{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:16:37Z","timestamp":1791274597659,"version":"4.1.0"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000765","name":"University College London","doi-asserted-by":"publisher","award":["IN-1160267"],"award-info":[{"award-number":["IN-1160267"]}],"id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Trigeminal neuralgia is accompanied by severe mechanical, thermal and chemical hypersensitivity of the orofacial area innervated by neurons of trigeminal ganglion (TG). We examined the role of the voltage-gated sodium channel subtype Na<jats:sub>v<\/jats:sub>1.9 in the development of trigeminal neuralgia. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> We found that Na<jats:sub>v<\/jats:sub>1.9 is required for the development of both thermal and mechanical hypersensitivity induced by constriction of the infraorbital nerve (CION). The CION model does not induce change on Na<jats:sub>v<\/jats:sub>1.9 mRNA expression in the ipsilateral TG neurons when evaluated 9 days after surgery. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> These results demonstrate that Na<jats:sub>v<\/jats:sub>1.9 channels play a critical role in the development of orofacial neuropathic pain. New routes for the treatment of orofacial neuropathic pain focussing on regulation of the voltage-gated Na<jats:sub>v<\/jats:sub>1.9 sodium channel activity should be investigated. <\/jats:p><\/jats:sec>","DOI":"10.1186\/s12990-015-0076-4","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T05:03:15Z","timestamp":1448427795000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["The Role of Na<sub>v<\/sub>1.9 Channel in the Development of Neuropathic Orofacial Pain Associated with Trigeminal Neuralgia"],"prefix":"10.1177","volume":"11","author":[{"given":"Ana Paula","family":"Lulz","sequence":"first","affiliation":[{"name":"Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, Gower St, London WC1E 6BT, 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