{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:46:31Z","timestamp":1792449991555,"version":"4.5.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T00:00:00Z","timestamp":1542153600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81160316 and 81260104"],"award-info":[{"award-number":["81160316 and 81260104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diagn Pathol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13000-018-0754-4","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T17:23:27Z","timestamp":1542216207000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Overexpression of the recently identified oncogene REDD1 correlates with tumor progression and is an independent unfavorable prognostic factor for ovarian carcinoma"],"prefix":"10.1186","volume":"13","author":[{"given":"Bin","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shugang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,14]]},"reference":[{"key":"754_CR1","doi-asserted-by":"publisher","first-page":"2283","DOI":"10.1128\/MCB.22.7.2283-2293.2002","volume":"22","author":"T Shoshani","year":"2002","unstructured":"Shoshani T, Faerman A, Mett I, Zelin E, Tenne T, Gorodin S, et al. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol Cell Biol. 2002;22:2283\u201393.","journal-title":"Mol Cell Biol"},{"key":"754_CR2","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/S1097-2765(02)00706-2","volume":"10","author":"LW Ellisen","year":"2002","unstructured":"Ellisen LW, Ramsayer KD, Johannessen CM, Yang A, Beppu H, Minda K, et al. REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Mol Cell. 2002;10:995\u20131005.","journal-title":"Mol Cell"},{"key":"754_CR3","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1101\/gad.1617608","volume":"22","author":"MP DeYoung","year":"2008","unstructured":"DeYoung MP, Horak P, Sofer A, Sgroi D, Ellisen LW. Hypoxia regulates TSC1\/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev. 2008;22:239\u201351.","journal-title":"Genes Dev"},{"key":"754_CR4","doi-asserted-by":"publisher","first-page":"4675","DOI":"10.1073\/pnas.0907705107","volume":"107","author":"P Horak","year":"2010","unstructured":"Horak P, Crawford AR, Vadysirisack DD, Nash ZM, DeYoung MP, Sgroi D, Ellisen LW. Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis. Proc Natl Acad Sci U S A. 2010;107:4675\u201380.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"754_CR5","doi-asserted-by":"publisher","first-page":"208","DOI":"10.4161\/auto.22801","volume":"9","author":"Y Cheng","year":"2013","unstructured":"Cheng Y, Ren X, Zhang Y, Shan Y, Huber-Keener KJ, Zhang L, et al. Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells. Autophagy. 2013;9:208\u201319.","journal-title":"Autophagy"},{"key":"754_CR6","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.4161\/cc.20683","volume":"11","author":"M Kolesnichenko","year":"2012","unstructured":"Kolesnichenko M, Hong L, Liao R, Vogt PK, Sun P. Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence. Cell Cycle. 2012;11:2391\u2013401.","journal-title":"Cell Cycle"},{"key":"754_CR7","doi-asserted-by":"publisher","first-page":"780","DOI":"10.4161\/cc.8.5.7887","volume":"8","author":"B Chang","year":"2009","unstructured":"Chang B, Liu G, Yang G, Mercado-Uribe I, Huang M, Liu J. REDD1 is required for RAS-mediated transformation of human ovarian epithelial cells. Cell Cycle. 2009;8:780\u20136.","journal-title":"Cell Cycle"},{"key":"754_CR8","first-page":"15","volume-title":"WHO Classification of tumours of female reproductive organs","author":"JD Seidmam","year":"2014","unstructured":"Seidmam JD, Bell DA, Crum CP, et al. Tumours of ovary. In: Kurman RJ, Carcangiu ML, Herrington CS, Young RH, editors. WHO Classification of tumours of female reproductive organs. 4th ed. Lyon Cedex: International Agency for Research on Cancer (IARC); 2014. p. 15\u201333.","edition":"4"},{"key":"754_CR9","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/modpathol.2009.35","volume":"22","author":"B Chang","year":"2009","unstructured":"Chang B, Liu G, Xue F, Rosen DG, Xiao L, Wang X, Liu J. ALDH1 expression correlates with favorable prognosis in ovarian cancers. Mod Pathol. 2009;22:817\u201323.","journal-title":"Mod Pathol"},{"key":"754_CR10","first-page":"5940","volume":"7","author":"W Jia","year":"2014","unstructured":"Jia W, Chang B, Sun L, Zhu H, Pang L, Tao L, et al. REDD1 and p-AKT over-expression may predict poor prognosis in ovarian cancer. Int J Clin Exp Pathol. 2014;7:5940\u20139.","journal-title":"Int J Clin Exp Pathol"},{"key":"754_CR11","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1242\/jcs.136432","volume":"127","author":"G Michel","year":"2014","unstructured":"Michel G, Matthes HW, Hachet-Haas M, El Baghdadi K, de Mey J, Pepperkok R, et al. Plasma membrane translocation of REDD1 governed by GPCRs contributes to mTORC1 activation. J Cell Sci. 2014;127:773\u201387.","journal-title":"J Cell Sci"},{"key":"754_CR12","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.4161\/cc.4.11.2139","volume":"4","author":"LW Ellisen","year":"2005","unstructured":"Ellisen LW. Growth control under stress: mTOR regulation through the REDD1-TSC pathway. Cell Cycle. 