{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:33:03Z","timestamp":1792801983722,"version":"4.5.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T00:00:00Z","timestamp":1667606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T00:00:00Z","timestamp":1667606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Occup Med Toxicol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Pyrometallurgical nickel production exposes workers to a wide range of occupational risk factors, including nickel aerosol, occupational noise and heat, but occupational (compensation) claims do not get enough attention in the literature. We, therefore, aimed to identify and analyze new occupational disease predictors in order to tailor prevention measures in the nickel pyrometallurgical production workers.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In a prospective observational study, a cohort of workers grouped in 16 occupations (N\u2009=\u20091424, 88% males, median age 39 (interquartile range (IQR) 31\u201347 years)), was fixed in 2007 at a large nickel production plant in the Russian High North. We then followed the cohort until 2021 and analyzed the association of selected predictors, including exposure to nickel and occupational group, with the risk of an occupational (compensation) claim in a Cox regression analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>With 18,843 person-years of observation, occupational disease claims were confirmed in 129 workers (9% of the initial cohort, N\u2009=\u2009108 men (84%)). Top three diagnoses were chronic bronchitis (3.81 cases\/1000 workers\/year), sensorineural deafness (2.36 cases\/1000 workers \/year) and musculoskeletal disorders (1.90 cases\/1000 workers\/year). Smoking was significantly associated with each diagnosis (adjusted hazard ratio (HR) ranged from 2.56 (95% confidence interval (CI) 1.17\u20135.57) for bronchitis to 6.69 (95% CI 1.46\u201330.64) for chronic obstructive pulmonary disease (COPD)). High nickel exposure was associated with occupational bronchitis and occupational asthma, whereas associations of occupational groups were also identified for COPD, asthma and musculoskeletal disorders.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Smoking, high exposure to nickel and specific exposure in the occupational groups increase the risk of occupational disease claims and should be prioritized directions for targeted intervention.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12995-022-00362-2","type":"journal-article","created":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T11:03:19Z","timestamp":1667646199000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Occupational disease predictors in the nickel pyrometallurgical production: a prospective cohort observation"],"prefix":"10.1186","volume":"17","author":[{"given":"Sergei","family":"Syurin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Vinnikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,5]]},"reference":[{"key":"362_CR1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3390\/inorganics7070089","volume":"7","author":"S Buxton","year":"2019","unstructured":"Buxton S, Garman E, Heim KE, Lyons-Darden T, Schlekat CE, Taylor MD, et al. Concise review of nickel human health toxicology and ecotoxicology. Inorganics. 2019;7:89.","journal-title":"Inorganics"},{"key":"362_CR2","doi-asserted-by":"publisher","first-page":"111006","DOI":"10.1016\/j.ecoenv.2020.111006","volume":"203","author":"H Guo","year":"2020","unstructured":"Guo H, Liu H, Jian Z, Cui H, Fang J, Zuo Z, et al. Immunotoxicity of nickel: Pathological and toxicological effects. Ecotoxicol Environ Saf. 2020;203:111006.","journal-title":"Ecotoxicol Environ Saf"},{"key":"362_CR3","doi-asserted-by":"publisher","first-page":"992","DOI":"10.2174\/1871530320666200128141900","volume":"20","author":"M Tramontana","year":"2020","unstructured":"Tramontana M, Bianchi L, Hansel K, Agostinelli D, Stingeni L. Nickel Allergy: Epidemiology, Pathomechanism, Clinical Patterns, Treatment and Prevention Programs. Endocr Metab Immune Disord Drug Targets. 2020;20:992\u20131002.","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"362_CR4","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.2174\/1871530320666200228124453","volume":"20","author":"M Gergovska","year":"2020","unstructured":"Gergovska M, Darlenski R, Kazandjieva J. Nickel Allergy of the Skin and Beyond. Endocr Metab Immune Disord Drug Targets. 