{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:34:20Z","timestamp":1740144860247,"version":"3.37.3"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007533","name":"Kobayashi Foundation for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007533","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diagn Pathol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ductal carcinoma of the prostate is a histological subtype with a higher mortality than acinar adenocarcinoma. The number of cases is small and there are no treatment guidelines. We believe that this is the first report of ductal carcinoma of the prostate with an adenomatosis polyposis coli (<jats:italic>APC<\/jats:italic>) gene mutation in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>An 85-year-old man presented with gross hematuria, and a papillary tumor in the prostatic urethra that was diagnosed as ductal carcinoma of the prostate following transurethral resection. Genetic analysis found an APC mutation with loss of heterozygosity. Immunostaining revealed focal nuclear translocation of \u03b2-catenin. APC mutations associated with loss of \u03b2-catenin degradation in the Wnt signaling pathway and result in over accumulation of \u03b2-catenin are thought to increase mortality. In this patient, \u03b2-catenin migrated into tumor cell nuclei.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To the best of our knowledge, this is the first report of ductal carcinoma of the prostate with an APC mutation in Japan. The development of a therapeutic Wnt inhibitor is discussed.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13000-020-01016-9","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:02:41Z","timestamp":1596672161000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Japanese patient with ductal carcinoma of the prostate carrying an adenomatosis polyposis coli gene mutation: a case report"],"prefix":"10.1186","volume":"15","author":[{"given":"Kota","family":"Umeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4371-4594","authenticated-orcid":false,"given":"Takeo","family":"Kosaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshikazu","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Mikami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nishihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mototsugu","family":"Oya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"1016_CR1","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1002\/1097-0142(196710)20:10<1715::AID-CNCR2820201022>3.0.CO;2-E","volume":"20","author":"MM Melicow","year":"1967","unstructured":"Melicow MM, Pachter MR. Endometrial carcinoma of proxtatic utricle (uterus masculinus). Cancer. 1967;20:1715\u201322.","journal-title":"Cancer."},{"key":"1016_CR2","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1111\/j.1464-410X.2011.10520.x","volume":"109","author":"JJ Meeks","year":"2012","unstructured":"Meeks JJ, Zhao LC, Cashy J, et al. Incidence and outcomes of ductal carcinoma of the prostate in the USA: analysis of data from the surveillance, epidemiology, and end results program. BJU Int. 2012;109:831\u20134.","journal-title":"BJU Int"},{"issue":"8","key":"1016_CR3","doi-asserted-by":"publisher","first-page":"djw332","DOI":"10.1093\/jnci\/djw332","volume":"109","author":"L Zhang","year":"2017","unstructured":"Zhang L, Shay JW. Multiple roles of APC and its therapeutic implications in colorectal cancer. J Natl Cancer Inst. 2017;109(8):djw332.","journal-title":"J Natl Cancer Inst"},{"key":"1016_CR4","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1126\/science.1651563","volume":"253","author":"I Nishisho","year":"1991","unstructured":"Nishisho I, Nakamura Y, Miyoshi Y, et al. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science. 1991;253:665\u20139.","journal-title":"Science."},{"key":"1016_CR5","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.3390\/ijms20092066","volume":"20","author":"N Khurana","year":"2019","unstructured":"Khurana N, Sikka SC. Interplay between SOX9, Wnt\/\u03b2-catenin and androgen receptor signaling in castration-resistant prostate cancer. Int J Mol Sci. 2019;20:2066.","journal-title":"Int J Mol Sci"},{"key":"1016_CR6","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.tcb.2009.01.003","volume":"19","author":"A Kikuchi","year":"2009","unstructured":"Kikuchi A, Yamamoto H, Sato A. Selective activation mechanisms of Wnt signaling pathways. Trends Cell Biol. 2009;19:119\u201329.","journal-title":"Trends Cell Biol"},{"key":"1016_CR7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1200\/PO.17.00029","volume":"1","author":"W Abida","year":"2017","unstructured":"Abida W, Armenia J, Gopalan A, et al. Prospective genomic profiling of prostate cancer across disease states reveals germline and somatic alterations that may affect clinical decision making. JCO Precis Oncol. 2017;1:1.","journal-title":"JCO Precis Oncol"},{"key":"1016_CR8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1200\/PO.18.00327","volume":"3","author":"MT Schweizer","year":"2019","unstructured":"Schweizer MT, Antonarakis ES, Bismar TA, et al. Genomic characterization of prostatic ductal adenocarcinoma identifies a high prevalence of DNA repair gene mutations. JCO Precis Oncol. 2019;3:1.","journal-title":"JCO Precis Oncol"},{"issue":"11","key":"1016_CR9","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/nrurol.2017.144","volume":"14","author":"V Murillo-Garzon","year":"2017","unstructured":"Murillo-Garzon V, Kypta R. WNT signaling in prostate cancer. Nat Rev Urol. 2017;14(11):683\u201396.","journal-title":"Nat Rev Urol"}],"container-title":["Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13000-020-01016-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13000-020-01016-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13000-020-01016-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T10:56:10Z","timestamp":1723373770000},"score":1,"resource":{"primary":{"URL":"https:\/\/diagnosticpathology.biomedcentral.com\/articles\/10.1186\/s13000-020-01016-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,6]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1016"],"URL":"https:\/\/doi.org\/10.1186\/s13000-020-01016-9","relation":{},"ISSN":["1746-1596"],"issn-type":[{"type":"electronic","value":"1746-1596"}],"subject":[],"published":{"date-parts":[[2020,8,6]]},"assertion":[{"value":"16 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Ethics Committee of Keio University Hospital (Approval number 20180015).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"102"}}