{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:40:55Z","timestamp":1790214055012,"version":"4.1.0"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100007194","name":"Wenzhou Science and Technology Bureau","doi-asserted-by":"crossref","award":["Y20210133"],"award-info":[{"award-number":["Y20210133"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Zhejiang Medical Association Clinical Medical Research special fund project","award":["2024ZYC-A10"],"award-info":[{"award-number":["2024ZYC-A10"]}]},{"name":"Zhejiang Medical and Health Science and Technology Program","award":["2023KY907"],"award-info":[{"award-number":["2023KY907"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Behav Brain Funct"],"DOI":"10.1186\/s12993-025-00283-0","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T07:35:02Z","timestamp":1749713702000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The gut microbiome and metabolomic alterations underlying colitis-induced encephalopathy in mice: mechanistic insight"],"prefix":"10.1186","volume":"21","author":[{"given":"Aimin","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingchao","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushuang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shize","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lele","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longfa","family":"Kou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"issue":"2","key":"283_CR1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.25122\/jml-2018-0075","volume":"12","author":"SS Seyedian","year":"2019","unstructured":"Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease. J Med Life. 2019;12(2):113\u201322. https:\/\/doi.org\/10.25122\/jml-2018-0075","journal-title":"J Med Life"},{"issue":"2","key":"283_CR2","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.chmed.2023.03.003","volume":"15","author":"Y Yang","year":"2023","unstructured":"Yang Y, Wang Y, Zhao L, Wang F, Li M, Wang Q, et al. Chinese herbal medicines for treating ulcerative colitis via regulating gut microbiota-intestinal immunity axis. Chin Herb Med. 2023;15(2):181\u2013200. https:\/\/doi.org\/10.1016\/j.chmed.2023.03.003","journal-title":"Chin Herb Med"},{"issue":"1","key":"283_CR3","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41572-020-0205-x","volume":"6","author":"T Kobayashi","year":"2020","unstructured":"Kobayashi T, Siegmund B, Le Berre C, Wei SC, Ferrante M, Shen B, et al. Ulcerative colitis. Nat Rev Dis Primers. 2020;6(1):74. https:\/\/doi.org\/10.1038\/s41572-020-0205-x","journal-title":"Nat Rev Dis Primers"},{"key":"283_CR4","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jpsychores.2016.06.001","volume":"87","author":"R Neuendorf","year":"2016","unstructured":"Neuendorf R, Harding A, Stello N, Hanes D, Wahbeh H. Depression and anxiety in patients with inflammatory bowel disease: A systematic review. J Psychosom Res. 2016;87:70\u201380. https:\/\/doi.org\/10.1016\/j.jpsychores.2016.06.001","journal-title":"J Psychosom Res"},{"issue":"3","key":"283_CR5","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1136\/ebmental-2020-300223","volume":"24","author":"P Irving","year":"2021","unstructured":"Irving P, Barrett K, Nijher M, de Lusignan S. Prevalence of depression and anxiety in people with inflammatory bowel disease and associated healthcare use: population-based cohort study. Evid Based Ment Health. 2021;24(3):102\u20139. https:\/\/doi.org\/10.1136\/ebmental-2020-300223","journal-title":"Evid Based Ment Health"},{"key":"283_CR6","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.yebeh.2016.05.041","volume":"63","author":"CR Camara-Lemarroy","year":"2016","unstructured":"Camara-Lemarroy CR, Escobedo-Z\u00fa\u00f1iga N, Ortiz-Zacarias D, Pe\u00f1a-Avenda\u00f1o J, Villarreal-Garza E, D\u00edaz-Torres MA. Prevalence and impact of irritable bowel syndrome in people with epilepsy. Epilepsy Behav. 2016;63:29\u201333. https:\/\/doi.org\/10.1016\/j.yebeh.2016.05.041","journal-title":"Epilepsy Behav"},{"issue":"2","key":"283_CR7","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1136\/gutjnl-2020-322429","volume":"70","author":"HS Lee","year":"2021","unstructured":"Lee HS, Lobbestael E, Vermeire S, Sabino J, Cleynen I. Inflammatory bowel disease and parkinson\u2019s disease: common pathophysiological links. Gut. 2021;70(2):408\u201317. https:\/\/doi.org\/10.1136\/gutjnl-2020-322429","journal-title":"Gut"},{"issue":"11","key":"283_CR8","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1111\/nmo.12219","volume":"25","author":"JW Berrill","year":"2013","unstructured":"Berrill JW, Gallacher J, Hood K, Green JT, Matthews SB, Campbell AK, et al. An observational study of cognitive function in patients with irritable bowel syndrome and inflammatory bowel disease. Neurogastroenterol Motil. 