{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T05:01:51Z","timestamp":1794546111655,"version":"4.9.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T00:00:00Z","timestamp":1430179200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diagn Pathol"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s13000-015-0276-2","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T16:34:43Z","timestamp":1430152483000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Persistence of chloroquine-resistant haplotypes of Plasmodium falciparum in children with uncomplicated Malaria in Lagos, Nigeria, four years after change of chloroquine as first-line antimalarial medicine"],"prefix":"10.1186","volume":"10","author":[{"given":"Oladosu O","family":"Oladipo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oyibo A","family":"Wellington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin J","family":"Sutherland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,4,28]]},"reference":[{"key":"276_CR1","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.meegid.2004.04.002","volume":"4","author":"AO Talisuna","year":"2004","unstructured":"Talisuna AO, Nalunkuma-Kazibwe A, Langi P, Mutabingwa TK, Watkins WW, Van Marck E, et al. Two mutations in dihydrofolatereductase combined with one in the dihydropteroate synthase gene predict sulphadoxine-pyrimethamine parasitological failure in Ugandan children with uncomplicated falciparum malaria. Infect Genet Evol. 2004;4:321\u20137.","journal-title":"Infect Genet Evol"},{"key":"276_CR2","volume-title":"Guidelines for the treatment of malaria","author":"WHO","year":"2010","unstructured":"WHO. Guidelines for the treatment of malaria. 2nd ed. Geneva: World Health Organization; 2010.","edition":"2"},{"key":"276_CR3","volume-title":"Antimalarial drug combination therapy: report of a WHO technical consultation","author":"WHO","year":"2001","unstructured":"WHO. Antimalarial drug combination therapy: report of a WHO technical consultation. Geneva, Switzerland: World Health Organization; 2001."},{"key":"276_CR4","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/S1097-2765(05)00077-8","volume":"6","author":"DA Fidock","year":"2000","unstructured":"Fidock DA, Nomura T, Talley AK, Cooper RA, Dzekunov SM, Ferdig MT, et al. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Mol Cell. 2000;6:861\u201371.","journal-title":"Mol Cell"},{"key":"276_CR5","doi-asserted-by":"publisher","first-page":"3500","DOI":"10.1128\/AAC.47.11.3500-3505.2003","volume":"47","author":"N Chen","year":"2003","unstructured":"Chen N, Kyle DE, Pasay C, Fowler EV, Baker J, Peters JM, et al. Pfcrt allelic types with two novel amino acid mutations in chloroquine-resistant Plasmodium falciparum isolates from the Philippines. Antimicrob Agents Chemother. 2003;47:3500\u20135.","journal-title":"Antimicrob Agents Chemother"},{"key":"276_CR6","doi-asserted-by":"crossref","first-page":"558","DOI":"10.4269\/ajtmh.2003.69.558","volume":"69","author":"AA Djimde","year":"2003","unstructured":"Djimde AA, Doumbo OK, Traore O, Guindo AB, Kayentao K, Diourte Y, et al. Clearance of drug-resistant parasites as a model for protective immunity in Plasmodium falciparum malaria. Am J Trop Med Hyg. 2003;69:558\u201363.","journal-title":"Am J Trop Med Hyg"},{"key":"276_CR7","doi-asserted-by":"crossref","first-page":"844","DOI":"10.4269\/ajtmh.2007.76.844","volume":"76","author":"J Ursing","year":"2007","unstructured":"Ursing J, Kofoed PE, Rodrigues A, Rombo L, Gil JP. Plasmodium falciparum genotypes associated with chloroquine and amodiaquine resistance in Guinea-Bissau. Am J Trop Med Hyg. 2007;76:844\u20138.","journal-title":"Am J Trop Med Hyg"},{"key":"276_CR8","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/0092-8674(89)90330-9","volume":"57","author":"SJ Foote","year":"1999","unstructured":"Foote SJ, Thompson JK, Cowman AF, Kemp DJ. Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum. Cell. 1999;57:921\u201330.","journal-title":"Cell"},{"key":"276_CR9","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1128\/AAC.49.2.840-842.2005","volume":"49","author":"R Hayward","year":"2005","unstructured":"Hayward R, Saliba KJ, Kirk K. Mutations in pfmdr1 modulate the sensitivity of Plasmodium falciparum to the intrinsic antiplasmodial activity of verapamil. Antimicrob Agents Chemother. 2005;49:840\u20132.","journal-title":"Antimicrob Agents Chemother"},{"key":"276_CR10","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1056\/NEJM200101253440403","volume":"344","author":"A Djimde","year":"2001","unstructured":"Djimde A, Doumbo OK, Cortese JF, Kayentao K, Doumbo S, Diourte Y, et al. A molecular marker for chloroquine-resistant falciparum malaria. N Engl J Med. 2001;344:257\u201363.","journal-title":"N Engl J Med"},{"key":"276_CR11","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1126\/science.1074045","volume":"298","author":"AB Sidhu","year":"2002","unstructured":"Sidhu AB, Verdier-Pinard D, Fidock DA. Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by Pfcrtmutations. Science. 2002;298:210\u20133.","journal-title":"Science"},{"issue":"Suppl 7","key":"276_CR12","doi-asserted-by":"publisher","first-page":"3737","DOI":"10.1128\/AAC.02472-14","volume":"58","author":"J Cheruiyot","year":"2014","unstructured":"Cheruiyot J, Ingasia LA, Omondi AA, Juma DW, Opot BH, Ndegwa JM, et al. Polymorphisms in Pfmdr1, Pfcrt, and Pfnhe1 genes are associated with reduced In Vitro Activities of Quinine in Plasmodium falciparum Isolates from Western Kenya. Antimic Agents Chemo. 2014;58 Suppl 7:3737\u201343.","journal-title":"Antimic Agents Chemo"},{"key":"276_CR13","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.actatropica.2005.04.008","volume":"94","author":"MT Duraisingh","year":"2005","unstructured":"Duraisingh MT, Cowman AF. Contribution of the pfmdr1gene to antimalarial drug resistance. Acta Trop. 2005;94:181\u201390.","journal-title":"Acta Trop"},{"key":"276_CR14","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1179\/136485905X46441","volume":"99","author":"IF Khalil","year":"2005","unstructured":"Khalil IF, Alifrangis M, Tarimo DS, Staalso T, Satti GM, Theander TG. The roles of the pfcrt 76\u00a0T and pfmdr1 86Y mutations, immunity and the initial level of parasitaemia, in predicting the outcome of chloroquine treatment in two areas with different transmission intensities. Ann Trop Med Parasitol. 2005;99:441\u20138.","journal-title":"Ann Trop Med Parasitol"},{"issue":"Suppl11","key":"276_CR15","doi-asserted-by":"publisher","first-page":"4588","DOI":"10.1128\/AAC.00610-09","volume":"53","author":"V Andriantsoanirina","year":"2009","unstructured":"Andriantsoanirina V, Ratsimbasoa A, Bouchier C, Jahevitra M, Rabearimanana S, Radrianjafy R, et al. Plasmodium falciparum drug resistance in Madagascar: facing the spread of unusual pfdhfr and pfmdr-1 haplotypes and the decrease of dihydroartemisinin susceptibility. Antimicrob Agents Chemother. 2009;53(Suppl11):4588\u201397.","journal-title":"Antimicrob Agents Chemother"},{"key":"276_CR16","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/1475-2875-9-74","volume":"9","author":"NB Gadalla","year":"2010","unstructured":"Gadalla NB, Elzaki SE, Mukhtar E, Warhurst DC, El-Sayed B, Sutherland CJ. Dynamics of pfcrt alleles CVMNK and CVIET in chloroquine-treated Sudanese patients infected with Plasmodium falciparum. Malaria J. 2010;9:74.","journal-title":"Malaria J"},{"key":"276_CR17","first-page":"1197","volume":"59","author":"CJ Sutherland","year":"2007","unstructured":"Sutherland CJ, Haustein T, Gadalla N, Armstrong M, Doherty JF, Chiodini PL. Chloroquine resistant Plasmodium falciparum infections among UK travellers returning with malaria after chloroquine prophylaxis. J Ant Chem. 2007;59:1197\u20139.","journal-title":"J