2020;20:1003\u20139.","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"362_CR5","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1136\/oemed-2017-104858","volume":"75","author":"C Marant Micallef","year":"2018","unstructured":"Marant Micallef C, Shield KD, Baldi I, Charbotel B, Fervers B, Gilg Soit Ilg A, et al. Occupational exposures and cancer: a review of agents and relative risk estimates. Occup Environ Med. 2018;75:604\u201314.","journal-title":"Occup Environ Med"},{"key":"362_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jtemb.2012.01.002","volume":"26","author":"D Schauml\u00f6ffel","year":"2012","unstructured":"Schauml\u00f6ffel D. Nickel species: analysis and toxic effects. J Trace Elem Med Biol Organ Soc Miner Trace Elem GMS. 2012;26:1\u20136.","journal-title":"J Trace Elem Med Biol Organ Soc Miner Trace Elem GMS"},{"key":"362_CR7","doi-asserted-by":"publisher","first-page":"679","DOI":"10.3390\/ijerph17030679","volume":"17","author":"G Genchi","year":"2020","unstructured":"Genchi G, Carocci A, Lauria G, Sinicropi MS, Catalano A. Nickel: Human Health and Environmental Toxicology. Int J Environ Res Public Health. 2020;17:679.","journal-title":"Int J Environ Res Public Health"},{"key":"362_CR8","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1093\/carcin\/23.1.47","volume":"23","author":"T Schwerdtle","year":"2002","unstructured":"Schwerdtle T, Seidel A, Hartwig A. Effect of soluble and particulate nickel compounds on the formation and repair of stable benzo[a]pyrene DNA adducts in human lung cells. Carcinogenesis. 2002;23:47\u201353.","journal-title":"Carcinogenesis"},{"key":"362_CR9","first-page":"50","volume":"57","author":"VV Shilov","year":"2015","unstructured":"Shilov VV, Syurin SA. [Bronchopulmonary pathology among nickel industry workers: development, diagnostics and clinical manifestations[. Prev Clin Med. 2015;57:50\u20137.","journal-title":"Prev Clin Med"},{"key":"362_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-022-11241-5","volume":"12","author":"S Syurin","year":"2022","unstructured":"Syurin S, Vinnikov D. Occupational disease claims and non-occupational morbidity in a prospective cohort observation of nickel electrolysis workers. Sci Rep. 2022;12:1\u20137.","journal-title":"Sci Rep"},{"key":"362_CR11","doi-asserted-by":"publisher","first-page":"18437","DOI":"10.3402\/ijch.v71i0.18437","volume":"71","author":"M Skandfer","year":"2012","unstructured":"Skandfer M, Siurin S, Talykova L, \u00d8vrum A, Brenn T, Vaktskjold A. How occupational health is assessed in mine workers in Murmansk Oblast. Int J Circumpolar Health. 2012;71:18437.","journal-title":"Int J Circumpolar Health"},{"key":"362_CR12","doi-asserted-by":"publisher","first-page":"968","DOI":"10.2174\/1871530320666200214123118","volume":"20","author":"A Salimi","year":"2020","unstructured":"Salimi A, Jamali Z, Atashbar S, Khezri S, Ghorbanpour AM, Etefaghi N. Pathogenic Mechanisms and Therapeutic Implication in Nickel-Induced Cell Damage. Endocr Metab Immune Disord Drug Targets. 2020;20:968\u201384.","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"362_CR13","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0003-4878(96)00033-6","volume":"41","author":"M Kiilunen","year":"1997","unstructured":"Kiilunen M, Aitio A, Tossavainen A. Occupational exposure to nickel salts in electrolytic plating. Ann Occup Hyg. 1997;41:189\u2013200.","journal-title":"Ann Occup Hyg"},{"key":"362_CR14","first-page":"171","volume":"38","author":"Kiilunen M","year":"1994","unstructured":"Kiilunen M. Occupational exposure to chromium and nickel in Finland\u2014analysis of registries of hygienic measurements and biological monitoring. Ann Occup Hyg. 1994;38:171\u201387.","journal-title":"Ann Occup Hyg"},{"key":"362_CR15","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/0048-9697(91)90106-O","volume":"101","author":"L Ulrich","year":"1991","unstructured":"Ulrich L, \u0160ulcov\u00e1 M, \u0160pa\u010dek L, Neumanov\u00e1 E, Vlad\u00e1r M. Investigation of professional nickel exposure in nickel refinery workers. Sci Total Environ. 