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For many people with persistent pain, mechanisms are increasingly understood as arising from altered regulation at multiple loci rather than simple ongoing tissue injury. This challenges chiropractic\u2019s long-standing reliance on body focused explanatory models centred on correcting structural lesions or dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Body<\/jats:title>\n                    <jats:p>Active Inference (AIF) provides a contemporary framework for understanding pain perception as an embodied, context-sensitive process of sense-making. Here, inferences concerning threat or safety are informed by information generated across multiple interacting levels (neural, physiological, psychological, behavioural, and socio-cultural), and pain emerges when threat-related inferences remain persistently weighted as trustworthy. From this perspective, manual therapy may be understood as a coherent ensemble of interacting sensory, affective, interpersonal, and contextual cues that together reshape expectations, meaning, and action. We revisit the concept of Contextually Aided Recovery (CARe), a lens that sees the therapeutic encounter as a rich space of potential contextual modulation and affordances and argue that chiropractic\u2019s distinctive contribution lies in combining skilled manual contact with the deliberate shaping of context to support adaptive regulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We propose that integrating AIF and CARe offers the chiropractic profession a coherent, evidence-aligned route toward a more contemporary identity, with implications for practice and education.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12998-026-00669-5","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T17:13:52Z","timestamp":1786382032000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prediction, pain, and the power of context: toward a contemporary identity for the chiropractic profession"],"prefix":"10.1186","volume":"34","author":[{"given":"Dave","family":"Newell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon","family":"Segal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Rossettini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"O\u2019Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Lothe-Raven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Lothe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Weiniger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alister","family":"DuRose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad","family":"Beira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge E.","family":"Esteves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mick","family":"Thacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"issue":"1","key":"669_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1162\/NECO_a_00912","volume":"29","author":"K Friston","year":"2017","unstructured":"Friston K, FitzGerald T, Rigoli F, Schwartenbeck P, Pezzulo G. 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