"issue":"1","key":"669_CR134","doi-asserted-by":"publisher","first-page":"4263","DOI":"10.1038\/s41598-025-89006-z","volume":"15","author":"E Persiani","year":"2025","unstructured":"Persiani E, Cecchettini A, Amato S, Ceccherini E, Gisone I, Sgalippa A, et al. Virgin and photo-degraded microplastics induce the activation of human vascular smooth muscle cells. Sci Rep. 2025;15(1):4263. https:\/\/doi.org\/10.1038\/s41598-025-89006-z.","journal-title":"Sci Rep"},{"issue":"5","key":"669_CR135","doi-asserted-by":"publisher","first-page":"H1068","DOI":"10.1152\/ajpheart.00690.2019","volume":"318","author":"Z Sun","year":"2020","unstructured":"Sun Z, Li L, Zhang L, Yan J, Shao C, Bao Z, et al. Macrophage galectin-3 enhances intimal translocation of vascular calcification in diabetes mellitus. Am J Physiol Heart Circ Physiol. 2020;318(5):H1068\u201379. https:\/\/doi.org\/10.1152\/ajpheart.00690.2019.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"3","key":"669_CR136","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1161\/ATVBAHA.107.159160","volume":"28","author":"M Papaspyridonos","year":"2008","unstructured":"Papaspyridonos M, McNeill E, de Bono JP, Smith A, Burnand KG, Channon KM, et al. Galectin-3 is an amplifier of inflammation in atherosclerotic plaque progression through macrophage activation and monocyte chemoattraction. Arterioscler Thromb Vasc Biol. 2008;28(3):433\u201340. https:\/\/doi.org\/10.1161\/ATVBAHA.107.159160.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"669_CR137","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s12964-022-00993-2","volume":"20","author":"G Cao","year":"2022","unstructured":"Cao G, Xuan X, Hu J, Zhang R, Jin H, Dong H. How vascular smooth muscle cell phenotype switching contributes to vascular disease. Cell Commun Signal. 2022;20(1):180. https:\/\/doi.org\/10.1186\/s12964-022-00993-2.","journal-title":"Cell Commun Signal"},{"issue":"7","key":"669_CR138","doi-asserted-by":"publisher","first-page":"e34","DOI":"10.1161\/circresaha.123.323156","volume":"134","author":"C Ma","year":"2024","unstructured":"Ma C, Li Y, Tian M, Deng Q, Qin X, Lu H, et al. Gs\u03b1 regulates macrophage foam cell formation during atherosclerosis. Circ Res. 2024;134(7):e34\u201351. https:\/\/doi.org\/10.1161\/circresaha.123.323156.","journal-title":"Circ Res"},{"key":"669_CR139","doi-asserted-by":"publisher","first-page":"119131","DOI":"10.1016\/j.atherosclerosis.2025.119131","volume":"404","author":"I Damiani","year":"2025","unstructured":"Damiani I, Solberg EH, Iyer M, Cheng P, Weldy CS, Kim JB. Environmental pollutants and atherosclerosis: epigenetic mechanisms linking genetic risk and disease. Atherosclerosis. 2025;404:119131. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2025.119131.","journal-title":"Atherosclerosis"},{"key":"669_CR140","doi-asserted-by":"publisher","first-page":"113612","DOI":"10.1016\/j.ecoenv.2022.113612","volume":"238","author":"I Florance","year":"2022","unstructured":"Florance I, Chandrasekaran N, Gopinath PM, Mukherjee A. Exposure to polystyrene nanoplastics impairs lipid metabolism in human and murine macrophages in vitro. Ecotoxicol Environ Saf. 2022;238:113612. https:\/\/doi.org\/10.1016\/j.ecoenv.2022.113612.","journal-title":"Ecotoxicol Environ Saf"},{"issue":"9","key":"669_CR141","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1161\/circresaha.124.324419","volume":"134","author":"J