2013;25(11):918\u2013e704. https:\/\/doi.org\/10.1111\/nmo.12219","journal-title":"Neurogastroenterol Motil"},{"issue":"6","key":"283_CR9","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1002\/ibd.20837","volume":"15","author":"CP Dancey","year":"2009","unstructured":"Dancey CP, Attree EA, Stuart G, Wilson C, Sonnet A. Words fail me: the verbal IQ deficit in inflammatory bowel disease and irritable bowel syndrome. Inflamm Bowel Dis. 2009;15(6):852\u20137. https:\/\/doi.org\/10.1002\/ibd.20837","journal-title":"Inflamm Bowel Dis"},{"issue":"1","key":"283_CR10","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1136\/gutjnl-2020-320789","volume":"70","author":"B Zhang","year":"2021","unstructured":"Zhang B, Wang HE, Bai YM, Tsai SJ, Su TP, Chen TJ, et al. Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study. Gut. 2021;70(1):85\u201391. https:\/\/doi.org\/10.1136\/gutjnl-2020-320789","journal-title":"Gut"},{"issue":"6","key":"283_CR11","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1053\/j.gastro.2018.01.027","volume":"154","author":"DJ Gracie","year":"2018","unstructured":"Gracie DJ, Guthrie EA, Hamlin PJ, Ford AC. Bi-directionality of Brain-Gut interactions in patients with inflammatory bowel disease. Gastroenterology. 2018;154(6):1635\u201346.e3. https:\/\/doi.org\/10.1053\/j.gastro.2018.01.027","journal-title":"Gastroenterology"},{"issue":"10","key":"283_CR12","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1093\/ibd\/izz045","volume":"25","author":"K Lewis","year":"2019","unstructured":"Lewis K, Marrie RA, Bernstein CN, Graff LA, Patten SB, Sareen J, et al. The prevalence and risk factors of undiagnosed depression and anxiety disorders among patients with inflammatory bowel disease. Inflamm Bowel Dis. 2019;25(10):1674\u201380. https:\/\/doi.org\/10.1093\/ibd\/izz045","journal-title":"Inflamm Bowel Dis"},{"issue":"5","key":"283_CR13","doi-asserted-by":"publisher","first-page":"199","DOI":"10.2220\/biomedres.41.199","volume":"41","author":"A Kuwahara","year":"2020","unstructured":"Kuwahara A, Matsuda K, Kuwahara Y, Asano S, Inui T, Marunaka Y. Microbiota-gut-brain axis: enteroendocrine cells and the enteric nervous system form an interface between the microbiota and the central nervous system. Biomed Res. 2020;41(5):199\u2013216. https:\/\/doi.org\/10.2220\/biomedres.41.199","journal-title":"Biomed Res"},{"issue":"4","key":"283_CR14","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.chmed.2023.12.003","volume":"16","author":"Q Wang","year":"2024","unstructured":"Wang Q, Zhao Y, Qin X, Tian J. Deciphering relationship between depression and microbial molecules based on multi-omics: A case study of Chaigui granules. Chin Herb Med. 2024;16(4):612\u201321. https:\/\/doi.org\/10.1016\/j.chmed.2023.12.003","journal-title":"Chin Herb Med"},{"key":"283_CR15","doi-asserted-by":"publisher","first-page":"1173660","DOI":"10.3389\/fnut.2023.1173660","volume":"10","author":"F Ansari","year":"2023","unstructured":"Ansari F, Neshat M, Pourjafar H, Jafari SM, Samakkhah SA, Mirzakhani E. The role of probiotics and prebiotics in modulating of the gut-brain axis. Front Nutr. 2023;10:1173660. https:\/\/doi.org\/10.3389\/fnut.2023.1173660","journal-title":"Front Nutr"},{"issue":"1","key":"283_CR16","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1186\/s40168-023-01623-w","volume":"11","author":"O Shtossel","year":"2023","unstructured":"Shtossel O, Turjeman S, Riumin A, Goldberg MR, Elizur A, Bekor Y, et al. Recipient-independent, high-accuracy FMT-response prediction and optimization in mice and humans. Microbiome. 2023;11(1):181. https:\/\/doi.org\/10.1186\/s40168-023-01623-w","journal-title":"Microbiome"},{"issue":"2","key":"283_CR17","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/s41380-022-01817-y","volume":"28","author":"K Berding","year":"2023","unstructured":"Berding K, Bastiaanssen TFS, Moloney GM, Boscaini S, Strain CR, Anesi A, et al. Feed your microbes to deal with stress: a psychobiotic diet impacts microbial stability and perceived stress in a healthy adult population. Mol Psychiatry. 2023;28(2):601\u201310. https:\/\/doi.org\/10.1038\/s41380-022-01817-y","journal-title":"Mol Psychiatry"},{"issue":"4","key":"283_CR18","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1249\/mss.0000000000001495","volume":"50","author":"JM Allen","year":"2018","unstructured":"Allen JM, Mailing LJ, Niemiro GM, Moore R, Cook MD, White BA, et al. Exercise alters gut microbiota composition and function in lean and obese humans. Med Sci Sports Exerc. 