Ant Chem"},{"key":"276_CR18","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1086\/504269","volume":"193","author":"M Alifrangis","year":"2006","unstructured":"Alifrangis M, Dalgaard MB, Lusingu JP, Vestergaard LS, Staalsoe T, Jensen AT, et al. Occurrence of the Southeast Asian\/South American SVMNT haplotype of the chloroquine resistance transporter gene in Plasmodium falciparum in Tanzania. J Infect Dis. 2006;193:1738\u201341.","journal-title":"J Infect Dis"},{"key":"276_CR19","doi-asserted-by":"publisher","first-page":"201","DOI":"10.2149\/tmh.33.201","volume":"33","author":"T Ogungbamigbe","year":"2005","unstructured":"Ogungbamigbe T, Ogunro P, Elemile P, Egbewale B, Olowu O, Abiodun O. Presciption patterns of antimalarial drugs among medical practitioners in Osogbo Metropolis, South-West Nigeria. Trop Med Health. 2005;33:201\u20138.","journal-title":"Trop Med Health"},{"issue":"Suppl 4","key":"276_CR20","first-page":"361","volume":"4","author":"YA Olukosi","year":"2005","unstructured":"Olukosi YA, Iwalokun BA, Magbagbeola EO, Akinwande O, Adewole TA, Agomo PU. Pattern of rural\u2013urban aquisition of Pfcrt T76 allele among Nigerian children with uncomplicated Plasmodium falciparum malaria. Afr J Biotec. 2005;4 Suppl 4:361\u20136.","journal-title":"Afr J Biotec"},{"issue":"Suppl 1","key":"276_CR21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.4269\/ajtmh.2006.75.155","volume":"75","author":"CT Happi","year":"2006","unstructured":"Happi CT, Gbotosho GO, Folarin OA, Bolaji OM, Sowunmi A, Kyle DE, et al. Association between mutations in plasmodium falciparum chloroquine resistance transporter and p. falciparum multidrug resistance 1 genes and in vivo amodiaquine resistance in p. falciparum malaria\u2013infected children in Nigeria. Am J Trop Med Hyg. 2006;75 Suppl 1:155\u201361.","journal-title":"Am J Trop Med Hyg"},{"key":"276_CR22","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/1475-2875-6-41","volume":"6","author":"O Ojurongbe","year":"2007","unstructured":"Ojurongbe O, Ogungbamigbe TO, Fagbenro-Beyioku AF, Fendel R, Kremsner PG, Kun JF. Rapid detection of Pfcrt and Pfmdr1 mutations in Plasmodium falciparum isolates by FRET and in vivo response to chloroquine among children from Osogbo, Nigeria. Malar J. 2007;6:41.","journal-title":"Malar J"},{"key":"276_CR23","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1056\/NEJMoa062032","volume":"355","author":"MK Laufer","year":"2006","unstructured":"Laufer MK, Thesing PC, Eddington ND, Masonga R, Dzinjalamala FK, Takala SL, et al. Return of chloroquine antimalarial efficacy in Malawi. N Engl J Med. 2006;355:1959\u201366.","journal-title":"N Engl J Med"},{"key":"276_CR24","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/1475-2875-8-106","volume":"8","author":"L Mwai","year":"2009","unstructured":"Mwai L, Ochong E, Abdirahman A, Kiara SM, Ward S, Kokwaro G, et al. Chloroquine resistance before and after its withdrawal in Kenya. Malaria J. 2009;8:106.","journal-title":"Malaria J"},{"key":"276_CR25","unstructured":"Nigerian muse Online: 7 February 2007. Available at: http:\/\/en.wikipedia.org\/wiki\/Lagos. Accessed 4 April 2013."},{"key":"276_CR26","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1128\/AAC.00875-06","volume":"51","author":"GA Humphreys","year":"2007","unstructured":"Humphreys GA, Merinopoulos I, Ahmed J, Whitty CJM, Mutabingwa TK, Sutherland CJ, et al. Amodiaquine and artemether-lumefantrine select distinct alleles of the Plasmodium falciparum pfmdr1 gene in Tanzanian children treated for uncomplicated malaria. Antimicrob Agents Chemother. 2007;51:991\u20137.","journal-title":"Antimicrob Agents Chemother"},{"issue":"Suppl 8","key":"276_CR27","doi-asserted-by":"publisher","first-page":"3405","DOI":"10.1128\/AAC.00024-09","volume":"53","author":"CJ Sutherland","year":"2009","unstructured":"Sutherland CJ, Fifer H, Pearce RJ, BinReza F, Nicholas M, Haustein T, et al. Novel pfdhpshaplotypes among imported cases of Plasmodium falciparum malaria in the UK. Antimicrob Agents Chemother. 