{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:20:18Z","timestamp":1787498418711,"version":"build-2736575974"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diagn Pathol"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13000-019-0779-3","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T12:02:26Z","timestamp":1547553746000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Mediastinal follicular dendritic cell sarcoma: a rare, potentially under-recognized, and often misdiagnosed disease"],"prefix":"10.1186","volume":"14","author":[{"given":"You-Li","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Ping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Chu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5564-4394","authenticated-orcid":false,"given":"Guang-Jie","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"key":"779_CR1","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.critrevonc.2013.05.006","volume":"88","author":"C Saygin","year":"2013","unstructured":"Saygin C, Uzunaslan D, Ozguroglu M, Senocak M, Tuzuner N. Dendritic cell sarcoma: a pooled analysis including 462 cases with presentation of our case series. Crit Rev Oncol Hematol. 2013;88:253\u201371.","journal-title":"Crit Rev Oncol Hematol"},{"key":"779_CR2","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1309\/AJCP7U8YISBUAVNW","volume":"133","author":"GJ Duan","year":"2010","unstructured":"Duan GJ, Wu F, Zhu J, et al. Extranodal follicular dendritic cell sarcoma of the pharyngeal region: a potential diagnostic pitfall, with literature review. Am J Clin Pathol. 2010;133:49\u201358.","journal-title":"Am J Clin Pathol"},{"key":"779_CR3","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1097\/00000478-199608000-00003","volume":"20","author":"B Perez-Ordonez","year":"1996","unstructured":"Perez-Ordonez B, Erlandson RA, Rosai J. Follicular dendritic cell tumor: report of 13 additional cases of a distinctive entity. Am J Surg Pathol. 1996;20:944\u201355.","journal-title":"Am J Surg Pathol"},{"key":"779_CR4","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1002\/(SICI)1097-0142(19970115)79:2<294::AID-CNCR13>3.0.CO;2-W","volume":"79","author":"JK Chan","year":"1997","unstructured":"Chan JK, Fletcher CD, Nayler SJ, Cooper K. Follicular dendritic cell sarcoma. Clinicopathologic analysis of 17 cases suggesting a malignant potential higher than currently recognized. Cancer. 1997;79:294\u2013313.","journal-title":"Cancer"},{"key":"779_CR5","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1053\/adpa.2001.29345","volume":"5","author":"A Fassina","year":"2001","unstructured":"Fassina A, Marino F, Poletti A, Rea F, Pennelli N, Ninfo V. Follicular dendritic cell tumor of the mediastinum. Ann Diagn Pathol. 2001;5:361\u20137.","journal-title":"Ann Diagn Pathol"},{"key":"779_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1046\/j.1365-2559.2002.01418.x","volume":"41","author":"SA Pileri","year":"2002","unstructured":"Pileri SA, Grogan TM, Harris NL, et al. Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the international lymphoma study group based on 61 cases. Histopathology. 2002;41:1\u201329.","journal-title":"Histopathology"},{"key":"779_CR7","first-page":"ECR04","volume":"88","author":"GL Ceresoli","year":"2003","unstructured":"Ceresoli GL, Zucchinelli P, Ponzoni M, Gregorc V, Bencardino K, Paties CT. Mediastinal follicular dendritic cell sarcoma. Haematologica. 2003;88:ECR04.","journal-title":"Haematologica"},{"key":"779_CR8","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.humpath.2003.09.008","volume":"35","author":"SM Kr\u00f6ber","year":"2004","unstructured":"Kr\u00f6ber SM, Marx A, Aebert H, Dohmen BM, Kaiserling E. Sarcoma of follicular dendritic cells in the dorsal mediastinum. Hum Pathol. 2004;35:259\u201363.","journal-title":"Hum Pathol"},{"key":"779_CR9","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1007\/s00428-005-0143-8","volume":"448","author":"C Guettier","year":"2006","unstructured":"Guettier C, Validire P, Emilie D, et al. Follicular dendritic cell tumor of the mediastinum: expression of fractalkine and SDF-1alpha as mast cell chemoattractants. Virchows Arch. 2006;448:218\u201322.","journal-title":"Virchows Arch"},{"key":"779_CR10","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.anndiagpath.2005.11.005","volume":"10","author":"L Jiang","year":"2006","unstructured":"Jiang L, Admirand JH, Moran C, Ford RJ, Bueso-Ramos CE. Mediastinal follicular dendritic cell sarcoma involving bone marrow: a case report and review of the literature. Ann Diagn Pathol. 