Zhao","year":"2024","unstructured":"Zhao J, Gomes D, Yuan F, Feng J, Zhang X, O\u2019Toole TE. Oral polystyrene consumption potentiates atherosclerotic lesion formation in ApoE(-\/-) mice. Circ Res. 2024;134(9):1228\u201330. https:\/\/doi.org\/10.1161\/circresaha.124.324419.","journal-title":"Circ Res"},{"key":"669_CR142","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-025-04963-6","author":"C Yan","year":"2026","unstructured":"Yan C, Liu T. Evaluating the toxicological effects of PET-MPs exposure on atherosclerosis through integrated network toxicology analysis and experimental validation. Naunyn Schmiedebergs Arch Pharmacol. 2026. https:\/\/doi.org\/10.1007\/s00210-025-04963-6.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"669_CR143","doi-asserted-by":"publisher","first-page":"152850","DOI":"10.1016\/j.tox.2021.152850","volume":"458","author":"I Florance","year":"2021","unstructured":"Florance I, Ramasubbu S, Mukherjee A, Chandrasekaran N. Polystyrene nanoplastics dysregulate lipid metabolism in murine macrophages in vitro. Toxicology. 2021;458:152850. https:\/\/doi.org\/10.1016\/j.tox.2021.152850.","journal-title":"Toxicology"},{"key":"669_CR144","doi-asserted-by":"publisher","first-page":"104294","DOI":"10.1016\/j.etap.2023.104294","volume":"104","author":"G Basini","year":"2023","unstructured":"Basini G, Grolli S, Bertini S, Bussolati S, Berni M, Berni P, et al. Nanoplastics induced oxidative stress and VEGF production in aortic endothelial cells. Environ Toxicol Pharmacol. 2023;104:104294. https:\/\/doi.org\/10.1016\/j.etap.2023.104294.","journal-title":"Environ Toxicol Pharmacol"},{"issue":"10","key":"669_CR145","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","volume":"97","author":"K Jomova","year":"2023","unstructured":"Jomova K, Raptova R, Alomar SY, Alwasel SH, Nepovimova E, Kuca K, et al. Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging. Arch Toxicol. 2023;97(10):2499\u2013574. https:\/\/doi.org\/10.1007\/s00204-023-03562-9.","journal-title":"Arch Toxicol"},{"issue":"5","key":"669_CR146","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1002\/tox.23095","volume":"36","author":"J Wei","year":"2021","unstructured":"Wei J, Wang X, Liu Q, Zhou N, Zhu S, Li Z, et al. The impact of polystyrene microplastics on cardiomyocytes pyroptosis through NLRP3\/Caspase-1 signaling pathway and oxidative stress in Wistar rats. Environ Toxicol. 2021;36(5):935\u201344. https:\/\/doi.org\/10.1002\/tox.23095.","journal-title":"Environ Toxicol"},{"key":"669_CR147","doi-asserted-by":"publisher","first-page":"144406","DOI":"10.1016\/j.chemosphere.2025.144406","volume":"379","author":"S Zangene","year":"2025","unstructured":"Zangene S, Goorani S, Morovvati H, Anbara H. Effects of polystyrene microplastics on mice cardiac tissue structure: protective role of resveratrol. Chemosphere. 2025;379:144406. https:\/\/doi.org\/10.1016\/j.chemosphere.2025.144406.","journal-title":"Chemosphere"},{"key":"669_CR148","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.fsi.2022.04.048","volume":"125","author":"H Wu","year":"2022","unstructured":"Wu H, Guo J, Yao Y, Xu S. Polystyrene nanoplastics induced cardiomyocyte apoptosis and myocardial inflammation in carp by promoting ROS production. Fish Shellfish Immunol. 