2009;53 Suppl 8:3405\u201310.","journal-title":"Antimicrob Agents Chemother"},{"key":"276_CR28","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.actatropica.2004.09.010","volume":"93","author":"PE Wilson","year":"2005","unstructured":"Wilson PE, Kazadi W, Kamwendo DD, Mwapasa V, Purfield A, Meshinick SR. Prevalence of pfcrt mutations in Congolese and Malawian Plasmodium falciparum isolates as determined by a new Taqman assay. Acta Trop. 2005;93:97\u2013106.","journal-title":"Acta Trop"},{"key":"276_CR29","doi-asserted-by":"publisher","first-page":"834","DOI":"10.2144\/000112890","volume":"44","author":"J Bell","year":"2008","unstructured":"Bell J. A simple way to treat PCR products prior to sequencing using ExoSAP-IT. Biotechniques. 2008;44:834.","journal-title":"Biotechniques"},{"key":"276_CR30","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1128\/AAC.47.4.1347-1354.2003","volume":"47","author":"RJ Pearce","year":"2003","unstructured":"Pearce RJ, Drakeley C, Chandramohan D, Mosha F, Roper C. Molecular determination of point mutation haplotypes in the dihydrofolatereductase and dihydropteroate synthase of Plasmodium falciparum in three districts of northern Tanzania. Antimicrob Agents Chemother. 2003;47:1347\u201354.","journal-title":"Antimicrob Agents Chemother"},{"key":"276_CR31","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.1128\/JCM.02291-06","volume":"45","author":"J Keen","year":"2007","unstructured":"Keen J, Farcas GA, Zhong K, Yohanna S, Dunne MW, Kain KC. Real-time PCR assay for rapid detection and analysis of PfCRT haplotypes of chloroquine resistant Plasmodium falciparum isolates from India. J Clin Microbiol. 2007;45:2889\u201393.","journal-title":"J Clin Microbiol"},{"key":"276_CR32","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/1475-2875-9-68","volume":"9","author":"SV Dlamini","year":"2010","unstructured":"Dlamini SV, Beshir K, Sutherland CJ. Markers of anti-malarial drug resistance in Plasmodium falciparum isolates from Swaziland: identification of pfmdr1-86\u00a0F in natural parasite isolates. Malaria J. 2010;9:68.","journal-title":"Malaria J"},{"key":"276_CR33","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/1475-2875-13-120","volume":"13","author":"L Golassa","year":"2014","unstructured":"Golassa L, Enweji N, Erko B, Aseffa A, Swedberg G. High prevalence of pfcrt-CVIET haplotype in isolates from asymptomatic and symptomatic patients in south-central Oromia, Ethiopia. Malar J. 2014;13:120.","journal-title":"Malar J"},{"key":"276_CR34","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/1475-2875-9-174","volume":"9","author":"BE Gama","year":"2010","unstructured":"Gama BE, Pereira de Carvalho GA, LutucutaKosi FJ, Almeida de Oliveira NK, Fortes F, Rosenthal PJ, et al. Plasmodium falciparum isolates from Angola show the StctVMNT haplotype in the pfcrt gene. Malar J. 2010;9:174.","journal-title":"Malar J"},{"key":"276_CR35","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/0166-6851(95)02492-1","volume":"74","author":"LK Basco","year":"1995","unstructured":"Basco LK, Bras JL, Rhoades Z, Wilson CM. Analysis of pfmdr1 and drug susceptibility in fresh isolates of Plasmodium falciparum from Sub-Saharan Africa. Mol Biochem Parasitol. 