2006;10:357\u201362.","journal-title":"Ann Diagn Pathol"},{"key":"779_CR11","doi-asserted-by":"publisher","first-page":"W554","DOI":"10.2214\/AJR.04.1530","volume":"188","author":"JA Leipsic","year":"2007","unstructured":"Leipsic JA, McAdams HP, Sporn TA. Follicular dendritic cell sarcoma of the mediastinum. AJR Am J Roentgenol. 2007;188:W554\u20136.","journal-title":"AJR Am J Roentgenol"},{"key":"779_CR12","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1002\/ajh.20852","volume":"82","author":"AO Soriano","year":"2007","unstructured":"Soriano AO, Thompson MA, Admirand JH, et al. Follicular dendritic cell sarcoma: a report of 14 cases and a review of the literature. Am J Hematol. 2007;82:725\u20138.","journal-title":"Am J Hematol"},{"key":"779_CR13","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1111\/j.1365-4632.2008.03444.x","volume":"47","author":"M Meijs","year":"2008","unstructured":"Meijs M, Mekkes J, van Noesel C, et al. Paraneoplastic pemphigus associated with follicular dendritic cell sarcoma without Castleman's disease; treatment with rituximab. Int J Dermatol. 2008;47:632\u20134.","journal-title":"Int J Dermatol"},{"key":"779_CR14","first-page":"77","volume":"3","author":"M Dakak","year":"2009","unstructured":"Dakak M, Y\u00fccel O, Genc O, Cicek AF, Guler A. Follicular dendritic cell sarcoma of mediastinum (case report). Anatol J Clin Investig. 2009;3:77\u20139.","journal-title":"Anatol J Clin Investig"},{"key":"779_CR15","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1097\/PAS.0b013e3181d7a2ee","volume":"34","author":"M Hartert","year":"2010","unstructured":"Hartert M, Str\u00f6bel P, Dahm M, Nix W, Marx A, Vahl CF. A follicular dendritic cell sarcoma of the mediastinum with immature T cells and association with myasthenia gravis. Am J Surg Pathol. 2010;34:742\u20135.","journal-title":"Am J Surg Pathol"},{"key":"779_CR16","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.3748\/wjg.v16.i20.2504","volume":"16","author":"L Li","year":"2010","unstructured":"Li L, Shi YH, Guo ZJ, et al. Clinicopathological features and prognosis assessment of extranodal follicular dendritic cell sarcoma. World J Gastroenterol. 2010;16:2504\u201319.","journal-title":"World J Gastroenterol"},{"key":"779_CR17","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1590\/S1806-37132010000600020","volume":"36","author":"FL Westphal","year":"2010","unstructured":"Westphal FL, Lima LC, Santana LC, Netto JC, Amaral VC, Silva Mdos S. Castleman's disease associated with follicular dendritic cell sarcoma and myasthenia gravis. J Bras Pneumol. 2010;36:819\u201323.","journal-title":"J Bras Pneumol"},{"key":"779_CR18","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3348\/kjr.2011.12.1.122","volume":"12","author":"Q Long-Hua","year":"2011","unstructured":"Long-Hua Q, Qin X, Ya-Jia G, Jian W, Xiao-Yuan F. Imaging findings of follicular dendritic cell sarcoma: report of four cases. Korean J Radiol. 2011;12:122\u20138.","journal-title":"Korean J Radiol"},{"key":"779_CR19","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1097\/RLU.0b013e31823ea1a5","volume":"37","author":"M Subesinghe","year":"2012","unstructured":"Subesinghe M, Smith JT, Chowdhury FU. F-18 FDG PET\/CT imaging of follicular dendritic cell sarcoma of the mediastinum. Clin Nucl Med. 2012;37:204\u20135.","journal-title":"Clin Nucl Med"},{"key":"779_CR20","first-page":"1","volume":"2","author":"S Sanna","year":"2013","unstructured":"Sanna S, Monteverde M, Taurchini M, Grossi W, Dubini A, Dell\u2019Amore D. Multimodal treatment of mediastinal follicular dendritic cell sarcoma: a case report successfully treated. World J Surg Med Radiat Oncol. 2013;2:1\u20135.","journal-title":"World J Surg Med Radiat Oncol"},{"key":"779_CR21","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/j.1759-7714.2012.00143.x","volume":"4","author":"H Kim","year":"2013","unstructured":"Kim H, Park CM, Jeon YK, Paeng JC, Goo JM, Lee HJ. Follicular dendritic cell sarcoma of the mediastinum: CT and 18F-fluoro-2-deoxyglucose PET findings. Thorac Cancer. 2013;4:203\u20136.","journal-title":"Thorac Cancer"},{"key":"779_CR22","doi-asserted-by":"publisher","first-page":"e101","DOI":"10.1016\/j.athoracsur.2013.11.081","volume":"97","author":"BE Lee","year":"2014","unstructured":"Lee BE, Korst RJ, Taskin M. Right pneumonectomy for resection of a posterior mediastinal follicular dendritic cell sarcoma arising from Castleman's disease. Ann Thorac Surg. 2014;97:e101\u20133.","journal-title":"Ann Thorac Surg"},{"key":"779_CR23","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1007\/s13193-014-0349-9","volume":"5","author":"K Bushan","year":"2014","unstructured":"Bushan K. Follicular dendritic cell sarcoma mediastinum - a case report. Indian J Surg Oncol. 