2018;50(4):747\u201357. https:\/\/doi.org\/10.1249\/mss.0000000000001495","journal-title":"Med Sci Sports Exerc"},{"issue":"12","key":"283_CR19","doi-asserted-by":"publisher","first-page":"4916","DOI":"10.1093\/brain\/awad303","volume":"146","author":"S Grabrucker","year":"2023","unstructured":"Grabrucker S, Marizzoni M, Silajd\u0625i\u0624\u00e7 E, Lopizzo N, Mombelli E, Nicolas S, et al. Microbiota from alzheimer\u2019s patients induce deficits in cognition and hippocampal neurogenesis. Brain. 2023;146(12):4916\u201334. https:\/\/doi.org\/10.1093\/brain\/awad303","journal-title":"Brain"},{"issue":"6","key":"283_CR20","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.14336\/ad.2023.0309","volume":"14","author":"Z Xie","year":"2023","unstructured":"Xie Z, Zhang M, Luo Y, Jin D, Guo X, Yang W, et al. Healthy human fecal microbiota transplantation into mice attenuates MPTP-Induced neurotoxicity via AMPK\/SOD2 pathway. Aging Dis. 2023;14(6):2193\u2013214. https:\/\/doi.org\/10.14336\/ad.2023.0309","journal-title":"Aging Dis"},{"issue":"1","key":"283_CR21","doi-asserted-by":"publisher","first-page":"2418988","DOI":"10.1080\/19490976.2024.2418988","volume":"16","author":"ND Nuzum","year":"2024","unstructured":"Nuzum ND, Deady C, Kittel-Schneider S, Cryan JF, O\u2019Mahony SM, Clarke G. More than just a number: the gut microbiota and brain function across the extremes of life. Gut Microbes. 2024;16(1):2418988. https:\/\/doi.org\/10.1080\/19490976.2024.2418988","journal-title":"Gut Microbes"},{"key":"283_CR22","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.bbi.2022.03.001","volume":"102","author":"FA Vicentini","year":"2022","unstructured":"Vicentini FA, Szamosi JC, Rossi L, Griffin L, Nieves K, Bihan D, et al. Colitis-associated microbiota drives changes in behaviour in male mice in the absence of inflammation. Brain Behav Immun. 2022;102:266\u201378. https:\/\/doi.org\/10.1016\/j.bbi.2022.03.001","journal-title":"Brain Behav Immun"},{"key":"283_CR23","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.bbrc.2023.05.112","volume":"669","author":"K Lee","year":"2023","unstructured":"Lee K, Kumazoe M, Marugame Y, Fujimura Y, Tachibana H. Dextran sulfate sodium-induced mild chronic colitis induced cognitive impairment accompanied by Inhibition of neuronal maturation in adolescent mice. Biochem Biophys Res Commun. 2023;669:46\u201353. https:\/\/doi.org\/10.1016\/j.bbrc.2023.05.112","journal-title":"Biochem Biophys Res Commun"},{"key":"283_CR24","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.neuroscience.2017.10.023","volume":"366","author":"A Haj-Mirzaian","year":"2017","unstructured":"Haj-Mirzaian A, Amiri S, Amini-Khoei H, Hosseini MJ, Haj-Mirzaian A, Momeny M, et al. Anxiety- and Depressive-Like behaviors are associated with altered hippocampal energy and inflammatory status in a mouse model of crohn\u2019s disease. Neuroscience. 2017;366:124\u201337. https:\/\/doi.org\/10.1016\/j.neuroscience.2017.10.023","journal-title":"Neuroscience"},{"issue":"5","key":"283_CR25","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/s2468-1253(21)00014-5","volume":"6","author":"B Barberio","year":"2021","unstructured":"Barberio B, Zamani M, Black CJ, Savarino EV, Ford AC. Prevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2021;6(5):359\u201370. https:\/\/doi.org\/10.1016\/s2468-1253(21)00014-5","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"4","key":"283_CR26","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/s41579-022-00703-2","volume":"20","author":"A Du Toit","year":"2022","unstructured":"Du Toit A. Gut microbiota and depression. Nat Rev Microbiol. 2022;20(4):190. https:\/\/doi.org\/10.1038\/s41579-022-00703-2","journal-title":"Nat Rev Microbiol"},{"issue":"6571","key":"283_CR27","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1126\/science.abi6087","volume":"374","author":"G Agirman","year":"2021","unstructured":"Agirman G, Yu KB, Hsiao EY. Signaling inflammation across the gut-brain axis. Science. 2021;374(6571):1087\u201392. https:\/\/doi.org\/10.1126\/science.abi6087","journal-title":"Science"},{"issue":"6","key":"283_CR28","doi-asserted-by":"publisher","first-page":"e6073","DOI":"10.1371\/journal.pone.0006073","volume":"4","author":"Y Yan","year":"2009","unstructured":"Yan Y, Kolachala V, Dalmasso G, Nguyen H, Laroui H, Sitaraman SV, et al. Temporal and Spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis. PLoS ONE. 2009;4(6):e6073. https:\/\/doi.org\/10.1371\/journal.pone.0006073","journal-title":"PLoS ONE"},{"issue":"4","key":"283_CR29","first-page":"103","volume":"107","author":"H El-Falougy","year":"2006","unstructured":"El-Falougy H, Benuska J. History, anatomical nomenclature, comparative anatomy and functions of the hippocampal formation. Bratisl Lek Listy. 