1995;74:157\u201366.","journal-title":"Mol Biochem Parasitol"},{"key":"276_CR36","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/S0035-9203(97)90281-9","volume":"91","author":"L von Seidlein","year":"1997","unstructured":"von Seidlein L, Duraisingh MT, Drakeley CJ, Bailey R, Greenwood BM, Pinder M. Polymorphism of the pfmdr1 gene and chloroquine resistance in Plasmodium falciparum in the Gambia. Trans R Soc Trop Med Hyg. 1997;91:450\u20133.","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"276_CR37","doi-asserted-by":"crossref","first-page":"633","DOI":"10.4269\/ajtmh.2008.78.633","volume":"78","author":"S Zakeri","year":"2008","unstructured":"Zakeri S, Afsharpad M, Kazemzadeh T, Mehdizadeh K, Shabani A, Djadid ND. Association of pfcrt but not pfmdr1 alleles with chloroquine resistance in Iranian isolates of Plasmodium falciparum. Am J Trop Med Hyg. 2008;78:633\u201340.","journal-title":"Am J Trop Med Hyg"},{"key":"276_CR38","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1186\/1475-2875-12-426","volume":"12","author":"ME ElBadry","year":"2013","unstructured":"ElBadry ME, Existe A, Victor YS, Memnon G, Fukuda M, Dame JB, et al. Survey of Plasmodium falciparum multidrug resistance-1 and chloroquine resistance transporter alleles in Haiti. Malar J. 2013;12:426.","journal-title":"Malar J"},{"key":"276_CR39","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0035-9203(01)90329-3","volume":"95","author":"HS Nagesha","year":"2001","unstructured":"Nagesha HS, Din S, Casey GJ, Susanti AI, Fryauff DJ, Reeder JC, et al. Mutations in the pfmdr1, dhfrand dhps genes of Plasmodium falciparum are associated with in-vivo drug resistance in west Papua, Indonesia. Trans R Soc Trop Med Hyg. 2001;95:43\u20139.","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"276_CR40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013281","volume":"5","author":"V Andriantsoanirina","year":"2010","unstructured":"Andriantsoanirina V, Ratsimbasoa A, Bouchier C, Tichit M, Jahevitra M, Rabearimanana S, et al. Chloroquine clinical failures in Plasmodium falciparum malaria are associated with mutant pfmdr-1, not pfcrt in Madagascar. PLoS One. 2010;5, e13281.","journal-title":"PLoS One"},{"issue":"Suppl 3","key":"276_CR41","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1128\/AAC.00968-08","volume":"53","author":"CT Happi","year":"2009","unstructured":"Happi CT, Gbotosho GO, Folarin OA, Sowunmi A, Hudson T, O\u2019Neil M, et al. Selection of Plasmodium falciparum multidrug resistance gene 1 alleles in asexual stages and gametocytes by artemether-lumefantrine in Nigerian children with uncomplicated falciparum malaria. Antimic Agents Chemoth. 2009;53 Suppl 3:888\u201395.","journal-title":"Antimic Agents Chemoth"},{"key":"276_CR42","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1017\/S0031182096008487","volume":"114","author":"MI Duraisingh","year":"1997","unstructured":"Duraisingh MI, Drakeley CI, Muller O, Bailey R, Snounou G, Targett GA, et al. Evidence for selection for the tyrosine 86 allele of pfmdr1 gene of Plasmodium falciparum by chloroquine and amodiaquine. Parasitology. 1997;114:205\u201311.","journal-title":"Parasitology"},{"key":"276_CR43","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.meegid.2005.09.001","volume":"6","author":"G Holmgren","year":"2006","unstructured":"Holmgren G, Gil GP, Ferreira PM, Veiga MI, Obonyo CO, Bjorkman A. Amodiaquine resistant Plasmodium falciparum malaria invivo is associated with selection of Pfcrt76T and Pfmdr1 86Y. Infect Genet Evol. 2006;6:309\u201314.","journal-title":"Infect Genet Evol"},{"key":"276_CR44","doi-asserted-by":"publisher","first-page":"74","DOI":"10.2174\/1874315300801010074","volume":"1","author":"OA Folarin","year":"2008","unstructured":"Folarin OA, Gbotosho GO, Sowunmi A, Olorunsogo OO, Oduola AMJ, Happi TC. Chloroquine resistant Plasmodium falciparum in Nigeria: relationship between pfcrtand pfmdr1 polymorphisms, In-Vitro resistance and treatment outcome. Open Trop Med J. 2008;1:74\u201382.","journal-title":"Open Trop Med J"},{"issue":"Suppl 2","key":"276_CR45","first-page":"39","volume":"5","author":"M Efunshile","year":"2011","unstructured":"Efunshile M, Runsewe-Abiodun T, Ghebremedhin B, Konig W, Konig B. Prevalence of the molecular marker of chloroquine resistance (pfcrt 76) in Nigeria 5\u00a0years after withdrawal of the drug as first-line antimalarial. A cross-sectional study. SAJCH. 