2005;4:1500\u20132.","journal-title":"Cell Cycle"},{"key":"754_CR13","doi-asserted-by":"publisher","first-page":"5834","DOI":"10.1128\/MCB.25.14.5834-5845.2005","volume":"25","author":"A Sofer","year":"2005","unstructured":"Sofer A, Lei K, Johannessen CM, Ellisen LW. Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol. 2005;25:5834\u201345.","journal-title":"Mol Cell Biol"},{"key":"754_CR14","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1101\/gad.1256804","volume":"18","author":"J Brugarolas","year":"2004","unstructured":"Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E, et al. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1\/TSC2 tumor suppressor complex. Genes Dev. 2004;18:2893\u2013904.","journal-title":"Genes Dev"},{"key":"754_CR15","doi-asserted-by":"publisher","first-page":"9769","DOI":"10.1074\/jbc.C400557200","volume":"280","author":"MN Corradetti","year":"2005","unstructured":"Corradetti MN, Inoki K, Guan KL. The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. J Biol Chem. 2005;280:9769\u201372.","journal-title":"J Biol Chem"},{"key":"754_CR16","doi-asserted-by":"publisher","first-page":"3465","DOI":"10.1074\/jbc.M706643200","volume":"283","author":"SR Kimball","year":"2008","unstructured":"Kimball SR, Do AN, Kutzler L, Cavener DR, Jefferson LS. Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis. J Biol Chem. 2008;283:3465\u201375.","journal-title":"J Biol Chem"},{"key":"754_CR17","doi-asserted-by":"publisher","first-page":"017","DOI":"10.1186\/s12964-017-0182-1","volume":"15","author":"S Lecomte","year":"2017","unstructured":"Lecomte S, Chalmel F, Ferriere F, Percevault F, Plu N, Saligaut C, et al. Glyceollins trigger anti-proliferative effects through estradiol-dependent and independent pathways in breast cancer cells. Cell Commun Signal. 2017;15:017\u20130182.","journal-title":"Cell Commun Signal"},{"key":"754_CR18","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1158\/1541-7786.MCR-11-0302","volume":"9","author":"B Kucejova","year":"2011","unstructured":"Kucejova B, Pena-Llopis S, Yamasaki T, Sivanand S, Tran TA, Alexander S, et al. Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma. Mol Cancer Res. 2011;9:1255\u201365.","journal-title":"Mol Cancer Res"},{"key":"754_CR19","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.canlet.2013.03.021","volume":"336","author":"HO Jin","year":"2013","unstructured":"Jin HO, Hong SE, Kim JH, Choi HN, Kim K, An S, et al. Sustained overexpression of Redd1 leads to Akt activation involved in cell survival. Cancer Lett. 2013;336:319\u201324.","journal-title":"Cancer Lett"},{"issue":"2","key":"754_CR20","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1158\/1078-0432.CCR-17-0419","volume":"24","author":"Q Zeng","year":"2018","unstructured":"Zeng Q, Liu J, Cao P, Li J, Liu X, Fan X, et al. Inhibition of REDD1 sensitizes bladder urothelial carcinoma to paclitaxel by inhibiting autophagy. Clin Cancer Res. 2018;24(2):445\u201359.","journal-title":"Clin Cancer Res"},{"key":"754_CR21","first-page":"1478","volume":"25","author":"MM Cao","year":"2005","unstructured":"Cao MM, Zhang JR, Wang SM, Hu XG, Hu LJ. Expression of DNA transcription- and repair-related genes in cisplatin-resistant human ovarian carcinoma cell line. J First Mil Med Univ. 2005;25:1478\u201381.","journal-title":"J First Mil Med Univ"}],"container-title":["Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13000-018-0754-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13000-018-0754-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13000-018-0754-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T19:10:00Z","timestamp":1573672200000},"score":1,"resource":{"primary":{"URL":"https:\/\/diagnosticpathology.biomedcentral.com\/articles\/10.1186\/s13000-018-0754-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,14]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["754"],"URL":"https:\/\/doi.org\/10.1186\/s13000-018-0754-4","relation":{},"ISSN":["1746-1596"],"issn-type":[{"value":"1746-1596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,14]]},"assertion":[{"value":"26 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Consent to participate was not required because this was a retrospective study of formalin-fixed, paraffin-embedded tissues obtained after pathological diagnosis. All samples were anonymized before initiating the study. The retrospective study protocol was reviewed and approved by the Institutional Review Board of Fudan University Shanghai Cancer Center with the condition of anonymization (050432\u20134-1212B). The Institutional Review Board approved the use of tissue blocks and chart reviews.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"87"}}