2014;5:290\u20132.","journal-title":"Indian J Surg Oncol"},{"key":"779_CR24","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1177\/0218492314561501","volume":"23","author":"SC Chow","year":"2015","unstructured":"Chow SC, Yeung EC, Ng CS, Wong RH, Fai To K, Wan IY. Mediastinal follicular dendritic cell sarcoma with paraneoplastic pemphigus. Asian Cardiovasc Thorac Ann. 2015;23:732\u20134.","journal-title":"Asian Cardiovasc Thorac Ann"},{"key":"779_CR25","doi-asserted-by":"publisher","first-page":"57","DOI":"10.2217\/fon.15.315","volume":"11","author":"C Spatola","year":"2015","unstructured":"Spatola C, Migliore M, Emanuele Liardo RL, et al. Follicular dendritic cell sarcoma of mediastinum: a key role of radiotherapy in a multidisciplinary approach. Future Oncol. 2015;11:57\u201361.","journal-title":"Future Oncol"},{"key":"779_CR26","first-page":"1","volume":"2","author":"AM Prakasan","year":"2016","unstructured":"Prakasan AM, Prabhu AJ, Velarasan K, Backianathan S, Ram TS. Paraneoplastic pemphigus associated with follicular dendritic cell tumor in the mediastinum. Case Rep Dermatol Med. 2016;2:1\u20134.","journal-title":"Case Rep Dermatol Med"},{"key":"779_CR27","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s13019-016-0464-5","volume":"11","author":"J Hu","year":"2016","unstructured":"Hu J, Dong D, Jiang Z, Hu H. Clinicopathological characteristics of mediastinal follicular dendritic cell sarcoma: report of three cases. J Cardiothorac Surg. 2016;11:56.","journal-title":"J Cardiothorac Surg"},{"key":"779_CR28","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1111\/his.12998","volume":"69","author":"P Viola","year":"2016","unstructured":"Viola P, Vroobel KM, Devaraj A, et al. Follicular dendritic cell tumour\/sarcoma: a commonly misdiagnosed tumour in the thorax. Histopathology. 2016;69:752\u201361.","journal-title":"Histopathology"},{"key":"779_CR29","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s40792-016-0155-4","volume":"2","author":"R Miyoshi","year":"2016","unstructured":"Miyoshi R, Sonobe M, Miyamoto E, Date H. Completely resected follicular dendritic cell sarcoma of the posterior mediastinum: report of a case. Surg Case Rep. 2016;2:28.","journal-title":"Surg Case Rep"},{"key":"779_CR30","doi-asserted-by":"publisher","unstructured":"Cingam SR, Al Shaarani M, Takalkar A, Peddi P. Follicular dendritic sarcoma masquerading as fibrosing mediastinitis. BMJ Case Rep. 2017. \n                    https:\/\/doi.org\/10.1136\/bcr-2016-218889\n                    \n                  .","DOI":"10.1136\/bcr-2016-218889"},{"key":"779_CR31","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1002\/hon.2275","volume":"35","author":"S Purkait","year":"2017","unstructured":"Purkait S, Mallick S, Joshi PP, et al. Retroperitoneal and mediastinal follicular dendritic cell sarcoma: report of 3 cases with review of literature. Hematol Oncol. 2017;35:374\u20139.","journal-title":"Hematol Oncol"},{"key":"779_CR32","doi-asserted-by":"publisher","first-page":"16463","DOI":"10.18632\/oncotarget.14864","volume":"8","author":"L Lorenzi","year":"2017","unstructured":"Lorenzi L, D\u00f6ring C, Rausch T, et al. Identification of novel follicular dendritic cell sarcoma markers, FDCSP and SRGN, by whole transcriptome sequencing. Oncotarget. 2017;8:16463\u201372.","journal-title":"Oncotarget"},{"key":"779_CR33","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1097\/00000478-200106000-00003","volume":"25","author":"W Cheuk","year":"2001","unstructured":"Cheuk W, Chan JK, Shek TW, et al. Inflammatory pseudotumor-like follicular dendritic cell tumor: a distinctive low-grade malignant intra-abdominal neoplasm with consistent Epstein-Barr virus association. Am J Surg Pathol. 2001;25:721\u201331.","journal-title":"Am J Surg Pathol"},{"key":"779_CR34","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s13000-017-0625-4","volume":"12","author":"GJ Duan","year":"2017","unstructured":"Duan GJ, Wu YL, Sun H, Lang L, Chen ZW, Yan XC. Primary follicular dendritic cell sarcoma of the urinary bladder: the first case report and potential diagnostic pitfalls. Diagn Pathol. 