2011;5 Suppl 2:39\u201342.","journal-title":"SAJCH"},{"key":"276_CR46","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1111\/j.1365-3156.2007.01882.x","volume":"12","author":"Z Yang","year":"2007","unstructured":"Yang Z, Zhang Z, Sun X, Wan W, Cui L, Zhang X, et al. Molecular analysis of chloroquine resistance in Plasmodium falciparumin Yunnan Province, China. Trop Med Intl Health. 2007;12:1051\u201360.","journal-title":"Trop Med Intl Health"},{"issue":"4","key":"276_CR47","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1590\/0074-0276140067","volume":"109","author":"GA Fontecha","year":"2014","unstructured":"Fontecha GA, Sanchez AL, Mendoza M, Banegas E, Mej\u00eda-Torres RE. A four-year surveillance program for detection of Plasmodium falciparum chloroquine resistance in Honduras. MemInst Oswaldo Cruz. 2014;109(4):492\u20139.","journal-title":"MemInst Oswaldo Cruz"},{"key":"276_CR48","doi-asserted-by":"crossref","first-page":"410","DOI":"10.4269\/ajtmh.2005.72.410","volume":"72","author":"X Wang","year":"2005","unstructured":"Wang X, Um J, Li Q, Chen P, Guo X, Fu L, et al. Decreased prevalence of the Plasmodium falciparum chloroquine resistance transporter 76\u00a0T marker associated with cessation of choroquine use against P. falciparum malaria in Hainan, people\u2019s Republic of China. Am J Trop Med Hyg. 2005;72:410\u20134.","journal-title":"Am J Trop Med Hyg"},{"key":"276_CR49","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.4269\/ajtmh.2006.75.1182","volume":"75","author":"EA Temu","year":"2006","unstructured":"Temu EA, Kimani I, Tuno N, Kawada H, Minjas JN, Takagi M. Monitoring chloroquine resistance using Plasmodium falciparum parasites isolated from wild mosquitoes in Tanzania. AmJ Trop Med Hyg. 2006;75:1182\u20137.","journal-title":"AmJ Trop Med Hyg"},{"key":"276_CR50","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1086\/375419","volume":"187","author":"JG Kublin","year":"2003","unstructured":"Kublin JG, Cortese JF, Njunju EM, Mukadam RA, Wirima JJ, Kazembe PN, et al. Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi. J Infect Dis. 2003;187:1870\u20135.","journal-title":"J Infect Dis"},{"key":"276_CR51","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1056\/NEJMc0805011","volume":"359","author":"H Noedl","year":"2008","unstructured":"Noedl H, Se Y, Schaecher K, Smith BL, Socheat D, Fukuda MM. Artemisinin Resistance in Cambodia 1 (ARC1) Study Consortium: evidence of artemisinin-resistant malaria in western Cambodia. N Eng J Med. 2008;359:2619\u201320.","journal-title":"N Eng J Med"},{"key":"276_CR52","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1056\/NEJMoa0808859","volume":"361","author":"AM Dondorp","year":"2009","unstructured":"Dondorp AM, Nosten F, Yi P, Das D, Phyo AP, Tarning J, et al. Artemisinin resistance in Plasmodium falciparum malaria. N Eng J Med. 2009;361:455\u201367.","journal-title":"N Eng J Med"}],"container-title":["Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13000-015-0276-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13000-015-0276-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13000-015-0276-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13000-015-0276-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T11:49:02Z","timestamp":1630583342000},"score":1,"resource":{"primary":{"URL":"https:\/\/diagnosticpathology.biomedcentral.com\/articles\/10.1186\/s13000-015-0276-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,28]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["276"],"URL":"https:\/\/doi.org\/10.1186\/s13000-015-0276-2","relation":{},"ISSN":["1746-1596"],"issn-type":[{"value":"1746-1596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,28]]},"assertion":[{"value":"11 September 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"41"}}