2006;107(4):103\u20136.","journal-title":"Bratisl Lek Listy"},{"issue":"11","key":"283_CR30","doi-asserted-by":"publisher","first-page":"5024","DOI":"10.1021\/acs.jproteome.1c00519","volume":"20","author":"P Deng","year":"2021","unstructured":"Deng P, Zhou Y, Wang X, Tang K, Jiang H, He W, et al. The protective effect of basic fibroblast growth factor in intestine of db\/db mice: A (1)H NMR-Based metabolomics investigation. J Proteome Res. 2021;20(11):5024\u201335. https:\/\/doi.org\/10.1021\/acs.jproteome.1c00519","journal-title":"J Proteome Res"},{"issue":"2","key":"283_CR31","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.jmr.2009.11.012","volume":"202","author":"F Savorani","year":"2010","unstructured":"Savorani F, Tomasi G, Engelsen SB. Icoshift: A versatile tool for the rapid alignment of 1D NMR spectra. J Magn Reson. 2010;202(2):190\u2013202. https:\/\/doi.org\/10.1016\/j.jmr.2009.11.012","journal-title":"J Magn Reson"},{"issue":"11","key":"283_CR32","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/s41575-022-00634-6","volume":"19","author":"TH Bisgaard","year":"2022","unstructured":"Bisgaard TH, Allin KH, Keefer L, Ananthakrishnan AN, Jess T. Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment. Nat Rev Gastroenterol Hepatol. 2022;19(11):717\u201326. https:\/\/doi.org\/10.1038\/s41575-022-00634-6","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"4","key":"283_CR33","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1093\/ecco-jcc\/jjab191","volume":"16","author":"J Luo","year":"2022","unstructured":"Luo J, Xu Z, Noordam R, van Heemst D, Li-Gao R. Depression and inflammatory bowel disease: A bidirectional Two-sample Mendelian randomization study. J Crohns Colitis. 2022;16(4):633\u201342. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjab191","journal-title":"J Crohns Colitis"},{"issue":"1","key":"283_CR34","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ajpath.2021.09.006","volume":"192","author":"J Mitchell","year":"2022","unstructured":"Mitchell J, Kim SJ, Howe C, Lee S, Her JY, Patel M, et al. Chronic intestinal inflammation suppresses brain activity by inducing neuroinflammation in mice. Am J Pathol. 2022;192(1):72\u201386. https:\/\/doi.org\/10.1016\/j.ajpath.2021.09.006","journal-title":"Am J Pathol"},{"issue":"4","key":"283_CR35","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1038\/s41380-020-0651-6","volume":"26","author":"IA Gampierakis","year":"2021","unstructured":"Gampierakis IA, Koutmani Y, Semitekolou M, Morianos I, Polissidis A, Katsouda A, et al. Hippocampal neural stem cells and microglia response to experimental inflammatory bowel disease (IBD). Mol Psychiatry. 2021;26(4):1248\u201363. https:\/\/doi.org\/10.1038\/s41380-020-0651-6","journal-title":"Mol Psychiatry"},{"key":"283_CR36","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.bbi.2023.06.003","volume":"112","author":"K Wu","year":"2023","unstructured":"Wu K, Liu YY, Shao S, Song W, Chen XH, Dong YT, et al. The microglial innate immune receptors TREM-1 and TREM-2 in the anterior cingulate cortex (ACC) drive visceral hypersensitivity and depressive-like behaviors following DSS-induced colitis. Brain Behav Immun. 2023;112:96\u2013117. https:\/\/doi.org\/10.1016\/j.bbi.2023.06.003","journal-title":"Brain Behav Immun"},{"key":"283_CR37","doi-asserted-by":"publisher","first-page":"p6244757","DOI":"10.1155\/2022\/6244757","volume":"2022","author":"F Zhang","year":"2022","unstructured":"Zhang F, Zhou Y, Chen H, Jiang H, Zhou F, Lv B, et al. Curcumin alleviates DSS-Induced Anxiety-Like behaviors via the Microbial-Brain-Gut Axis. Oxid Med Cell Longev. 2022;2022:p6244757. https:\/\/doi.org\/10.1155\/2022\/6244757","journal-title":"Oxid Med Cell Longev"},{"issue":"4","key":"283_CR38","first-page":"421","volume":"57","author":"SW Ko","year":"2005","unstructured":"Ko SW, Ao HS, Mendel AG, Qiu CS, Wei F, Milbrandt J, et al. Transcription factor Egr-1 is required for long-term fear memory and anxiety. Sheng Li Xue Bao. 2005;57(4):421\u201332.","journal-title":"Sheng Li Xue Bao"},{"key":"283_CR39","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.bbr.2019.03.011","volume":"365","author":"C Zorzo","year":"2019","unstructured":"Zorzo C, M\u00e9ndez-L\u00f3pez M, M\u00e9ndez M, Arias JL. Adult social isolation leads to anxiety and Spatial memory impairment: brain activity pattern of COx and c-Fos. Behav Brain Res. 2019;365:170\u20137. https:\/\/doi.org\/10.1016\/j.bbr.2019.03.011","journal-title":"Behav Brain Res"},{"issue":"1","key":"283_CR40","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.pjnns.2016.10.001","volume":"51","author":"J Siuda","year":"2017","unstructured":"Siuda J, Patalong-Ogiewa M, \u017bmuda W, Targosz-Gajniak M, Niewiadomska E, Matuszek I, et al. Cognitive impairment and BDNF serum levels. Neurol Neurochir Pol. 2017;51(1):24\u201332. https:\/\/doi.org\/10.1016\/j.pjnns.2016.10.001","journal-title":"Neurol Neurochir Pol"},{"issue":"3","key":"283_CR41","doi-asserted-by":"publisher","first-page":"e13886","DOI":"10.1111\/apha.13886","volume":"236","author":"MS Eriksen","year":"2022","unstructured":"Eriksen MS, Bramham CR. Molecular physiology of Arc\/Arg3.1: the oligomeric state hypothesis of synaptic plasticity. Acta Physiol (Oxf). 