2022;125:1\u20138. https:\/\/doi.org\/10.1016\/j.fsi.2022.04.048.","journal-title":"Fish Shellfish Immunol"},{"key":"669_CR149","doi-asserted-by":"publisher","first-page":"114574","DOI":"10.1016\/j.ecoenv.2023.114574","volume":"252","author":"J Chen","year":"2023","unstructured":"Chen J, Xu Z, Liu Y, Mei A, Wang X, Shi Q. Cellular absorption of polystyrene nanoplastics with different surface functionalization and the toxicity to RAW264.7 macrophage cells. Ecotoxicol Environ Saf. 2023;252:114574. https:\/\/doi.org\/10.1016\/j.ecoenv.2023.114574.","journal-title":"Ecotoxicol Environ Saf"},{"issue":"4","key":"669_CR150","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/s42255-023-00783-1","volume":"5","author":"AS Monzel","year":"2023","unstructured":"Monzel AS, Enr\u00edquez JA, Picard M. Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction. Nat Metab. 2023;5(4):546\u201362. https:\/\/doi.org\/10.1038\/s42255-023-00783-1.","journal-title":"Nat Metab"},{"key":"669_CR151","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2025.115489","author":"J Ma","year":"2025","unstructured":"Ma J, Ladd DM, Kaval N, Wang H-S. Toxicity of long term exposure to low dose polystyrene microplastics and nanoplastics in human iPSC-derived cardiomyocytes. Food Chem Toxicol. 2025. https:\/\/doi.org\/10.1016\/j.fct.2025.115489.","journal-title":"Food Chem Toxicol"},{"issue":"45","key":"669_CR152","doi-asserted-by":"publisher","first-page":"31569","DOI":"10.1021\/acsnano.4c13262","volume":"18","author":"T Zhang","year":"2024","unstructured":"Zhang T, Yang S, Ge Y, Yin L, Pu Y, Gu Z, et al. Unveiling the heart\u2019s hidden enemy: dynamic insights into polystyrene nanoplastic-induced cardiotoxicity based on cardiac organoid-on-a-chip. ACS Nano. 2024;18(45):31569\u201385. https:\/\/doi.org\/10.1021\/acsnano.4c13262.","journal-title":"ACS Nano"},{"key":"669_CR153","doi-asserted-by":"publisher","first-page":"167406","DOI":"10.1016\/j.scitotenv.2023.167406","volume":"906","author":"J Li","year":"2024","unstructured":"Li J, Weng H, Liu S, Li F, Xu K, Wen S, et al. Embryonic exposure of polystyrene nanoplastics affects cardiac development. Sci Total Environ. 2024;906:167406. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.167406.","journal-title":"Sci Total Environ"},{"key":"669_CR154","doi-asserted-by":"publisher","first-page":"173253","DOI":"10.1016\/j.scitotenv.2024.173253","volume":"934","author":"W Liu","year":"2024","unstructured":"Liu W, Zeng M, Zhan C, Wen J, Wang J. Polystyrene nanoplastics exert cardiotoxicity through the Notch and Wnt pathways in zebrafish (Danio rerio). Sci Total Environ. 2024;934:173253. https:\/\/doi.org\/10.1016\/j.scitotenv.2024.173253.","journal-title":"Sci Total Environ"},{"issue":"1","key":"669_CR155","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s12951-024-02375-x","volume":"22","author":"K Wang","year":"2024","unstructured":"Wang K, Du Y, Li P, Guan C, Zhou M, Wu L, et al. Nanoplastics causes heart aging\/myocardial cell senescence through the Ca(2+)\/mtDNA\/cGAS-STING signaling cascade. J Nanobiotechnol. 2024;22(1):96. https:\/\/doi.org\/10.1186\/s12951-024-02375-x.","journal-title":"J Nanobiotechnol"},{"key":"669_CR156","doi-asserted-by":"publisher","first-page":"151736","DOI":"10.1016\/j.bbrc.2025.151736","volume":"762","author":"G Liu","year":"2025","unstructured":"Liu G, Bao Q, Zhang C, Zhong Y, Deng M, Huang Y, et al. PVC nanoplastics impair cardiac function via lysosomal and mitochondrial dysfunction. Biochem Biophys Res Commun. 