{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:20:12Z","timestamp":1783524012141,"version":"3.55.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diagn Pathol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13000-018-0691-2","type":"journal-article","created":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T00:55:04Z","timestamp":1519088104000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["De novo mast cell leukemia without CD25 expression and KIT mutations: a rare case report in a 13-year-old child"],"prefix":"10.1186","volume":"13","author":[{"given":"Yalin","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Nong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,20]]},"reference":[{"issue":"1","key":"691_CR1","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1002\/(SICI)1096-8652(199905)61:1<66::AID-AJH12>3.0.CO;2-3","volume":"61","author":"F Wimazal","year":"1999","unstructured":"Wimazal F, Sperr WR, Horny HP, Carroll V, Binder BR, Fonatsch C, et al. Hyperfibrinolysis in a case of myelodysplastic syndrome with leukemic spread of mast cells. Am J Hematol. 1999 May;61(1):66\u201377.","journal-title":"Am J Hematol"},{"key":"691_CR2","first-page":"54","volume-title":"WHO classification of tumors of hematopoietic and lymphoid tissues","author":"HP Horny","year":"2008","unstructured":"Horny HP, Metcalfe DD, Bennett JM, Bain BJ, Akin C, Escribano L, et al. Mastocytosis. In: Swerdlow SH, Campo E, et al., editors. WHO classification of tumors of hematopoietic and lymphoid tissues. 4th ed. Lyon: International Agency for Research on Cancer (IARC); 2008. p. 54\u201363.","edition":"4"},{"key":"691_CR3","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1182\/blood-2016-03-643544","volume":"127","author":"DA Arber","year":"2016","unstructured":"Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127:2391\u2013405.","journal-title":"Blood"},{"key":"691_CR4","first-page":"62","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"SH Swerdlow","year":"2017","unstructured":"Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Revised 4th ed. Lyon: IARC Press; 2017. p. 62\u20139.","edition":"Revised 4th ed"},{"key":"691_CR5","unstructured":"George TI, Sotlar K, Valent P, Horny HP. Mastocytosis. In: Jaffe ES, Arber DA, Campo E, Harris NL, Quintanilla-Martinez L, editors. Hematopathology. 2nd ed: Elsevier; 2017. p. 911\u201330."},{"issue":"8","key":"691_CR6","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1182\/blood-2012-07-442400","volume":"121","author":"S Georgin-Lavialle","year":"2013","unstructured":"Georgin-Lavialle S, Lhermitte L, Dubreuil P, Chandesris MO, Hermine O, Damaj G. Mast cell leukemia. Blood. 2013;121(8):1285\u201395.","journal-title":"Blood"},{"key":"691_CR7","first-page":"437","volume":"87","author":"G Joachim","year":"1906","unstructured":"Joachim G. Uber Mastzellenleukamien. Deutsches Archives fur Klinische Medizin. 1906;87:437.","journal-title":"Deutsches Archives fur Klinische Medizin"},{"key":"691_CR8","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1002\/ajh.21713","volume":"85","author":"AR Arredondo","year":"2010","unstructured":"Arredondo AR, Gotlib J, Shier L, Medeiros B, Wong K, Cherry A, et al. Myelomastocytic leukemia versus mast cell leukemia versus systemic mastocytosis associated with acute myeloid leukemia: a diagnostic challenge. Am J Hematol. 2010;85:600\u20136.","journal-title":"Am J Hematol"},{"key":"691_CR9","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1093\/annonc\/mdu047","volume":"25","author":"P Valent","year":"2014","unstructured":"Valent P, Sotlar K, Sperr WR, Escribano L, Yavuz S, Reiter A, et al. Redefined diagnostic criteria and classification of mast cell leukemia (MCL) and myelomastocytic leukemia (MML): a consensus proposal. Ann Oncol. 2014;25:1691\u2013700.","journal-title":"Ann Oncol"},{"key":"691_CR10","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1080\/1042819021000039965","volume":"43","author":"WR Sperr","year":"2002","unstructured":"Sperr WR, Hauswirth AW, Valent P. Tryptase a novel biochemical marker of acute myeloid leukemia. Leuk Lymphoma. 2002;43:2257\u201361.","journal-title":"Leuk Lymphoma"},{"key":"691_CR11","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.1182\/blood.V98.7.2200","volume":"98","author":"WR Sperr","year":"2001","unstructured":"Sperr WR, Jordan JH, Baghestanian M, Kiener HP, Samorapoompichit P, Semper H, et al. Expression of mast cell tryptase by myeloblasts in a group of patients with acute myeloid leukemia. Blood. 2001;98:2200\u20139.","journal-title":"Blood"},{"key":"691_CR12","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1586\/17474086.2014.942280","volume":"7","author":"HP Horny","year":"2014","unstructured":"Horny HP, Sotlar K, Reiter A, Valent P. Myelomastocytic leukemia: histopathological features, diagnostic criteria and differential diagnosis. Expert Rev Hematol. 2014;7:431\u20137.","journal-title":"Expert Rev Hematol"},{"key":"691_CR13","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1159\/000305552","volume":"77","author":"HP Horny","year":"2010","unstructured":"Horny HP, Sotlar K, Valent P. Differential diagnoses of systemic mastocytosis in routinely processed bone marrow biopsy specimens: a review. Pathobiology. 2010;77:169\u201380.","journal-title":"Pathobiology"}],"container-title":["Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13000-018-0691-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:43:50Z","timestamp":1550623430000},"score":1,"resource":{"primary":{"URL":"https:\/\/diagnosticpathology.biomedcentral.com\/articles\/10.1186\/s13000-018-0691-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,20]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["691"],"URL":"https:\/\/doi.org\/10.1186\/s13000-018-0691-2","relation":{},"ISSN":["1746-1596"],"issn-type":[{"value":"1746-1596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,20]]},"assertion":[{"value":"16 July 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by the ethics committee of Peking University First Hospital (No. 2013[571]).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication was obtained from the patient\u2019s legal guardian and is available for review by the editors of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"14"}}