2017;12:35.","journal-title":"Diagn Pathol"},{"key":"779_CR35","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/s00428-017-2176-1","volume":"471","author":"F Facchetti","year":"2017","unstructured":"Facchetti F, Pileri SA, Lorenzi L, et al. Histiocytic and dendritic cell neoplasms: what have we learnt by studying 67 cases. Virchows Arch. 2017;471:467\u201389.","journal-title":"Virchows Arch"},{"key":"779_CR36","doi-asserted-by":"publisher","first-page":"E2241","DOI":"10.1002\/hed.24115","volume":"38","author":"J Pang","year":"2016","unstructured":"Pang J, Mydlarz WK, Gooi Z, et al. Follicular dendritic cell sarcoma of the head and neck: case report, literature review, and pooled analysis of 97 cases. Head Neck. 2016;38:E2241\u20139.","journal-title":"Head Neck"},{"key":"779_CR37","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1002\/ajh.24603","volume":"92","author":"P Jain","year":"2017","unstructured":"Jain P, Prieto VG, Manning JT, Fowler N, Medeiros LJ, Kanagal-Shamanna R. Synchronous presentation of intra-nodal follicular dendritic cell sarcoma and Castleman disease. Am J Hematol. 2017;92:478\u20139.","journal-title":"Am J Hematol"},{"key":"779_CR38","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1046\/j.1365-2559.2001.01134.x","volume":"38","author":"AC Chan","year":"2001","unstructured":"Chan AC, Chan KW, Chan JK, Au WY, Ho WK, Ng WM. Development of follicular dendritic cell sarcoma in hyaline-vascular Castleman\u2019s disease of the nasopharynx: tracing its evolution by sequential biopsies. Histopathology. 2001;38:510\u20138.","journal-title":"Histopathology"},{"key":"779_CR39","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1111\/his.12851","volume":"68","author":"Y Chen","year":"2016","unstructured":"Chen Y, Shi H, Li H, Zhen T, Han A. Clinicopathological features of inflammatory pseudotumour-like follicular dendritic cell tumour of the abdomen. Histopathology. 2016;68:858\u201365.","journal-title":"Histopathology"},{"key":"779_CR40","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/his.12416","volume":"65","author":"H Go","year":"2014","unstructured":"Go H, Jeon YK, Huh J, et al. Frequent detection of BRAF (V600E) mutations in histiocytic and dendritic cell neoplasms. Histopathology. 2014;65:261\u201372.","journal-title":"Histopathology"},{"key":"779_CR41","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/modpathol.2015.130","volume":"29","author":"GK Griffin","year":"2016","unstructured":"Griffin GK, Sholl LM, Lindeman NI, Fletcher CD, Hornick JL. Targeted genomic sequencing of follicular dendritic cell sarcoma reveals recurrent alterations in NF-\u03baB regulatory genes. Mod Pathol. 2016;29:67\u201374.","journal-title":"Mod Pathol"},{"key":"779_CR42","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.ejca.2016.06.004","volume":"64","author":"S Hartmann","year":"2016","unstructured":"Hartmann S, Doring C, Agostinelli C, et al. miRNA expression profiling divides follicular dendritic cell sarcomas into two groups, related to fibroblasts and myopericytomas or Castleman\u2019s disease. Eur J Cancer. 2016;64:159\u201366.","journal-title":"Eur J Cancer"},{"key":"779_CR43","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1158\/1541-7786.MCR-16-0301","volume":"15","author":"MA Laginestra","year":"2017","unstructured":"Laginestra MA, Tripodo C, Agostinelli C, et al. Distinctive histogenesis and immunological microenvironment based on transcriptional profiles of follicular dendritic cell sarcomas. Mol Cancer Res. 2017;15:541\u20132.","journal-title":"Mol Cancer Res"}],"container-title":["Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13000-019-0779-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13000-019-0779-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13000-019-0779-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T09:19:19Z","timestamp":1580721559000},"score":1,"resource":{"primary":{"URL":"https:\/\/diagnosticpathology.biomedcentral.com\/articles\/10.1186\/s13000-019-0779-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,15]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["779"],"URL":"https:\/\/doi.org\/10.1186\/s13000-019-0779-3","relation":{},"ISSN":["1746-1596"],"issn-type":[{"value":"1746-1596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,15]]},"assertion":[{"value":"22 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by the Ethics Committee of Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China (No. KY201818). Written informed consent was obtained from the patients for the storage of samples and data, follow-up contact, and further use of samples and data for research purposes.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"5"}}