2022;236(3):e13886. https:\/\/doi.org\/10.1111\/apha.13886","journal-title":"Acta Physiol (Oxf)"},{"key":"283_CR42","doi-asserted-by":"publisher","unstructured":"Stojanov S, Berlec A, \u0160trukelj B. The influence of probiotics on the firmicutes\/bacteroidetes ratio in the treatment of obesity and inflammatory bowel disease. Microorganisms. 2020;8(11). https:\/\/doi.org\/10.3390\/microorganisms8111715","DOI":"10.3390\/microorganisms8111715"},{"key":"283_CR43","doi-asserted-by":"publisher","unstructured":"Magne F, Gotteland M, Gauthier L, Zazueta A, Pesoa S, Navarrete P, et al. The firmicutes\/bacteroidetes ratio: A relevant marker of gut dysbiosis in obese patients?? Nutrients. 2020;12(5). https:\/\/doi.org\/10.3390\/nu12051474","DOI":"10.3390\/nu12051474"},{"issue":"5","key":"283_CR44","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/nrgastro.2010.39","volume":"7","author":"SP Colgan","year":"2010","unstructured":"Colgan SP, Taylor CT. Hypoxia: an alarm signal during intestinal inflammation. Nat Rev Gastroenterol Hepatol. 2010;7(5):281\u20137. https:\/\/doi.org\/10.1038\/nrgastro.2010.39","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"9","key":"283_CR45","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1093\/ibd\/izac024","volume":"28","author":"M \u0623\u00fbzsoy","year":"2022","unstructured":"\u0623\u00fbzsoy M, Stummer N, Zimmermann FA, Feichtinger RG, Sperl W, Weghuber D, et al. Role of energy metabolism and mitochondrial function in inflammatory bowel disease. Inflamm Bowel Dis. 2022;28(9):1443\u201350. https:\/\/doi.org\/10.1093\/ibd\/izac024","journal-title":"Inflamm Bowel Dis"},{"issue":"10","key":"283_CR46","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1042\/bcj20200275","volume":"477","author":"A Cai","year":"2020","unstructured":"Cai A, Zheng H, Chen Z, Lin X, Li C, Yao Q, et al. Synergism between SLC6A14 Blockade and gemcitabine in pancreactic cancer: a 1H-NMR-based metabolomic study in pancreatic cancer cells. Biochem J. 2020;477(10):1923\u201337. https:\/\/doi.org\/10.1042\/bcj20200275","journal-title":"Biochem J"},{"issue":"8","key":"283_CR47","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41574-020-0365-5","volume":"16","author":"L Kazak","year":"2020","unstructured":"Kazak L, Cohen P. Creatine metabolism: energy homeostasis, immunity and cancer biology. Nat Rev Endocrinol. 2020;16(8):421\u201336. https:\/\/doi.org\/10.1038\/s41574-020-0365-5","journal-title":"Nat Rev Endocrinol"},{"issue":"7","key":"283_CR48","doi-asserted-by":"publisher","first-page":"E1273","DOI":"10.1073\/pnas.1621400114","volume":"114","author":"E Turer","year":"2017","unstructured":"Turer E, McAlpine W, Wang KW, Lu T, Li X, Tang M, et al. Creatine maintains intestinal homeostasis and protects against colitis. Proc Natl Acad Sci U S A. 2017;114(7):E1273\u201381. https:\/\/doi.org\/10.1073\/pnas.1621400114","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"283_CR49","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41577-019-0259-8","volume":"20","author":"LB Ivashkiv","year":"2020","unstructured":"Ivashkiv LB. The hypoxia-lactate axis tempers inflammation. Nat Rev Immunol. 2020;20(2):85\u20136. https:\/\/doi.org\/10.1038\/s41577-019-0259-8","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"283_CR50","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.cell.2011.02.018","volume":"144","author":"A Suzuki","year":"2011","unstructured":"Suzuki A, Stern SA, Bozdagi O, Huntley GW, Walker RH, Magistretti PJ, et al. Astrocyte-neuron lactate transport is required for long-term memory formation. Cell. 2011;144(5):810\u201323. https:\/\/doi.org\/10.1016\/j.cell.2011.02.018","journal-title":"Cell"},{"issue":"6","key":"283_CR51","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/j.stem.2019.09.009","volume":"25","author":"J Wang","year":"2019","unstructured":"Wang J, Cui Y, Yu Z, Wang W, Cheng X, Ji W, et al. Brain endothelial cells maintain lactate homeostasis and control adult hippocampal neurogenesis. Cell Stem Cell. 2019;25(6):754\u2013e7679. https:\/\/doi.org\/10.1016\/j.stem.2019.09.009","journal-title":"Cell Stem Cell"},{"issue":"1","key":"283_CR52","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.bbadis.2016.11.003","volume":"1863","author":"H Zheng","year":"2017","unstructured":"Zheng H, Zheng Y, Zhao L, Chen M, Bai G, Hu Y, et al. Cognitive decline in type 2 diabetic db\/db mice May be associated with brain region-specific metabolic disorders. Biochim Biophys Acta Mol