2025;762:151736. https:\/\/doi.org\/10.1016\/j.bbrc.2025.151736.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"669_CR157","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/s41392-023-01570-w","volume":"8","author":"X Chen","year":"2023","unstructured":"Chen X, Shi C, He M, Xiong S, Xia X. Endoplasmic reticulum stress: molecular mechanism and therapeutic targets. Signal Transduct Target Ther. 2023;8(1):352. https:\/\/doi.org\/10.1038\/s41392-023-01570-w.","journal-title":"Signal Transduct Target Ther"},{"issue":"7","key":"669_CR158","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/s41569-021-00511-w","volume":"18","author":"J Ren","year":"2021","unstructured":"Ren J, Bi Y, Sowers JR, Hetz C, Zhang Y. Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases. Nat Rev Cardiol. 2021;18(7):499\u2013521. https:\/\/doi.org\/10.1038\/s41569-021-00511-w.","journal-title":"Nat Rev Cardiol"},{"issue":"1","key":"669_CR159","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1002\/jcp.30913","volume":"238","author":"Z Li","year":"2023","unstructured":"Li Z, Xu T, Peng L, Tang X, Chi Q, Li M, et al. Polystyrene nanoplastics aggravates lipopolysaccharide-induced apoptosis in mouse kidney cells by regulating IRE1\/XBP1 endoplasmic reticulum stress pathway via oxidative stress. J Cell Physiol. 2023;238(1):151\u201364. https:\/\/doi.org\/10.1002\/jcp.30913.","journal-title":"J Cell Physiol"},{"key":"669_CR160","doi-asserted-by":"publisher","first-page":"113818","DOI":"10.1016\/j.foodres.2023.113818","volume":"175","author":"Z Wang","year":"2024","unstructured":"Wang Z, Liu S, Cheng Z, Xu G, Li F, Bu Q, et al. Endoplasmic reticulum stress exacerbates microplastics-induced toxicity in animal cells. Food Res Int. 2024;175:113818. https:\/\/doi.org\/10.1016\/j.foodres.2023.113818.","journal-title":"Food Res Int"},{"key":"669_CR161","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2025.179048","author":"D Xue","year":"2025","unstructured":"Xue D, Huang J, Sun X, Zhang W, Ma H, Yin D, et al. Dissection of the potential mechanism of polystyrene microplastic exposure on cardiomyocytes. Sci Total Environ. 2025. https:\/\/doi.org\/10.1016\/j.scitotenv.2025.179048.","journal-title":"Sci Total Environ"},{"issue":"1","key":"669_CR162","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s12989-024-00595-5","volume":"21","author":"J Bai","year":"2024","unstructured":"Bai J, Wang Y, Deng S, Yang Y, Chen S, Wu Z. Microplastics caused embryonic growth retardation and placental dysfunction in pregnant mice by activating GRP78\/IRE1\u03b1\/JNK axis induced apoptosis and endoplasmic reticulum stress. Part Fibre Toxicol. 2024;21(1):36. https:\/\/doi.org\/10.1186\/s12989-024-00595-5.","journal-title":"Part Fibre Toxicol"},{"key":"669_CR163","doi-asserted-by":"publisher","first-page":"119963","DOI":"10.1016\/j.envpol.2022.119963","volume":"311","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Wang D, Yin K, Zhao H, Lu H, Meng X, et al. Endoplasmic reticulum stress-controlled autophagic pathway promotes polystyrene microplastics-induced myocardial dysplasia in birds. Environ Pollut. 2022;311:119963. https:\/\/doi.org\/10.1016\/j.envpol.2022.119963.","journal-title":"Environ Pollut"},{"key":"669_CR164","doi-asserted-by":"publisher","DOI":"10.3390\/toxics13110913","author":"L Liu","year":"2025","unstructured":"Liu L, Tu P, Niu H, Li X, Gong X, Chen Z, et al. Cellular impact of micro(nano)plastics on human health: a review. Toxics. 