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The aim of this randomized controlled crossover study is to assess the impact of FFP2 induced breathing resistance on pulmonary function, blood gas values and discomfort during walking and stair climbing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200916 healthy adults (24.8\u2009\u00b1\u20092.2 years; 10 females, ) participated. Interventions included (1) six minutes of walking in a 16-meter-long hallway (612\u00a0m) and (2) eight minutes of stair climbing in a two-story staircase (420 stairs), both with and without a FFP2 (&gt;\u200948\u00a0h wash-out). Spiroergometric data (Ventilation, breathing frequency, tidal volume, oxygen uptake and carbon dioxide exhalation (primary outcome), end tidal carbon dioxide- and oxygen pressure) and self-reported response (Perceived exertion, dyspnoea and pain) were assessed during activities. Blood gas analysis (capillary carbon dioxide- (pCO\n                      <jats:sub>2<\/jats:sub>\n                      ) (primary outcome) and oxygen partial pressure (pO\n                      <jats:sub>2<\/jats:sub>\n                      ), pH, lactate and base excess) was measured immediately after cessation of activities. Manipulation effects (FFP2 versus no mask) were tested using repeated measures analyses of variance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Analysis showed no effect of FFP2 on pCO\n                      <jats:sub>2<\/jats:sub>\n                      or other blood-gas parameters but on carbon dioxide exhalation during walking: (mean 1067, SD 209\u00a0ml\/min) (mean 1908, SD 426\u00a0ml\/min) (F(15)\u2009=\u200919.5;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; \u03b7\n                      <jats:sub>p<\/jats:sub>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.566) compared to no mask wearing (mean 1237, SD 173\u00a0ml\/min; mean 1908, SD 426\u00a0ml\/min). Ventilation was decreased and dyspnoea was increased by FFP2 during activities. FFP2 led to lower oxygen uptake and lower end tidal oxygen but higher end tidal carbon dioxide during stair climbing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>FFP2 decreased ventilation based on slower breathing patterns and led to limitations in pulmonary gas exchange and increased subjective dyspnoea. However, invasive diagnostics revealed no signs of clinically relevant metabolic effects immediately after everyday physical activities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12995-024-00428-3","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T05:05:07Z","timestamp":1722229507000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["FFP2 induced breathing resistance does not affect metabolism and well-being during brisk walking and stair climbing - a randomized controlled trial"],"prefix":"10.1186","volume":"19","author":[{"given":"Tobias","family":"Engeroff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niclas","family":"Hartel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Niederer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Nienhaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Groneberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"428_CR1","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/jebm.12381","volume":"13","author":"Y Long","year":"2020","unstructured":"Long Y, Hu T, Liu L, Chen R, Guo Q, Yang L, et al. 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