Basis Dis. 2017;1863(1):266\u201373. https:\/\/doi.org\/10.1016\/j.bbadis.2016.11.003","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"1","key":"283_CR53","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s12937-021-00670-z","volume":"20","author":"G Koochakpoor","year":"2021","unstructured":"Koochakpoor G, Salari-Moghaddam A, Keshteli AH, Afshar H, Esmaillzadeh A, Adibi P. Dietary intake of branched-chain amino acids in relation to depression, anxiety and psychological distress. Nutr J. 2021;20(1):11. https:\/\/doi.org\/10.1186\/s12937-021-00670-z","journal-title":"Nutr J"},{"issue":"8","key":"283_CR54","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1111\/j.1399-6576.2005.00786.x","volume":"49","author":"RY Gundersen","year":"2005","unstructured":"Gundersen RY, Vaagenes P, Breivik T, Fonnum F, Opstad PK. Glycine\u2013an important neurotransmitter and cytoprotective agent. Acta Anaesthesiol Scand. 2005;49(8):1108\u201316. https:\/\/doi.org\/10.1111\/j.1399-6576.2005.00786.x","journal-title":"Acta Anaesthesiol Scand"},{"issue":"1","key":"283_CR55","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1186\/s12974-020-01989-w","volume":"17","author":"R Ullah","year":"2020","unstructured":"Ullah R, Jo MH, Riaz M, Alam SI, Saeed K, Ali W, et al. Glycine, the smallest amino acid, confers neuroprotection against D-galactose-induced neurodegeneration and memory impairment by regulating c-Jun N-terminal kinase in the mouse brain. J Neuroinflammation. 2020;17(1):303. https:\/\/doi.org\/10.1186\/s12974-020-01989-w","journal-title":"J Neuroinflammation"},{"issue":"15","key":"283_CR56","doi-asserted-by":"publisher","first-page":"e2001065","DOI":"10.1002\/mnfr.202001065","volume":"65","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Jiang D, Jin Y, Jia H, Yang Y, Kim IH, et al. Glycine attenuates Citrobacter rodentium-Induced colitis by regulating ATF6-Mediated Endoplasmic reticulum stress in mice. Mol Nutr Food Res. 2021;65(15):e2001065. https:\/\/doi.org\/10.1002\/mnfr.202001065","journal-title":"Mol Nutr Food Res"},{"issue":"3","key":"283_CR57","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1017\/s1092852918001013","volume":"23","author":"SM Stahl","year":"2018","unstructured":"Stahl SM. Beyond the dopamine hypothesis of schizophrenia to three neural networks of psychosis: dopamine, serotonin, and glutamate. CNS Spectr. 2018;23(3):187\u201391. https:\/\/doi.org\/10.1017\/s1092852918001013","journal-title":"CNS Spectr"},{"key":"283_CR58","doi-asserted-by":"publisher","first-page":"105629","DOI":"10.1016\/j.neuint.2023.105629","volume":"171","author":"PD Szigetvari","year":"2023","unstructured":"Szigetvari PD, Patil S, Birkeland E, Kleppe R, Haavik J. The effects of phenylalanine and tyrosine levels on dopamine production in rat PC12 cells. Implications for treatment of phenylketonuria, tyrosinemia type 1 and comorbid neurodevelopmental disorders. Neurochem Int. 2023;171:105629. https:\/\/doi.org\/10.1016\/j.neuint.2023.105629","journal-title":"Neurochem Int"},{"key":"283_CR59","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.jpsychires.2018.01.019","volume":"99","author":"T Teraishi","year":"2018","unstructured":"Teraishi T, Kajiwara M, Hori H, Sasayama D, Hidese S, Matsuo J, et al. (13)C-phenylalanine breath test and serum biopterin in schizophrenia, bipolar disorder and major depressive disorder. J Psychiatr Res. 2018;99:142\u201350. https:\/\/doi.org\/10.1016\/j.jpsychires.2018.01.019","journal-title":"J Psychiatr Res"},{"key":"283_CR60","doi-asserted-by":"publisher","first-page":"104710","DOI":"10.1016\/j.neuint.2020.104710","volume":"135","author":"F Franscescon","year":"2020","unstructured":"Franscescon F, M\u0623ller TE, Bertoncello KT, Rosemberg DB. Neuroprotective role of taurine on MK-801-induced memory impairment and hyperlocomotion in zebrafish. Neurochem Int. 2020;135:104710. https:\/\/doi.org\/10.1016\/j.neuint.2020.104710","journal-title":"Neurochem Int"},{"issue":"3","key":"283_CR61","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.biopsych.2005.06.032","volume":"59","author":"GE Tsai","year":"2006","unstructured":"Tsai GE, Yang P, Chang YC, Chong MY. D-alanine added to antipsychotics for the treatment of schizophrenia. Biol Psychiatry. 2006;59(3):230\u20134. https:\/\/doi.org\/10.1016\/j.biopsych.2005.06.032","journal-title":"Biol Psychiatry"},{"key":"283_CR62","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.neuro.2021.01.002","volume":"83","author":"K Wang","year":"2021","unstructured":"Wang K, Shi Y, Liu W, Liu S, Sun MZ. Taurine improves neuron injuries and cognitive impairment in a mouse parkinson\u2019s disease model through Inhibition of microglial activation. Neurotoxicology. 