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This study aims to assess to what extent the occupational exposure to WD and FA, albeit within regulatory limits, could result in OS induction in a woodworkers\u2019 population.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The sample population consisted of 127 woodworkers from 4 factories and 111 unexposed controls. Individual exposure was assessed by personal air-samplers. Each participant enrolled in the study filled out a questionnaire and provided a urinary sample to quantify OS biomarkers, namely 15-F<jats:sub>2t<\/jats:sub>-IsoProstane (15-F<jats:sub>2t<\/jats:sub>-IsoP) and 7,8-dihydro-8-oxo-2\u2032-deoxyguanosine (8-oxo-dGuo). The main confounding factor for OS, i.e. tobacco smoking exposure, was assessed by measuring cotinine in urine samples.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Woodworkers were exposed to significantly higher amounts of WD and FA as compared to controls (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001). Among OS biomarkers, 15-F<jats:sub>2t<\/jats:sub>-IsoP showed statistically significant higher values in woodworkers compared to controls (<jats:italic>p<\/jats:italic>\u00a0=\u20090.004). A significant, positive correlation was observed between 15-F<jats:sub>2t<\/jats:sub>-IsoP and 8-oxo-dGuo (<jats:italic>p<\/jats:italic>\u00a0=\u20090.005), cotinine (<jats:italic>p<\/jats:italic>\u00a0=\u20090.05), FA (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001) and WD (<jats:italic>p<\/jats:italic>\u00a0=\u20090.01); 8-oxo-dGuo was significantly correlated with cotinine (<jats:italic>p<\/jats:italic>\u00a0=\u20090.001) and WD (<jats:italic>p<\/jats:italic>\u00a0=\u20090.004). In addition, WD and FA were significantly correlated each other (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The study confirms that WD and FA may induce OS in woodworkers, and highlights that even the compliance with occupational exposure limits can result in measurable biological outcomes.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12995-021-00293-4","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T11:10:35Z","timestamp":1612869035000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Oxidative stress induction in woodworkers occupationally exposed to wood dust and formaldehyde"],"prefix":"10.1186","volume":"16","author":[{"given":"Federica","family":"Ghelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Bellisario","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Squillacioti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Grignani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Garzaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Buglisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Bergamaschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2471-6594","authenticated-orcid":false,"given":"Roberto","family":"Bono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,9]]},"reference":[{"issue":"2","key":"293_CR1","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1080\/10773525.2018.1428265","volume":"23","author":"IF Gaballah","year":"2017","unstructured":"Gaballah IF, Helal SF, Mourad BH. 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