2025. https:\/\/doi.org\/10.3390\/toxics13110913.","journal-title":"Toxics"},{"key":"669_CR165","doi-asserted-by":"publisher","first-page":"108470","DOI":"10.1016\/j.fsi.2022.108470","volume":"132","author":"J Cao","year":"2023","unstructured":"Cao J, Xu R, Wang F, Geng Y, Xu T, Zhu M, et al. Polyethylene microplastics trigger cell apoptosis and inflammation via inducing oxidative stress and activation of the NLRP3 inflammasome in carp gills. Fish Shellfish Immunol. 2023;132:108470. https:\/\/doi.org\/10.1016\/j.fsi.2022.108470.","journal-title":"Fish Shellfish Immunol"},{"key":"669_CR166","doi-asserted-by":"publisher","first-page":"116925","DOI":"10.1016\/j.ecoenv.2024.116925","volume":"284","author":"J Shi","year":"2024","unstructured":"Shi J, Yu X, Zhao J, Wang T, Li N, Yu J, et al. Integrated transcriptomics and metabolomics reveal the mechanism of polystyrene nanoplastics toxicity to mice. Ecotoxicol Environ Saf. 2024;284:116925. https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116925.","journal-title":"Ecotoxicol Environ Saf"},{"key":"669_CR167","doi-asserted-by":"publisher","first-page":"143131","DOI":"10.1016\/j.chemosphere.2024.143131","volume":"364","author":"N Aloi","year":"2024","unstructured":"Aloi N, Calarco A, Curcuruto G, Di Natale M, Augello G, Carroccio SC, et al. Photoaging of polystyrene-based microplastics amplifies inflammatory response in macrophages. Chemosphere. 2024;364:143131. https:\/\/doi.org\/10.1016\/j.chemosphere.2024.143131.","journal-title":"Chemosphere"},{"issue":"11","key":"669_CR168","doi-asserted-by":"publisher","first-page":"e0260181","DOI":"10.1371\/journal.pone.0260181","volume":"16","author":"AK Vlacil","year":"2021","unstructured":"Vlacil AK, B\u00e4nfer S, Jacob R, Trippel N, Kuzu I, Schieffer B, et al. Polystyrene microplastic particles induce endothelial activation. PLoS ONE. 2021;16(11):e0260181. https:\/\/doi.org\/10.1371\/journal.pone.0260181.","journal-title":"PLoS ONE"},{"key":"669_CR169","doi-asserted-by":"publisher","first-page":"118692","DOI":"10.1016\/j.ecoenv.2025.118692","volume":"302","author":"L Xie","year":"2025","unstructured":"Xie L, Zhao Y, Pan Y, Shang Y, Kong Y, Gu Y, et al. The impact of polyethylene terephthalate microplastics on the pathogenesis of atherosclerosis: Focusing on network toxicology and target gene detection. Ecotoxicol Environ Saf. 2025;302:118692. https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118692.","journal-title":"Ecotoxicol Environ Saf"},{"key":"669_CR170","doi-asserted-by":"publisher","first-page":"132503","DOI":"10.1016\/j.jhazmat.2023.132503","volume":"461","author":"Z Zhang","year":"2024","unstructured":"Zhang Z, Chen W, Chan H, Peng J, Zhu P, Li J, et al. Polystyrene microplastics induce size-dependent multi-organ damage in mice: Insights into gut microbiota and fecal metabolites. J Hazard Mater. 2024;461:132503. https:\/\/doi.org\/10.1016\/j.jhazmat.2023.132503.","journal-title":"J Hazard Mater"},{"issue":"11","key":"669_CR171","doi-asserted-by":"publisher","first-page":"4541","DOI":"10.1021\/acsapm.0c00645","volume":"2","author":"S Han","year":"2020","unstructured":"Han S, Bang J, Choi D, Hwang J, Kim T, Oh Y, et al. Surface pattern analysis of microplastics and their impact on human-derived cells. ACS Appl Polym Mater. 