2021;83:129\u201336. https:\/\/doi.org\/10.1016\/j.neuro.2021.01.002","journal-title":"Neurotoxicology"},{"key":"283_CR63","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-023-04872-3","author":"F Huf","year":"2023","unstructured":"Huf F, Gutierres JM, da Silva GN, Zago AM, Koenig LFC, Fernandes MC. Neuroprotection elicited by taurine in sporadic Alzheimer-like disease: benefits on memory and control of neuroinflammation in the hippocampus of rats. Mol Cell Biochem. 2023. https:\/\/doi.org\/10.1007\/s11010-023-04872-3","journal-title":"Mol Cell Biochem"},{"key":"283_CR64","doi-asserted-by":"publisher","first-page":"154052","DOI":"10.1016\/j.phymed.2022.154052","volume":"100","author":"MX Li","year":"2022","unstructured":"Li MX, Li MY, Lei JX, Wu YZ, Li ZH, Chen LM, et al. Huangqin Decoction ameliorates DSS-induced ulcerative colitis: role of gut microbiota and amino acid metabolism, mTOR pathway and intestinal epithelial barrier. Phytomedicine. 2022;100:154052. https:\/\/doi.org\/10.1016\/j.phymed.2022.154052","journal-title":"Phytomedicine"},{"key":"283_CR65","doi-asserted-by":"publisher","unstructured":"Portincasa P, Bonfrate L, Vacca M, De Angelis M, Farella I, Lanza E, et al. Gut microbiota and short chain fatty acids: implications in glucose homeostasis. Int J Mol Sci. 2022;23(3). https:\/\/doi.org\/10.3390\/ijms23031105","DOI":"10.3390\/ijms23031105"},{"issue":"7331","key":"283_CR66","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/nature09646","volume":"469","author":"S Fukuda","year":"2011","unstructured":"Fukuda S, Toh H, Hase K, Oshima K, Nakanishi Y, Yoshimura K, et al. Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature. 2011;469(7331):543\u20137. https:\/\/doi.org\/10.1038\/nature09646","journal-title":"Nature"},{"issue":"1","key":"283_CR67","doi-asserted-by":"publisher","first-page":"G80","DOI":"10.1152\/ajpgi.00448.2016","volume":"313","author":"Y Bhattarai","year":"2017","unstructured":"Bhattarai Y, Schmidt BA, Linden DR, Larson ED, Grover M, Beyder A, et al. Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT(3) receptor expression via acetate production. Am J Physiol Gastrointest Liver Physiol. 2017;313(1):G80\u20137. https:\/\/doi.org\/10.1152\/ajpgi.00448.2016","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"8","key":"283_CR68","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/s41575-019-0157-3","volume":"16","author":"B Dalile","year":"2019","unstructured":"Dalile B, Van Oudenhove L, Vervliet B, Verbeke K. The role of short-chain fatty acids in microbiota-gut-brain communication. Nat Rev Gastroenterol Hepatol. 2019;16(8):461\u201378. https:\/\/doi.org\/10.1038\/s41575-019-0157-3","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"283_CR69","doi-asserted-by":"publisher","unstructured":"Wang J, Zhu N, Su X, Gao Y, Yang R. Gut-Microbiota-Derived metabolites maintain gut and systemic immune homeostasis. Cells. 2023;12(5). https:\/\/doi.org\/10.3390\/cells12050793","DOI":"10.3390\/cells12050793"},{"issue":"1","key":"283_CR70","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s40168-024-01752-w","volume":"12","author":"F De Santa","year":"2024","unstructured":"De Santa F, Strimpakos G, Marchetti N, Gargari G, Torcinaro A, Arioli S, et al. Effect of a multi-strain probiotic mixture consumption on anxiety and depression symptoms induced in adult mice by postnatal maternal separation. Microbiome. 2024;12(1):29. https:\/\/doi.org\/10.1186\/s40168-024-01752-w","journal-title":"Microbiome"},{"issue":"1","key":"283_CR71","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s40168-021-01088-9","volume":"9","author":"H Zheng","year":"2021","unstructured":"Zheng H, Xu P, Jiang Q, Xu Q, Zheng Y, Yan J, et al. Depletion of acetate-producing bacteria from the gut microbiota facilitates cognitive impairment through the gut-brain neural mechanism in diabetic mice. Microbiome. 2021;9(1):145. https:\/\/doi.org\/10.1186\/s40168-021-01088-9","journal-title":"Microbiome"},{"key":"283_CR72","doi-asserted-by":"publisher","first-page":"109660","DOI":"10.1016\/j.jnutbio.2024.109660","volume":"130","author":"LMP Behrens","year":"2024","unstructured":"Behrens LMP, Gasparotto J, Rampelotto PH, Escalona MAR, da Silva LDS, Carazza-Kessler FG, et al. Sodium propionate oral supplementation ameliorates depressive-like behavior through gut Microbiome and histone 3 epigenetic regulation. J Nutr Biochem. 2024;130:109660. https:\/\/doi.org\/10.1016\/j.jnutbio.2024.109660","journal-title":"J Nutr Biochem"},{"key":"283_CR73","doi-asserted-by":"publisher","first-page":"113902","DOI":"10.1016\/j.biopha.2022.113902","volume":"156","author":"Y Yang","year":"2022","unstructured":"Yang Y, Zhong Z, Wang B, Wang Y. Xiaoyao San ameliorates high-fat diet-induced anxiety and depression via regulating gut microbiota in mice. Biomed Pharmacother. 