1991;101:91\u20136.","journal-title":"Sci Total Environ"},{"key":"362_CR16","first-page":"8","volume":"54","author":"GW Hughson","year":"2010","unstructured":"Hughson GW, Galea KS, Heim KE. Characterization and assessment of dermal and inhalable nickel exposures in nickel production and primary user industries. Ann Occup Hyg. 2010;54:8\u201322.","journal-title":"Ann Occup Hyg"},{"key":"362_CR17","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1080\/09603120701372698","volume":"17","author":"JL Harmse","year":"2007","unstructured":"Harmse JL, Engelbrecht JC. Air sampling of nickel in a refinery. Int J Environ Health Res. 2007;17:319\u201325.","journal-title":"Int J Environ Health Res"},{"key":"362_CR18","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s12995-016-0114-9","volume":"11","author":"D Vinnikov","year":"2016","unstructured":"Vinnikov D. Drillers and mill operators in an open-pit gold mine are at risk for impaired lung function. J Occup Med Toxicol. 2016;11:27.","journal-title":"J Occup Med Toxicol"},{"key":"362_CR19","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1097\/JOM.0b013e3182a641e7","volume":"55","author":"D Vinnikov","year":"2013","unstructured":"Vinnikov D, Blanc PD, Brimkulov N, Redding-Jones R. Five-Year Lung Function Observations and Associations With a Smoking Ban Among Healthy Miners at High Altitude (4000 m). J Occup Environ Med. 2013;55:1421\u20135.","journal-title":"J Occup Environ Med"},{"key":"362_CR20","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/S2215-0366(20)30145-0","volume":"7","author":"C de Oliveira","year":"2020","unstructured":"de Oliveira C, Cho E, Kavelaars R, Jamieson M, Bao B, Rehm J. Economic analyses of mental health and substance use interventions in the workplace: a systematic literature review and narrative synthesis. Lancet Psychiatry. 2020;7:893\u2013910.","journal-title":"Lancet Psychiatry"},{"key":"362_CR21","doi-asserted-by":"crossref","unstructured":"Cahill K, Lancaster T. Workplace interventions for smoking cessation. Cochrane Database Syst Rev. 2014;:CD003440.","DOI":"10.1002\/14651858.CD003440.pub4"},{"key":"362_CR22","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/add.12015","volume":"108","author":"SF Weng","year":"2013","unstructured":"Weng SF, Ali S, Leonardi-Bee J. Smoking and absence from work: systematic review and meta-analysis of occupational studies. Addict Abingdon Engl. 2013;108:307\u201319.","journal-title":"Addict Abingdon Engl"},{"key":"362_CR23","doi-asserted-by":"crossref","unstructured":"Vinnikov D, Rybina T, Strizhakov L, Babanov S, Mukatova I. Occupational Burden of Chronic Obstructive Pulmonary Disease in the Commonwealth of Independent States: Systematic Review and Meta-Analysis. Front Med. 2021;7.","DOI":"10.3389\/fmed.2020.614827"},{"key":"362_CR24","doi-asserted-by":"crossref","unstructured":"Galarneau J-M, Beach J, Cherry N. Urinary Metals as a Marker of Exposure in Men and Women in the Welding and Electrical Trades: A Canadian Cohort Study. Ann Work Expo Health. 2022;:wxac005.","DOI":"10.1093\/annweh\/wxac005"},{"key":"362_CR25","first-page":"921","volume":"38","author":"RE Rendall","year":"1994","unstructured":"Rendall RE, Phillips JI, Renton KA. Death following exposure to fine particulate nickel from a metal arc process. Ann Occup Hyg. 1994;38:921\u201330.","journal-title":"Ann Occup Hyg"},{"key":"362_CR26","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1039\/b105848g","volume":"3","author":"JH Vincent","year":"2001","unstructured":"Vincent JH, Ramachandran G, Kerr SM. Particle size and chemical species \u2018fingerprinting\u2019of aerosols in primary nickel production industry workplaces. J Environ Monit. 2001;3:565\u201374.","journal-title":"J Environ Monit"}],"container-title":["Journal of Occupational Medicine and Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12995-022-00362-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12995-022-00362-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12995-022-00362-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T15:48:52Z","timestamp":1667922532000},"score":1,"resource":{"primary":{"URL":"https:\/\/occup-med.biomedcentral.com\/articles\/10.1186\/s12995-022-00362-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,5]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["362"],"URL":"https:\/\/doi.org\/10.1186\/s12995-022-00362-2","relation":{},"ISSN":["1745-6673"],"issn-type":[{"value":"1745-6673","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,5]]},"assertion":[{"value":"21 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Committee of Bioethics of the Northwest Public Health Research Center. Every participant signed an informed consent to participate. All methods were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"21"}}