2020;2(11):4541\u201350. https:\/\/doi.org\/10.1021\/acsapm.0c00645.","journal-title":"ACS Appl Polym Mater"},{"key":"669_CR172","doi-asserted-by":"publisher","DOI":"10.3390\/biom12081095","author":"M Busch","year":"2022","unstructured":"Busch M, Bredeck G, Waag F, Rahimi K, Ramachandran H, Bessel T, et al. Assessing the NLRP3 inflammasome activating potential of a large panel of micro- and nanoplastics in THP-1 cells. Biomolecules. 2022. https:\/\/doi.org\/10.3390\/biom12081095.","journal-title":"Biomolecules"},{"issue":"12","key":"669_CR173","doi-asserted-by":"publisher","first-page":"9648","DOI":"10.1021\/nn203596e","volume":"5","author":"O Lunov","year":"2011","unstructured":"Lunov O, Syrovets T, Loos C, Nienhaus GU, Mail\u00e4nder V, Landfester K, et al. Amino-functionalized polystyrene nanoparticles activate the NLRP3 inflammasome in human macrophages. ACS Nano. 2011;5(12):9648\u201357. https:\/\/doi.org\/10.1021\/nn203596e.","journal-title":"ACS Nano"},{"key":"669_CR174","doi-asserted-by":"publisher","first-page":"107173","DOI":"10.1016\/j.envint.2022.107173","volume":"163","author":"A Weber","year":"2022","unstructured":"Weber A, Schwiebs A, Solhaug H, Stenvik J, Nilsen AM, Wagner M, et al. Nanoplastics affect the inflammatory cytokine release by primary human monocytes and dendritic cells. Environ Int. 2022;163:107173. https:\/\/doi.org\/10.1016\/j.envint.2022.107173.","journal-title":"Environ Int"},{"key":"669_CR175","doi-asserted-by":"publisher","first-page":"109501","DOI":"10.1016\/j.envint.2025.109501","volume":"199","author":"A Dai","year":"2025","unstructured":"Dai A, Liu X, Chen Y, Wang Y, Qi H, Zeng Y, et al. Co-exposure to ozone and polystyrene nanoplastic exacerbates cognitive impairment and anxiety-like behavior by regulating neuronal pyroptosis in mice. Environ Int. 2025;199:109501. https:\/\/doi.org\/10.1016\/j.envint.2025.109501.","journal-title":"Environ Int"},{"key":"669_CR176","doi-asserted-by":"publisher","first-page":"108690","DOI":"10.1016\/j.fsi.2023.108690","volume":"135","author":"Q Zhang","year":"2023","unstructured":"Zhang Q, Wang F, Xu S, Cui J, Li K, Shiwen X, et al. Polystyrene microplastics induce myocardial inflammation and cell death via the TLR4\/NF-\u03baB pathway in carp. Fish Shellfish Immunol. 2023;135:108690. https:\/\/doi.org\/10.1016\/j.fsi.2023.108690.","journal-title":"Fish Shellfish Immunol"},{"issue":"4","key":"669_CR177","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/s41569-023-00946-3","volume":"21","author":"S Toldo","year":"2024","unstructured":"Toldo S, Abbate A. The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases. Nat Rev Cardiol. 2024;21(4):219\u201337. https:\/\/doi.org\/10.1038\/s41569-023-00946-3.","journal-title":"Nat Rev Cardiol"},{"key":"669_CR178","doi-asserted-by":"publisher","first-page":"117471","DOI":"10.1016\/j.ecoenv.2024.117471","volume":"289","author":"EH Kim","year":"2025","unstructured":"Kim EH, Baek SM, Park HJ, Bian Y, Chung HY, Bae ON. Polystyrene nanoplastics promote the blood-brain barrier dysfunction through autophagy pathway and excessive erythrophagocytosis. Ecotoxicol Environ Saf. 2025;289:117471. https:\/\/doi.org\/10.1016\/j.ecoenv.2024.117471.","journal-title":"Ecotoxicol Environ Saf"},{"key":"669_CR179","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.jes.2025.04.059","volume":"159","author":"D Huang","year":"2026","unstructured":"Huang D, Kang H, Liu Z, Zhang W, Wang J, Wang Z, et al. Ferroptosis involved in inhaled polystyrene microplastics leaded myocardial fibrosis through HIF-ROS-SLC7A11\/GPX4 Pathway. J Environ Sci (China). 