2022;156:113902. https:\/\/doi.org\/10.1016\/j.biopha.2022.113902","journal-title":"Biomed Pharmacother"},{"key":"283_CR74","doi-asserted-by":"publisher","unstructured":"Schneider KM, Mohs A, Kilic K, Candels LS, Elfers C, Bennek E, et al. Intestinal microbiota protects against MCD Diet-Induced steatohepatitis. Int J Mol Sci. 2019;20(2). https:\/\/doi.org\/10.3390\/ijms20020308","DOI":"10.3390\/ijms20020308"},{"issue":"2","key":"283_CR75","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/jnc.15683","volume":"163","author":"C Orciani","year":"2022","unstructured":"Orciani C, Hall H, Pentz R, Foret MK, Do Carmo S, Cuello AC. Long-term nucleus basalis cholinergic depletion induces attentional deficits and impacts cortical neurons and BDNF levels without affecting the NGF synthesis. J Neurochem. 2022;163(2):149\u201367. https:\/\/doi.org\/10.1111\/jnc.15683","journal-title":"J Neurochem"},{"key":"283_CR76","doi-asserted-by":"publisher","unstructured":"Eslami M, Alibabaei F, Babaeizad A, Banihashemian SZ, Mazandarani M, Hoseini A, et al. The importance of gut microbiota on choline metabolism in neurodegenerative diseases. Biomolecules. 2024;14(11). https:\/\/doi.org\/10.3390\/biom14111345","DOI":"10.3390\/biom14111345"},{"issue":"18","key":"283_CR77","doi-asserted-by":"publisher","first-page":"e1801407","DOI":"10.1002\/mnfr.201801407","volume":"63","author":"Y Wang","year":"2019","unstructured":"Wang Y, Guan X, Chen X, Cai Y, Ma Y, Ma J, et al. Choline supplementation ameliorates behavioral deficits and alzheimer\u2019s Disease-Like pathology in Transgenic APP\/PS1 mice. Mol Nutr Food Res. 2019;63(18):e1801407. https:\/\/doi.org\/10.1002\/mnfr.201801407","journal-title":"Mol Nutr Food Res"},{"issue":"6","key":"283_CR78","doi-asserted-by":"publisher","first-page":"e13037","DOI":"10.1111\/acel.13037","volume":"18","author":"R Velazquez","year":"2019","unstructured":"Velazquez R, Ferreira E, Knowles S, Fux C, Rodin A, Winslow W, et al. Lifelong choline supplementation ameliorates alzheimer\u2019s disease pathology and associated cognitive deficits by attenuating microglia activation. Aging Cell. 2019;18(6):e13037. https:\/\/doi.org\/10.1111\/acel.13037","journal-title":"Aging Cell"},{"issue":"4","key":"283_CR79","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s00401-023-02616-7","volume":"146","author":"JM Judd","year":"2023","unstructured":"Judd JM, Jasbi P, Winslow W, Serrano GE, Beach TG, Klein-Seetharaman J, et al. Inflammation and the pathological progression of alzheimer\u2019s disease are associated with low Circulating choline levels. Acta Neuropathol. 2023;146(4):565\u201383. https:\/\/doi.org\/10.1007\/s00401-023-02616-7","journal-title":"Acta Neuropathol"},{"key":"283_CR80","doi-asserted-by":"publisher","first-page":"106390","DOI":"10.1016\/j.nbd.2023.106390","volume":"191","author":"F Zhang","year":"2024","unstructured":"Zhang F, Guo L, Shi J, Jiang H, Zhou F, Zhou Y, et al. Choline metabolism in regulating inflammatory bowel disease-linked anxiety disorders: A multi-omics exploration of the gut-brain axis. Neurobiol Dis. 2024;191:106390. https:\/\/doi.org\/10.1016\/j.nbd.2023.106390","journal-title":"Neurobiol Dis"},{"key":"283_CR81","doi-asserted-by":"publisher","first-page":"115845","DOI":"10.1016\/j.bcp.2023.115845","volume":"217","author":"L Guo","year":"2023","unstructured":"Guo L, Chen Q, Gao Y, Jiang H, Zhou F, Zhang F, et al. CDP-choline modulates cholinergic signaling and gut microbiota to alleviate DSS-induced inflammatory bowel disease. Biochem Pharmacol. 2023;217:115845. https:\/\/doi.org\/10.1016\/j.bcp.2023.115845","journal-title":"Biochem Pharmacol"}],"container-title":["Behavioral and Brain Functions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12993-025-00283-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12993-025-00283-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12993-025-00283-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T07:35:04Z","timestamp":1749713704000},"score":1,"resource":{"primary":{"URL":"https:\/\/behavioralandbrainfunctions.biomedcentral.com\/articles\/10.1186\/s12993-025-00283-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,12]]},"references-count":81,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["283"],"URL":"https:\/\/doi.org\/10.1186\/s12993-025-00283-0","relation":{},"ISSN":["1744-9081"],"issn-type":[{"value":"1744-9081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,12]]},"assertion":[{"value":"16 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Institutional Animal Care and Use Committee of Wenzhou Medical University approved all the animal experiments (approval number 109 xmsq2022\u20131008).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors agree to publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17"}}