2026;159:391\u2013402. https:\/\/doi.org\/10.1016\/j.jes.2025.04.059.","journal-title":"J Environ Sci (China)"},{"key":"669_CR180","doi-asserted-by":"publisher","first-page":"140148","DOI":"10.1016\/j.jhazmat.2025.140148","volume":"499","author":"JG Cui","year":"2025","unstructured":"Cui JG, Zhang H, Zhang YQ, Sun B, Li XN, Zhao Y, et al. A new insight into the mechanism of DEHP-induced cardiotoxicity: triggering pyroptosis of cardiomyocytes by disrupting sphingolipid metabolism. J Hazard Mater. 2025;499:140148. https:\/\/doi.org\/10.1016\/j.jhazmat.2025.140148.","journal-title":"J Hazard Mater"},{"issue":"2","key":"669_CR181","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.tem.2024.07.013","volume":"36","author":"Y Pan","year":"2025","unstructured":"Pan Y, Xu S, Yang X. Standardizing methodologies to study microplastics and nanoplastics in cardiovascular diseases. Trends Endocrinol Metab. 2025;36(2):105\u20138. https:\/\/doi.org\/10.1016\/j.tem.2024.07.013.","journal-title":"Trends Endocrinol Metab"},{"key":"669_CR182","doi-asserted-by":"publisher","first-page":"100567","DOI":"10.1016\/j.impact.2025.100567","volume":"38","author":"M Das","year":"2025","unstructured":"Das M, Calderon L, Singh D, Majumder S, Bazina L, Vaze N, et al. Development and characterization of reference environmentally relevant micro-nano-plastics for risk assessment studies. NanoImpact. 2025;38:100567. https:\/\/doi.org\/10.1016\/j.impact.2025.100567.","journal-title":"NanoImpact"},{"key":"669_CR183","doi-asserted-by":"publisher","first-page":"117248","DOI":"10.1016\/j.ecoenv.2024.117248","volume":"286","author":"J Bian","year":"2024","unstructured":"Bian J, Peng N, Zhou Z, Yang J, Wang X. A critical review of co-pollution of microplastics and heavy metals in agricultural soil environments. Ecotoxicol Environ Saf. 2024;286:117248. https:\/\/doi.org\/10.1016\/j.ecoenv.2024.117248.","journal-title":"Ecotoxicol Environ Saf"},{"issue":"12","key":"669_CR184","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1161\/CIRCULATIONAHA.124.069801","volume":"150","author":"DH Lee","year":"2024","unstructured":"Lee DH. Microplastics and cardiovascular diseases: importance of coexisting environmental pollutants. Circulation. 2024;150(12):908\u201310. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.124.069801.","journal-title":"Circulation"}],"container-title":["Particle and Fibre Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12989-026-00669-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12989-026-00669-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12989-026-00669-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:58:21Z","timestamp":1773907101000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12989-026-00669-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":184,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["669"],"URL":"https:\/\/doi.org\/10.1186\/s12989-026-00669-6","relation":{},"ISSN":["1743-8977"],"issn-type":[{"value":"1743-8977","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]},"assertion":[{"value":"24 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"16"}}